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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBR4
Full Name:
E3 ubiquitin-protein ligase UBR4
Alias:
FLJ41863; KIAA0462; KIAA1307; N-recognin-4; P600; RBAF600; Retinoblastoma-associated factor 600 kDa; RP5-1126H10.1; Ubiquitin protein ligase E3 component n-recognin 4; Zinc finger, UBR1 type 1; ZUBR1
Type:
Ligase; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
573841
Number AA:
5183
UniProt ID:
Q5T4S7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
A
A
A
P
A
P
G
T
P
A
T
G
A
D
T
Site 2
T21
P
A
P
G
T
P
A
T
G
A
D
T
T
P
G
Site 3
T26
P
A
T
G
A
D
T
T
P
G
W
E
V
A
V
Site 4
S40
V
R
P
L
L
S
A
S
Y
S
A
F
E
M
K
Site 5
S55
E
L
P
Q
L
V
A
S
V
I
E
S
E
S
E
Site 6
Y70
I
L
H
H
E
K
Q
Y
E
P
F
Y
S
S
F
Site 7
Y74
E
K
Q
Y
E
P
F
Y
S
S
F
V
A
L
S
Site 8
S75
K
Q
Y
E
P
F
Y
S
S
F
V
A
L
S
T
Site 9
S76
Q
Y
E
P
F
Y
S
S
F
V
A
L
S
T
H
Site 10
S111
C
K
V
L
I
E
F
S
L
L
R
L
E
N
P
Site 11
S141
K
G
L
C
T
G
C
S
R
L
D
R
T
E
I
Site 12
T146
G
C
S
R
L
D
R
T
E
I
I
T
F
T
A
Site 13
T152
R
T
E
I
I
T
F
T
A
M
M
K
S
A
K
Site 14
T163
K
S
A
K
L
P
Q
T
V
K
T
L
S
D
V
Site 15
T166
K
L
P
Q
T
V
K
T
L
S
D
V
E
D
Q
Site 16
S168
P
Q
T
V
K
T
L
S
D
V
E
D
Q
K
E
Site 17
S178
E
D
Q
K
E
L
A
S
P
V
S
P
E
L
R
Site 18
S181
K
E
L
A
S
P
V
S
P
E
L
R
Q
K
E
Site 19
S199
N
F
L
N
Q
L
T
S
V
F
N
P
R
T
V
Site 20
T205
T
S
V
F
N
P
R
T
V
A
S
Q
P
I
S
Site 21
S208
F
N
P
R
T
V
A
S
Q
P
I
S
T
Q
T
Site 22
T215
S
Q
P
I
S
T
Q
T
L
V
E
G
E
N
D
Site 23
S225
E
G
E
N
D
E
Q
S
S
T
D
Q
A
S
A
Site 24
T227
E
N
D
E
Q
S
S
T
D
Q
A
S
A
I
K
Site 25
S231
Q
S
S
T
D
Q
A
S
A
I
K
T
K
N
V
Site 26
T235
D
Q
A
S
A
I
K
T
K
N
V
F
I
A
Q
Site 27
S253
S
L
Q
E
L
G
G
S
E
K
L
L
R
V
C
Site 28
Y269
N
L
P
Y
F
L
R
Y
I
N
R
F
Q
D
A
Site 29
T293
P
A
T
V
A
D
A
T
A
V
R
N
G
F
H
Site 30
T360
G
S
A
Q
Q
V
R
T
G
S
T
S
S
K
E
Site 31
S362
A
Q
Q
V
R
T
G
S
T
S
S
K
E
D
D
Site 32
T363
Q
Q
V
R
T
G
S
T
S
S
K
E
D
D
Y
Site 33
S364
Q
V
R
T
G
S
T
S
S
K
E
D
D
Y
E
Site 34
S365
V
R
T
G
S
T
S
S
K
E
D
D
Y
E
S
Site 35
Y370
T
S
S
K
E
D
D
Y
E
S
D
A
A
T
I
Site 36
S372
S
K
E
D
D
Y
E
S
D
A
A
T
I
V
Q
Site 37
T376
D
Y
E
S
D
A
A
T
I
V
Q
K
C
L
E
Site 38
S393
D
M
I
G
Q
A
I
S
S
S
R
R
A
G
G
Site 39
S394
M
I
G
Q
A
I
S
S
S
R
R
A
G
G
E
Site 40
S395
I
G
Q
A
I
S
S
S
R
R
A
G
G
E
H
Site 41
Y403
R
R
A
G
G
E
H
Y
Q
N
F
Q
L
L
G
Site 42
S449
L
R
V
R
D
I
L
S
R
T
K
E
G
V
G
Site 43
T451
V
R
D
I
L
S
R
T
K
E
G
V
G
S
P
Site 44
S457
R
T
K
E
G
V
G
S
P
K
L
G
P
G
K
Site 45
S510
D
G
P
P
A
A
L
S
I
M
A
Q
S
T
S
Site 46
S517
S
I
M
A
Q
S
T
S
I
Q
R
I
Q
R
L
Site 47
S555
L
Q
R
Q
R
K
G
S
M
S
S
D
A
S
A
Site 48
S557
R
Q
R
K
G
S
M
S
S
D
A
S
A
S
T
Site 49
S558
Q
R
K
G
S
M
S
S
D
A
S
A
S
T
D
Site 50
S561
G
S
M
S
S
D
A
S
A
S
T
D
S
N
T
Site 51
S563
M
S
S
D
A
S
A
S
T
D
S
N
T
Y
Y
Site 52
S566
D
A
S
A
S
T
D
S
N
T
Y
Y
E
D
D
Site 53
T568
S
A
S
T
D
S
N
T
Y
Y
E
D
D
F
S
Site 54
Y570
S
T
D
S
N
T
Y
Y
E
D
D
F
S
S
T
Site 55
S575
T
Y
Y
E
D
D
F
S
S
T
E
E
D
S
S
Site 56
S576
Y
Y
E
D
D
F
S
S
T
E
E
D
S
S
Q
Site 57
T577
Y
E
D
D
F
S
S
T
E
E
D
S
S
Q
D
Site 58
S582
S
S
T
E
E
D
S
S
Q
D
D
D
S
E
P
Site 59
S587
D
S
S
Q
D
D
D
S
E
P
I
L
G
Q
W
Site 60
T598
L
G
Q
W
F
E
E
T
I
S
P
S
K
E
K
Site 61
S600
Q
W
F
E
E
T
I
S
P
S
K
E
K
A
A
Site 62
S619
P
P
P
P
P
L
E
S
S
P
R
V
K
S
P
Site 63
S620
P
P
P
P
L
E
S
S
P
R
V
K
S
P
S
Site 64
S625
E
S
S
P
R
V
K
S
P
S
K
Q
A
P
G
Site 65
S627
S
P
R
V
K
S
P
S
K
Q
A
P
G
E
K
Site 66
T659
S
N
I
L
N
F
I
T
S
S
M
L
N
S
R
Site 67
S660
N
I
L
N
F
I
T
S
S
M
L
N
S
R
N
Site 68
S661
I
L
N
F
I
T
S
S
M
L
N
S
R
N
N
Site 69
S665
I
T
S
S
M
L
N
S
R
N
N
F
I
R
N
Site 70
Y673
R
N
N
F
I
R
N
Y
L
S
V
S
L
S
E
Site 71
S675
N
F
I
R
N
Y
L
S
V
S
L
S
E
H
H
Site 72
S677
I
R
N
Y
L
S
V
S
L
S
E
H
H
M
A
Site 73
S679
N
Y
L
S
V
S
L
S
E
H
H
M
A
T
L
Site 74
S702
K
D
G
L
K
G
S
S
D
E
E
F
A
A
A
Site 75
S716
A
L
Y
H
F
N
H
S
L
V
T
S
D
L
Q
Site 76
S720
F
N
H
S
L
V
T
S
D
L
Q
S
P
N
L
Site 77
S724
L
V
T
S
D
L
Q
S
P
N
L
Q
N
T
L
Site 78
T730
Q
S
P
N
L
Q
N
T
L
L
Q
Q
L
G
V
Site 79
S741
Q
L
G
V
A
P
F
S
E
G
P
W
P
L
Y
Site 80
Y748
S
E
G
P
W
P
L
Y
I
H
P
Q
S
L
S
Site 81
S788
K
V
W
D
R
F
L
S
T
M
K
Q
N
A
L
Site 82
T824
I
F
H
N
F
T
E
T
G
R
R
A
I
L
S
Site 83
Y875
Q
Y
S
K
A
P
V
Y
L
F
E
Q
V
Q
H
Site 84
S886
Q
V
Q
H
N
L
L
S
P
P
F
G
W
A
S
Site 85
S893
S
P
P
F
G
W
A
S
G
S
Q
D
S
N
S
Site 86
S895
P
F
G
W
A
S
G
S
Q
D
S
N
S
R
R
Site 87
S898
W
A
S
G
S
Q
D
S
N
S
R
R
A
T
T
Site 88
S900
S
G
S
Q
D
S
N
S
R
R
A
T
T
P
L
Site 89
T904
D
S
N
S
R
R
A
T
T
P
L
Y
H
G
F
Site 90
T905
S
N
S
R
R
A
T
T
P
L
Y
H
G
F
K
Site 91
Y908
R
R
A
T
T
P
L
Y
H
G
F
K
E
V
E
Site 92
S919
K
E
V
E
E
N
W
S
K
H
F
S
S
D
A
Site 93
S923
E
N
W
S
K
H
F
S
S
D
A
V
P
H
P
Site 94
S924
N
W
S
K
H
F
S
S
D
A
V
P
H
P
R
Site 95
S937
P
R
F
Y
C
V
L
S
P
E
A
S
E
D
D
Site 96
S941
C
V
L
S
P
E
A
S
E
D
D
L
N
R
L
Site 97
Y963
L
F
S
K
L
V
K
Y
D
E
L
Y
A
A
L
Site 98
T982
A
A
G
S
Q
L
D
T
V
R
R
K
E
N
K
Site 99
T1018
G
I
L
P
P
S
K
T
Y
I
N
Q
L
S
M
Site 100
S1024
K
T
Y
I
N
Q
L
S
M
N
S
P
E
M
S
Site 101
S1027
I
N
Q
L
S
M
N
S
P
E
M
S
E
C
D
Site 102
S1031
S
M
N
S
P
E
M
S
E
C
D
I
L
H
T
Site 103
T1038
S
E
C
D
I
L
H
T
L
R
W
S
S
R
L
Site 104
S1042
I
L
H
T
L
R
W
S
S
R
L
R
I
S
S
Site 105
S1043
L
H
T
L
R
W
S
S
R
L
R
I
S
S
Y
Site 106
S1049
S
S
R
L
R
I
S
S
Y
V
N
W
I
K
D
Site 107
Y1050
S
R
L
R
I
S
S
Y
V
N
W
I
K
D
H
Site 108
S1070
M
K
A
E
H
A
S
S
L
L
E
L
A
S
T
Site 109
Y1085
T
K
C
S
S
V
K
Y
D
V
E
I
V
E
E
Site 110
Y1093
D
V
E
I
V
E
E
Y
F
A
R
Q
I
S
S
Site 111
S1134
A
I
S
K
V
Q
V
S
L
D
E
H
F
S
K
Site 112
S1151
A
E
T
D
P
H
K
S
S
E
I
T
K
N
L
Site 113
Y1176
Y
A
S
F
T
R
A
Y
L
L
Q
N
F
N
E
Site 114
T1187
N
F
N
E
E
G
T
T
E
K
P
S
K
E
K
Site 115
S1191
E
G
T
T
E
K
P
S
K
E
K
L
Q
G
F
Site 116
T1213
S
S
R
C
K
A
N
T
L
G
P
T
L
V
Q
Site 117
T1228
N
L
P
S
S
V
Q
T
V
C
E
S
W
N
N
Site 118
T1255
R
N
A
F
A
N
D
T
I
P
S
E
S
Y
I
Site 119
S1302
T
G
D
L
I
V
W
S
D
E
M
N
P
P
Q
Site 120
S1325
L
L
E
S
S
T
E
S
V
A
E
I
S
S
N
Site 121
S1343
R
I
L
G
P
A
E
S
D
E
F
L
A
R
V
Site 122
S1370
A
N
H
A
D
P
N
S
G
L
D
E
S
I
L
Site 123
S1375
P
N
S
G
L
D
E
S
I
L
E
E
C
L
Q
Site 124
Y1383
I
L
E
E
C
L
Q
Y
L
E
K
Q
L
E
S
Site 125
S1391
L
E
K
Q
L
E
S
S
Q
A
R
K
A
M
E
Site 126
S1402
K
A
M
E
E
F
F
S
D
S
G
E
L
V
Q
Site 127
S1441
L
F
Q
L
T
E
K
S
P
N
P
S
L
L
H
Site 128
S1445
T
E
K
S
P
N
P
S
L
L
H
L
C
G
S
Site 129
T1469
V
R
L
Q
A
W
L
T
R
M
T
T
S
P
P
Site 130
T1472
Q
A
W
L
T
R
M
T
T
S
P
P
K
D
S
Site 131
T1473
A
W
L
T
R
M
T
T
S
P
P
K
D
S
D
Site 132
S1474
W
L
T
R
M
T
T
S
P
P
K
D
S
D
Q
Site 133
S1479
T
T
S
P
P
K
D
S
D
Q
L
D
V
I
Q
Site 134
T1496
R
Q
L
L
Q
L
L
T
T
Y
I
V
R
E
N
Site 135
S1504
T
Y
I
V
R
E
N
S
Q
V
G
E
G
V
C
Site 136
S1565
N
A
A
V
D
W
L
S
R
C
K
K
Y
L
S
Site 137
Y1570
W
L
S
R
C
K
K
Y
L
S
Q
K
N
V
V
Site 138
S1572
S
R
C
K
K
Y
L
S
Q
K
N
V
V
E
K
Site 139
T1607
M
S
Y
L
A
D
V
T
N
A
L
S
Q
S
N
Site 140
S1611
A
D
V
T
N
A
L
S
Q
S
N
G
Q
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Site 444
T4762
S
S
D
E
G
I
G
T
L
A
E
N
L
L
E
Site 445
T4788
I
D
A
A
R
R
E
T
R
A
E
K
K
R
M
Site 446
T4821
K
G
Q
V
V
T
K
T
A
L
L
K
Q
M
E
Site 447
T4850
E
G
Y
K
F
Q
P
T
K
V
L
G
I
Y
T
Site 448
Y4877
K
P
R
K
Q
Q
G
Y
S
T
V
S
H
F
N
Site 449
T4879
R
K
Q
Q
G
Y
S
T
V
S
H
F
N
I
V
Site 450
S4906
R
G
R
E
E
W
E
S
A
A
L
Q
N
A
N
Site 451
T4934
V
P
E
S
A
F
A
T
C
L
A
R
H
N
T
Site 452
T4941
T
C
L
A
R
H
N
T
Y
L
Q
E
C
T
G
Site 453
T4953
C
T
G
Q
R
E
P
T
Y
Q
L
N
I
H
D
Site 454
Y4954
T
G
Q
R
E
P
T
Y
Q
L
N
I
H
D
I
Site 455
S4973
L
R
F
A
M
E
Q
S
F
S
A
D
T
G
G
Site 456
S4975
F
A
M
E
Q
S
F
S
A
D
T
G
G
G
G
Site 457
S4985
T
G
G
G
G
R
E
S
N
I
H
L
I
P
Y
Site 458
T5003
T
V
L
Y
V
L
N
T
T
R
A
T
S
R
E
Site 459
T5007
V
L
N
T
T
R
A
T
S
R
E
E
K
N
L
Site 460
S5008
L
N
T
T
R
A
T
S
R
E
E
K
N
L
Q
Site 461
T5054
P
P
E
Q
W
R
A
T
R
V
E
I
L
R
R
Site 462
T5080
P
G
G
A
T
R
L
T
D
K
A
V
K
D
Y
Site 463
Y5087
T
D
K
A
V
K
D
Y
S
A
Y
R
S
S
L
Site 464
S5088
D
K
A
V
K
D
Y
S
A
Y
R
S
S
L
L
Site 465
Y5090
A
V
K
D
Y
S
A
Y
R
S
S
L
L
F
W
Site 466
S5092
K
D
Y
S
A
Y
R
S
S
L
L
F
W
A
L
Site 467
S5113
M
F
K
K
V
P
T
S
N
T
E
G
G
W
S
Site 468
T5115
K
K
V
P
T
S
N
T
E
G
G
W
S
C
S
Site 469
S5120
S
N
T
E
G
G
W
S
C
S
L
A
E
Y
I
Site 470
S5122
T
E
G
G
W
S
C
S
L
A
E
Y
I
R
H
Site 471
Y5126
W
S
C
S
L
A
E
Y
I
R
H
N
D
M
P
Site 472
Y5135
R
H
N
D
M
P
I
Y
E
A
A
D
K
A
L
Site 473
T5144
A
A
D
K
A
L
K
T
F
Q
E
E
F
M
P
Site 474
T5169
A
G
L
L
S
E
I
T
D
P
E
S
F
L
K
Site 475
S5173
S
E
I
T
D
P
E
S
F
L
K
D
L
L
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation