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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM63B
Full Name:
Transmembrane protein 63B
Alias:
C6orf110; DJ421H19.2; DKFZp434P0531; TM63B
Type:
Mass (Da):
94958
Number AA:
832
UniProt ID:
Q5T3F8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
N
N
S
N
P
K
D
Y
C
Y
S
A
R
I
R
Site 2
Y24
S
N
P
K
D
Y
C
Y
S
A
R
I
R
S
T
Site 3
S25
N
P
K
D
Y
C
Y
S
A
R
I
R
S
T
V
Site 4
T76
Y
G
R
L
A
L
V
T
D
A
D
R
L
R
R
Site 5
Y93
R
D
R
V
E
Q
E
Y
V
A
S
A
M
H
G
Site 6
S96
V
E
Q
E
Y
V
A
S
A
M
H
G
D
S
H
Site 7
S102
A
S
A
M
H
G
D
S
H
D
R
Y
E
R
L
Site 8
Y106
H
G
D
S
H
D
R
Y
E
R
L
T
S
V
S
Site 9
T110
H
D
R
Y
E
R
L
T
S
V
S
S
S
V
D
Site 10
S111
D
R
Y
E
R
L
T
S
V
S
S
S
V
D
F
Site 11
S113
Y
E
R
L
T
S
V
S
S
S
V
D
F
D
Q
Site 12
S114
E
R
L
T
S
V
S
S
S
V
D
F
D
Q
R
Site 13
S115
R
L
T
S
V
S
S
S
V
D
F
D
Q
R
D
Site 14
Y151
C
G
G
D
A
V
H
Y
L
S
F
Q
R
H
I
Site 15
Y188
D
L
L
E
N
N
A
Y
S
F
G
R
T
T
I
Site 16
S189
L
L
E
N
N
A
Y
S
F
G
R
T
T
I
A
Site 17
T193
N
A
Y
S
F
G
R
T
T
I
A
N
L
K
S
Site 18
T194
A
Y
S
F
G
R
T
T
I
A
N
L
K
S
G
Site 19
S222
Y
L
L
L
T
V
Y
S
M
R
R
H
T
S
K
Site 20
T227
V
Y
S
M
R
R
H
T
S
K
M
R
Y
K
E
Site 21
S228
Y
S
M
R
R
H
T
S
K
M
R
Y
K
E
D
Site 22
Y232
R
H
T
S
K
M
R
Y
K
E
D
D
L
V
K
Site 23
S248
T
L
F
I
N
G
I
S
K
Y
A
E
S
E
K
Site 24
Y250
F
I
N
G
I
S
K
Y
A
E
S
E
K
I
K
Site 25
S253
G
I
S
K
Y
A
E
S
E
K
I
K
K
H
F
Site 26
Y264
K
K
H
F
E
E
A
Y
P
N
C
T
V
L
E
Site 27
Y297
K
A
E
R
G
K
L
Y
F
T
N
L
Q
S
K
Site 28
T299
E
R
G
K
L
Y
F
T
N
L
Q
S
K
E
N
Site 29
S303
L
Y
F
T
N
L
Q
S
K
E
N
V
P
T
M
Site 30
T309
Q
S
K
E
N
V
P
T
M
I
N
P
K
P
C
Site 31
Y335
E
Q
V
E
A
I
E
Y
Y
T
K
L
E
Q
K
Site 32
Y347
E
Q
K
L
K
E
D
Y
K
R
E
K
E
K
V
Site 33
S396
C
R
G
E
P
R
P
S
S
C
S
E
S
L
H
Site 34
S397
R
G
E
P
R
P
S
S
C
S
E
S
L
H
I
Site 35
S399
E
P
R
P
S
S
C
S
E
S
L
H
I
S
N
Site 36
S401
R
P
S
S
C
S
E
S
L
H
I
S
N
W
T
Site 37
T408
S
L
H
I
S
N
W
T
V
S
Y
A
P
D
P
Site 38
Y419
A
P
D
P
Q
N
I
Y
W
E
H
L
S
I
R
Site 39
T506
A
F
F
E
A
H
W
T
R
S
G
E
N
R
T
Site 40
T514
R
S
G
E
N
R
T
T
M
H
K
C
Y
T
F
Site 41
Y616
N
V
K
R
H
Q
A
Y
E
F
Q
F
G
A
A
Site 42
Y661
L
K
H
L
V
D
R
Y
N
L
Y
Y
A
Y
L
Site 43
Y664
L
V
D
R
Y
N
L
Y
Y
A
Y
L
P
A
K
Site 44
Y665
V
D
R
Y
N
L
Y
Y
A
Y
L
P
A
K
L
Site 45
Y667
R
Y
N
L
Y
Y
A
Y
L
P
A
K
L
D
K
Site 46
Y735
V
C
F
G
H
F
K
Y
L
S
A
H
N
Y
K
Site 47
Y741
K
Y
L
S
A
H
N
Y
K
I
E
H
T
E
T
Site 48
T748
Y
K
I
E
H
T
E
T
D
T
V
D
P
R
S
Site 49
T750
I
E
H
T
E
T
D
T
V
D
P
R
S
N
G
Site 50
S755
T
D
T
V
D
P
R
S
N
G
R
P
P
T
A
Site 51
T761
R
S
N
G
R
P
P
T
A
A
A
V
P
K
S
Site 52
S779
I
A
Q
V
L
Q
D
S
E
V
D
G
D
G
D
Site 53
S791
D
G
D
G
A
P
G
S
S
G
D
E
P
P
S
Site 54
S792
G
D
G
A
P
G
S
S
G
D
E
P
P
S
S
Site 55
S798
S
S
G
D
E
P
P
S
S
S
S
Q
D
E
E
Site 56
S799
S
G
D
E
P
P
S
S
S
S
Q
D
E
E
L
Site 57
S801
D
E
P
P
S
S
S
S
Q
D
E
E
L
L
M
Site 58
T814
L
M
P
P
D
A
L
T
D
T
D
F
Q
S
C
Site 59
T816
P
P
D
A
L
T
D
T
D
F
Q
S
C
E
D
Site 60
S820
L
T
D
T
D
F
Q
S
C
E
D
S
L
I
E
Site 61
S824
D
F
Q
S
C
E
D
S
L
I
E
N
E
I
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation