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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLJ23588
Full Name:
EF-hand calcium-binding domain-containing protein 6
Alias:
CAP-binding protein complex interacting protein 1; CAP-binding protein complex-interacting protein 1; DJ185D5.1; DJ-1-binding protein; DJBP; EFCB6; EF-hand calcium binding domain 6; HSCBCIP1; KIAA1672
Type:
Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Mass (Da):
172930
Number AA:
1501
UniProt ID:
Q5THR3
International Prot ID:
IPI00009724
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
I
I
P
D
W
L
R
S
H
P
H
T
R
K
F
Site 2
T17
W
L
R
S
H
P
H
T
R
K
F
T
H
S
R
Site 3
T21
H
P
H
T
R
K
F
T
H
S
R
P
H
S
S
Site 4
S23
H
T
R
K
F
T
H
S
R
P
H
S
S
P
C
Site 5
S27
F
T
H
S
R
P
H
S
S
P
C
R
V
Y
S
Site 6
S28
T
H
S
R
P
H
S
S
P
C
R
V
Y
S
R
Site 7
Y33
H
S
S
P
C
R
V
Y
S
R
N
G
S
P
N
Site 8
S34
S
S
P
C
R
V
Y
S
R
N
G
S
P
N
K
Site 9
S38
R
V
Y
S
R
N
G
S
P
N
K
F
R
S
S
Site 10
S44
G
S
P
N
K
F
R
S
S
S
T
T
A
V
A
Site 11
S45
S
P
N
K
F
R
S
S
S
T
T
A
V
A
N
Site 12
S46
P
N
K
F
R
S
S
S
T
T
A
V
A
N
P
Site 13
T48
K
F
R
S
S
S
T
T
A
V
A
N
P
T
L
Site 14
T69
R
I
L
F
Q
K
I
T
D
R
G
D
E
L
Q
Site 15
T89
L
D
T
G
Q
N
L
T
V
S
K
S
E
L
R
Site 16
S91
T
G
Q
N
L
T
V
S
K
S
E
L
R
R
I
Site 17
S93
Q
N
L
T
V
S
K
S
E
L
R
R
I
I
T
Site 18
T100
S
E
L
R
R
I
I
T
D
F
L
M
P
L
T
Site 19
T107
T
D
F
L
M
P
L
T
R
E
Q
F
Q
D
V
Site 20
Y141
R
F
G
G
I
D
L
Y
I
N
G
I
K
R
G
Site 21
T158
N
E
M
N
C
C
R
T
L
R
E
L
E
I
Q
Site 22
T203
E
L
R
R
V
L
E
T
F
C
M
K
L
R
D
Site 23
Y213
M
K
L
R
D
E
E
Y
E
K
F
S
K
H
Y
Site 24
Y230
H
K
D
T
A
V
D
Y
N
V
F
L
K
N
L
Site 25
S255
C
M
G
N
Q
E
V
S
L
E
N
Q
Q
A
K
Site 26
S272
K
K
E
R
L
L
G
S
A
S
S
E
D
I
W
Site 27
S274
E
R
L
L
G
S
A
S
S
E
D
I
W
R
N
Site 28
S275
R
L
L
G
S
A
S
S
E
D
I
W
R
N
Y
Site 29
Y282
S
E
D
I
W
R
N
Y
S
L
D
E
I
E
R
Site 30
S283
E
D
I
W
R
N
Y
S
L
D
E
I
E
R
N
Site 31
S296
R
N
F
C
L
Q
L
S
K
S
Y
E
K
V
E
Site 32
S298
F
C
L
Q
L
S
K
S
Y
E
K
V
E
K
A
Site 33
S307
E
K
V
E
K
A
L
S
A
G
D
P
C
K
G
Site 34
Y316
G
D
P
C
K
G
G
Y
V
S
F
N
Y
L
K
Site 35
T377
V
S
S
K
G
P
L
T
K
R
N
S
I
N
S
Site 36
S381
G
P
L
T
K
R
N
S
I
N
S
R
N
E
S
Site 37
S384
T
K
R
N
S
I
N
S
R
N
E
S
H
K
E
Site 38
S388
S
I
N
S
R
N
E
S
H
K
E
N
I
I
T
Site 39
T395
S
H
K
E
N
I
I
T
K
L
F
R
H
T
E
Site 40
T401
I
T
K
L
F
R
H
T
E
D
H
S
A
S
L
Site 41
S405
F
R
H
T
E
D
H
S
A
S
L
K
K
A
L
Site 42
S407
H
T
E
D
H
S
A
S
L
K
K
A
L
L
I
Site 43
T424
T
K
P
D
G
P
I
T
R
E
E
F
R
Y
I
Site 44
S440
N
C
M
A
V
K
L
S
D
S
E
F
K
E
L
Site 45
S442
M
A
V
K
L
S
D
S
E
F
K
E
L
M
Q
Site 46
T456
Q
M
L
D
P
G
D
T
G
V
V
N
T
S
M
Site 47
T477
E
N
C
R
M
R
K
T
S
P
C
T
D
A
K
Site 48
S478
N
C
R
M
R
K
T
S
P
C
T
D
A
K
T
Site 49
T481
M
R
K
T
S
P
C
T
D
A
K
T
P
F
L
Site 50
T485
S
P
C
T
D
A
K
T
P
F
L
L
A
W
D
Site 51
T501
V
E
E
I
V
H
D
T
I
T
R
N
L
Q
A
Site 52
T503
E
I
V
H
D
T
I
T
R
N
L
Q
A
F
Y
Site 53
Y510
T
R
N
L
Q
A
F
Y
N
M
L
R
S
Y
D
Site 54
S515
A
F
Y
N
M
L
R
S
Y
D
L
G
D
T
G
Site 55
Y516
F
Y
N
M
L
R
S
Y
D
L
G
D
T
G
R
Site 56
T521
R
S
Y
D
L
G
D
T
G
R
I
G
R
N
N
Site 57
S557
S
K
I
Q
D
I
G
S
G
R
I
L
Y
K
K
Site 58
S603
E
Q
Q
Q
P
D
L
S
E
R
T
K
L
T
E
Site 59
T613
T
K
L
T
E
D
K
T
T
L
T
K
K
M
T
Site 60
T614
K
L
T
E
D
K
T
T
L
T
K
K
M
T
T
Site 61
S647
K
K
R
F
L
D
F
S
K
E
P
N
G
K
I
Site 62
T666
F
K
K
V
L
E
D
T
G
M
P
M
D
D
D
Site 63
Y675
M
P
M
D
D
D
Q
Y
A
L
L
T
T
K
I
Site 64
S690
G
F
E
K
E
G
M
S
Y
L
D
F
A
A
G
Site 65
Y691
F
E
K
E
G
M
S
Y
L
D
F
A
A
G
F
Site 66
T708
P
P
M
R
G
P
E
T
T
P
P
Q
P
P
T
Site 67
T709
P
M
R
G
P
E
T
T
P
P
Q
P
P
T
P
Site 68
T715
T
T
P
P
Q
P
P
T
P
S
K
S
Y
V
N
Site 69
S717
P
P
Q
P
P
T
P
S
K
S
Y
V
N
S
H
Site 70
S719
Q
P
P
T
P
S
K
S
Y
V
N
S
H
F
I
Site 71
Y720
P
P
T
P
S
K
S
Y
V
N
S
H
F
I
T
Site 72
S723
P
S
K
S
Y
V
N
S
H
F
I
T
A
E
E
Site 73
S742
F
P
R
R
L
K
E
S
F
R
D
P
Y
S
A
Site 74
Y747
K
E
S
F
R
D
P
Y
S
A
F
F
K
T
D
Site 75
S748
E
S
F
R
D
P
Y
S
A
F
F
K
T
D
A
Site 76
T753
P
Y
S
A
F
F
K
T
D
A
D
R
D
G
I
Site 77
S830
P
K
Q
K
V
A
D
S
E
L
A
C
E
Q
A
Site 78
Y840
A
C
E
Q
A
H
Q
Y
L
V
T
K
A
K
N
Site 79
S850
T
K
A
K
N
R
W
S
D
L
S
K
N
F
L
Site 80
S853
K
N
R
W
S
D
L
S
K
N
F
L
E
T
D
Site 81
Y877
R
D
I
K
N
A
L
Y
G
F
D
I
P
L
T
Site 82
T884
Y
G
F
D
I
P
L
T
P
R
E
F
E
K
L
Site 83
Y895
F
E
K
L
W
A
R
Y
D
T
E
G
K
G
H
Site 84
T897
K
L
W
A
R
Y
D
T
E
G
K
G
H
I
T
Site 85
Y905
E
G
K
G
H
I
T
Y
Q
E
F
L
Q
K
L
Site 86
S917
Q
K
L
G
I
N
Y
S
P
A
V
H
R
P
C
Site 87
S951
E
M
K
E
L
Q
Q
S
T
E
K
A
V
A
A
Site 88
T952
M
K
E
L
Q
Q
S
T
E
K
A
V
A
A
R
Site 89
S970
M
D
R
H
Q
D
I
S
K
A
F
T
K
T
D
Site 90
T974
Q
D
I
S
K
A
F
T
K
T
D
Q
S
K
T
Site 91
T976
I
S
K
A
F
T
K
T
D
Q
S
K
T
N
Y
Site 92
T981
T
K
T
D
Q
S
K
T
N
Y
I
S
I
C
K
Site 93
Y983
T
D
Q
S
K
T
N
Y
I
S
I
C
K
M
Q
Site 94
T1001
E
E
C
G
C
S
L
T
E
G
E
L
T
H
L
Site 95
T1006
S
L
T
E
G
E
L
T
H
L
L
N
S
W
G
Site 96
S1011
E
L
T
H
L
L
N
S
W
G
V
S
R
H
D
Site 97
Y1023
R
H
D
N
A
I
N
Y
L
D
F
L
R
A
V
Site 98
S1033
F
L
R
A
V
E
N
S
K
S
T
G
A
Q
P
Site 99
S1035
R
A
V
E
N
S
K
S
T
G
A
Q
P
K
E
Site 100
S1046
Q
P
K
E
K
E
E
S
M
P
I
N
F
A
T
Site 101
S1069
K
I
Q
E
V
V
E
S
S
Q
L
A
L
S
T
Site 102
T1086
S
A
L
D
K
E
D
T
G
F
V
K
A
T
E
Site 103
Y1103
Q
V
L
K
D
F
C
Y
K
L
T
D
N
Q
Y
Site 104
Y1110
Y
K
L
T
D
N
Q
Y
H
Y
F
L
R
K
L
Site 105
Y1112
L
T
D
N
Q
Y
H
Y
F
L
R
K
L
R
I
Site 106
T1122
R
K
L
R
I
H
L
T
P
Y
I
N
W
K
Y
Site 107
S1157
P
K
G
P
P
P
T
S
P
K
A
T
A
D
R
Site 108
T1190
Q
E
F
E
N
F
D
T
M
K
T
N
T
I
S
Site 109
T1193
E
N
F
D
T
M
K
T
N
T
I
S
R
E
E
Site 110
S1197
T
M
K
T
N
T
I
S
R
E
E
F
R
A
I
Site 111
T1213
N
R
R
V
Q
I
L
T
D
E
Q
F
D
R
L
Site 112
Y1234
N
A
K
G
R
L
K
Y
P
D
F
L
S
R
F
Site 113
S1239
L
K
Y
P
D
F
L
S
R
F
S
S
E
T
A
Site 114
S1242
P
D
F
L
S
R
F
S
S
E
T
A
A
T
P
Site 115
S1243
D
F
L
S
R
F
S
S
E
T
A
A
T
P
M
Site 116
T1245
L
S
R
F
S
S
E
T
A
A
T
P
M
A
T
Site 117
T1248
F
S
S
E
T
A
A
T
P
M
A
T
G
D
S
Site 118
S1262
S
A
V
A
Q
R
G
S
S
V
P
D
V
S
E
Site 119
S1263
A
V
A
Q
R
G
S
S
V
P
D
V
S
E
G
Site 120
S1268
G
S
S
V
P
D
V
S
E
G
T
R
S
A
L
Site 121
S1273
D
V
S
E
G
T
R
S
A
L
S
L
P
T
Q
Site 122
S1286
T
Q
E
L
R
P
G
S
K
S
Q
S
H
P
C
Site 123
S1288
E
L
R
P
G
S
K
S
Q
S
H
P
C
T
P
Site 124
S1290
R
P
G
S
K
S
Q
S
H
P
C
T
P
A
S
Site 125
T1294
K
S
Q
S
H
P
C
T
P
A
S
T
T
V
I
Site 126
S1297
S
H
P
C
T
P
A
S
T
T
V
I
P
G
T
Site 127
T1299
P
C
T
P
A
S
T
T
V
I
P
G
T
P
P
Site 128
T1304
S
T
T
V
I
P
G
T
P
P
L
Q
N
C
D
Site 129
S1346
R
Q
G
D
I
N
A
S
D
F
L
A
L
V
E
Site 130
S1360
E
K
F
N
L
D
I
S
K
E
E
C
Q
Q
L
Site 131
Y1371
C
Q
Q
L
I
I
K
Y
D
L
K
S
N
G
K
Site 132
Y1381
K
S
N
G
K
F
A
Y
C
D
F
I
Q
S
C
Site 133
S1397
L
L
L
K
A
K
E
S
S
L
M
H
R
M
K
Site 134
T1418
M
K
E
A
G
A
E
T
P
S
F
Y
S
A
L
Site 135
S1420
E
A
G
A
E
T
P
S
F
Y
S
A
L
L
R
Site 136
S1445
P
M
R
R
T
F
K
S
Y
D
E
A
G
T
G
Site 137
Y1446
M
R
R
T
F
K
S
Y
D
E
A
G
T
G
L
Site 138
Y1466
F
R
T
V
L
R
Q
Y
S
I
N
L
S
E
E
Site 139
S1467
R
T
V
L
R
Q
Y
S
I
N
L
S
E
E
E
Site 140
S1471
R
Q
Y
S
I
N
L
S
E
E
E
F
F
H
I
Site 141
Y1481
E
F
F
H
I
L
E
Y
Y
D
K
T
L
S
S
Site 142
Y1482
F
F
H
I
L
E
Y
Y
D
K
T
L
S
S
K
Site 143
T1485
I
L
E
Y
Y
D
K
T
L
S
S
K
I
S
Y
Site 144
S1487
E
Y
Y
D
K
T
L
S
S
K
I
S
Y
N
D
Site 145
S1488
Y
Y
D
K
T
L
S
S
K
I
S
Y
N
D
F
Site 146
S1491
K
T
L
S
S
K
I
S
Y
N
D
F
L
R
A
Site 147
Y1492
T
L
S
S
K
I
S
Y
N
D
F
L
R
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation