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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CPSF3L
Full Name:
Integrator complex subunit 11
Alias:
Int11
Type:
Mass (Da):
67645
Number AA:
600
UniProt ID:
Q5TA45
International Prot ID:
IPI00063404
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0016787
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
P
E
I
R
V
T
P
L
G
A
G
Q
D
Site 2
S49
D
R
R
F
P
D
F
S
Y
I
T
Q
N
G
R
Site 3
Y50
R
R
F
P
D
F
S
Y
I
T
Q
N
G
R
L
Site 4
Y79
D
H
C
G
A
L
P
Y
F
S
E
M
V
G
Y
Site 5
Y86
Y
F
S
E
M
V
G
Y
D
G
P
I
Y
M
T
Site 6
Y91
V
G
Y
D
G
P
I
Y
M
T
H
P
T
Q
A
Site 7
Y107
C
P
I
L
L
E
D
Y
R
K
I
A
V
D
K
Site 8
Y153
D
E
L
E
I
K
A
Y
Y
A
G
H
V
L
G
Site 9
S172
Q
I
K
V
G
S
E
S
V
V
Y
T
G
D
Y
Site 10
Y175
V
G
S
E
S
V
V
Y
T
G
D
Y
N
M
T
Site 11
T176
G
S
E
S
V
V
Y
T
G
D
Y
N
M
T
P
Site 12
Y179
S
V
V
Y
T
G
D
Y
N
M
T
P
D
R
H
Site 13
T182
Y
T
G
D
Y
N
M
T
P
D
R
H
L
G
A
Site 14
S204
P
N
L
L
I
T
E
S
T
Y
A
T
T
I
R
Site 15
Y206
L
L
I
T
E
S
T
Y
A
T
T
I
R
D
S
Site 16
T208
I
T
E
S
T
Y
A
T
T
I
R
D
S
K
R
Site 17
T209
T
E
S
T
Y
A
T
T
I
R
D
S
K
R
C
Site 18
S213
Y
A
T
T
I
R
D
S
K
R
C
R
E
R
D
Site 19
T228
F
L
K
K
V
H
E
T
V
E
R
G
G
K
V
Site 20
Y278
L
T
E
K
A
N
H
Y
Y
K
L
F
I
P
W
Site 21
Y279
T
E
K
A
N
H
Y
Y
K
L
F
I
P
W
T
Site 22
S365
T
V
G
H
K
I
L
S
G
Q
R
K
L
E
M
Site 23
Y386
E
V
K
M
Q
V
E
Y
M
S
F
S
A
H
A
Site 24
S388
K
M
Q
V
E
Y
M
S
F
S
A
H
A
D
A
Site 25
Y436
Q
E
L
R
V
N
C
Y
M
P
A
N
G
E
T
Site 26
T445
P
A
N
G
E
T
V
T
L
P
T
S
P
S
I
Site 27
T482
K
P
R
L
L
H
G
T
L
I
M
K
D
S
N
Site 28
S488
G
T
L
I
M
K
D
S
N
F
R
L
V
S
S
Site 29
S494
D
S
N
F
R
L
V
S
S
E
Q
A
L
K
E
Site 30
S495
S
N
F
R
L
V
S
S
E
Q
A
L
K
E
L
Site 31
T512
A
E
H
Q
L
R
F
T
C
R
V
H
L
H
D
Site 32
T526
D
T
R
K
E
Q
E
T
A
L
R
V
Y
S
H
Site 33
Y531
Q
E
T
A
L
R
V
Y
S
H
L
K
S
V
L
Site 34
S532
E
T
A
L
R
V
Y
S
H
L
K
S
V
L
K
Site 35
S536
R
V
Y
S
H
L
K
S
V
L
K
D
H
C
V
Site 36
S564
L
L
Q
A
A
A
P
S
E
D
P
G
T
K
V
Site 37
T569
A
P
S
E
D
P
G
T
K
V
L
L
V
S
W
Site 38
Y578
V
L
L
V
S
W
T
Y
Q
D
E
E
L
G
S
Site 39
S585
Y
Q
D
E
E
L
G
S
F
L
T
S
L
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation