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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KPRP
Full Name:
Keratinocyte proline-rich protein
Alias:
C1orf45; HKPRP; Kprp
Type:
Mass (Da):
64136
Number AA:
579
UniProt ID:
Q5T749
International Prot ID:
IPI00514908
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
Q
C
C
V
K
G
P
S
F
C
S
S
Q
S
P
Site 2
S26
K
G
P
S
F
C
S
S
Q
S
P
F
A
Q
S
Site 3
S28
P
S
F
C
S
S
Q
S
P
F
A
Q
S
Q
V
Site 4
S33
S
Q
S
P
F
A
Q
S
Q
V
V
V
Q
A
P
Site 5
S67
S
D
Q
A
P
C
Q
S
Q
T
T
Q
V
K
C
Site 6
S89
K
G
Q
A
Q
C
Q
S
K
T
T
Q
V
K
G
Site 7
S100
Q
V
K
G
Q
A
A
S
Q
S
Q
T
S
S
V
Site 8
S102
K
G
Q
A
A
S
Q
S
Q
T
S
S
V
Q
S
Site 9
T104
Q
A
A
S
Q
S
Q
T
S
S
V
Q
S
Q
A
Site 10
S105
A
A
S
Q
S
Q
T
S
S
V
Q
S
Q
A
P
Site 11
S106
A
S
Q
S
Q
T
S
S
V
Q
S
Q
A
P
C
Site 12
S109
S
Q
T
S
S
V
Q
S
Q
A
P
C
Q
S
E
Site 13
S115
Q
S
Q
A
P
C
Q
S
E
V
S
Y
V
Q
C
Site 14
Y119
P
C
Q
S
E
V
S
Y
V
Q
C
E
A
S
Q
Site 15
Y153
V
E
C
P
V
Q
N
Y
V
P
C
P
A
P
Q
Site 16
T180
Q
P
Q
G
R
F
S
T
Q
C
Q
Y
Q
G
S
Site 17
Y184
R
F
S
T
Q
C
Q
Y
Q
G
S
Y
S
S
C
Site 18
S187
T
Q
C
Q
Y
Q
G
S
Y
S
S
C
G
P
Q
Site 19
Y188
Q
C
Q
Y
Q
G
S
Y
S
S
C
G
P
Q
F
Site 20
S190
Q
Y
Q
G
S
Y
S
S
C
G
P
Q
F
Q
S
Site 21
T200
P
Q
F
Q
S
R
A
T
C
N
N
Y
T
P
Q
Site 22
Y204
S
R
A
T
C
N
N
Y
T
P
Q
F
Q
L
R
Site 23
T205
R
A
T
C
N
N
Y
T
P
Q
F
Q
L
R
P
Site 24
S213
P
Q
F
Q
L
R
P
S
Y
S
S
C
F
P
Q
Site 25
Y214
Q
F
Q
L
R
P
S
Y
S
S
C
F
P
Q
Y
Site 26
S215
F
Q
L
R
P
S
Y
S
S
C
F
P
Q
Y
R
Site 27
S216
Q
L
R
P
S
Y
S
S
C
F
P
Q
Y
R
S
Site 28
Y221
Y
S
S
C
F
P
Q
Y
R
S
R
T
S
F
S
Site 29
S223
S
C
F
P
Q
Y
R
S
R
T
S
F
S
P
C
Site 30
T225
F
P
Q
Y
R
S
R
T
S
F
S
P
C
V
P
Site 31
S226
P
Q
Y
R
S
R
T
S
F
S
P
C
V
P
Q
Site 32
S228
Y
R
S
R
T
S
F
S
P
C
V
P
Q
C
Q
Site 33
S239
P
Q
C
Q
T
Q
G
S
Y
G
S
F
T
E
Q
Site 34
S242
Q
T
Q
G
S
Y
G
S
F
T
E
Q
H
R
S
Site 35
T244
Q
G
S
Y
G
S
F
T
E
Q
H
R
S
R
S
Site 36
S249
S
F
T
E
Q
H
R
S
R
S
T
S
R
C
L
Site 37
S251
T
E
Q
H
R
S
R
S
T
S
R
C
L
P
P
Site 38
T252
E
Q
H
R
S
R
S
T
S
R
C
L
P
P
P
Site 39
S253
Q
H
R
S
R
S
T
S
R
C
L
P
P
P
R
Site 40
S268
R
L
Q
L
F
P
R
S
C
S
P
P
R
R
F
Site 41
S270
Q
L
F
P
R
S
C
S
P
P
R
R
F
E
P
Site 42
S279
P
R
R
F
E
P
C
S
S
S
Y
L
P
L
R
Site 43
S280
R
R
F
E
P
C
S
S
S
Y
L
P
L
R
P
Site 44
S281
R
F
E
P
C
S
S
S
Y
L
P
L
R
P
S
Site 45
Y282
F
E
P
C
S
S
S
Y
L
P
L
R
P
S
E
Site 46
S288
S
Y
L
P
L
R
P
S
E
G
F
P
N
Y
C
Site 47
Y294
P
S
E
G
F
P
N
Y
C
T
P
P
R
R
S
Site 48
T296
E
G
F
P
N
Y
C
T
P
P
R
R
S
E
P
Site 49
S301
Y
C
T
P
P
R
R
S
E
P
I
Y
N
S
R
Site 50
Y305
P
R
R
S
E
P
I
Y
N
S
R
C
P
R
R
Site 51
S307
R
S
E
P
I
Y
N
S
R
C
P
R
R
P
I
Site 52
S315
R
C
P
R
R
P
I
S
S
C
S
Q
R
R
G
Site 53
S316
C
P
R
R
P
I
S
S
C
S
Q
R
R
G
P
Site 54
S318
R
R
P
I
S
S
C
S
Q
R
R
G
P
K
C
Site 55
S330
P
K
C
R
I
E
I
S
S
P
C
C
P
R
Q
Site 56
S331
K
C
R
I
E
I
S
S
P
C
C
P
R
Q
V
Site 57
S354
I
P
P
I
R
R
R
S
Q
S
C
G
P
Q
P
Site 58
S356
P
I
R
R
R
S
Q
S
C
G
P
Q
P
S
W
Site 59
S362
Q
S
C
G
P
Q
P
S
W
G
A
S
C
P
E
Site 60
S366
P
Q
P
S
W
G
A
S
C
P
E
L
R
P
H
Site 61
S381
V
E
P
R
P
L
P
S
F
C
P
P
R
R
L
Site 62
S394
R
L
D
Q
C
P
E
S
P
L
Q
R
C
P
P
Site 63
S415
L
R
P
E
P
C
I
S
L
E
P
R
P
R
P
Site 64
S428
R
P
L
P
R
Q
L
S
E
P
C
L
Y
P
E
Site 65
Y433
Q
L
S
E
P
C
L
Y
P
E
P
L
P
A
L
Site 66
T443
P
L
P
A
L
R
P
T
P
R
P
V
P
L
P
Site 67
S487
P
L
P
A
P
C
P
S
P
E
P
C
R
E
T
Site 68
T494
S
P
E
P
C
R
E
T
W
R
S
P
S
P
C
Site 69
S497
P
C
R
E
T
W
R
S
P
S
P
C
W
G
P
Site 70
S499
R
E
T
W
R
S
P
S
P
C
W
G
P
N
P
Site 71
Y509
W
G
P
N
P
V
P
Y
P
G
D
L
G
C
H
Site 72
S518
G
D
L
G
C
H
E
S
S
P
H
R
L
D
T
Site 73
S519
D
L
G
C
H
E
S
S
P
H
R
L
D
T
E
Site 74
T525
S
S
P
H
R
L
D
T
E
A
P
Y
C
G
P
Site 75
Y529
R
L
D
T
E
A
P
Y
C
G
P
S
S
Y
N
Site 76
S534
A
P
Y
C
G
P
S
S
Y
N
Q
G
Q
E
S
Site 77
Y535
P
Y
C
G
P
S
S
Y
N
Q
G
Q
E
S
G
Site 78
S541
S
Y
N
Q
G
Q
E
S
G
A
G
C
G
P
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation