KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EYS
Full Name:
Protein eyes shut homolog
Alias:
Epidermal growth factor-like protein 10;Epidermal growth factor-like protein 11;Protein spacemaker homolog
Type:
Mass (Da):
350780
Number AA:
3165
UniProt ID:
Q5T1H1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
S
S
F
I
N
G
K
T
C
R
R
Q
L
V
E
Site 2
T135
C
R
L
K
G
M
H
T
V
N
S
K
W
L
S
Site 3
S177
K
Q
Q
F
C
Q
E
S
L
S
S
E
F
C
S
Site 4
S179
Q
F
C
Q
E
S
L
S
S
E
F
C
S
G
H
Site 5
S180
F
C
Q
E
S
L
S
S
E
F
C
S
G
H
G
Site 6
S184
S
L
S
S
E
F
C
S
G
H
G
K
C
L
S
Site 7
S191
S
G
H
G
K
C
L
S
E
A
W
S
K
T
Y
Site 8
Y240
E
N
W
D
E
Q
A
Y
E
C
V
C
H
P
P
Site 9
S312
K
R
G
I
C
P
N
S
S
S
A
Y
T
Y
E
Site 10
S313
R
G
I
C
P
N
S
S
S
A
Y
T
Y
E
C
Site 11
T317
P
N
S
S
S
A
Y
T
Y
E
C
P
K
G
S
Site 12
Y318
N
S
S
S
A
Y
T
Y
E
C
P
K
G
S
S
Site 13
S326
E
C
P
K
G
S
S
S
Q
N
G
E
T
D
V
Site 14
T331
S
S
S
Q
N
G
E
T
D
V
S
E
F
S
L
Site 15
S334
Q
N
G
E
T
D
V
S
E
F
S
L
V
P
C
Site 16
S337
E
T
D
V
S
E
F
S
L
V
P
C
Q
N
G
Site 17
S369
F
T
D
L
L
C
K
S
I
Q
T
S
C
E
S
Site 18
S373
L
C
K
S
I
Q
T
S
C
E
S
F
P
L
R
Site 19
S376
S
I
Q
T
S
C
E
S
F
P
L
R
N
N
A
Site 20
Y392
C
K
K
C
E
K
D
Y
P
C
S
C
I
S
G
Site 21
Y479
K
G
P
A
Q
F
E
Y
V
W
Q
L
G
F
A
Site 22
S488
W
Q
L
G
F
A
G
S
E
G
E
K
C
Q
G
Site 23
T512
A
N
C
T
E
D
A
T
Y
V
N
D
P
E
D
Site 24
Y513
N
C
T
E
D
A
T
Y
V
N
D
P
E
D
N
Site 25
S543
A
N
G
C
S
C
L
S
E
E
D
S
Q
E
Y
Site 26
S547
S
C
L
S
E
E
D
S
Q
E
Y
R
Y
L
C
Site 27
Y552
E
D
S
Q
E
Y
R
Y
L
C
F
L
R
W
A
Site 28
Y563
L
R
W
A
G
N
M
Y
L
E
N
T
T
D
D
Site 29
S591
E
I
N
R
P
R
C
S
C
S
L
S
Y
I
G
Site 30
S593
N
R
P
R
C
S
C
S
L
S
Y
I
G
R
L
Site 31
Y635
N
C
S
G
L
Q
R
Y
E
R
N
I
C
E
I
Site 32
T644
R
N
I
C
E
I
D
T
E
D
C
K
S
A
S
Site 33
S649
I
D
T
E
D
C
K
S
A
S
C
K
N
G
T
Site 34
S651
T
E
D
C
K
S
A
S
C
K
N
G
T
T
S
Site 35
Y664
T
S
T
H
L
R
G
Y
F
F
R
K
C
V
P
Site 36
Y725
S
C
L
C
N
P
G
Y
V
G
I
R
C
E
Q
Site 37
T747
N
A
C
E
H
N
S
T
C
K
D
L
H
L
S
Site 38
Y790
N
S
T
C
T
D
L
Y
K
S
Y
R
C
E
C
Site 39
S923
C
R
P
G
F
S
G
S
L
C
E
I
E
I
N
Site 40
S973
D
V
N
K
C
K
I
S
P
C
L
D
E
E
N
Site 41
Y983
L
D
E
E
N
C
V
Y
R
T
D
G
Y
N
C
Site 42
Y988
C
V
Y
R
T
D
G
Y
N
C
L
C
A
P
G
Site 43
S1010
I
N
L
D
E
C
L
S
E
P
C
L
H
D
G
Site 44
Y1026
C
I
D
G
I
N
H
Y
T
C
D
C
K
S
G
Site 45
Y1063
C
T
E
L
I
N
E
Y
P
C
S
C
D
A
D
Site 46
S1066
L
I
N
E
Y
P
C
S
C
D
A
D
G
T
S
Site 47
Y1109
T
C
I
C
P
R
G
Y
T
G
A
Y
C
E
K
Site 48
Y1113
P
R
G
Y
T
G
A
Y
C
E
K
S
I
D
N
Site 49
S1166
E
I
N
I
N
E
C
S
S
S
P
C
L
H
G
Site 50
S1167
I
N
I
N
E
C
S
S
S
P
C
L
H
G
A
Site 51
S1168
N
I
N
E
C
S
S
S
P
C
L
H
G
A
D
Site 52
Y1183
C
E
D
H
I
N
G
Y
V
C
K
C
Q
P
G
Site 53
T1220
M
E
N
E
P
G
S
T
C
L
C
T
P
G
F
Site 54
T1244
G
D
E
I
R
R
I
T
C
L
T
P
I
F
Q
Site 55
T1247
I
R
R
I
T
C
L
T
P
I
F
Q
R
T
D
Site 56
T1253
L
T
P
I
F
Q
R
T
D
P
I
S
T
Q
T
Site 57
S1257
F
Q
R
T
D
P
I
S
T
Q
T
Y
T
I
P
Site 58
Y1261
D
P
I
S
T
Q
T
Y
T
I
P
P
S
E
T
Site 59
T1262
P
I
S
T
Q
T
Y
T
I
P
P
S
E
T
L
Site 60
S1266
Q
T
Y
T
I
P
P
S
E
T
L
V
S
S
F
Site 61
T1268
Y
T
I
P
P
S
E
T
L
V
S
S
F
P
S
Site 62
S1271
P
P
S
E
T
L
V
S
S
F
P
S
I
K
A
Site 63
S1272
P
S
E
T
L
V
S
S
F
P
S
I
K
A
T
Site 64
T1287
R
I
P
A
I
M
D
T
Y
P
V
D
Q
G
P
Site 65
Y1288
I
P
A
I
M
D
T
Y
P
V
D
Q
G
P
K
Site 66
S1338
R
E
L
S
A
K
H
S
L
L
S
S
A
D
V
Site 67
S1341
S
A
K
H
S
L
L
S
S
A
D
V
S
S
S
Site 68
S1342
A
K
H
S
L
L
S
S
A
D
V
S
S
S
R
Site 69
S1347
L
S
S
A
D
V
S
S
S
R
F
L
N
F
G
Site 70
S1348
S
S
A
D
V
S
S
S
R
F
L
N
F
G
I
Site 71
T1366
A
Q
I
V
Q
D
K
T
S
V
S
H
M
P
I
Site 72
S1367
Q
I
V
Q
D
K
T
S
V
S
H
M
P
I
R
Site 73
S1369
V
Q
D
K
T
S
V
S
H
M
P
I
R
T
S
Site 74
T1391
F
P
D
R
R
A
R
T
P
F
I
M
S
S
L
Site 75
S1430
P
T
T
S
V
I
R
S
I
P
G
A
D
I
E
Site 76
S1442
D
I
E
L
N
R
Q
S
L
L
S
R
G
F
L
Site 77
Y1472
A
Q
E
D
I
E
E
Y
S
A
D
S
L
I
S
Site 78
S1473
Q
E
D
I
E
E
Y
S
A
D
S
L
I
S
R
Site 79
S1476
I
E
E
Y
S
A
D
S
L
I
S
R
R
E
H
Site 80
S1479
Y
S
A
D
S
L
I
S
R
R
E
H
W
R
L
Site 81
S1488
R
E
H
W
R
L
L
S
P
S
M
S
P
I
F
Site 82
S1490
H
W
R
L
L
S
P
S
M
S
P
I
F
P
A
Site 83
S1517
S
S
A
L
H
R
F
S
T
K
A
F
N
P
S
Site 84
T1518
S
A
L
H
R
F
S
T
K
A
F
N
P
S
E
Site 85
T1530
P
S
E
Y
Q
A
I
T
E
A
S
S
N
Q
R
Site 86
T1539
A
S
S
N
Q
R
L
T
N
I
K
S
Q
A
A
Site 87
S1543
Q
R
L
T
N
I
K
S
Q
A
A
D
S
L
R
Site 88
S1548
I
K
S
Q
A
A
D
S
L
R
E
L
S
Q
T
Site 89
S1553
A
D
S
L
R
E
L
S
Q
T
C
A
T
C
S
Site 90
T1555
S
L
R
E
L
S
Q
T
C
A
T
C
S
M
T
Site 91
S1560
S
Q
T
C
A
T
C
S
M
T
E
I
K
S
S
Site 92
T1562
T
C
A
T
C
S
M
T
E
I
K
S
S
R
E
Site 93
S1566
C
S
M
T
E
I
K
S
S
R
E
F
S
D
Q
Site 94
S1567
S
M
T
E
I
K
S
S
R
E
F
S
D
Q
V
Site 95
S1571
I
K
S
S
R
E
F
S
D
Q
V
L
H
S
K
Site 96
S1577
F
S
D
Q
V
L
H
S
K
Q
S
H
F
Y
E
Site 97
T1606
L
M
G
A
Q
T
I
T
S
G
H
S
F
S
S
Site 98
S1607
M
G
A
Q
T
I
T
S
G
H
S
F
S
S
A
Site 99
S1610
Q
T
I
T
S
G
H
S
F
S
S
A
T
E
I
Site 100
S1613
T
S
G
H
S
F
S
S
A
T
E
I
T
P
S
Site 101
S1628
V
A
F
T
E
V
P
S
L
F
P
S
K
K
S
Site 102
S1632
E
V
P
S
L
F
P
S
K
K
S
A
K
R
T
Site 103
S1635
S
L
F
P
S
K
K
S
A
K
R
T
I
L
S
Site 104
T1639
S
K
K
S
A
K
R
T
I
L
S
S
S
L
E
Site 105
S1642
S
A
K
R
T
I
L
S
S
S
L
E
E
S
I
Site 106
S1643
A
K
R
T
I
L
S
S
S
L
E
E
S
I
T
Site 107
S1644
K
R
T
I
L
S
S
S
L
E
E
S
I
T
L
Site 108
S1648
L
S
S
S
L
E
E
S
I
T
L
S
S
N
L
Site 109
T1650
S
S
L
E
E
S
I
T
L
S
S
N
L
D
V
Site 110
S1675
I
V
P
S
Q
T
I
S
S
D
L
M
N
S
D
Site 111
S1676
V
P
S
Q
T
I
S
S
D
L
M
N
S
D
L
Site 112
S1681
I
S
S
D
L
M
N
S
D
L
T
S
K
M
T
Site 113
S1685
L
M
N
S
D
L
T
S
K
M
T
T
D
E
L
Site 114
T1689
D
L
T
S
K
M
T
T
D
E
L
S
V
S
E
Site 115
S1693
K
M
T
T
D
E
L
S
V
S
E
N
I
L
K
Site 116
Y1707
K
L
L
K
I
R
Q
Y
G
I
T
M
G
P
T
Site 117
T1710
K
I
R
Q
Y
G
I
T
M
G
P
T
E
V
L
Site 118
S1728
S
L
L
D
M
E
K
S
K
G
S
H
T
L
F
Site 119
T1733
E
K
S
K
G
S
H
T
L
F
K
L
H
P
S
Site 120
S1740
T
L
F
K
L
H
P
S
D
S
S
L
D
F
E
Site 121
S1742
F
K
L
H
P
S
D
S
S
L
D
F
E
L
N
Site 122
S1743
K
L
H
P
S
D
S
S
L
D
F
E
L
N
L
Site 123
T1757
L
Q
I
Y
P
D
V
T
L
K
T
Y
S
E
I
Site 124
T1760
Y
P
D
V
T
L
K
T
Y
S
E
I
T
H
A
Site 125
T1778
K
N
N
L
P
P
L
T
G
S
V
P
D
F
S
Site 126
S1780
N
L
P
P
L
T
G
S
V
P
D
F
S
E
V
Site 127
S1785
T
G
S
V
P
D
F
S
E
V
T
T
N
V
A
Site 128
S1809
L
S
I
Q
T
S
S
S
M
S
V
I
R
P
D
Site 129
S1811
I
Q
T
S
S
S
M
S
V
I
R
P
D
W
P
Site 130
Y1819
V
I
R
P
D
W
P
Y
F
T
D
Y
M
T
S
Site 131
Y1823
D
W
P
Y
F
T
D
Y
M
T
S
L
K
K
E
Site 132
T1833
S
L
K
K
E
V
K
T
S
S
E
W
S
K
W
Site 133
S1834
L
K
K
E
V
K
T
S
S
E
W
S
K
W
E
Site 134
S1835
K
K
E
V
K
T
S
S
E
W
S
K
W
E
L
Site 135
S1838
V
K
T
S
S
E
W
S
K
W
E
L
Q
P
S
Site 136
S1845
S
K
W
E
L
Q
P
S
V
Q
Y
Q
E
F
P
Site 137
T1861
A
S
R
H
L
P
F
T
R
S
L
T
L
S
S
Site 138
S1863
R
H
L
P
F
T
R
S
L
T
L
S
S
L
E
Site 139
Y1888
S
D
F
S
C
V
R
Y
Y
G
D
S
Y
L
E
Site 140
Y1889
D
F
S
C
V
R
Y
Y
G
D
S
Y
L
E
F
Site 141
Y1893
V
R
Y
Y
G
D
S
Y
L
E
F
Q
N
V
A
Site 142
S1908
L
N
P
Q
N
N
I
S
L
E
F
Q
T
F
S
Site 143
Y1922
S
S
Y
G
L
L
L
Y
V
K
Q
D
S
N
L
Site 144
Y1946
I
E
N
G
T
L
K
Y
H
F
Y
C
P
G
E
Site 145
Y1949
G
T
L
K
Y
H
F
Y
C
P
G
E
A
K
F
Site 146
S1958
P
G
E
A
K
F
K
S
I
N
T
T
V
R
V
Site 147
T1962
K
F
K
S
I
N
T
T
V
R
V
D
N
G
Q
Site 148
Y1971
R
V
D
N
G
Q
K
Y
T
L
L
I
R
Q
E
Site 149
S2048
I
E
I
N
N
W
R
S
F
I
P
S
K
A
V
Site 150
S2071
R
S
Q
G
F
M
L
S
P
T
A
S
F
V
D
Site 151
S2080
T
A
S
F
V
D
A
S
D
V
T
Q
G
V
D
Site 152
T2088
D
V
T
Q
G
V
D
T
M
W
T
S
V
S
P
Site 153
S2094
D
T
M
W
T
S
V
S
P
S
V
A
A
P
S
Site 154
S2149
D
A
G
L
F
F
P
S
F
N
G
N
S
Y
L
Site 155
Y2155
P
S
F
N
G
N
S
Y
L
E
L
P
F
L
K
Site 156
T2172
L
E
K
E
H
N
R
T
V
T
I
Y
L
T
I
Site 157
T2174
K
E
H
N
R
T
V
T
I
Y
L
T
I
K
T
Site 158
Y2176
H
N
R
T
V
T
I
Y
L
T
I
K
T
N
S
Site 159
T2178
R
T
V
T
I
Y
L
T
I
K
T
N
S
L
N
Site 160
T2187
K
T
N
S
L
N
G
T
I
L
Y
S
N
G
N
Site 161
Y2190
S
L
N
G
T
I
L
Y
S
N
G
N
N
C
G
Site 162
S2211
F
L
V
E
G
R
P
S
V
K
Y
G
C
G
N
Site 163
Y2214
E
G
R
P
S
V
K
Y
G
C
G
N
S
Q
N
Site 164
S2219
V
K
Y
G
C
G
N
S
Q
N
I
L
T
V
S
Site 165
T2224
G
N
S
Q
N
I
L
T
V
S
A
N
Y
S
I
Site 166
S2226
S
Q
N
I
L
T
V
S
A
N
Y
S
I
N
T
Site 167
T2237
S
I
N
T
N
A
F
T
P
I
T
I
R
Y
T
Site 168
T2244
T
P
I
T
I
R
Y
T
T
P
V
G
S
P
G
Site 169
T2271
P
P
V
Q
K
K
D
T
E
I
S
H
A
S
Q
Site 170
S2277
D
T
E
I
S
H
A
S
Q
A
Y
F
E
S
M
Site 171
Y2303
H
K
K
A
G
P
V
Y
G
F
R
G
C
I
L
Site 172
Y2365
F
C
E
C
P
R
L
Y
S
G
K
L
C
Q
F
Site 173
T2385
N
P
C
G
N
G
A
T
C
V
P
K
S
G
T
Site 174
T2414
C
T
D
A
I
N
I
T
Q
P
R
F
S
G
T
Site 175
S2419
N
I
T
Q
P
R
F
S
G
T
D
A
F
G
Y
Site 176
Y2426
S
G
T
D
A
F
G
Y
T
S
F
L
A
Y
S
Site 177
Y2432
G
Y
T
S
F
L
A
Y
S
R
I
S
D
I
S
Site 178
S2436
F
L
A
Y
S
R
I
S
D
I
S
F
H
Y
E
Site 179
S2499
N
L
G
S
G
I
A
S
I
R
S
E
P
L
N
Site 180
S2508
R
S
E
P
L
N
L
S
L
G
V
H
T
V
H
Site 181
S2534
V
D
D
H
K
N
K
S
I
I
A
P
G
R
L
Site 182
Y2551
L
N
V
F
S
Q
F
Y
V
G
G
Y
S
E
Y
Site 183
Y2558
Y
V
G
G
Y
S
E
Y
T
P
D
L
L
P
N
Site 184
T2559
V
G
G
Y
S
E
Y
T
P
D
L
L
P
N
G
Site 185
T2579
G
F
Q
G
C
I
F
T
L
Q
V
R
T
E
K
Site 186
Y2633
I
E
S
G
T
S
V
Y
C
N
C
T
T
G
W
Site 187
T2648
K
G
S
F
C
T
E
T
V
S
T
C
D
P
E
Site 188
S2650
S
F
C
T
E
T
V
S
T
C
D
P
E
H
D
Site 189
T2651
F
C
T
E
T
V
S
T
C
D
P
E
H
D
P
Site 190
T2667
H
H
C
S
R
G
A
T
C
I
S
L
P
H
G
Site 191
S2670
S
R
G
A
T
C
I
S
L
P
H
G
Y
T
C
Site 192
S2714
K
V
K
K
E
A
L
S
I
S
D
P
S
F
R
Site 193
S2716
K
K
E
A
L
S
I
S
D
P
S
F
R
S
N
Site 194
S2719
A
L
S
I
S
D
P
S
F
R
S
N
E
L
S
Site 195
S2722
I
S
D
P
S
F
R
S
N
E
L
S
W
M
S
Site 196
S2726
S
F
R
S
N
E
L
S
W
M
S
F
A
S
F
Site 197
S2729
S
N
E
L
S
W
M
S
F
A
S
F
H
V
R
Site 198
S2732
L
S
W
M
S
F
A
S
F
H
V
R
K
K
T
Site 199
T2739
S
F
H
V
R
K
K
T
H
I
Q
L
Q
F
Q
Site 200
T2788
R
Y
N
L
G
D
R
T
I
I
L
E
T
L
Q
Site 201
Y2817
G
R
V
G
A
E
G
Y
L
D
L
D
G
I
N
Site 202
T2831
N
V
T
E
K
A
S
T
K
M
S
S
L
D
T
Site 203
S2834
E
K
A
S
T
K
M
S
S
L
D
T
N
T
D
Site 204
T2838
T
K
M
S
S
L
D
T
N
T
D
F
Y
I
G
Site 205
T2840
M
S
S
L
D
T
N
T
D
F
Y
I
G
G
V
Site 206
T2882
N
N
Q
E
L
Q
L
T
E
F
G
A
K
G
G
Site 207
S2890
E
F
G
A
K
G
G
S
N
V
G
D
C
D
G
Site 208
T2912
C
R
N
G
G
E
C
T
V
N
G
T
T
F
S
Site 209
T2930
L
P
D
W
A
G
N
T
C
N
Q
S
V
S
C
Site 210
Y2968
T
L
G
W
V
G
R
Y
C
E
N
K
T
S
F
Site 211
Y2985
A
K
F
M
G
N
S
Y
I
K
Y
I
D
P
N
Site 212
Y2988
M
G
N
S
Y
I
K
Y
I
D
P
N
Y
R
M
Site 213
Y2993
I
K
Y
I
D
P
N
Y
R
M
R
N
L
Q
F
Site 214
T3001
R
M
R
N
L
Q
F
T
T
I
S
L
N
F
S
Site 215
S3004
N
L
Q
F
T
T
I
S
L
N
F
S
T
T
K
Site 216
S3008
T
T
I
S
L
N
F
S
T
T
K
T
E
G
L
Site 217
S3050
V
N
L
G
E
R
I
S
V
P
M
S
Y
N
N
Site 218
S3088
I
N
N
S
L
I
L
S
E
D
I
D
P
H
K
Site 219
T3127
V
T
Q
E
I
F
K
T
N
F
V
G
K
I
K
Site 220
Y3153
E
L
I
K
L
E
G
Y
N
V
Y
D
G
D
E
Site 221
Y3156
K
L
E
G
Y
N
V
Y
D
G
D
E
Q
N
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation