KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FAM75A2
Full Name:
Protein FAM75A2
Alias:
Type:
Membrane protein
Mass (Da):
148657
Number AA:
1347
UniProt ID:
Q5RGS2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
P
L
K
L
L
S
A
S
S
L
N
A
P
S
S
Site 2
S20
A
S
S
L
N
A
P
S
S
T
P
W
V
L
D
Site 3
S21
S
S
L
N
A
P
S
S
T
P
W
V
L
D
I
Site 4
Y48
L
L
L
P
Y
L
S
Y
F
R
C
D
D
P
P
Site 5
S56
F
R
C
D
D
P
P
S
P
S
P
G
K
R
K
Site 6
S58
C
D
D
P
P
S
P
S
P
G
K
R
K
C
P
Site 7
S80
R
G
R
M
K
N
H
S
L
R
A
G
R
E
C
Site 8
T94
C
R
R
G
L
Q
E
T
S
D
L
L
S
Q
L
Site 9
S95
R
R
G
L
Q
E
T
S
D
L
L
S
Q
L
Q
Site 10
S99
Q
E
T
S
D
L
L
S
Q
L
Q
S
L
L
G
Site 11
S103
D
L
L
S
Q
L
Q
S
L
L
G
P
H
L
D
Site 12
S118
K
G
D
F
G
Q
L
S
G
P
D
P
P
G
E
Site 13
S135
E
R
A
P
D
G
A
S
Q
S
S
H
E
P
M
Site 14
S137
A
P
D
G
A
S
Q
S
S
H
E
P
M
E
D
Site 15
S150
E
D
A
A
P
I
L
S
P
L
A
S
P
D
P
Site 16
S154
P
I
L
S
P
L
A
S
P
D
P
Q
A
K
H
Site 17
S167
K
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
Site 18
T168
H
P
Q
D
L
A
S
T
P
S
P
G
P
M
T
Site 19
S170
Q
D
L
A
S
T
P
S
P
G
P
M
T
T
S
Site 20
T175
T
P
S
P
G
P
M
T
T
S
V
S
S
L
S
Site 21
T176
P
S
P
G
P
M
T
T
S
V
S
S
L
S
A
Site 22
S177
S
P
G
P
M
T
T
S
V
S
S
L
S
A
S
Site 23
S179
G
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
Site 24
S180
P
M
T
T
S
V
S
S
L
S
A
S
Q
P
P
Site 25
S182
T
T
S
V
S
S
L
S
A
S
Q
P
P
E
P
Site 26
S184
S
V
S
S
L
S
A
S
Q
P
P
E
P
S
L
Site 27
S190
A
S
Q
P
P
E
P
S
L
P
L
E
H
P
S
Site 28
S197
S
L
P
L
E
H
P
S
P
E
P
P
A
L
F
Site 29
T210
L
F
P
H
P
P
H
T
P
D
P
L
A
C
S
Site 30
S217
T
P
D
P
L
A
C
S
P
P
P
P
K
G
F
Site 31
T225
P
P
P
P
K
G
F
T
A
P
P
L
R
D
S
Site 32
S232
T
A
P
P
L
R
D
S
T
L
I
T
P
S
H
Site 33
T233
A
P
P
L
R
D
S
T
L
I
T
P
S
H
C
Site 34
T236
L
R
D
S
T
L
I
T
P
S
H
C
D
S
V
Site 35
S253
P
L
G
T
V
P
Q
S
L
S
P
H
E
D
L
Site 36
S255
G
T
V
P
Q
S
L
S
P
H
E
D
L
V
A
Site 37
S273
A
I
S
G
L
G
G
S
N
S
H
V
S
A
S
Site 38
S275
S
G
L
G
G
S
N
S
H
V
S
A
S
S
R
Site 39
S278
G
G
S
N
S
H
V
S
A
S
S
R
W
Q
E
Site 40
S280
S
N
S
H
V
S
A
S
S
R
W
Q
E
T
A
Site 41
T286
A
S
S
R
W
Q
E
T
A
R
T
S
C
A
F
Site 42
T289
R
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
Site 43
S290
W
Q
E
T
A
R
T
S
C
A
F
N
S
S
V
Site 44
S295
R
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
Site 45
S296
T
S
C
A
F
N
S
S
V
Q
Q
D
H
L
S
Site 46
S303
S
V
Q
Q
D
H
L
S
R
H
P
P
E
T
Y
Site 47
T309
L
S
R
H
P
P
E
T
Y
Q
M
E
A
G
S
Site 48
Y310
S
R
H
P
P
E
T
Y
Q
M
E
A
G
S
L
Site 49
S316
T
Y
Q
M
E
A
G
S
L
F
L
L
S
S
D
Site 50
S349
E
E
K
E
N
V
G
S
F
T
D
R
M
T
P
Site 51
T351
K
E
N
V
G
S
F
T
D
R
M
T
P
E
K
Site 52
T355
G
S
F
T
D
R
M
T
P
E
K
H
L
N
S
Site 53
S362
T
P
E
K
H
L
N
S
L
R
N
L
A
K
S
Site 54
S369
S
L
R
N
L
A
K
S
L
D
A
E
Q
D
T
Site 55
T376
S
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
Site 56
T377
L
D
A
E
Q
D
T
T
N
P
K
P
F
W
N
Site 57
T434
L
V
A
N
A
W
V
T
D
R
S
Y
T
L
Q
Site 58
S437
N
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
Site 59
Y438
A
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
Site 60
T439
W
V
T
D
R
S
Y
T
L
Q
S
P
P
F
L
Site 61
S442
D
R
S
Y
T
L
Q
S
P
P
F
L
F
N
E
Site 62
T461
C
P
I
Q
R
E
T
T
M
S
P
L
L
F
Q
Site 63
S463
I
Q
R
E
T
T
M
S
P
L
L
F
Q
A
Q
Site 64
S473
L
F
Q
A
Q
P
P
S
H
L
G
P
E
C
Q
Site 65
S485
E
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
Site 66
T486
C
Q
P
F
I
S
S
T
P
Q
F
R
P
T
P
Site 67
T492
S
T
P
Q
F
R
P
T
P
M
A
Q
A
E
A
Site 68
S505
E
A
Q
A
H
L
Q
S
S
F
P
V
L
S
P
Site 69
S536
Q
N
K
V
Q
A
L
S
L
P
E
T
Q
H
P
Site 70
T540
Q
A
L
S
L
P
E
T
Q
H
P
E
W
P
L
Site 71
S560
E
G
R
L
A
L
P
S
R
V
Q
K
S
Q
D
Site 72
S565
L
P
S
R
V
Q
K
S
Q
D
V
F
S
V
S
Site 73
S570
Q
K
S
Q
D
V
F
S
V
S
T
P
N
L
P
Site 74
S572
S
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
Site 75
T573
Q
D
V
F
S
V
S
T
P
N
L
P
Q
E
S
Site 76
S580
T
P
N
L
P
Q
E
S
L
T
S
I
L
P
E
Site 77
S583
L
P
Q
E
S
L
T
S
I
L
P
E
N
F
P
Site 78
S592
L
P
E
N
F
P
V
S
P
E
L
R
R
Q
L
Site 79
S630
L
M
Q
L
R
D
E
S
P
G
T
S
Q
A
K
Site 80
T633
L
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
Site 81
S634
R
D
E
S
P
G
T
S
Q
A
K
G
K
P
S
Site 82
S641
S
Q
A
K
G
K
P
S
P
W
Q
S
S
M
S
Site 83
S645
G
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
Site 84
S646
K
P
S
P
W
Q
S
S
M
S
T
G
E
S
S
Site 85
S648
S
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
Site 86
T649
P
W
Q
S
S
M
S
T
G
E
S
S
K
E
A
Site 87
S652
S
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
Site 88
S653
S
M
S
T
G
E
S
S
K
E
A
Q
K
V
K
Site 89
T678
L
G
Q
I
L
G
E
T
P
Q
N
L
S
R
D
Site 90
S683
G
E
T
P
Q
N
L
S
R
D
M
K
S
F
P
Site 91
S688
N
L
S
R
D
M
K
S
F
P
R
K
V
L
G
Site 92
S698
R
K
V
L
G
V
T
S
E
E
S
E
R
N
L
Site 93
S701
L
G
V
T
S
E
E
S
E
R
N
L
R
K
P
Site 94
S711
N
L
R
K
P
L
R
S
D
S
G
S
D
L
L
Site 95
S713
R
K
P
L
R
S
D
S
G
S
D
L
L
R
C
Site 96
S715
P
L
R
S
D
S
G
S
D
L
L
R
C
T
E
Site 97
T721
G
S
D
L
L
R
C
T
E
R
T
H
I
E
N
Site 98
T724
L
L
R
C
T
E
R
T
H
I
E
N
I
L
K
Site 99
T741
M
G
R
N
L
G
Q
T
N
E
G
L
I
P
V
Site 100
S753
I
P
V
R
V
R
R
S
W
L
A
V
N
Q
A
Site 101
S764
V
N
Q
A
L
P
V
S
N
T
H
V
K
T
S
Site 102
T766
Q
A
L
P
V
S
N
T
H
V
K
T
S
N
L
Site 103
S778
S
N
L
A
A
P
K
S
G
K
A
C
V
N
T
Site 104
T796
L
S
F
L
E
P
C
T
Q
Q
G
L
G
A
H
Site 105
T837
K
V
S
S
L
S
L
T
Q
L
A
G
P
S
S
Site 106
S844
T
Q
L
A
G
P
S
S
A
T
C
E
S
G
A
Site 107
S849
P
S
S
A
T
C
E
S
G
A
G
S
E
V
E
Site 108
S853
T
C
E
S
G
A
G
S
E
V
E
V
D
M
F
Site 109
S868
L
R
K
P
P
M
A
S
L
R
K
Q
V
L
T
Site 110
T875
S
L
R
K
Q
V
L
T
K
A
S
D
H
M
P
Site 111
S884
A
S
D
H
M
P
E
S
L
L
A
S
S
P
A
Site 112
S888
M
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Site 113
S889
P
E
S
L
L
A
S
S
P
A
W
K
Q
F
Q
Site 114
S904
R
A
P
R
G
I
P
S
W
N
D
H
G
P
L
Site 115
S924
G
Q
E
G
R
W
P
S
K
P
L
T
Y
S
L
Site 116
T928
R
W
P
S
K
P
L
T
Y
S
L
T
G
S
T
Site 117
S930
P
S
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
Site 118
T932
K
P
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
Site 119
S934
L
T
Y
S
L
T
G
S
T
Q
Q
S
R
S
L
Site 120
S938
L
T
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
Site 121
S940
G
S
T
Q
Q
S
R
S
L
G
A
Q
S
S
K
Site 122
S946
R
S
L
G
A
Q
S
S
K
A
G
E
T
R
E
Site 123
T985
H
G
F
E
A
P
G
T
S
K
S
S
L
H
P
Site 124
S986
G
F
E
A
P
G
T
S
K
S
S
L
H
P
R
Site 125
S988
E
A
P
G
T
S
K
S
S
L
H
P
R
V
S
Site 126
S989
A
P
G
T
S
K
S
S
L
H
P
R
V
S
V
Site 127
S995
S
S
L
H
P
R
V
S
V
S
Q
D
P
R
K
Site 128
S997
L
H
P
R
V
S
V
S
Q
D
P
R
K
L
C
Site 129
S1021
E
P
G
M
A
T
K
S
E
T
Q
P
Q
V
C
Site 130
S1040
L
L
P
D
G
Q
A
S
V
V
P
H
A
S
E
Site 131
S1051
H
A
S
E
N
L
V
S
Q
V
P
Q
G
H
L
Site 132
S1060
V
P
Q
G
H
L
Q
S
M
P
T
G
N
M
R
Site 133
S1069
P
T
G
N
M
R
A
S
Q
E
L
H
D
L
M
Site 134
S1081
D
L
M
A
A
R
R
S
K
L
V
H
E
E
P
Site 135
S1110
M
F
P
P
I
H
K
S
E
K
S
R
K
P
N
Site 136
S1113
P
I
H
K
S
E
K
S
R
K
P
N
L
E
K
Site 137
T1130
E
R
L
E
G
L
R
T
P
Q
L
T
P
V
R
Site 138
T1134
G
L
R
T
P
Q
L
T
P
V
R
K
T
E
D
Site 139
T1139
Q
L
T
P
V
R
K
T
E
D
T
H
Q
D
E
Site 140
T1142
P
V
R
K
T
E
D
T
H
Q
D
E
G
V
Q
Site 141
S1153
E
G
V
Q
L
L
P
S
K
K
Q
P
P
S
V
Site 142
S1159
P
S
K
K
Q
P
P
S
V
S
H
F
G
G
N
Site 143
S1161
K
K
Q
P
P
S
V
S
H
F
G
G
N
I
K
Site 144
S1180
W
I
F
S
K
K
K
S
K
P
A
P
V
T
A
Site 145
S1189
P
A
P
V
T
A
E
S
Q
K
T
V
K
N
R
Site 146
T1192
V
T
A
E
S
Q
K
T
V
K
N
R
S
C
V
Site 147
S1197
Q
K
T
V
K
N
R
S
C
V
Y
S
S
S
A
Site 148
S1201
K
N
R
S
C
V
Y
S
S
S
A
E
A
Q
G
Site 149
S1203
R
S
C
V
Y
S
S
S
A
E
A
Q
G
L
M
Site 150
S1256
N
H
R
H
L
F
Y
S
E
H
G
R
I
L
S
Site 151
S1263
S
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
Site 152
Y1264
E
H
G
R
I
L
S
Y
A
A
S
S
Q
Q
A
Site 153
S1267
R
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
Site 154
S1268
I
L
S
Y
A
A
S
S
Q
Q
A
T
L
K
S
Site 155
T1272
A
A
S
S
Q
Q
A
T
L
K
S
Q
G
C
P
Site 156
S1275
S
Q
Q
A
T
L
K
S
Q
G
C
P
N
R
D
Site 157
S1293
R
N
Q
Q
P
L
K
S
V
R
C
N
N
E
Q
Site 158
S1316
L
H
P
K
K
A
V
S
P
V
S
P
L
Q
H
Site 159
S1319
K
K
A
V
S
P
V
S
P
L
Q
H
W
P
K
Site 160
T1327
P
L
Q
H
W
P
K
T
S
G
A
S
S
H
H
Site 161
S1332
P
K
T
S
G
A
S
S
H
H
H
H
C
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation