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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3R6
Full Name:
Phosphoinositide 3-kinase regulatory subunit 6
Alias:
C17orf38; FLJ34500; HsT41028; P87 PI3K adapter protein; P87PIKAP; Phosphoinositide 3-kinase gamma adapter protein of 87 kDa; Phosphoinositide 3-kinase regulatory 6; Phosphoinositide-3-kinase, regulatory subunit 6; PI3R6
Type:
Mass (Da):
84260
Number AA:
UniProt ID:
Q5UE93
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
V
E
L
D
L
Q
R
S
V
Q
A
V
L
R
E
Site 2
S22
Q
A
V
L
R
E
L
S
T
Q
A
P
A
L
Q
Site 3
T23
A
V
L
R
E
L
S
T
Q
A
P
A
L
Q
S
Site 4
S38
N
Q
G
M
W
R
W
S
L
H
K
K
V
E
R
Site 5
S50
V
E
R
D
P
G
K
S
P
V
L
V
R
I
L
Site 6
S66
R
E
L
E
K
A
E
S
Q
D
L
R
H
V
I
Site 7
Y95
T
G
I
T
E
E
L
Y
Q
R
I
Y
A
F
C
Site 8
Y99
E
E
L
Y
Q
R
I
Y
A
F
C
T
R
L
L
Site 9
T145
V
I
A
E
Q
N
L
T
N
E
L
Y
P
Y
Q
Site 10
Y149
Q
N
L
T
N
E
L
Y
P
Y
Q
E
R
V
F
Site 11
Y151
L
T
N
E
L
Y
P
Y
Q
E
R
V
F
L
F
Site 12
T184
E
A
A
Q
A
Q
Q
T
P
E
T
C
M
R
H
Site 13
S217
L
H
R
K
L
Q
A
S
P
R
R
T
L
E
H
Site 14
T221
L
Q
A
S
P
R
R
T
L
E
H
Y
F
H
A
Site 15
Y225
P
R
R
T
L
E
H
Y
F
H
A
V
V
A
A
Site 16
S238
A
A
L
E
Q
M
A
S
E
A
S
P
S
R
E
Site 17
S241
E
Q
M
A
S
E
A
S
P
S
R
E
G
H
V
Site 18
S243
M
A
S
E
A
S
P
S
R
E
G
H
V
E
R
Site 19
Y255
V
E
R
L
E
E
I
Y
C
S
L
L
G
P
A
Site 20
S277
L
V
Q
E
R
P
P
S
I
P
L
P
S
P
Y
Site 21
T286
P
L
P
S
P
Y
I
T
F
H
L
W
T
G
E
Site 22
S308
V
L
F
L
R
P
R
S
Q
L
R
L
S
A
D
Site 23
S313
P
R
S
Q
L
R
L
S
A
D
L
E
V
L
D
Site 24
S334
D
R
E
L
A
R
V
S
V
L
S
T
D
S
G
Site 25
S337
L
A
R
V
S
V
L
S
T
D
S
G
I
E
R
Site 26
T338
A
R
V
S
V
L
S
T
D
S
G
I
E
R
D
Site 27
S340
V
S
V
L
S
T
D
S
G
I
E
R
D
L
P
Site 28
T348
G
I
E
R
D
L
P
T
G
A
D
E
L
P
A
Site 29
S358
D
E
L
P
A
P
G
S
P
E
M
E
R
A
G
Site 30
T397
P
P
G
L
H
R
R
T
G
R
P
S
G
D
G
Site 31
S401
H
R
R
T
G
R
P
S
G
D
G
E
M
L
P
Site 32
Y434
L
G
R
L
A
Q
A
Y
H
R
L
R
K
R
E
Site 33
T442
H
R
L
R
K
R
E
T
Q
K
F
C
L
T
P
Site 34
T448
E
T
Q
K
F
C
L
T
P
R
L
S
L
Q
L
Site 35
T479
P
E
L
G
E
L
A
T
F
L
G
R
V
D
P
Site 36
Y488
L
G
R
V
D
P
W
Y
Q
S
N
V
N
T
L
Site 37
S508
K
L
A
E
M
P
P
S
L
D
T
S
R
T
V
Site 38
T511
E
M
P
P
S
L
D
T
S
R
T
V
D
P
F
Site 39
S512
M
P
P
S
L
D
T
S
R
T
V
D
P
F
I
Site 40
T514
P
S
L
D
T
S
R
T
V
D
P
F
I
L
D
Site 41
Y535
R
M
G
T
Q
P
I
Y
F
Q
I
Y
T
V
K
Site 42
S549
K
I
F
F
S
D
L
S
Q
D
P
T
E
D
I
Site 43
T553
S
D
L
S
Q
D
P
T
E
D
I
F
L
I
E
Site 44
S568
L
K
V
K
I
Q
D
S
K
F
P
K
D
G
F
Site 45
S576
K
F
P
K
D
G
F
S
P
R
R
R
G
V
A
Site 46
S591
E
G
P
G
A
E
L
S
L
C
Y
Q
K
A
L
Site 47
S600
C
Y
Q
K
A
L
L
S
H
R
P
R
E
V
T
Site 48
T607
S
H
R
P
R
E
V
T
V
S
L
R
A
T
G
Site 49
S609
R
P
R
E
V
T
V
S
L
R
A
T
G
L
I
Site 50
T613
V
T
V
S
L
R
A
T
G
L
I
L
K
A
I
Site 51
T625
K
A
I
P
A
S
D
T
E
V
S
G
S
S
H
Site 52
S628
P
A
S
D
T
E
V
S
G
S
S
H
C
P
L
Site 53
S630
S
D
T
E
V
S
G
S
S
H
C
P
L
P
A
Site 54
S631
D
T
E
V
S
G
S
S
H
C
P
L
P
A
A
Site 55
S656
N
V
T
E
V
V
K
S
S
N
L
A
G
K
S
Site 56
S663
S
S
N
L
A
G
K
S
F
S
T
V
T
N
T
Site 57
S665
N
L
A
G
K
S
F
S
T
V
T
N
T
F
R
Site 58
T666
L
A
G
K
S
F
S
T
V
T
N
T
F
R
T
Site 59
T670
S
F
S
T
V
T
N
T
F
R
T
N
N
I
Q
Site 60
T687
S
R
D
Q
R
L
L
T
L
S
L
D
K
D
D
Site 61
S689
D
Q
R
L
L
T
L
S
L
D
K
D
D
Q
R
Site 62
T697
L
D
K
D
D
Q
R
T
F
R
D
V
V
R
F
Site 63
S714
A
P
C
P
E
P
C
S
G
A
Q
K
S
K
A
Site 64
S719
P
C
S
G
A
Q
K
S
K
A
P
W
L
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation