PhosphoNET

           
Protein Info 
   
Short Name:  HES3
Full Name:  Transcription factor HES-3
Alias:  Class B basic helix-loop-helix protein 43;Hairy and enhancer of split 3
Type: 
Mass (Da):  19968
Number AA:  186
UniProt ID:  Q5TGS1
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S12RRARINVSLEQLKSL
Site 2S18VSLEQLKSLLEKHYS
Site 3S25SLLEKHYSHQIRKRK
Site 4S42KADILELSVKYMRSL
Site 5Y45ILELSVKYMRSLQNS
Site 6S48LSVKYMRSLQNSLQG
Site 7S52YMRSLQNSLQGLWPV
Site 8S67PRGAEQPSGFRSCLP
Site 9S71EQPSGFRSCLPGVSQ
Site 10S77RSCLPGVSQLLRRGD
Site 11S88RRGDEVGSGLRCPLV
Site 12S98RCPLVPESAAGSTMD
Site 13S102VPESAAGSTMDSAGL
Site 14S106AAGSTMDSAGLGQEA
Site 15S150LPESLPGSSASVPPP
Site 16S151PESLPGSSASVPPPQ
Site 17S153SLPGSSASVPPPQPA
Site 18S161VPPPQPASSRCAESP
Site 19S162PPPQPASSRCAESPG
Site 20S167ASSRCAESPGLGLRV
Site 21S180RVWRPWGSPGDDLN_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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