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Updated November 2019
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Protein Info
Short Name:
FAM83B
Full Name:
Protein FAM83B
Alias:
C6orf143; FA83B; Family with sequence similarity 83, member B; FLJ30642; LOC222584
Type:
Unknown function
Mass (Da):
114799
Number AA:
1011
UniProt ID:
Q5T0W9
International Prot ID:
IPI00304527
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
E
T
S
S
M
L
S
S
L
N
D
Site 2
S8
M
E
T
S
S
M
L
S
S
L
N
D
E
C
K
Site 3
S9
E
T
S
S
M
L
S
S
L
N
D
E
C
K
S
Site 4
S16
S
L
N
D
E
C
K
S
D
N
Y
I
E
P
H
Site 5
Y19
D
E
C
K
S
D
N
Y
I
E
P
H
Y
K
E
Site 6
Y24
D
N
Y
I
E
P
H
Y
K
E
W
Y
R
V
A
Site 7
S53
F
L
V
Q
E
R
V
S
D
F
L
A
E
E
E
Site 8
Y63
L
A
E
E
E
I
N
Y
I
L
K
N
V
Q
K
Site 9
S82
T
A
H
G
T
D
D
S
C
D
D
T
L
S
S
Site 10
T86
T
D
D
S
C
D
D
T
L
S
S
G
T
Y
W
Site 11
S88
D
S
C
D
D
T
L
S
S
G
T
Y
W
P
V
Site 12
S89
S
C
D
D
T
L
S
S
G
T
Y
W
P
V
E
Site 13
Y92
D
T
L
S
S
G
T
Y
W
P
V
E
S
D
V
Site 14
S97
G
T
Y
W
P
V
E
S
D
V
E
A
P
N
L
Site 15
T134
P
P
R
A
H
L
L
T
I
K
E
T
I
R
K
Site 16
S170
F
K
E
I
V
E
A
S
T
R
G
V
S
V
Y
Site 17
T171
K
E
I
V
E
A
S
T
R
G
V
S
V
Y
I
Site 18
S175
E
A
S
T
R
G
V
S
V
Y
I
L
L
D
E
Site 19
Y177
S
T
R
G
V
S
V
Y
I
L
L
D
E
S
N
Site 20
T209
L
R
N
I
R
V
R
T
V
K
G
Q
D
Y
L
Site 21
Y215
R
T
V
K
G
Q
D
Y
L
S
K
T
G
A
K
Site 22
S217
V
K
G
Q
D
Y
L
S
K
T
G
A
K
F
H
Site 23
T219
G
Q
D
Y
L
S
K
T
G
A
K
F
H
G
K
Site 24
S249
G
S
Y
S
Y
M
W
S
F
E
K
A
H
L
S
Site 25
S268
I
T
G
Q
L
V
E
S
F
D
E
E
F
R
T
Site 26
T275
S
F
D
E
E
F
R
T
L
Y
A
R
S
C
V
Site 27
Y277
D
E
E
F
R
T
L
Y
A
R
S
C
V
P
S
Site 28
S284
Y
A
R
S
C
V
P
S
S
F
A
Q
E
E
S
Site 29
S285
A
R
S
C
V
P
S
S
F
A
Q
E
E
S
A
Site 30
S291
S
S
F
A
Q
E
E
S
A
R
V
K
H
G
K
Site 31
T305
K
A
L
W
E
N
G
T
Y
Q
H
S
V
S
S
Site 32
Y306
A
L
W
E
N
G
T
Y
Q
H
S
V
S
S
L
Site 33
S309
E
N
G
T
Y
Q
H
S
V
S
S
L
A
S
V
Site 34
S311
G
T
Y
Q
H
S
V
S
S
L
A
S
V
S
S
Site 35
S312
T
Y
Q
H
S
V
S
S
L
A
S
V
S
S
Q
Site 36
S315
H
S
V
S
S
L
A
S
V
S
S
Q
R
N
L
Site 37
S317
V
S
S
L
A
S
V
S
S
Q
R
N
L
F
G
Site 38
S318
S
S
L
A
S
V
S
S
Q
R
N
L
F
G
R
Site 39
S334
D
K
I
H
K
L
D
S
S
Y
F
K
N
R
G
Site 40
S335
K
I
H
K
L
D
S
S
Y
F
K
N
R
G
I
Site 41
Y336
I
H
K
L
D
S
S
Y
F
K
N
R
G
I
Y
Site 42
Y343
Y
F
K
N
R
G
I
Y
T
L
N
E
H
D
K
Site 43
Y351
T
L
N
E
H
D
K
Y
N
I
R
S
H
G
Y
Site 44
S388
N
E
N
W
K
R
H
S
Y
A
G
E
Q
P
E
Site 45
Y389
E
N
W
K
R
H
S
Y
A
G
E
Q
P
E
T
Site 46
T396
Y
A
G
E
Q
P
E
T
V
P
Y
L
L
L
N
Site 47
Y399
E
Q
P
E
T
V
P
Y
L
L
L
N
R
A
L
Site 48
T409
L
N
R
A
L
N
R
T
N
N
P
P
G
N
W
Site 49
S420
P
G
N
W
K
K
P
S
D
S
L
S
V
A
S
Site 50
S422
N
W
K
K
P
S
D
S
L
S
V
A
S
S
S
Site 51
S424
K
K
P
S
D
S
L
S
V
A
S
S
S
R
E
Site 52
S427
S
D
S
L
S
V
A
S
S
S
R
E
G
Y
V
Site 53
S428
D
S
L
S
V
A
S
S
S
R
E
G
Y
V
S
Site 54
S429
S
L
S
V
A
S
S
S
R
E
G
Y
V
S
H
Site 55
Y433
A
S
S
S
R
E
G
Y
V
S
H
H
N
T
P
Site 56
S435
S
S
R
E
G
Y
V
S
H
H
N
T
P
A
Q
Site 57
T439
G
Y
V
S
H
H
N
T
P
A
Q
S
F
A
N
Site 58
S443
H
H
N
T
P
A
Q
S
F
A
N
R
L
A
Q
Site 59
T453
N
R
L
A
Q
R
K
T
T
N
L
A
D
R
N
Site 60
T454
R
L
A
Q
R
K
T
T
N
L
A
D
R
N
S
Site 61
S461
T
N
L
A
D
R
N
S
N
V
R
R
S
F
N
Site 62
S466
R
N
S
N
V
R
R
S
F
N
G
T
D
N
H
Site 63
T470
V
R
R
S
F
N
G
T
D
N
H
I
R
F
L
Site 64
T483
F
L
Q
Q
R
M
P
T
L
E
H
T
T
K
S
Site 65
T487
R
M
P
T
L
E
H
T
T
K
S
F
L
R
N
Site 66
S490
T
L
E
H
T
T
K
S
F
L
R
N
W
R
I
Site 67
S499
L
R
N
W
R
I
E
S
Y
L
N
D
H
S
E
Site 68
Y500
R
N
W
R
I
E
S
Y
L
N
D
H
S
E
A
Site 69
S505
E
S
Y
L
N
D
H
S
E
A
T
P
D
S
N
Site 70
T508
L
N
D
H
S
E
A
T
P
D
S
N
G
S
A
Site 71
S511
H
S
E
A
T
P
D
S
N
G
S
A
L
G
D
Site 72
Y523
L
G
D
R
F
E
G
Y
D
N
P
E
N
L
K
Site 73
Y535
N
L
K
A
N
A
L
Y
T
H
S
R
L
R
S
Site 74
T536
L
K
A
N
A
L
Y
T
H
S
R
L
R
S
S
Site 75
S538
A
N
A
L
Y
T
H
S
R
L
R
S
S
L
V
Site 76
S542
Y
T
H
S
R
L
R
S
S
L
V
F
K
P
T
Site 77
S543
T
H
S
R
L
R
S
S
L
V
F
K
P
T
L
Site 78
T549
S
S
L
V
F
K
P
T
L
P
E
Q
K
E
V
Site 79
S563
V
N
S
C
T
T
G
S
S
N
S
T
I
I
G
Site 80
S564
N
S
C
T
T
G
S
S
N
S
T
I
I
G
S
Site 81
S566
C
T
T
G
S
S
N
S
T
I
I
G
S
Q
G
Site 82
T567
T
T
G
S
S
N
S
T
I
I
G
S
Q
G
S
Site 83
S571
S
N
S
T
I
I
G
S
Q
G
S
E
T
P
K
Site 84
S574
T
I
I
G
S
Q
G
S
E
T
P
K
E
V
P
Site 85
T576
I
G
S
Q
G
S
E
T
P
K
E
V
P
D
T
Site 86
T583
T
P
K
E
V
P
D
T
P
T
N
V
Q
H
L
Site 87
T585
K
E
V
P
D
T
P
T
N
V
Q
H
L
T
D
Site 88
T591
P
T
N
V
Q
H
L
T
D
K
P
L
P
E
S
Site 89
S598
T
D
K
P
L
P
E
S
I
P
K
L
P
L
Q
Site 90
S621
L
Q
V
P
E
N
H
S
V
A
L
N
Q
T
T
Site 91
T632
N
Q
T
T
N
G
H
T
E
S
N
N
Y
I
Y
Site 92
S634
T
T
N
G
H
T
E
S
N
N
Y
I
Y
K
T
Site 93
Y637
G
H
T
E
S
N
N
Y
I
Y
K
T
L
G
V
Site 94
Y639
T
E
S
N
N
Y
I
Y
K
T
L
G
V
N
K
Site 95
T641
S
N
N
Y
I
Y
K
T
L
G
V
N
K
Q
T
Site 96
S664
E
N
L
L
K
R
R
S
F
P
L
F
D
N
S
Site 97
S671
S
F
P
L
F
D
N
S
K
A
N
L
D
P
G
Site 98
S680
A
N
L
D
P
G
N
S
K
H
Y
V
Y
S
T
Site 99
Y683
D
P
G
N
S
K
H
Y
V
Y
S
T
L
T
R
Site 100
Y685
G
N
S
K
H
Y
V
Y
S
T
L
T
R
N
R
Site 101
S686
N
S
K
H
Y
V
Y
S
T
L
T
R
N
R
V
Site 102
T687
S
K
H
Y
V
Y
S
T
L
T
R
N
R
V
R
Site 103
S706
P
K
E
D
L
L
K
S
S
K
S
M
H
N
V
Site 104
S709
D
L
L
K
S
S
K
S
M
H
N
V
T
H
N
Site 105
T725
E
E
D
E
E
E
V
T
K
R
N
S
P
S
G
Site 106
S729
E
E
V
T
K
R
N
S
P
S
G
T
T
T
K
Site 107
T733
K
R
N
S
P
S
G
T
T
T
K
S
V
S
I
Site 108
T735
N
S
P
S
G
T
T
T
K
S
V
S
I
A
A
Site 109
S764
S
K
K
E
V
K
G
S
P
S
F
L
K
K
G
Site 110
S766
K
E
V
K
G
S
P
S
F
L
K
K
G
S
Q
Site 111
S772
P
S
F
L
K
K
G
S
Q
K
L
R
S
L
L
Site 112
S777
K
G
S
Q
K
L
R
S
L
L
S
L
T
P
D
Site 113
S780
Q
K
L
R
S
L
L
S
L
T
P
D
K
K
E
Site 114
T782
L
R
S
L
L
S
L
T
P
D
K
K
E
N
L
Site 115
S790
P
D
K
K
E
N
L
S
K
N
K
A
P
A
F
Site 116
Y798
K
N
K
A
P
A
F
Y
R
L
C
S
S
S
D
Site 117
S802
P
A
F
Y
R
L
C
S
S
S
D
T
L
V
S
Site 118
S803
A
F
Y
R
L
C
S
S
S
D
T
L
V
S
E
Site 119
S804
F
Y
R
L
C
S
S
S
D
T
L
V
S
E
G
Site 120
T806
R
L
C
S
S
S
D
T
L
V
S
E
G
E
E
Site 121
S809
S
S
S
D
T
L
V
S
E
G
E
E
N
Q
K
Site 122
S820
E
N
Q
K
P
K
K
S
D
T
K
V
D
S
S
Site 123
T822
Q
K
P
K
K
S
D
T
K
V
D
S
S
P
R
Site 124
S826
K
S
D
T
K
V
D
S
S
P
R
R
K
H
S
Site 125
S827
S
D
T
K
V
D
S
S
P
R
R
K
H
S
S
Site 126
S833
S
S
P
R
R
K
H
S
S
S
S
N
S
Q
G
Site 127
S834
S
P
R
R
K
H
S
S
S
S
N
S
Q
G
S
Site 128
S835
P
R
R
K
H
S
S
S
S
N
S
Q
G
S
I
Site 129
S836
R
R
K
H
S
S
S
S
N
S
Q
G
S
I
H
Site 130
S838
K
H
S
S
S
S
N
S
Q
G
S
I
H
K
S
Site 131
S841
S
S
S
N
S
Q
G
S
I
H
K
S
K
E
D
Site 132
S845
S
Q
G
S
I
H
K
S
K
E
D
V
T
V
S
Site 133
T850
H
K
S
K
E
D
V
T
V
S
P
S
Q
E
I
Site 134
S852
S
K
E
D
V
T
V
S
P
S
Q
E
I
N
A
Site 135
S854
E
D
V
T
V
S
P
S
Q
E
I
N
A
P
P
Site 136
T867
P
P
D
E
N
K
R
T
P
S
P
G
P
V
E
Site 137
S869
D
E
N
K
R
T
P
S
P
G
P
V
E
S
K
Site 138
S875
P
S
P
G
P
V
E
S
K
F
L
E
R
A
G
Site 139
S885
L
E
R
A
G
D
A
S
A
P
R
F
N
T
E
Site 140
T891
A
S
A
P
R
F
N
T
E
Q
I
Q
Y
R
D
Site 141
Y896
F
N
T
E
Q
I
Q
Y
R
D
S
R
E
I
N
Site 142
S899
E
Q
I
Q
Y
R
D
S
R
E
I
N
A
V
V
Site 143
T907
R
E
I
N
A
V
V
T
P
E
R
R
P
T
S
Site 144
T913
V
T
P
E
R
R
P
T
S
S
P
R
P
T
S
Site 145
S914
T
P
E
R
R
P
T
S
S
P
R
P
T
S
S
Site 146
S915
P
E
R
R
P
T
S
S
P
R
P
T
S
S
E
Site 147
T919
P
T
S
S
P
R
P
T
S
S
E
L
L
R
S
Site 148
S920
T
S
S
P
R
P
T
S
S
E
L
L
R
S
H
Site 149
S921
S
S
P
R
P
T
S
S
E
L
L
R
S
H
S
Site 150
S926
T
S
S
E
L
L
R
S
H
S
T
D
R
R
V
Site 151
S928
S
E
L
L
R
S
H
S
T
D
R
R
V
Y
S
Site 152
T929
E
L
L
R
S
H
S
T
D
R
R
V
Y
S
R
Site 153
Y934
H
S
T
D
R
R
V
Y
S
R
F
E
P
F
C
Site 154
S935
S
T
D
R
R
V
Y
S
R
F
E
P
F
C
K
Site 155
S946
P
F
C
K
I
E
S
S
I
Q
P
T
S
N
M
Site 156
S951
E
S
S
I
Q
P
T
S
N
M
P
N
T
S
I
Site 157
T956
P
T
S
N
M
P
N
T
S
I
N
R
P
E
I
Site 158
S957
T
S
N
M
P
N
T
S
I
N
R
P
E
I
K
Site 159
S965
I
N
R
P
E
I
K
S
A
T
M
G
N
S
Y
Site 160
T967
R
P
E
I
K
S
A
T
M
G
N
S
Y
G
R
Site 161
S971
K
S
A
T
M
G
N
S
Y
G
R
S
S
P
L
Site 162
Y972
S
A
T
M
G
N
S
Y
G
R
S
S
P
L
L
Site 163
S975
M
G
N
S
Y
G
R
S
S
P
L
L
N
Y
N
Site 164
S976
G
N
S
Y
G
R
S
S
P
L
L
N
Y
N
T
Site 165
Y981
R
S
S
P
L
L
N
Y
N
T
G
V
Y
R
S
Site 166
T983
S
P
L
L
N
Y
N
T
G
V
Y
R
S
Y
Q
Site 167
Y986
L
N
Y
N
T
G
V
Y
R
S
Y
Q
P
N
E
Site 168
Y989
N
T
G
V
Y
R
S
Y
Q
P
N
E
N
K
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation