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Updated November 2019
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Protein Info
Short Name:
SH3PXD2A
Full Name:
SH3 and PX domain-containing protein 2A
Alias:
Adaptor protein TKS5; FISH; Five SH3 domain-containing protein; Five SH3 domains; KIAA0418; SH3 and PX domains 2A; SH3 multiple domains 1; SH3 multiple domains protein 1; SH3MD1; SPD2A
Type:
Adaptor/scaffold
Mass (Da):
125289
Number AA:
1133
UniProt ID:
Q5TCZ1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042995
GO:0005737
GO:0002102
Uniprot
OncoNet
Molecular Function:
GO:0035091
GO:0005515
GO:0005543
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0009987
GO:0007154
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
A
Y
C
V
Q
D
A
T
V
V
D
V
E
K
R
Site 2
S21
V
E
K
R
R
N
P
S
K
H
Y
V
Y
I
I
Site 3
Y24
R
R
N
P
S
K
H
Y
V
Y
I
I
N
V
T
Site 4
S35
I
N
V
T
W
S
D
S
T
S
Q
T
I
Y
R
Site 5
S37
V
T
W
S
D
S
T
S
Q
T
I
Y
R
R
Y
Site 6
T39
W
S
D
S
T
S
Q
T
I
Y
R
R
Y
S
K
Site 7
Y41
D
S
T
S
Q
T
I
Y
R
R
Y
S
K
F
F
Site 8
Y44
S
Q
T
I
Y
R
R
Y
S
K
F
F
D
L
Q
Site 9
S84
G
K
I
L
F
R
R
S
H
I
R
D
V
A
V
Site 10
Y100
R
L
K
P
I
D
E
Y
C
R
A
L
V
R
L
Site 11
S112
V
R
L
P
P
H
I
S
Q
C
D
E
V
F
R
Site 12
Y135
V
N
P
P
K
E
D
Y
G
S
S
K
R
K
S
Site 13
S137
P
P
K
E
D
Y
G
S
S
K
R
K
S
V
W
Site 14
S138
P
K
E
D
Y
G
S
S
K
R
K
S
V
W
L
Site 15
S142
Y
G
S
S
K
R
K
S
V
W
L
S
S
W
A
Site 16
S146
K
R
K
S
V
W
L
S
S
W
A
E
S
P
K
Site 17
S147
R
K
S
V
W
L
S
S
W
A
E
S
P
K
K
Site 18
S151
W
L
S
S
W
A
E
S
P
K
K
D
V
T
G
Site 19
T157
E
S
P
K
K
D
V
T
G
A
D
A
T
A
E
Site 20
Y171
E
P
M
I
L
E
Q
Y
V
V
V
S
N
Y
K
Site 21
S186
K
Q
E
N
S
E
L
S
L
Q
A
G
E
V
V
Site 22
Y219
Q
G
W
V
P
A
T
Y
L
E
A
Q
N
G
T
Site 23
S230
Q
N
G
T
R
D
D
S
D
I
N
T
S
K
T
Site 24
T234
R
D
D
S
D
I
N
T
S
K
T
G
E
V
S
Site 25
S235
D
D
S
D
I
N
T
S
K
T
G
E
V
S
K
Site 26
T237
S
D
I
N
T
S
K
T
G
E
V
S
K
R
R
Site 27
S241
T
S
K
T
G
E
V
S
K
R
R
K
A
H
L
Site 28
T256
R
R
L
D
R
R
W
T
L
G
G
M
V
N
R
Site 29
S266
G
M
V
N
R
Q
H
S
R
E
E
K
Y
V
T
Site 30
Y271
Q
H
S
R
E
E
K
Y
V
T
V
Q
P
Y
T
Site 31
T273
S
R
E
E
K
Y
V
T
V
Q
P
Y
T
S
Q
Site 32
S279
V
T
V
Q
P
Y
T
S
Q
S
K
D
E
I
G
Site 33
S281
V
Q
P
Y
T
S
Q
S
K
D
E
I
G
F
E
Site 34
T292
I
G
F
E
K
G
V
T
V
E
V
I
R
K
N
Site 35
Y305
K
N
L
E
G
W
W
Y
I
R
Y
L
G
K
E
Site 36
Y308
E
G
W
W
Y
I
R
Y
L
G
K
E
G
W
A
Site 37
S318
K
E
G
W
A
P
A
S
Y
L
K
K
A
K
D
Site 38
Y319
E
G
W
A
P
A
S
Y
L
K
K
A
K
D
D
Site 39
S356
N
L
L
N
K
K
A
S
G
D
K
E
T
P
P
Site 40
T361
K
A
S
G
D
K
E
T
P
P
A
E
G
E
G
Site 41
T398
A
V
G
V
P
D
R
T
V
S
R
L
A
Q
G
Site 42
S400
G
V
P
D
R
T
V
S
R
L
A
Q
G
S
P
Site 43
S406
V
S
R
L
A
Q
G
S
P
A
V
A
R
I
A
Site 44
S420
A
P
Q
R
A
Q
I
S
S
P
N
L
R
T
R
Site 45
S421
P
Q
R
A
Q
I
S
S
P
N
L
R
T
R
P
Site 46
S434
R
P
P
P
R
R
E
S
S
L
G
F
Q
L
P
Site 47
S435
P
P
P
R
R
E
S
S
L
G
F
Q
L
P
K
Site 48
S448
P
K
P
P
E
P
P
S
V
E
V
E
Y
Y
T
Site 49
Y453
P
P
S
V
E
V
E
Y
Y
T
I
A
E
F
Q
Site 50
Y454
P
S
V
E
V
E
Y
Y
T
I
A
E
F
Q
S
Site 51
S464
A
E
F
Q
S
C
I
S
D
G
I
S
F
R
G
Site 52
S468
S
C
I
S
D
G
I
S
F
R
G
G
Q
K
A
Site 53
Y487
K
N
S
G
G
W
W
Y
V
Q
I
G
E
K
E
Site 54
S500
K
E
G
W
A
P
A
S
Y
I
D
K
R
K
K
Site 55
Y501
E
G
W
A
P
A
S
Y
I
D
K
R
K
K
P
Site 56
S511
K
R
K
K
P
N
L
S
R
R
T
S
T
L
T
Site 57
T514
K
P
N
L
S
R
R
T
S
T
L
T
R
P
K
Site 58
S515
P
N
L
S
R
R
T
S
T
L
T
R
P
K
V
Site 59
T516
N
L
S
R
R
T
S
T
L
T
R
P
K
V
P
Site 60
T518
S
R
R
T
S
T
L
T
R
P
K
V
P
P
P
Site 61
S529
V
P
P
P
A
P
P
S
K
P
K
E
A
E
E
Site 62
T539
K
E
A
E
E
G
P
T
G
A
S
E
S
Q
D
Site 63
S542
E
E
G
P
T
G
A
S
E
S
Q
D
S
P
R
Site 64
S544
G
P
T
G
A
S
E
S
Q
D
S
P
R
K
L
Site 65
S547
G
A
S
E
S
Q
D
S
P
R
K
L
K
Y
E
Site 66
Y553
D
S
P
R
K
L
K
Y
E
E
P
E
Y
D
I
Site 67
Y558
L
K
Y
E
E
P
E
Y
D
I
P
A
F
G
F
Site 68
S567
I
P
A
F
G
F
D
S
E
P
E
L
S
E
E
Site 69
S572
F
D
S
E
P
E
L
S
E
E
P
V
E
D
R
Site 70
S581
E
P
V
E
D
R
A
S
G
E
R
R
P
A
Q
Site 71
S593
P
A
Q
P
H
R
P
S
P
A
S
S
L
Q
R
Site 72
S596
P
H
R
P
S
P
A
S
S
L
Q
R
A
R
F
Site 73
S597
H
R
P
S
P
A
S
S
L
Q
R
A
R
F
K
Site 74
S609
R
F
K
V
G
E
S
S
E
D
V
A
L
E
E
Site 75
Y620
A
L
E
E
E
T
I
Y
E
N
E
G
F
R
P
Site 76
Y628
E
N
E
G
F
R
P
Y
A
E
D
T
L
S
A
Site 77
T632
F
R
P
Y
A
E
D
T
L
S
A
R
G
S
S
Site 78
S634
P
Y
A
E
D
T
L
S
A
R
G
S
S
G
D
Site 79
S638
D
T
L
S
A
R
G
S
S
G
D
S
D
S
P
Site 80
S639
T
L
S
A
R
G
S
S
G
D
S
D
S
P
G
Site 81
S642
A
R
G
S
S
G
D
S
D
S
P
G
S
S
S
Site 82
S644
G
S
S
G
D
S
D
S
P
G
S
S
S
L
S
Site 83
S647
G
D
S
D
S
P
G
S
S
S
L
S
L
T
R
Site 84
S648
D
S
D
S
P
G
S
S
S
L
S
L
T
R
K
Site 85
S649
S
D
S
P
G
S
S
S
L
S
L
T
R
K
N
Site 86
S651
S
P
G
S
S
S
L
S
L
T
R
K
N
S
P
Site 87
T653
G
S
S
S
L
S
L
T
R
K
N
S
P
K
S
Site 88
S657
L
S
L
T
R
K
N
S
P
K
S
G
S
P
K
Site 89
S660
T
R
K
N
S
P
K
S
G
S
P
K
S
S
S
Site 90
S662
K
N
S
P
K
S
G
S
P
K
S
S
S
L
L
Site 91
S665
P
K
S
G
S
P
K
S
S
S
L
L
K
L
K
Site 92
S666
K
S
G
S
P
K
S
S
S
L
L
K
L
K
A
Site 93
S667
S
G
S
P
K
S
S
S
L
L
K
L
K
A
E
Site 94
S686
A
E
M
G
K
N
H
S
S
A
S
F
S
S
S
Site 95
S687
E
M
G
K
N
H
S
S
A
S
F
S
S
S
I
Site 96
S689
G
K
N
H
S
S
A
S
F
S
S
S
I
T
I
Site 97
S691
N
H
S
S
A
S
F
S
S
S
I
T
I
N
T
Site 98
T698
S
S
S
I
T
I
N
T
T
C
C
S
S
S
S
Site 99
T699
S
S
I
T
I
N
T
T
C
C
S
S
S
S
S
Site 100
S702
T
I
N
T
T
C
C
S
S
S
S
S
S
S
S
Site 101
S703
I
N
T
T
C
C
S
S
S
S
S
S
S
S
S
Site 102
S704
N
T
T
C
C
S
S
S
S
S
S
S
S
S
L
Site 103
S705
T
T
C
C
S
S
S
S
S
S
S
S
S
L
S
Site 104
S706
T
C
C
S
S
S
S
S
S
S
S
S
L
S
K
Site 105
S707
C
C
S
S
S
S
S
S
S
S
S
L
S
K
T
Site 106
S708
C
S
S
S
S
S
S
S
S
S
L
S
K
T
S
Site 107
S709
S
S
S
S
S
S
S
S
S
L
S
K
T
S
G
Site 108
S710
S
S
S
S
S
S
S
S
L
S
K
T
S
G
D
Site 109
S712
S
S
S
S
S
S
L
S
K
T
S
G
D
L
K
Site 110
T714
S
S
S
S
L
S
K
T
S
G
D
L
K
P
R
Site 111
S715
S
S
S
L
S
K
T
S
G
D
L
K
P
R
S
Site 112
S722
S
G
D
L
K
P
R
S
A
S
D
A
G
I
R
Site 113
S724
D
L
K
P
R
S
A
S
D
A
G
I
R
G
T
Site 114
T731
S
D
A
G
I
R
G
T
P
K
V
R
A
K
K
Site 115
T747
A
D
A
N
A
G
L
T
S
C
P
R
A
K
P
Site 116
S755
S
C
P
R
A
K
P
S
V
R
P
K
P
F
L
Site 117
S767
P
F
L
N
R
A
E
S
Q
S
Q
E
K
M
D
Site 118
S769
L
N
R
A
E
S
Q
S
Q
E
K
M
D
I
S
Site 119
S776
S
Q
E
K
M
D
I
S
T
L
R
R
Q
L
R
Site 120
T777
Q
E
K
M
D
I
S
T
L
R
R
Q
L
R
P
Site 121
T785
L
R
R
Q
L
R
P
T
G
Q
L
R
G
G
L
Site 122
S795
L
R
G
G
L
K
G
S
K
S
E
D
S
E
L
Site 123
S797
G
G
L
K
G
S
K
S
E
D
S
E
L
P
P
Site 124
S800
K
G
S
K
S
E
D
S
E
L
P
P
Q
T
A
Site 125
T806
D
S
E
L
P
P
Q
T
A
S
E
A
P
S
E
Site 126
S808
E
L
P
P
Q
T
A
S
E
A
P
S
E
G
S
Site 127
S812
Q
T
A
S
E
A
P
S
E
G
S
R
R
S
S
Site 128
S815
S
E
A
P
S
E
G
S
R
R
S
S
S
D
L
Site 129
S818
P
S
E
G
S
R
R
S
S
S
D
L
I
T
L
Site 130
S819
S
E
G
S
R
R
S
S
S
D
L
I
T
L
P
Site 131
S820
E
G
S
R
R
S
S
S
D
L
I
T
L
P
A
Site 132
T824
R
S
S
S
D
L
I
T
L
P
A
T
T
P
P
Site 133
T828
D
L
I
T
L
P
A
T
T
P
P
C
P
T
K
Site 134
T829
L
I
T
L
P
A
T
T
P
P
C
P
T
K
K
Site 135
T843
K
E
W
E
G
P
A
T
S
Y
M
T
C
S
A
Site 136
Y845
W
E
G
P
A
T
S
Y
M
T
C
S
A
Y
Q
Site 137
Y851
S
Y
M
T
C
S
A
Y
Q
K
V
Q
D
S
E
Site 138
S857
A
Y
Q
K
V
Q
D
S
E
I
S
F
P
A
G
Site 139
S860
K
V
Q
D
S
E
I
S
F
P
A
G
V
E
V
Site 140
Y879
K
Q
E
S
G
W
W
Y
V
R
F
G
E
L
E
Site 141
Y893
E
G
W
A
P
S
H
Y
L
V
L
D
E
N
E
Site 142
S905
E
N
E
Q
P
D
P
S
G
K
E
L
D
T
V
Site 143
T911
P
S
G
K
E
L
D
T
V
P
A
K
G
R
Q
Site 144
S923
G
R
Q
N
E
G
K
S
D
S
L
E
K
I
E
Site 145
S925
Q
N
E
G
K
S
D
S
L
E
K
I
E
R
R
Site 146
T938
R
R
V
Q
A
L
N
T
V
N
Q
S
K
K
A
Site 147
T946
V
N
Q
S
K
K
A
T
P
P
I
P
S
K
P
Site 148
S951
K
A
T
P
P
I
P
S
K
P
P
G
G
F
G
Site 149
S961
P
G
G
F
G
K
T
S
G
T
P
A
V
K
M
Site 150
T963
G
F
G
K
T
S
G
T
P
A
V
K
M
R
N
Site 151
S981
Q
V
A
V
R
P
Q
S
V
F
V
S
P
P
P
Site 152
S985
R
P
Q
S
V
F
V
S
P
P
P
K
D
N
N
Site 153
S1002
C
A
L
R
R
N
E
S
L
T
A
T
D
G
L
Site 154
T1004
L
R
R
N
E
S
L
T
A
T
D
G
L
R
G
Site 155
T1006
R
N
E
S
L
T
A
T
D
G
L
R
G
V
R
Site 156
S1016
L
R
G
V
R
R
N
S
S
F
S
T
A
R
S
Site 157
S1017
R
G
V
R
R
N
S
S
F
S
T
A
R
S
A
Site 158
S1019
V
R
R
N
S
S
F
S
T
A
R
S
A
A
A
Site 159
T1020
R
R
N
S
S
F
S
T
A
R
S
A
A
A
E
Site 160
S1023
S
S
F
S
T
A
R
S
A
A
A
E
A
K
G
Site 161
S1038
R
L
A
E
R
A
A
S
Q
G
S
D
S
P
L
Site 162
S1041
E
R
A
A
S
Q
G
S
D
S
P
L
L
P
A
Site 163
S1043
A
A
S
Q
G
S
D
S
P
L
L
P
A
Q
R
Site 164
S1052
L
L
P
A
Q
R
N
S
I
P
V
S
P
V
R
Site 165
S1056
Q
R
N
S
I
P
V
S
P
V
R
P
K
P
I
Site 166
S1066
R
P
K
P
I
E
K
S
Q
F
I
H
N
N
L
Site 167
Y1077
H
N
N
L
K
D
V
Y
V
S
I
A
D
Y
E
Site 168
Y1083
V
Y
V
S
I
A
D
Y
E
G
D
E
E
T
A
Site 169
Y1128
K
G
W
V
P
S
N
Y
L
E
K
K
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation