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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HECTD2
Full Name:
Probable E3 ubiquitin-protein ligase HECTD2
Alias:
E3 ubiquitin-protein ligase HECTD2; FLJ37306; HECD2; HECT domain containing 2; HECT domain-containing protein 2
Type:
Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.-
Mass (Da):
88104
Number AA:
776
UniProt ID:
Q5U5R9
International Prot ID:
IPI00291138
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0016881
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
E
A
V
R
V
P
S
P
A
T
P
L
V
V
Site 2
S29
E
E
R
K
G
K
E
S
E
R
E
K
L
P
P
Site 3
S57
R
G
A
K
G
Q
I
S
T
F
S
S
F
I
S
Site 4
S64
S
T
F
S
S
F
I
S
A
V
S
P
K
K
E
Site 5
S67
S
S
F
I
S
A
V
S
P
K
K
E
A
A
E
Site 6
S78
E
A
A
E
N
R
S
S
P
A
H
L
V
F
P
Site 7
T106
D
V
R
Q
K
Q
R
T
S
M
D
A
S
S
S
Site 8
S107
V
R
Q
K
Q
R
T
S
M
D
A
S
S
S
E
Site 9
S111
Q
R
T
S
M
D
A
S
S
S
E
M
K
A
P
Site 10
S112
R
T
S
M
D
A
S
S
S
E
M
K
A
P
V
Site 11
S113
T
S
M
D
A
S
S
S
E
M
K
A
P
V
L
Site 12
T131
I
L
P
I
Q
P
K
T
V
K
D
F
Q
E
D
Site 13
S144
E
D
V
E
K
V
K
S
S
G
D
W
K
A
V
Site 14
Y155
W
K
A
V
H
D
F
Y
L
T
T
F
D
S
F
Site 15
T157
A
V
H
D
F
Y
L
T
T
F
D
S
F
P
E
Site 16
T174
A
A
F
K
K
D
A
T
A
S
F
N
T
I
E
Site 17
S176
F
K
K
D
A
T
A
S
F
N
T
I
E
D
S
Site 18
S183
S
F
N
T
I
E
D
S
G
I
N
A
K
F
V
Site 19
T196
F
V
N
A
V
Y
D
T
L
L
N
T
P
Q
D
Site 20
T200
V
Y
D
T
L
L
N
T
P
Q
D
V
Q
K
T
Site 21
T207
T
P
Q
D
V
Q
K
T
V
L
K
G
I
I
N
Site 22
T225
R
E
W
K
G
P
R
T
K
D
D
L
R
A
Y
Site 23
Y232
T
K
D
D
L
R
A
Y
F
I
L
L
Q
N
P
Site 24
T259
H
L
L
R
Q
I
A
T
L
V
E
A
D
H
H
Site 25
Y337
V
H
P
P
L
I
P
Y
T
D
F
Y
N
S
T
Site 26
T338
H
P
P
L
I
P
Y
T
D
F
Y
N
S
T
L
Site 27
Y341
L
I
P
Y
T
D
F
Y
N
S
T
L
D
H
I
Site 28
S399
M
I
N
I
A
R
Q
S
L
V
D
K
V
S
R
Site 29
S405
Q
S
L
V
D
K
V
S
R
R
Q
R
P
D
M
Site 30
T424
L
N
M
K
V
R
R
T
H
L
V
S
D
S
L
Site 31
S428
V
R
R
T
H
L
V
S
D
S
L
D
E
L
T
Site 32
S430
R
T
H
L
V
S
D
S
L
D
E
L
T
R
K
Site 33
T435
S
D
S
L
D
E
L
T
R
K
R
A
D
L
K
Site 34
Y477
R
Q
I
F
H
P
D
Y
G
M
F
T
Y
H
K
Site 35
Y499
S
S
F
K
C
D
N
Y
S
E
F
R
L
V
G
Site 36
S567
P
E
L
A
H
G
L
S
E
L
L
S
H
E
G
Site 37
S571
H
G
L
S
E
L
L
S
H
E
G
N
V
E
E
Site 38
Y581
G
N
V
E
E
D
F
Y
S
T
F
Q
V
F
Q
Site 39
T583
V
E
E
D
F
Y
S
T
F
Q
V
F
Q
E
E
Site 40
S596
E
E
F
G
I
I
K
S
Y
N
L
K
P
G
G
Site 41
Y597
E
F
G
I
I
K
S
Y
N
L
K
P
G
G
D
Site 42
S607
K
P
G
G
D
K
I
S
V
T
N
Q
N
R
K
Site 43
T609
G
G
D
K
I
S
V
T
N
Q
N
R
K
E
Y
Site 44
Y616
T
N
Q
N
R
K
E
Y
V
Q
L
Y
T
D
F
Site 45
Y620
R
K
E
Y
V
Q
L
Y
T
D
F
L
L
N
K
Site 46
S628
T
D
F
L
L
N
K
S
I
Y
K
Q
F
A
A
Site 47
T676
M
H
A
L
Q
R
S
T
Q
Y
D
G
Y
A
K
Site 48
Y681
R
S
T
Q
Y
D
G
Y
A
K
T
D
L
T
I
Site 49
T711
K
K
L
L
H
F
T
T
G
S
D
R
V
P
V
Site 50
S729
A
D
L
N
F
K
I
S
K
N
E
T
S
T
N
Site 51
T733
F
K
I
S
K
N
E
T
S
T
N
C
L
P
V
Site 52
Y753
N
Q
L
C
L
P
P
Y
K
S
K
K
D
L
K
Site 53
S755
L
C
L
P
P
Y
K
S
K
K
D
L
K
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation