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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC18
Full Name:
Coiled-coil domain-containing protein 18
Alias:
CCD18; Coiled-coil domain containing 18; DJ717I23.1; NY-SAR-41; RP4-717I23.1; Sarcoma antigen NY-SAR-24
Type:
Unknown function
Mass (Da):
168962
Number AA:
1454
UniProt ID:
Q5T9S5
International Prot ID:
IPI00642206
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
E
S
S
S
S
D
Y
Y
N
K
D
N
E
E
Site 2
Y9
E
S
S
S
S
D
Y
Y
N
K
D
N
E
E
E
Site 3
S17
N
K
D
N
E
E
E
S
L
L
A
N
V
A
S
Site 4
T32
L
R
H
E
L
K
I
T
E
W
S
L
Q
S
L
Site 5
S35
E
L
K
I
T
E
W
S
L
Q
S
L
G
E
E
Site 6
S38
I
T
E
W
S
L
Q
S
L
G
E
E
L
S
S
Site 7
S44
Q
S
L
G
E
E
L
S
S
V
S
P
S
E
N
Site 8
S45
S
L
G
E
E
L
S
S
V
S
P
S
E
N
S
Site 9
S47
G
E
E
L
S
S
V
S
P
S
E
N
S
D
Y
Site 10
S49
E
L
S
S
V
S
P
S
E
N
S
D
Y
A
P
Site 11
S52
S
V
S
P
S
E
N
S
D
Y
A
P
N
P
S
Site 12
Y54
S
P
S
E
N
S
D
Y
A
P
N
P
S
R
S
Site 13
S59
S
D
Y
A
P
N
P
S
R
S
E
K
L
I
L
Site 14
S61
Y
A
P
N
P
S
R
S
E
K
L
I
L
D
V
Site 15
Y78
S
H
P
G
L
L
N
Y
S
P
Y
E
N
V
C
Site 16
S79
H
P
G
L
L
N
Y
S
P
Y
E
N
V
C
K
Site 17
Y81
G
L
L
N
Y
S
P
Y
E
N
V
C
K
I
S
Site 18
S88
Y
E
N
V
C
K
I
S
G
S
S
T
D
F
Q
Site 19
S90
N
V
C
K
I
S
G
S
S
T
D
F
Q
K
K
Site 20
T92
C
K
I
S
G
S
S
T
D
F
Q
K
K
P
R
Site 21
S104
K
P
R
D
K
M
F
S
S
S
A
P
V
D
Q
Site 22
S106
R
D
K
M
F
S
S
S
A
P
V
D
Q
E
I
Site 23
S115
P
V
D
Q
E
I
K
S
L
R
E
K
L
N
K
Site 24
T149
E
S
I
H
F
E
L
T
Q
S
R
A
K
V
S
Site 25
S151
I
H
F
E
L
T
Q
S
R
A
K
V
S
M
L
Site 26
S156
T
Q
S
R
A
K
V
S
M
L
E
S
A
Q
Q
Site 27
S160
A
K
V
S
M
L
E
S
A
Q
Q
Q
A
A
S
Site 28
S167
S
A
Q
Q
Q
A
A
S
V
P
I
L
E
E
Q
Site 29
S183
I
N
L
E
A
E
V
S
A
Q
D
K
V
L
R
Site 30
S199
A
E
N
K
L
E
Q
S
Q
K
M
V
I
E
K
Site 31
S209
M
V
I
E
K
E
Q
S
L
Q
E
S
K
E
E
Site 32
S213
K
E
Q
S
L
Q
E
S
K
E
E
C
I
K
L
Site 33
Y243
R
Q
R
N
E
A
L
Y
N
A
E
E
L
S
K
Site 34
T278
E
I
L
E
R
N
L
T
N
C
E
K
E
N
K
Site 35
Y294
L
Q
E
R
C
G
L
Y
K
S
E
L
E
I
L
Site 36
S296
E
R
C
G
L
Y
K
S
E
L
E
I
L
K
E
Site 37
T334
S
E
V
M
A
Q
L
T
E
S
R
Q
S
I
L
Site 38
S339
Q
L
T
E
S
R
Q
S
I
L
K
L
E
S
E
Site 39
S359
E
I
L
R
D
K
F
S
L
M
N
E
N
R
E
Site 40
S387
L
C
Q
Q
E
I
E
S
S
R
V
E
L
R
S
Site 41
S388
C
Q
Q
E
I
E
S
S
R
V
E
L
R
S
L
Site 42
S394
S
S
R
V
E
L
R
S
L
E
K
I
I
S
Q
Site 43
S400
R
S
L
E
K
I
I
S
Q
L
P
L
K
R
E
Site 44
S413
R
E
L
F
G
F
K
S
Y
L
S
K
Y
Q
M
Site 45
Y414
E
L
F
G
F
K
S
Y
L
S
K
Y
Q
M
S
Site 46
S416
F
G
F
K
S
Y
L
S
K
Y
Q
M
S
S
F
Site 47
Y418
F
K
S
Y
L
S
K
Y
Q
M
S
S
F
S
N
Site 48
S422
L
S
K
Y
Q
M
S
S
F
S
N
K
E
D
R
Site 49
T463
Q
K
L
H
A
N
L
T
A
N
Q
L
S
Q
S
Site 50
S468
N
L
T
A
N
Q
L
S
Q
S
L
I
T
C
N
Site 51
S477
S
L
I
T
C
N
D
S
Q
E
S
S
K
L
S
Site 52
S481
C
N
D
S
Q
E
S
S
K
L
S
S
L
E
T
Site 53
S484
S
Q
E
S
S
K
L
S
S
L
E
T
E
P
V
Site 54
S485
Q
E
S
S
K
L
S
S
L
E
T
E
P
V
K
Site 55
T488
S
K
L
S
S
L
E
T
E
P
V
K
L
G
G
Site 56
S500
L
G
G
H
Q
V
E
S
V
K
D
Q
N
Q
H
Site 57
T522
K
E
R
Q
R
L
V
T
G
I
E
E
L
R
T
Site 58
T529
T
G
I
E
E
L
R
T
K
L
I
Q
I
E
A
Site 59
S539
I
Q
I
E
A
E
N
S
D
L
K
V
N
M
A
Site 60
S550
V
N
M
A
H
R
T
S
Q
F
Q
L
I
Q
E
Site 61
S564
E
E
L
L
E
K
A
S
N
S
S
K
L
E
S
Site 62
S566
L
L
E
K
A
S
N
S
S
K
L
E
S
E
M
Site 63
S571
S
N
S
S
K
L
E
S
E
M
T
K
K
C
S
Site 64
T574
S
K
L
E
S
E
M
T
K
K
C
S
Q
L
L
Site 65
S578
S
E
M
T
K
K
C
S
Q
L
L
T
L
E
K
Site 66
T582
K
K
C
S
Q
L
L
T
L
E
K
Q
L
E
E
Site 67
S596
E
K
I
V
A
Y
S
S
I
A
A
K
N
A
E
Site 68
S617
E
K
N
E
K
I
R
S
L
E
T
N
I
N
T
Site 69
T671
Q
F
K
E
Q
E
K
T
M
S
M
L
Q
Q
D
Site 70
S673
K
E
Q
E
K
T
M
S
M
L
Q
Q
D
I
I
Site 71
S688
C
K
Q
H
H
L
E
S
L
D
R
L
L
T
E
Site 72
T694
E
S
L
D
R
L
L
T
E
S
K
G
E
M
K
Site 73
S696
L
D
R
L
L
T
E
S
K
G
E
M
K
K
E
Site 74
S761
E
K
Q
L
K
K
K
S
E
E
V
Y
C
L
Q
Site 75
Y765
K
K
K
S
E
E
V
Y
C
L
Q
K
E
L
K
Site 76
S777
E
L
K
I
K
N
H
S
L
Q
E
T
S
E
Q
Site 77
T781
K
N
H
S
L
Q
E
T
S
E
Q
N
V
I
L
Site 78
T812
R
N
G
E
L
E
D
T
Q
T
K
L
E
K
Q
Site 79
T814
G
E
L
E
D
T
Q
T
K
L
E
K
Q
V
S
Site 80
S821
T
K
L
E
K
Q
V
S
K
L
E
Q
E
L
Q
Site 81
S833
E
L
Q
K
Q
R
E
S
S
A
E
K
L
R
K
Site 82
S834
L
Q
K
Q
R
E
S
S
A
E
K
L
R
K
M
Site 83
T865
K
V
I
E
L
T
G
T
A
R
Q
V
K
I
E
Site 84
Y876
V
K
I
E
M
D
Q
Y
K
E
E
L
S
K
M
Site 85
S881
D
Q
Y
K
E
E
L
S
K
M
E
K
E
I
M
Site 86
S902
E
N
K
A
M
H
L
S
Q
L
D
M
I
L
D
Site 87
T911
L
D
M
I
L
D
Q
T
K
T
E
L
E
K
K
Site 88
T913
M
I
L
D
Q
T
K
T
E
L
E
K
K
T
N
Site 89
S931
E
L
E
K
L
Q
H
S
T
E
T
E
L
T
E
Site 90
T937
H
S
T
E
T
E
L
T
E
A
L
Q
K
R
E
Site 91
T948
Q
K
R
E
V
L
E
T
E
L
Q
N
A
H
G
Site 92
S959
N
A
H
G
E
L
K
S
T
L
R
Q
L
Q
E
Site 93
T960
A
H
G
E
L
K
S
T
L
R
Q
L
Q
E
L
Site 94
S977
V
L
Q
K
A
Q
L
S
L
E
E
K
Y
T
T
Site 95
T983
L
S
L
E
E
K
Y
T
T
I
K
D
L
T
A
Site 96
T984
S
L
E
E
K
Y
T
T
I
K
D
L
T
A
E
Site 97
T989
Y
T
T
I
K
D
L
T
A
E
L
R
E
C
K
Site 98
T1028
K
Q
R
A
A
Q
V
T
H
L
D
M
T
I
R
Site 99
T1033
Q
V
T
H
L
D
M
T
I
R
E
H
R
G
E
Site 100
T1051
K
I
I
K
L
E
G
T
L
E
K
S
E
L
E
Site 101
S1055
L
E
G
T
L
E
K
S
E
L
E
L
K
E
C
Site 102
S1068
E
C
N
K
Q
I
E
S
L
N
D
K
L
Q
N
Site 103
S1095
L
Q
N
E
Q
E
I
S
Q
L
K
K
E
I
E
Site 104
T1104
L
K
K
E
I
E
R
T
Q
Q
R
M
K
E
M
Site 105
Y1121
V
M
K
E
Q
E
Q
Y
I
A
T
Q
Y
K
E
Site 106
T1139
L
G
Q
E
L
R
L
T
R
E
Q
V
Q
N
S
Site 107
S1168
Q
R
E
I
E
R
L
S
S
E
L
E
D
M
K
Site 108
S1169
R
E
I
E
R
L
S
S
E
L
E
D
M
K
Q
Site 109
S1195
L
A
E
E
L
G
A
S
K
V
R
E
A
H
L
Site 110
S1214
Q
A
E
I
K
K
L
S
A
E
V
E
S
L
K
Site 111
S1241
N
H
A
K
W
K
I
S
A
D
S
Q
K
S
S
Site 112
S1244
K
W
K
I
S
A
D
S
Q
K
S
S
V
Q
Q
Site 113
S1247
I
S
A
D
S
Q
K
S
S
V
Q
Q
L
N
E
Site 114
S1248
S
A
D
S
Q
K
S
S
V
Q
Q
L
N
E
Q
Site 115
T1269
E
L
E
E
A
Q
D
T
V
S
N
L
H
Q
Q
Site 116
S1271
E
E
A
Q
D
T
V
S
N
L
H
Q
Q
V
Q
Site 117
T1293
A
A
N
E
A
L
L
T
K
E
S
E
L
T
R
Site 118
S1296
E
A
L
L
T
K
E
S
E
L
T
R
L
Q
A
Site 119
S1306
T
R
L
Q
A
K
I
S
G
H
E
K
A
E
D
Site 120
S1353
K
C
T
K
L
R
R
S
I
S
A
S
D
L
T
Site 121
S1355
T
K
L
R
R
S
I
S
A
S
D
L
T
F
K
Site 122
S1357
L
R
R
S
I
S
A
S
D
L
T
F
K
I
H
Site 123
T1360
S
I
S
A
S
D
L
T
F
K
I
H
G
D
E
Site 124
S1370
I
H
G
D
E
D
L
S
E
E
L
L
Q
D
L
Site 125
S1386
K
M
Q
L
E
Q
P
S
T
L
E
E
S
H
K
Site 126
T1387
M
Q
L
E
Q
P
S
T
L
E
E
S
H
K
N
Site 127
S1391
Q
P
S
T
L
E
E
S
H
K
N
L
T
Y
T
Site 128
Y1397
E
S
H
K
N
L
T
Y
T
Q
P
D
S
F
K
Site 129
T1398
S
H
K
N
L
T
Y
T
Q
P
D
S
F
K
P
Site 130
S1402
L
T
Y
T
Q
P
D
S
F
K
P
L
T
Y
N
Site 131
T1407
P
D
S
F
K
P
L
T
Y
N
L
E
A
D
S
Site 132
S1415
Y
N
L
E
A
D
S
S
E
N
N
D
F
N
T
Site 133
T1422
S
E
N
N
D
F
N
T
L
S
G
M
L
R
Y
Site 134
S1440
E
V
R
L
L
K
K
S
S
M
Q
T
G
A
G
Site 135
S1441
V
R
L
L
K
K
S
S
M
Q
T
G
A
G
L
Site 136
T1444
L
K
K
S
S
M
Q
T
G
A
G
L
N
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation