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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTC18
Full Name:
Tetratricopeptide repeat protein 18
Alias:
FLJ25765; Tetratricopeptide repeat 18; Tetratricopeptide repeat domain 18; TPR repeat 18
Type:
Unknown function
Mass (Da):
125721
Number AA:
1121
UniProt ID:
Q5T0N1
International Prot ID:
IPI00217938
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
L
K
G
F
K
G
D
T
P
V
T
F
I
R
A
Site 2
T31
F
K
G
D
T
P
V
T
F
I
R
A
E
F
N
Site 3
T49
L
G
D
S
A
K
I
T
V
S
P
E
G
S
A
Site 4
S51
D
S
A
K
I
T
V
S
P
E
G
S
A
K
Y
Site 5
S55
I
T
V
S
P
E
G
S
A
K
Y
N
F
T
S
Site 6
Y58
S
P
E
G
S
A
K
Y
N
F
T
S
S
F
E
Site 7
S62
S
A
K
Y
N
F
T
S
S
F
E
F
N
P
E
Site 8
S63
A
K
Y
N
F
T
S
S
F
E
F
N
P
E
G
Site 9
T73
F
N
P
E
G
G
I
T
S
D
D
L
A
H
K
Site 10
T101
K
K
Q
K
E
E
K
T
L
I
L
G
Q
A
V
Site 11
S120
P
L
L
E
G
Q
S
S
F
Q
T
T
V
P
L
Site 12
T123
E
G
Q
S
S
F
Q
T
T
V
P
L
H
P
V
Site 13
T124
G
Q
S
S
F
Q
T
T
V
P
L
H
P
V
Q
Site 14
S133
P
L
H
P
V
Q
G
S
P
L
E
T
P
R
S
Site 15
T137
V
Q
G
S
P
L
E
T
P
R
S
S
A
K
Q
Site 16
S140
S
P
L
E
T
P
R
S
S
A
K
Q
C
S
L
Site 17
S141
P
L
E
T
P
R
S
S
A
K
Q
C
S
L
E
Site 18
S146
R
S
S
A
K
Q
C
S
L
E
V
K
V
L
V
Site 19
T186
V
P
E
S
F
I
P
T
G
P
G
Q
N
Y
M
Site 20
Y192
P
T
G
P
G
Q
N
Y
M
V
G
L
Q
V
P
Site 21
Y206
P
S
L
G
E
K
D
Y
P
I
L
F
K
N
G
Site 22
T214
P
I
L
F
K
N
G
T
L
K
L
G
G
E
R
Site 23
Y253
A
F
I
V
G
G
P
Y
E
E
E
E
G
E
L
Site 24
Y288
W
D
L
E
S
R
C
Y
L
D
P
S
A
V
V
Site 25
S292
S
R
C
Y
L
D
P
S
A
V
V
S
F
Q
K
Site 26
S296
L
D
P
S
A
V
V
S
F
Q
K
R
I
A
D
Site 27
S337
T
D
E
E
A
Q
L
S
F
H
G
V
A
Y
V
Site 28
S369
H
V
Y
P
Y
L
D
S
V
V
H
E
K
T
K
Site 29
S380
E
K
T
K
C
L
L
S
L
F
R
D
I
G
H
Site 30
S400
N
K
I
G
G
I
N
S
L
L
S
K
Q
A
V
Site 31
S403
G
G
I
N
S
L
L
S
K
Q
A
V
S
K
N
Site 32
S435
P
G
D
V
Q
A
P
S
I
K
S
Q
S
S
D
Site 33
S438
V
Q
A
P
S
I
K
S
Q
S
S
D
T
P
L
Site 34
S440
A
P
S
I
K
S
Q
S
S
D
T
P
L
E
G
Site 35
S441
P
S
I
K
S
Q
S
S
D
T
P
L
E
G
E
Site 36
T443
I
K
S
Q
S
S
D
T
P
L
E
G
E
P
P
Site 37
S452
L
E
G
E
P
P
L
S
H
N
P
E
G
Q
Q
Site 38
Y460
H
N
P
E
G
Q
Q
Y
V
E
A
G
T
Y
I
Site 39
T501
I
P
P
R
P
P
L
T
R
R
T
G
G
A
Q
Site 40
T504
R
P
P
L
T
R
R
T
G
G
A
Q
K
A
M
Site 41
Y514
A
Q
K
A
M
S
D
Y
H
I
Q
I
K
N
I
Site 42
Y529
S
R
A
I
L
D
E
Y
Y
R
M
F
G
K
Q
Site 43
Y530
R
A
I
L
D
E
Y
Y
R
M
F
G
K
Q
V
Site 44
S542
K
Q
V
A
K
L
E
S
D
M
D
S
E
T
L
Site 45
S546
K
L
E
S
D
M
D
S
E
T
L
E
E
Q
K
Site 46
T548
E
S
D
M
D
S
E
T
L
E
E
Q
K
C
Q
Site 47
S557
E
E
Q
K
C
Q
L
S
Y
E
L
N
C
S
G
Site 48
Y558
E
Q
K
C
Q
L
S
Y
E
L
N
C
S
G
K
Site 49
Y566
E
L
N
C
S
G
K
Y
F
A
F
K
E
Q
L
Site 50
Y585
V
K
I
V
R
D
K
Y
L
K
T
T
S
F
E
Site 51
T588
V
R
D
K
Y
L
K
T
T
S
F
E
S
Q
E
Site 52
S590
D
K
Y
L
K
T
T
S
F
E
S
Q
E
E
L
Site 53
T599
E
S
Q
E
E
L
Q
T
F
I
S
E
L
Y
V
Site 54
Y632
Q
G
T
V
A
T
I
Y
T
S
S
E
Q
L
Q
Site 55
S697
E
C
F
Q
K
A
L
S
L
N
Q
S
H
I
H
Site 56
Y746
A
W
T
L
L
G
L
Y
Y
E
I
Q
N
N
D
Site 57
S781
A
Q
V
T
K
Q
K
S
T
G
V
E
D
T
E
Site 58
T787
K
S
T
G
V
E
D
T
E
E
R
G
K
R
E
Site 59
S795
E
E
R
G
K
R
E
S
S
L
G
P
W
G
I
Site 60
S796
E
R
G
K
R
E
S
S
L
G
P
W
G
I
T
Site 61
T803
S
L
G
P
W
G
I
T
N
G
S
A
T
A
I
Site 62
S806
P
W
G
I
T
N
G
S
A
T
A
I
K
V
E
Site 63
S833
D
K
F
L
E
E
S
S
K
L
Q
S
D
S
Q
Site 64
S837
E
E
S
S
K
L
Q
S
D
S
Q
E
P
I
L
Site 65
S839
S
S
K
L
Q
S
D
S
Q
E
P
I
L
T
T
Site 66
T845
D
S
Q
E
P
I
L
T
T
Q
T
W
D
P
S
Site 67
T846
S
Q
E
P
I
L
T
T
Q
T
W
D
P
S
I
Site 68
T848
E
P
I
L
T
T
Q
T
W
D
P
S
I
S
Q
Site 69
S852
T
T
Q
T
W
D
P
S
I
S
Q
K
P
S
N
Site 70
S854
Q
T
W
D
P
S
I
S
Q
K
P
S
N
T
F
Site 71
S858
P
S
I
S
Q
K
P
S
N
T
F
I
K
E
I
Site 72
T860
I
S
Q
K
P
S
N
T
F
I
K
E
I
P
T
Site 73
S877
E
A
S
K
C
Q
D
S
S
A
L
L
H
P
G
Site 74
S878
A
S
K
C
Q
D
S
S
A
L
L
H
P
G
L
Site 75
Y931
Q
G
G
P
S
C
E
Y
Y
L
V
L
A
Q
T
Site 76
Y932
G
G
P
S
C
E
Y
Y
L
V
L
A
Q
T
H
Site 77
Y960
Q
Q
A
A
Q
M
D
Y
L
N
P
N
V
W
G
Site 78
Y973
W
G
L
K
G
H
L
Y
F
L
S
G
N
H
S
Site 79
S976
K
G
H
L
Y
F
L
S
G
N
H
S
E
A
K
Site 80
S980
Y
F
L
S
G
N
H
S
E
A
K
A
C
Y
E
Site 81
Y986
H
S
E
A
K
A
C
Y
E
R
T
I
S
F
V
Site 82
T989
A
K
A
C
Y
E
R
T
I
S
F
V
V
D
A
Site 83
S991
A
C
Y
E
R
T
I
S
F
V
V
D
A
S
E
Site 84
Y1010
F
L
R
L
G
L
I
Y
L
E
E
K
E
Y
E
Site 85
Y1016
I
Y
L
E
E
K
E
Y
E
K
A
K
K
T
Y
Site 86
Y1023
Y
E
K
A
K
K
T
Y
M
Q
A
C
K
R
S
Site 87
S1032
Q
A
C
K
R
S
P
S
C
L
T
W
L
G
L
Site 88
T1050
C
Y
R
L
E
E
L
T
E
A
E
D
A
L
S
Site 89
S1057
T
E
A
E
D
A
L
S
E
A
N
A
L
N
N
Site 90
Y1065
E
A
N
A
L
N
N
Y
N
A
E
V
W
A
Y
Site 91
Y1092
E
A
E
Q
A
Y
K
Y
M
I
K
L
K
L
K
Site 92
T1113
E
I
H
T
L
Q
E
T
V
G
F
G
N
P
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation