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Updated November 2019
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Protein Info
Short Name:
DACT2
Full Name:
Dapper homolog 2
Alias:
Type:
Mass (Da):
82700
Number AA:
774
UniProt ID:
Q5SW24
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
P
G
G
P
P
G
S
A
G
W
D
R
R
R
Site 2
T38
E
L
Q
G
L
R
A
T
Q
Q
E
R
V
R
G
Site 3
S83
A
A
L
Q
E
Q
L
S
R
L
R
Q
Q
D
I
Site 4
T94
Q
Q
D
I
G
L
K
T
H
L
D
Q
L
D
L
Site 5
S114
Q
L
D
V
G
T
A
S
G
E
A
L
D
S
D
Site 6
S120
A
S
G
E
A
L
D
S
D
S
R
P
S
S
G
Site 7
S122
G
E
A
L
D
S
D
S
R
P
S
S
G
F
Y
Site 8
S125
L
D
S
D
S
R
P
S
S
G
F
Y
E
M
S
Site 9
S126
D
S
D
S
R
P
S
S
G
F
Y
E
M
S
D
Site 10
Y129
S
R
P
S
S
G
F
Y
E
M
S
D
G
G
S
Site 11
S132
S
S
G
F
Y
E
M
S
D
G
G
S
C
S
L
Site 12
S136
Y
E
M
S
D
G
G
S
C
S
L
S
T
S
C
Site 13
S138
M
S
D
G
G
S
C
S
L
S
T
S
C
A
S
Site 14
S170
Q
A
H
K
A
R
P
S
M
G
D
W
R
P
R
Site 15
S178
M
G
D
W
R
P
R
S
V
D
E
T
T
V
P
Site 16
T182
R
P
R
S
V
D
E
T
T
V
P
A
W
R
P
Site 17
T183
P
R
S
V
D
E
T
T
V
P
A
W
R
P
Q
Site 18
S201
E
G
A
R
P
P
G
S
V
E
D
A
G
Q
P
Site 19
T211
D
A
G
Q
P
W
G
T
F
W
P
R
P
V
S
Site 20
S218
T
F
W
P
R
P
V
S
T
G
D
L
D
R
A
Site 21
T230
D
R
A
L
P
A
D
T
G
L
Q
K
A
S
A
Site 22
Y260
L
H
V
P
D
P
K
Y
R
Q
D
L
V
S
Q
Site 23
S266
K
Y
R
Q
D
L
V
S
Q
G
G
R
E
V
Y
Site 24
Y273
S
Q
G
G
R
E
V
Y
P
Y
P
S
P
L
H
Site 25
Y275
G
G
R
E
V
Y
P
Y
P
S
P
L
H
A
V
Site 26
S277
R
E
V
Y
P
Y
P
S
P
L
H
A
V
A
L
Site 27
T295
L
F
V
L
T
K
E
T
P
Q
R
G
G
P
S
Site 28
S302
T
P
Q
R
G
G
P
S
F
P
R
E
S
P
R
Site 29
S307
G
P
S
F
P
R
E
S
P
R
G
P
A
G
L
Site 30
Y333
G
P
A
R
A
R
A
Y
I
D
R
L
L
H
L
Site 31
T345
L
H
L
W
G
R
E
T
P
A
K
G
S
E
G
Site 32
S362
G
P
L
R
H
A
A
S
P
S
P
Q
R
Q
G
Site 33
S364
L
R
H
A
A
S
P
S
P
Q
R
Q
G
G
W
Site 34
S372
P
Q
R
Q
G
G
W
S
T
D
G
G
G
R
L
Site 35
Y408
G
G
P
Q
Q
Q
G
Y
M
P
L
E
G
P
Q
Site 36
S419
E
G
P
Q
Q
S
G
S
L
P
E
E
G
S
K
Site 37
S425
G
S
L
P
E
E
G
S
K
P
S
N
S
C
V
Site 38
S428
P
E
E
G
S
K
P
S
N
S
C
V
L
R
E
Site 39
S430
E
G
S
K
P
S
N
S
C
V
L
R
E
T
M
Site 40
T436
N
S
C
V
L
R
E
T
M
V
Q
A
S
P
S
Site 41
S441
R
E
T
M
V
Q
A
S
P
S
S
K
A
Q
Q
Site 42
S444
M
V
Q
A
S
P
S
S
K
A
Q
Q
T
P
S
Site 43
T449
P
S
S
K
A
Q
Q
T
P
S
A
Q
D
Y
G
Site 44
S451
S
K
A
Q
Q
T
P
S
A
Q
D
Y
G
R
G
Site 45
Y455
Q
T
P
S
A
Q
D
Y
G
R
G
N
I
I
S
Site 46
S462
Y
G
R
G
N
I
I
S
P
S
R
M
L
D
K
Site 47
S464
R
G
N
I
I
S
P
S
R
M
L
D
K
S
P
Site 48
S470
P
S
R
M
L
D
K
S
P
S
P
A
S
G
H
Site 49
S472
R
M
L
D
K
S
P
S
P
A
S
G
H
F
A
Site 50
S475
D
K
S
P
S
P
A
S
G
H
F
A
H
P
S
Site 51
S482
S
G
H
F
A
H
P
S
F
A
A
S
L
K
M
Site 52
S486
A
H
P
S
F
A
A
S
L
K
M
G
P
P
K
Site 53
S494
L
K
M
G
P
P
K
S
K
A
E
K
I
K
R
Site 54
S502
K
A
E
K
I
K
R
S
P
M
D
K
V
L
R
Site 55
S531
A
H
A
A
P
Q
P
S
L
E
W
D
P
A
H
Site 56
T541
W
D
P
A
H
W
P
T
G
R
G
G
L
Q
R
Site 57
S560
A
W
E
A
P
G
R
S
C
S
E
S
T
L
Y
Site 58
S562
E
A
P
G
R
S
C
S
E
S
T
L
Y
P
M
Site 59
S564
P
G
R
S
C
S
E
S
T
L
Y
P
M
P
V
Site 60
T565
G
R
S
C
S
E
S
T
L
Y
P
M
P
V
L
Site 61
S582
L
A
V
A
P
Q
E
S
H
R
T
S
A
Q
A
Site 62
T585
A
P
Q
E
S
H
R
T
S
A
Q
A
L
F
P
Site 63
S586
P
Q
E
S
H
R
T
S
A
Q
A
L
F
P
F
Site 64
S600
F
E
A
S
L
L
T
S
V
A
R
R
K
H
R
Site 65
S611
R
K
H
R
R
W
Q
S
T
V
E
I
S
A
R
Site 66
T612
K
H
R
R
W
Q
S
T
V
E
I
S
A
R
A
Site 67
S616
W
Q
S
T
V
E
I
S
A
R
A
R
L
A
S
Site 68
S623
S
A
R
A
R
L
A
S
C
P
E
S
N
L
G
Site 69
S627
R
L
A
S
C
P
E
S
N
L
G
P
P
R
P
Site 70
S649
P
L
A
R
G
R
P
S
L
V
R
Q
D
A
Y
Site 71
Y656
S
L
V
R
Q
D
A
Y
T
R
S
D
S
E
P
Site 72
T657
L
V
R
Q
D
A
Y
T
R
S
D
S
E
P
S
Site 73
S659
R
Q
D
A
Y
T
R
S
D
S
E
P
S
K
H
Site 74
S661
D
A
Y
T
R
S
D
S
E
P
S
K
H
S
A
Site 75
S667
D
S
E
P
S
K
H
S
A
E
C
D
P
R
F
Site 76
S676
E
C
D
P
R
F
P
S
V
I
P
E
T
S
E
Site 77
T681
F
P
S
V
I
P
E
T
S
E
G
E
S
S
D
Site 78
S682
P
S
V
I
P
E
T
S
E
G
E
S
S
D
H
Site 79
S686
P
E
T
S
E
G
E
S
S
D
H
T
T
N
R
Site 80
S687
E
T
S
E
G
E
S
S
D
H
T
T
N
R
F
Site 81
T690
E
G
E
S
S
D
H
T
T
N
R
F
G
D
R
Site 82
T691
G
E
S
S
D
H
T
T
N
R
F
G
D
R
E
Site 83
S699
N
R
F
G
D
R
E
S
S
S
S
D
E
E
G
Site 84
S700
R
F
G
D
R
E
S
S
S
S
D
E
E
G
G
Site 85
S701
F
G
D
R
E
S
S
S
S
D
E
E
G
G
A
Site 86
S702
G
D
R
E
S
S
S
S
D
E
E
G
G
A
Q
Site 87
T730
G
H
A
E
L
A
W
T
Q
E
A
P
V
S
S
Site 88
S736
W
T
Q
E
A
P
V
S
S
G
P
L
L
S
P
Site 89
T766
K
I
R
R
F
Q
P
T
A
L
K
V
M
T
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation