KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HP1BP3
Full Name:
Heterochromatin protein 1-binding protein 3
Alias:
Heterochromatin protein 1, binding protein 3; HP1-BP74
Type:
DNA binding protein
Mass (Da):
61207
Number AA:
553
UniProt ID:
Q5SSJ5
International Prot ID:
IPI00448752
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000786
GO:0005634
GO:0005694
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006334
GO:0006334
GO:0006996
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
D
T
S
Q
G
E
L
Site 2
T5
_
_
_
M
A
T
D
T
S
Q
G
E
L
V
H
Site 3
S6
_
_
M
A
T
D
T
S
Q
G
E
L
V
H
P
Site 4
S37
L
G
E
K
V
E
D
S
T
M
P
I
R
R
T
Site 5
T44
S
T
M
P
I
R
R
T
V
N
S
T
R
E
T
Site 6
S47
P
I
R
R
T
V
N
S
T
R
E
T
P
P
K
Site 7
T48
I
R
R
T
V
N
S
T
R
E
T
P
P
K
S
Site 8
T51
T
V
N
S
T
R
E
T
P
P
K
S
K
L
A
Site 9
S55
T
R
E
T
P
P
K
S
K
L
A
E
G
E
E
Site 10
S70
E
K
P
E
P
D
I
S
S
E
E
S
V
S
T
Site 11
S71
K
P
E
P
D
I
S
S
E
E
S
V
S
T
V
Site 12
S74
P
D
I
S
S
E
E
S
V
S
T
V
E
E
Q
Site 13
S76
I
S
S
E
E
S
V
S
T
V
E
E
Q
E
N
Site 14
T77
S
S
E
E
S
V
S
T
V
E
E
Q
E
N
E
Site 15
T85
V
E
E
Q
E
N
E
T
P
P
A
T
S
S
E
Site 16
S91
E
T
P
P
A
T
S
S
E
A
E
Q
P
K
G
Site 17
S110
E
E
K
E
E
N
K
S
S
E
E
T
K
K
D
Site 18
S111
E
K
E
E
N
K
S
S
E
E
T
K
K
D
E
Site 19
S122
K
K
D
E
K
D
Q
S
K
E
K
E
K
K
V
Site 20
S135
K
V
K
K
T
I
P
S
W
A
T
L
S
A
S
Site 21
S140
I
P
S
W
A
T
L
S
A
S
Q
L
A
R
A
Site 22
S142
S
W
A
T
L
S
A
S
Q
L
A
R
A
Q
K
Site 23
T151
L
A
R
A
Q
K
Q
T
P
M
A
S
S
P
R
Site 24
S155
Q
K
Q
T
P
M
A
S
S
P
R
P
K
M
D
Site 25
S156
K
Q
T
P
M
A
S
S
P
R
P
K
M
D
A
Site 26
S176
I
K
A
C
F
Q
K
S
G
A
S
V
V
A
I
Site 27
Y191
R
K
Y
I
I
H
K
Y
P
S
L
E
L
E
R
Site 28
S193
Y
I
I
H
K
Y
P
S
L
E
L
E
R
R
G
Site 29
Y201
L
E
L
E
R
R
G
Y
L
L
K
Q
A
L
K
Site 30
S225
Q
V
K
G
K
G
A
S
G
S
F
V
V
V
Q
Site 31
S227
K
G
K
G
A
S
G
S
F
V
V
V
Q
K
S
Site 32
S234
S
F
V
V
V
Q
K
S
R
K
T
P
Q
K
S
Site 33
T237
V
V
Q
K
S
R
K
T
P
Q
K
S
R
N
R
Site 34
S241
S
R
K
T
P
Q
K
S
R
N
R
K
N
R
S
Site 35
S248
S
R
N
R
K
N
R
S
S
A
V
D
P
E
P
Site 36
S249
R
N
R
K
N
R
S
S
A
V
D
P
E
P
Q
Site 37
S279
E
P
K
E
A
S
Y
S
L
I
R
K
Y
V
S
Site 38
Y284
S
Y
S
L
I
R
K
Y
V
S
Q
Y
Y
P
K
Site 39
S286
S
L
I
R
K
Y
V
S
Q
Y
Y
P
K
L
R
Site 40
Y288
I
R
K
Y
V
S
Q
Y
Y
P
K
L
R
V
D
Site 41
Y289
R
K
Y
V
S
Q
Y
Y
P
K
L
R
V
D
I
Site 42
T325
T
G
K
G
A
S
G
T
F
Q
L
K
K
S
G
Site 43
S331
G
T
F
Q
L
K
K
S
G
E
K
P
L
L
G
Site 44
T358
A
A
M
N
E
P
K
T
C
S
T
T
A
L
K
Site 45
Y367
S
T
T
A
L
K
K
Y
V
L
E
N
H
P
G
Site 46
T375
V
L
E
N
H
P
G
T
N
S
N
Y
Q
M
H
Site 47
S377
E
N
H
P
G
T
N
S
N
Y
Q
M
H
L
L
Site 48
Y379
H
P
G
T
N
S
N
Y
Q
M
H
L
L
K
K
Site 49
T387
Q
M
H
L
L
K
K
T
L
Q
K
C
E
K
N
Site 50
T408
S
G
K
G
F
S
G
T
F
Q
L
C
F
P
Y
Site 51
S431
P
K
K
E
P
D
D
S
R
D
E
D
E
D
E
Site 52
S441
E
D
E
D
E
D
E
S
S
E
E
D
S
E
D
Site 53
S442
D
E
D
E
D
E
S
S
E
E
D
S
E
D
E
Site 54
S446
D
E
S
S
E
E
D
S
E
D
E
E
P
P
P
Site 55
T461
K
R
R
L
Q
K
K
T
P
A
K
S
P
G
K
Site 56
S465
Q
K
K
T
P
A
K
S
P
G
K
A
A
S
V
Site 57
S471
K
S
P
G
K
A
A
S
V
K
Q
R
G
S
K
Site 58
S477
A
S
V
K
Q
R
G
S
K
P
A
P
K
V
S
Site 59
T504
K
A
P
P
K
A
K
T
P
A
K
K
T
R
P
Site 60
T509
A
K
T
P
A
K
K
T
R
P
S
S
T
V
I
Site 61
S512
P
A
K
K
T
R
P
S
S
T
V
I
K
K
P
Site 62
S513
A
K
K
T
R
P
S
S
T
V
I
K
K
P
S
Site 63
T514
K
K
T
R
P
S
S
T
V
I
K
K
P
S
G
Site 64
S520
S
T
V
I
K
K
P
S
G
G
S
S
K
K
P
Site 65
S523
I
K
K
P
S
G
G
S
S
K
K
P
A
T
S
Site 66
S524
K
K
P
S
G
G
S
S
K
K
P
A
T
S
A
Site 67
T529
G
S
S
K
K
P
A
T
S
A
R
K
E
V
K
Site 68
S530
S
S
K
K
P
A
T
S
A
R
K
E
V
K
L
Site 69
S543
K
L
P
G
K
G
K
S
T
M
K
K
S
F
R
Site 70
T544
L
P
G
K
G
K
S
T
M
K
K
S
F
R
V
Site 71
S548
G
K
S
T
M
K
K
S
F
R
V
K
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation