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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP21
Full Name:
Rho GTPase-activating protein 21
Alias:
ARHGAP10; KIAA1424; RHG21; Rho GTPase activating protein 21; Rho GTPase-activating protein 10; Rho-GTPase activating protein 10; Rho-type GTPase-activating protein 21
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
217331
Number AA:
1957
UniProt ID:
Q5T5U3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030054
GO:0031410
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
T
R
R
T
G
L
S
E
G
D
G
Site 2
S9
A
T
R
R
T
G
L
S
E
G
D
G
D
K
L
Site 3
S31
N
K
D
G
K
E
Q
S
E
T
V
S
L
S
E
Site 4
T33
D
G
K
E
Q
S
E
T
V
S
L
S
E
D
E
Site 5
S35
K
E
Q
S
E
T
V
S
L
S
E
D
E
T
F
Site 6
S37
Q
S
E
T
V
S
L
S
E
D
E
T
F
S
W
Site 7
T41
V
S
L
S
E
D
E
T
F
S
W
P
G
P
K
Site 8
S43
L
S
E
D
E
T
F
S
W
P
G
P
K
T
V
Site 9
T49
F
S
W
P
G
P
K
T
V
T
L
K
R
T
S
Site 10
T51
W
P
G
P
K
T
V
T
L
K
R
T
S
Q
G
Site 11
T55
K
T
V
T
L
K
R
T
S
Q
G
F
G
F
T
Site 12
S56
T
V
T
L
K
R
T
S
Q
G
F
G
F
T
L
Site 13
Y69
T
L
R
H
F
I
V
Y
P
P
E
S
A
I
Q
Site 14
S78
P
E
S
A
I
Q
F
S
Y
K
D
E
E
N
G
Site 15
T100
N
R
L
E
P
M
D
T
I
F
V
K
Q
V
K
Site 16
S153
S
D
T
T
L
E
L
S
V
M
P
K
D
E
D
Site 17
T172
L
Q
F
T
K
D
V
T
A
L
A
Y
S
Q
D
Site 18
S177
D
V
T
A
L
A
Y
S
Q
D
A
Y
L
K
G
Site 19
Y181
L
A
Y
S
Q
D
A
Y
L
K
G
N
E
A
Y
Site 20
Y203
P
E
P
P
P
I
C
Y
P
W
L
P
S
A
P
Site 21
S211
P
W
L
P
S
A
P
S
A
M
A
Q
P
V
E
Site 22
S220
M
A
Q
P
V
E
I
S
P
P
D
S
S
L
S
Site 23
S224
V
E
I
S
P
P
D
S
S
L
S
K
Q
Q
T
Site 24
S225
E
I
S
P
P
D
S
S
L
S
K
Q
Q
T
S
Site 25
S227
S
P
P
D
S
S
L
S
K
Q
Q
T
S
T
P
Site 26
T231
S
S
L
S
K
Q
Q
T
S
T
P
V
L
T
Q
Site 27
T233
L
S
K
Q
Q
T
S
T
P
V
L
T
Q
P
G
Site 28
Y243
L
T
Q
P
G
R
A
Y
R
M
E
I
Q
V
P
Site 29
S252
M
E
I
Q
V
P
P
S
P
T
D
V
A
K
S
Site 30
T272
V
C
N
E
S
V
R
T
V
I
V
P
S
E
K
Site 31
S285
E
K
V
V
D
L
L
S
N
R
N
N
H
T
G
Site 32
Y302
H
R
T
E
E
V
R
Y
G
V
S
E
Q
T
S
Site 33
S309
Y
G
V
S
E
Q
T
S
L
K
T
V
S
R
T
Site 34
T312
S
E
Q
T
S
L
K
T
V
S
R
T
T
S
P
Site 35
S314
Q
T
S
L
K
T
V
S
R
T
T
S
P
P
L
Site 36
T316
S
L
K
T
V
S
R
T
T
S
P
P
L
S
I
Site 37
T317
L
K
T
V
S
R
T
T
S
P
P
L
S
I
P
Site 38
S318
K
T
V
S
R
T
T
S
P
P
L
S
I
P
T
Site 39
S322
R
T
T
S
P
P
L
S
I
P
T
T
H
L
I
Site 40
T325
S
P
P
L
S
I
P
T
T
H
L
I
H
Q
P
Site 41
T326
P
P
L
S
I
P
T
T
H
L
I
H
Q
P
A
Site 42
S335
L
I
H
Q
P
A
G
S
R
S
L
E
P
S
G
Site 43
S337
H
Q
P
A
G
S
R
S
L
E
P
S
G
I
L
Site 44
S341
G
S
R
S
L
E
P
S
G
I
L
L
K
S
G
Site 45
S347
P
S
G
I
L
L
K
S
G
N
Y
S
G
H
S
Site 46
Y350
I
L
L
K
S
G
N
Y
S
G
H
S
D
G
I
Site 47
S351
L
L
K
S
G
N
Y
S
G
H
S
D
G
I
S
Site 48
S354
S
G
N
Y
S
G
H
S
D
G
I
S
S
S
R
Site 49
S358
S
G
H
S
D
G
I
S
S
S
R
S
Q
A
V
Site 50
S359
G
H
S
D
G
I
S
S
S
R
S
Q
A
V
E
Site 51
S360
H
S
D
G
I
S
S
S
R
S
Q
A
V
E
A
Site 52
S362
D
G
I
S
S
S
R
S
Q
A
V
E
A
P
S
Site 53
S369
S
Q
A
V
E
A
P
S
V
S
V
N
H
Y
S
Site 54
S371
A
V
E
A
P
S
V
S
V
N
H
Y
S
P
N
Site 55
Y375
P
S
V
S
V
N
H
Y
S
P
N
S
H
Q
H
Site 56
S376
S
V
S
V
N
H
Y
S
P
N
S
H
Q
H
I
Site 57
S379
V
N
H
Y
S
P
N
S
H
Q
H
I
D
W
K
Site 58
Y391
D
W
K
N
Y
K
T
Y
K
E
Y
I
D
N
R
Site 59
Y394
N
Y
K
T
Y
K
E
Y
I
D
N
R
R
L
H
Site 60
S413
T
I
Q
E
R
L
D
S
L
R
A
A
S
Q
S
Site 61
S418
L
D
S
L
R
A
A
S
Q
S
T
T
D
Y
N
Site 62
S420
S
L
R
A
A
S
Q
S
T
T
D
Y
N
Q
V
Site 63
T422
R
A
A
S
Q
S
T
T
D
Y
N
Q
V
V
P
Site 64
Y424
A
S
Q
S
T
T
D
Y
N
Q
V
V
P
N
R
Site 65
T433
Q
V
V
P
N
R
T
T
L
Q
G
R
R
R
S
Site 66
S440
T
L
Q
G
R
R
R
S
T
S
H
D
R
V
P
Site 67
T441
L
Q
G
R
R
R
S
T
S
H
D
R
V
P
Q
Site 68
S442
Q
G
R
R
R
S
T
S
H
D
R
V
P
Q
S
Site 69
S449
S
H
D
R
V
P
Q
S
V
Q
I
R
Q
R
S
Site 70
S456
S
V
Q
I
R
Q
R
S
V
S
Q
E
R
L
E
Site 71
S458
Q
I
R
Q
R
S
V
S
Q
E
R
L
E
D
S
Site 72
S465
S
Q
E
R
L
E
D
S
V
L
M
K
Y
C
P
Site 73
Y470
E
D
S
V
L
M
K
Y
C
P
R
S
A
S
Q
Site 74
S474
L
M
K
Y
C
P
R
S
A
S
Q
G
A
L
T
Site 75
S476
K
Y
C
P
R
S
A
S
Q
G
A
L
T
S
P
Site 76
T481
S
A
S
Q
G
A
L
T
S
P
S
V
S
F
S
Site 77
S482
A
S
Q
G
A
L
T
S
P
S
V
S
F
S
N
Site 78
S484
Q
G
A
L
T
S
P
S
V
S
F
S
N
H
R
Site 79
S486
A
L
T
S
P
S
V
S
F
S
N
H
R
T
R
Site 80
S488
T
S
P
S
V
S
F
S
N
H
R
T
R
S
W
Site 81
T492
V
S
F
S
N
H
R
T
R
S
W
D
Y
I
E
Site 82
Y497
H
R
T
R
S
W
D
Y
I
E
G
Q
D
E
T
Site 83
T504
Y
I
E
G
Q
D
E
T
L
E
N
V
N
S
G
Site 84
S510
E
T
L
E
N
V
N
S
G
T
P
I
P
D
S
Site 85
T512
L
E
N
V
N
S
G
T
P
I
P
D
S
N
G
Site 86
S517
S
G
T
P
I
P
D
S
N
G
E
K
K
Q
T
Site 87
T524
S
N
G
E
K
K
Q
T
Y
K
W
S
G
F
T
Site 88
Y525
N
G
E
K
K
Q
T
Y
K
W
S
G
F
T
E
Site 89
S551
R
Q
Q
E
I
H
K
S
F
R
G
S
N
F
T
Site 90
S555
I
H
K
S
F
R
G
S
N
F
T
V
A
P
S
Site 91
S562
S
N
F
T
V
A
P
S
V
V
N
S
D
N
R
Site 92
S566
V
A
P
S
V
V
N
S
D
N
R
R
M
S
G
Site 93
S572
N
S
D
N
R
R
M
S
G
R
G
V
G
S
V
Site 94
S578
M
S
G
R
G
V
G
S
V
S
Q
F
K
K
I
Site 95
S580
G
R
G
V
G
S
V
S
Q
F
K
K
I
P
P
Site 96
T591
K
I
P
P
D
L
K
T
L
Q
S
N
R
N
F
Site 97
S594
P
D
L
K
T
L
Q
S
N
R
N
F
Q
T
T
Site 98
T600
Q
S
N
R
N
F
Q
T
T
C
G
M
S
L
P
Site 99
T601
S
N
R
N
F
Q
T
T
C
G
M
S
L
P
R
Site 100
S605
F
Q
T
T
C
G
M
S
L
P
R
G
I
S
Q
Site 101
S611
M
S
L
P
R
G
I
S
Q
D
R
S
P
L
V
Site 102
S615
R
G
I
S
Q
D
R
S
P
L
V
K
V
R
S
Site 103
S622
S
P
L
V
K
V
R
S
N
S
L
K
A
P
S
Site 104
S624
L
V
K
V
R
S
N
S
L
K
A
P
S
T
H
Site 105
T630
N
S
L
K
A
P
S
T
H
V
T
K
P
S
F
Site 106
T633
K
A
P
S
T
H
V
T
K
P
S
F
S
Q
K
Site 107
S636
S
T
H
V
T
K
P
S
F
S
Q
K
S
F
V
Site 108
S638
H
V
T
K
P
S
F
S
Q
K
S
F
V
S
I
Site 109
S641
K
P
S
F
S
Q
K
S
F
V
S
I
K
D
Q
Site 110
T664
N
S
L
L
N
Q
Q
T
W
V
R
T
D
S
A
Site 111
S670
Q
T
W
V
R
T
D
S
A
P
D
Q
Q
V
E
Site 112
S681
Q
Q
V
E
T
G
K
S
P
S
L
S
G
A
S
Site 113
S683
V
E
T
G
K
S
P
S
L
S
G
A
S
A
K
Site 114
S685
T
G
K
S
P
S
L
S
G
A
S
A
K
P
A
Site 115
S688
S
P
S
L
S
G
A
S
A
K
P
A
P
Q
S
Site 116
S695
S
A
K
P
A
P
Q
S
S
E
N
A
G
T
S
Site 117
S696
A
K
P
A
P
Q
S
S
E
N
A
G
T
S
D
Site 118
T701
Q
S
S
E
N
A
G
T
S
D
L
E
L
P
V
Site 119
S702
S
S
E
N
A
G
T
S
D
L
E
L
P
V
S
Site 120
S709
S
D
L
E
L
P
V
S
Q
R
N
Q
D
L
S
Site 121
S716
S
Q
R
N
Q
D
L
S
L
Q
E
A
E
T
E
Site 122
S725
Q
E
A
E
T
E
Q
S
D
T
L
D
N
K
E
Site 123
T727
A
E
T
E
Q
S
D
T
L
D
N
K
E
A
V
Site 124
S742
I
L
R
E
K
P
P
S
G
R
Q
T
P
Q
P
Site 125
T746
K
P
P
S
G
R
Q
T
P
Q
P
L
R
H
Q
Site 126
S754
P
Q
P
L
R
H
Q
S
Y
I
L
A
V
N
D
Site 127
T764
L
A
V
N
D
Q
E
T
G
S
D
T
T
C
W
Site 128
S766
V
N
D
Q
E
T
G
S
D
T
T
C
W
L
P
Site 129
T768
D
Q
E
T
G
S
D
T
T
C
W
L
P
N
D
Site 130
S791
R
M
E
E
R
K
A
S
S
T
S
P
P
G
D
Site 131
S792
M
E
E
R
K
A
S
S
T
S
P
P
G
D
S
Site 132
T793
E
E
R
K
A
S
S
T
S
P
P
G
D
S
L
Site 133
S794
E
R
K
A
S
S
T
S
P
P
G
D
S
L
A
Site 134
S802
P
P
G
D
S
L
A
S
I
P
F
I
D
E
P
Site 135
T810
I
P
F
I
D
E
P
T
S
P
S
I
D
H
D
Site 136
S811
P
F
I
D
E
P
T
S
P
S
I
D
H
D
I
Site 137
S856
P
L
I
R
R
Q
L
S
H
D
H
E
S
V
G
Site 138
S861
Q
L
S
H
D
H
E
S
V
G
P
P
S
L
D
Site 139
S866
H
E
S
V
G
P
P
S
L
D
A
Q
P
N
S
Site 140
S873
S
L
D
A
Q
P
N
S
K
T
E
R
S
K
S
Site 141
T875
D
A
Q
P
N
S
K
T
E
R
S
K
S
Y
D
Site 142
S878
P
N
S
K
T
E
R
S
K
S
Y
D
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S
L
L
T
P
T
R
G
Site 295
T1747
K
S
T
G
S
L
L
T
P
T
R
G
E
S
E
Site 296
T1749
T
G
S
L
L
T
P
T
R
G
E
S
E
K
Q
Site 297
S1753
L
T
P
T
R
G
E
S
E
K
Q
E
P
T
W
Site 298
S1796
A
E
T
A
K
R
K
S
I
R
R
R
H
T
L
Site 299
T1802
K
S
I
R
R
R
H
T
L
G
G
H
R
D
A
Site 300
T1810
L
G
G
H
R
D
A
T
E
I
S
V
L
N
F
Site 301
S1824
F
W
K
V
H
E
Q
S
G
E
R
E
S
E
L
Site 302
S1829
E
Q
S
G
E
R
E
S
E
L
S
A
V
N
R
Site 303
S1832
G
E
R
E
S
E
L
S
A
V
N
R
L
K
P
Site 304
S1842
N
R
L
K
P
K
C
S
A
Q
D
L
S
I
S
Site 305
S1847
K
C
S
A
Q
D
L
S
I
S
D
W
L
A
R
Site 306
S1849
S
A
Q
D
L
S
I
S
D
W
L
A
R
E
R
Site 307
T1859
L
A
R
E
R
L
R
T
S
T
S
D
L
S
R
Site 308
S1860
A
R
E
R
L
R
T
S
T
S
D
L
S
R
G
Site 309
T1861
R
E
R
L
R
T
S
T
S
D
L
S
R
G
E
Site 310
S1862
E
R
L
R
T
S
T
S
D
L
S
R
G
E
I
Site 311
S1865
R
T
S
T
S
D
L
S
R
G
E
I
G
D
P
Site 312
T1874
G
E
I
G
D
P
Q
T
E
N
P
S
T
R
E
Site 313
T1879
P
Q
T
E
N
P
S
T
R
E
I
A
T
T
D
Site 314
T1885
S
T
R
E
I
A
T
T
D
T
P
L
S
L
H
Site 315
T1887
R
E
I
A
T
T
D
T
P
L
S
L
H
C
N
Site 316
S1890
A
T
T
D
T
P
L
S
L
H
C
N
T
G
S
Site 317
T1895
P
L
S
L
H
C
N
T
G
S
S
S
S
T
L
Site 318
S1897
S
L
H
C
N
T
G
S
S
S
S
T
L
A
S
Site 319
S1898
L
H
C
N
T
G
S
S
S
S
T
L
A
S
T
Site 320
S1899
H
C
N
T
G
S
S
S
S
T
L
A
S
T
N
Site 321
S1900
C
N
T
G
S
S
S
S
T
L
A
S
T
N
R
Site 322
T1901
N
T
G
S
S
S
S
T
L
A
S
T
N
R
P
Site 323
S1904
S
S
S
S
T
L
A
S
T
N
R
P
L
L
S
Site 324
T1905
S
S
S
T
L
A
S
T
N
R
P
L
L
S
I
Site 325
S1911
S
T
N
R
P
L
L
S
I
P
P
Q
S
P
D
Site 326
S1916
L
L
S
I
P
P
Q
S
P
D
Q
I
N
G
E
Site 327
S1924
P
D
Q
I
N
G
E
S
F
Q
N
V
S
K
N
Site 328
S1929
G
E
S
F
Q
N
V
S
K
N
A
S
S
A
A
Site 329
S1933
Q
N
V
S
K
N
A
S
S
A
A
N
A
Q
P
Site 330
S1944
N
A
Q
P
H
K
L
S
E
T
P
G
S
K
A
Site 331
T1946
Q
P
H
K
L
S
E
T
P
G
S
K
A
E
F
Site 332
S1949
K
L
S
E
T
P
G
S
K
A
E
F
H
P
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation