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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VARS2
Full Name:
Valyl-tRNA synthetase, mitochondrial
Alias:
EC 6.1.1.9; KIAA1885; Valyl-tRNA synthetase 2, mitochondrial (putative); Vars2; Vars2L; VarsL
Type:
Cytoplasm, Mitochondrion protein
Mass (Da):
118462
Number AA:
1063
UniProt ID:
Q5ST30
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004832
PhosphoSite+
KinaseNET
Biological Process:
GO:0006438
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
H
L
P
L
A
S
F
R
P
P
F
W
G
Site 2
S19
P
F
W
G
L
R
H
S
R
G
L
P
R
F
H
Site 3
S27
R
G
L
P
R
F
H
S
V
S
T
Q
S
E
P
Site 4
S29
L
P
R
F
H
S
V
S
T
Q
S
E
P
H
G
Site 5
S32
F
H
S
V
S
T
Q
S
E
P
H
G
S
P
I
Site 6
S37
T
Q
S
E
P
H
G
S
P
I
S
R
R
N
R
Site 7
S40
E
P
H
G
S
P
I
S
R
R
N
R
E
A
K
Site 8
T57
R
L
R
E
K
Q
A
T
L
E
A
E
I
A
G
Site 9
S66
E
A
E
I
A
G
E
S
K
S
P
A
E
S
I
Site 10
S68
E
I
A
G
E
S
K
S
P
A
E
S
I
K
A
Site 11
S72
E
S
K
S
P
A
E
S
I
K
A
W
R
P
K
Site 12
Y84
R
P
K
E
L
V
L
Y
E
I
P
T
K
P
G
Site 13
S97
P
G
E
K
K
D
V
S
G
P
L
P
P
A
Y
Site 14
Y104
S
G
P
L
P
P
A
Y
S
P
R
Y
V
E
A
Site 15
S105
G
P
L
P
P
A
Y
S
P
R
Y
V
E
A
A
Site 16
Y108
P
P
A
Y
S
P
R
Y
V
E
A
A
W
Y
P
Site 17
Y127
E
G
F
F
K
P
E
Y
Q
A
R
L
P
Q
A
Site 18
T135
Q
A
R
L
P
Q
A
T
G
E
T
F
S
M
C
Site 19
S140
Q
A
T
G
E
T
F
S
M
C
I
P
P
P
N
Site 20
S151
P
P
P
N
V
T
G
S
L
H
I
G
H
A
L
Site 21
S210
G
V
R
R
H
E
L
S
R
E
A
F
L
R
E
Site 22
S239
Q
L
R
A
L
G
A
S
L
D
W
D
R
E
C
Site 23
Y271
L
Y
K
A
G
L
L
Y
R
N
H
Q
L
V
N
Site 24
S288
C
A
L
R
S
A
I
S
D
I
E
V
E
N
R
Site 25
T301
N
R
P
L
P
G
H
T
Q
L
R
L
P
G
C
Site 26
T336
D
A
E
V
V
V
G
T
T
R
P
E
T
L
P
Site 27
S355
V
A
V
H
P
D
D
S
R
Y
T
H
L
H
G
Site 28
Y357
V
H
P
D
D
S
R
Y
T
H
L
H
G
R
Q
Site 29
T358
H
P
D
D
S
R
Y
T
H
L
H
G
R
Q
L
Site 30
T394
G
T
G
A
V
K
V
T
P
A
H
S
P
A
D
Site 31
S398
V
K
V
T
P
A
H
S
P
A
D
A
E
M
G
Site 32
S424
A
E
D
G
T
M
T
S
L
C
G
D
W
L
Q
Site 33
Y474
R
S
G
D
V
I
E
Y
L
L
K
N
Q
W
F
Site 34
S497
R
A
A
K
A
V
E
S
G
A
L
E
L
S
P
Site 35
S503
E
S
G
A
L
E
L
S
P
S
F
H
Q
K
N
Site 36
S505
G
A
L
E
L
S
P
S
F
H
Q
K
N
W
Q
Site 37
Y536
W
G
H
Q
I
P
A
Y
L
V
V
E
D
H
A
Site 38
T567
R
E
V
A
A
E
L
T
G
R
P
G
A
E
L
Site 39
T575
G
R
P
G
A
E
L
T
L
E
R
D
P
D
V
Site 40
T585
R
D
P
D
V
L
D
T
W
F
S
S
A
L
F
Site 41
S595
S
S
A
L
F
P
F
S
A
L
G
W
P
Q
E
Site 42
T603
A
L
G
W
P
Q
E
T
P
D
L
A
R
F
Y
Site 43
S660
D
R
Q
G
R
K
M
S
K
S
L
G
N
V
L
Site 44
S662
Q
G
R
K
M
S
K
S
L
G
N
V
L
D
P
Site 45
S674
L
D
P
R
D
I
I
S
G
V
E
M
Q
V
L
Site 46
S687
V
L
Q
E
K
L
R
S
G
N
L
D
P
A
E
Site 47
T721
G
T
D
A
L
R
F
T
L
C
S
H
G
V
Q
Site 48
S735
Q
A
G
D
L
H
L
S
V
S
E
V
Q
S
C
Site 49
S737
G
D
L
H
L
S
V
S
E
V
Q
S
C
R
H
Site 50
S741
L
S
V
S
E
V
Q
S
C
R
H
F
C
N
K
Site 51
S773
P
Q
P
A
E
E
L
S
P
S
S
P
M
D
A
Site 52
S775
P
A
E
E
L
S
P
S
S
P
M
D
A
W
I
Site 53
S776
A
E
E
L
S
P
S
S
P
M
D
A
W
I
L
Site 54
T799
E
C
E
R
G
F
L
T
R
E
L
S
L
V
T
Site 55
S832
V
K
P
V
L
W
H
S
P
R
P
L
G
P
P
Site 56
S879
P
G
C
P
P
A
P
S
I
S
V
A
P
Y
P
Site 57
S887
I
S
V
A
P
Y
P
S
A
C
S
L
E
H
W
Site 58
S890
A
P
Y
P
S
A
C
S
L
E
H
W
R
Q
P
Site 59
S904
P
E
L
E
R
R
F
S
R
V
Q
E
V
V
Q
Site 60
T919
V
L
R
A
L
R
A
T
Y
Q
L
T
K
A
R
Site 61
Y920
L
R
A
L
R
A
T
Y
Q
L
T
K
A
R
P
Site 62
S933
R
P
R
V
L
L
Q
S
S
E
P
G
D
Q
G
Site 63
S934
P
R
V
L
L
Q
S
S
E
P
G
D
Q
G
L
Site 64
S977
G
W
A
Q
A
P
L
S
D
T
A
Q
V
Y
M
Site 65
T979
A
Q
A
P
L
S
D
T
A
Q
V
Y
M
E
L
Site 66
Y1004
P
L
L
A
A
R
R
Y
K
L
Q
K
Q
L
D
Site 67
S1012
K
L
Q
K
Q
L
D
S
L
T
A
R
T
P
S
Site 68
T1014
Q
K
Q
L
D
S
L
T
A
R
T
P
S
E
G
Site 69
T1017
L
D
S
L
T
A
R
T
P
S
E
G
E
A
G
Site 70
S1019
S
L
T
A
R
T
P
S
E
G
E
A
G
T
Q
Site 71
S1032
T
Q
R
Q
Q
K
L
S
S
L
Q
L
E
L
S
Site 72
S1033
Q
R
Q
Q
K
L
S
S
L
Q
L
E
L
S
K
Site 73
S1039
S
S
L
Q
L
E
L
S
K
L
D
K
A
A
S
Site 74
S1046
S
K
L
D
K
A
A
S
H
L
Q
Q
L
M
D
Site 75
S1060
D
E
P
P
A
P
G
S
P
E
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation