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Updated November 2019
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Protein Info
Short Name:
NUP188
Full Name:
Nucleoporin NUP188 homolog
Alias:
hNup188; KIAA0169; NU188; nucleoporin 188kDa; nucleoporin NUP188
Type:
Nucleoporin
Mass (Da):
196043
Number AA:
1749
UniProt ID:
Q5SRE5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005643
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0015031
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
G
G
P
C
V
R
S
S
R
E
L
W
T
I
Site 2
S13
G
G
P
C
V
R
S
S
R
E
L
W
T
I
L
Site 3
S24
W
T
I
L
L
G
R
S
A
L
R
E
L
S
Q
Site 4
S30
R
S
A
L
R
E
L
S
Q
I
E
A
E
L
N
Site 5
S48
R
R
L
L
E
G
L
S
Y
Y
K
P
P
S
P
Site 6
Y49
R
L
L
E
G
L
S
Y
Y
K
P
P
S
P
S
Site 7
Y50
L
L
E
G
L
S
Y
Y
K
P
P
S
P
S
S
Site 8
S54
L
S
Y
Y
K
P
P
S
P
S
S
A
E
K
V
Site 9
S57
Y
K
P
P
S
P
S
S
A
E
K
V
K
A
N
Site 10
S69
K
A
N
K
D
V
A
S
P
L
K
E
L
G
L
Site 11
S79
K
E
L
G
L
R
I
S
K
F
L
G
L
D
E
Site 12
S89
L
G
L
D
E
E
Q
S
V
Q
L
L
Q
C
Y
Site 13
Y96
S
V
Q
L
L
Q
C
Y
L
Q
E
D
Y
R
G
Site 14
Y101
Q
C
Y
L
Q
E
D
Y
R
G
T
R
D
S
V
Site 15
T104
L
Q
E
D
Y
R
G
T
R
D
S
V
K
T
V
Site 16
S107
D
Y
R
G
T
R
D
S
V
K
T
V
L
Q
D
Site 17
T110
G
T
R
D
S
V
K
T
V
L
Q
D
E
R
Q
Site 18
S118
V
L
Q
D
E
R
Q
S
Q
A
L
I
L
K
I
Site 19
Y128
L
I
L
K
I
A
D
Y
Y
Y
E
E
R
T
C
Site 20
Y129
I
L
K
I
A
D
Y
Y
Y
E
E
R
T
C
I
Site 21
Y130
L
K
I
A
D
Y
Y
Y
E
E
R
T
C
I
L
Site 22
Y146
C
V
L
H
L
L
T
Y
F
Q
D
E
R
H
P
Site 23
Y154
F
Q
D
E
R
H
P
Y
R
V
E
Y
A
D
C
Site 24
Y158
R
H
P
Y
R
V
E
Y
A
D
C
V
D
K
L
Site 25
Y173
E
K
E
L
V
S
K
Y
R
Q
Q
F
E
E
L
Site 26
Y181
R
Q
Q
F
E
E
L
Y
K
T
E
A
P
T
W
Site 27
T183
Q
F
E
E
L
Y
K
T
E
A
P
T
W
E
T
Site 28
T196
E
T
H
G
N
L
M
T
E
R
Q
V
S
R
W
Site 29
S212
V
Q
C
L
R
E
Q
S
M
L
L
E
I
I
F
Site 30
T236
P
S
D
L
L
V
L
T
K
M
F
K
E
Q
G
Site 31
S246
F
K
E
Q
G
F
G
S
R
Q
T
N
R
H
L
Site 32
T249
Q
G
F
G
S
R
Q
T
N
R
H
L
V
D
E
Site 33
T257
N
R
H
L
V
D
E
T
M
D
P
F
V
D
R
Site 34
S281
V
E
G
M
D
I
E
S
L
H
K
C
A
L
D
Site 35
T332
A
W
A
L
L
R
H
T
L
N
P
E
E
T
S
Site 36
S340
L
N
P
E
E
T
S
S
V
V
R
K
I
G
G
Site 37
S364
Y
L
T
R
L
L
Q
S
L
A
S
G
G
N
D
Site 38
S367
R
L
L
Q
S
L
A
S
G
G
N
D
C
T
T
Site 39
T373
A
S
G
G
N
D
C
T
T
S
T
A
C
M
C
Site 40
T406
N
Q
Q
D
I
I
D
T
A
C
E
V
L
A
D
Site 41
T423
L
P
E
L
F
W
G
T
E
P
T
S
G
L
G
Site 42
S456
Q
L
L
R
A
L
V
S
G
K
S
T
A
K
K
Site 43
S459
R
A
L
V
S
G
K
S
T
A
K
K
V
Y
S
Site 44
T460
A
L
V
S
G
K
S
T
A
K
K
V
Y
S
F
Site 45
S466
S
T
A
K
K
V
Y
S
F
L
D
K
M
S
F
Site 46
Y474
F
L
D
K
M
S
F
Y
N
E
L
Y
K
H
K
Site 47
T492
V
I
S
H
E
D
G
T
L
W
R
R
Q
T
P
Site 48
T498
G
T
L
W
R
R
Q
T
P
K
L
L
Y
P
L
Site 49
Y503
R
Q
T
P
K
L
L
Y
P
L
G
G
Q
T
N
Site 50
Y528
V
M
L
D
D
R
A
Y
L
V
R
W
E
Y
S
Site 51
Y534
A
Y
L
V
R
W
E
Y
S
Y
S
S
W
T
L
Site 52
Y536
L
V
R
W
E
Y
S
Y
S
S
W
T
L
F
T
Site 53
S650
A
H
P
V
S
S
L
S
Q
M
I
S
A
E
G
Site 54
S654
S
S
L
S
Q
M
I
S
A
E
G
M
N
A
G
Site 55
Y663
E
G
M
N
A
G
G
Y
G
N
L
L
M
N
S
Site 56
S670
Y
G
N
L
L
M
N
S
E
Q
P
Q
G
E
Y
Site 57
S697
L
V
K
G
Q
L
G
S
T
Q
S
Q
G
L
V
Site 58
Y718
L
K
E
M
L
P
S
Y
H
K
W
R
Y
N
S
Site 59
Y723
P
S
Y
H
K
W
R
Y
N
S
H
G
V
R
E
Site 60
T750
I
L
N
L
C
H
E
T
D
L
H
S
S
H
T
Site 61
S755
H
E
T
D
L
H
S
S
H
T
P
S
L
Q
F
Site 62
T757
T
D
L
H
S
S
H
T
P
S
L
Q
F
L
C
Site 63
S798
V
M
A
A
Q
P
R
S
D
G
A
E
G
Q
G
Site 64
S835
K
P
P
S
N
V
V
S
P
L
E
Q
A
L
S
Site 65
S842
S
P
L
E
Q
A
L
S
Q
H
G
A
H
G
N
Site 66
Y860
A
V
L
A
K
Y
I
Y
H
K
H
D
P
A
L
Site 67
T903
A
I
R
D
A
F
L
T
R
L
Q
S
K
I
E
Site 68
S907
A
F
L
T
R
L
Q
S
K
I
E
D
M
R
I
Site 69
S945
N
L
E
V
K
D
G
S
D
G
S
K
E
F
S
Site 70
S948
V
K
D
G
S
D
G
S
K
E
F
S
L
G
M
Site 71
S952
S
D
G
S
K
E
F
S
L
G
M
W
S
C
L
Site 72
S968
A
V
L
E
L
I
D
S
Q
Q
Q
D
R
Y
W
Site 73
Y974
D
S
Q
Q
Q
D
R
Y
W
C
P
P
L
L
H
Site 74
S998
L
W
Q
D
R
R
D
S
A
M
L
V
L
R
T
Site 75
S1015
K
F
W
E
N
L
T
S
P
L
F
G
T
L
S
Site 76
T1020
L
T
S
P
L
F
G
T
L
S
P
P
S
E
T
Site 77
S1022
S
P
L
F
G
T
L
S
P
P
S
E
T
S
E
Site 78
S1025
F
G
T
L
S
P
P
S
E
T
S
E
P
S
I
Site 79
T1027
T
L
S
P
P
S
E
T
S
E
P
S
I
L
E
Site 80
S1028
L
S
P
P
S
E
T
S
E
P
S
I
L
E
T
Site 81
S1054
I
Y
Y
V
V
K
G
S
L
D
Q
S
L
K
D
Site 82
S1058
V
K
G
S
L
D
Q
S
L
K
D
T
L
K
K
Site 83
T1062
L
D
Q
S
L
K
D
T
L
K
K
F
S
I
E
Site 84
Y1074
S
I
E
K
R
F
A
Y
W
S
G
Y
V
K
S
Site 85
S1076
E
K
R
F
A
Y
W
S
G
Y
V
K
S
L
A
Site 86
Y1078
R
F
A
Y
W
S
G
Y
V
K
S
L
A
V
H
Site 87
S1092
H
V
A
E
T
E
G
S
S
C
T
S
L
L
E
Site 88
S1093
V
A
E
T
E
G
S
S
C
T
S
L
L
E
Y
Site 89
S1096
T
E
G
S
S
C
T
S
L
L
E
Y
Q
M
L
Site 90
T1124
H
A
D
I
M
H
L
T
D
S
V
V
R
R
Q
Site 91
S1126
D
I
M
H
L
T
D
S
V
V
R
R
Q
L
F
Site 92
S1176
Q
W
K
R
E
L
G
S
V
D
E
I
L
G
P
Site 93
S1222
Q
M
K
E
M
K
V
S
D
I
P
Q
Y
S
Q
Site 94
S1252
L
F
D
Q
T
R
H
S
L
A
L
G
S
A
T
Site 95
S1257
R
H
S
L
A
L
G
S
A
T
E
D
K
D
S
Site 96
S1264
S
A
T
E
D
K
D
S
M
E
T
D
D
C
S
Site 97
S1271
S
M
E
T
D
D
C
S
R
S
R
H
R
D
Q
Site 98
S1302
E
V
D
E
D
G
D
S
W
L
Q
V
T
R
R
Site 99
T1377
Y
Q
L
S
T
N
G
T
A
Q
T
P
S
A
S
Site 100
T1380
S
T
N
G
T
A
Q
T
P
S
A
S
R
K
S
Site 101
S1382
N
G
T
A
Q
T
P
S
A
S
R
K
S
L
D
Site 102
S1387
T
P
S
A
S
R
K
S
L
D
A
P
S
W
P
Site 103
S1392
R
K
S
L
D
A
P
S
W
P
G
V
Y
R
L
Site 104
S1400
W
P
G
V
Y
R
L
S
M
S
L
M
E
Q
L
Site 105
S1402
G
V
Y
R
L
S
M
S
L
M
E
Q
L
L
K
Site 106
Y1501
S
R
K
M
L
Q
H
Y
L
Q
N
K
N
G
D
Site 107
S1523
Q
R
V
Q
R
P
P
S
A
A
S
A
A
P
S
Site 108
S1526
Q
R
P
P
S
A
A
S
A
A
P
S
S
S
K
Site 109
S1530
S
A
A
S
A
A
P
S
S
S
K
Q
P
A
A
Site 110
S1532
A
S
A
A
P
S
S
S
K
Q
P
A
A
D
T
Site 111
T1539
S
K
Q
P
A
A
D
T
E
A
S
E
Q
Q
A
Site 112
T1549
S
E
Q
Q
A
L
H
T
V
Q
Y
G
L
L
K
Site 113
S1580
C
Q
I
L
L
D
Q
S
L
D
L
A
E
Y
N
Site 114
S1601
F
T
T
P
T
F
D
S
E
V
A
P
S
F
G
Site 115
S1606
P
A
T
G
V
L
P
S
P
Q
G
K
S
T
S
Site 116
T1632
D
K
K
K
E
P
L
T
Q
A
V
G
L
S
T
Site 117
T1646
T
Q
A
E
G
T
R
T
L
K
S
L
L
M
F
Site 118
S1649
E
G
T
R
T
L
K
S
L
L
M
F
T
M
E
Site 119
Y1660
F
T
M
E
N
C
F
Y
L
L
I
S
Q
A
M
Site 120
Y1669
L
I
S
Q
A
M
R
Y
L
R
D
P
A
V
H
Site 121
S1688
Q
R
M
K
Q
E
L
S
S
E
L
S
T
L
L
Site 122
S1689
R
M
K
Q
E
L
S
S
E
L
S
T
L
L
S
Site 123
S1692
Q
E
L
S
S
E
L
S
T
L
L
S
S
L
S
Site 124
T1693
E
L
S
S
E
L
S
T
L
L
S
S
L
S
R
Site 125
S1696
S
E
L
S
T
L
L
S
S
L
S
R
Y
F
R
Site 126
S1697
E
L
S
T
L
L
S
S
L
S
R
Y
F
R
R
Site 127
S1699
S
T
L
L
S
S
L
S
R
Y
F
R
R
G
A
Site 128
Y1701
L
L
S
S
L
S
R
Y
F
R
R
G
A
P
S
Site 129
S1708
Y
F
R
R
G
A
P
S
S
P
A
T
G
V
L
Site 130
S1709
F
R
R
G
A
P
S
S
P
A
T
G
V
L
P
Site 131
T1712
G
A
P
S
S
P
A
T
G
V
L
P
S
P
Q
Site 132
S1717
P
A
T
G
V
L
P
S
P
Q
G
K
S
T
S
Site 133
S1722
L
P
S
P
Q
G
K
S
T
S
L
S
K
A
S
Site 134
S1724
S
P
Q
G
K
S
T
S
L
S
K
A
S
P
E
Site 135
S1726
Q
G
K
S
T
S
L
S
K
A
S
P
E
S
Q
Site 136
S1729
S
T
S
L
S
K
A
S
P
E
S
Q
E
P
L
Site 137
S1732
L
S
K
A
S
P
E
S
Q
E
P
L
I
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation