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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D18
Full Name:
Rab GTPase-activating protein 1-like
Alias:
expressed in hematopoietic cells, heart, liver; expressed in hematopoietic cells, heart, liver (HLL); HHL; KIAA0471; RAB GTPase activating protein 1-like; RABGAP1L
Type:
Mass (Da):
92494
Number AA:
815
UniProt ID:
Q5R372
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
V
R
A
S
L
Q
K
V
S
G
S
Site 2
S11
R
A
S
L
Q
K
V
S
G
S
S
D
S
V
A
Site 3
S16
K
V
S
G
S
S
D
S
V
A
T
M
N
S
E
Site 4
Y31
E
F
V
L
V
P
Q
Y
A
D
D
N
S
T
K
Site 5
S36
P
Q
Y
A
D
D
N
S
T
K
H
E
E
K
P
Site 6
S49
K
P
Q
L
K
I
V
S
N
G
D
E
Q
L
E
Site 7
S66
M
E
E
I
L
R
D
S
E
K
R
P
S
S
L
Site 8
S71
R
D
S
E
K
R
P
S
S
L
L
V
D
C
Q
Site 9
S72
D
S
E
K
R
P
S
S
L
L
V
D
C
Q
S
Site 10
S79
S
L
L
V
D
C
Q
S
S
S
E
I
S
D
H
Site 11
S80
L
L
V
D
C
Q
S
S
S
E
I
S
D
H
S
Site 12
S81
L
V
D
C
Q
S
S
S
E
I
S
D
H
S
F
Site 13
S84
C
Q
S
S
S
E
I
S
D
H
S
F
G
D
I
Site 14
S87
S
S
E
I
S
D
H
S
F
G
D
I
P
A
S
Site 15
S94
S
F
G
D
I
P
A
S
Q
T
N
K
P
S
L
Site 16
T96
G
D
I
P
A
S
Q
T
N
K
P
S
L
Q
L
Site 17
S100
A
S
Q
T
N
K
P
S
L
Q
L
I
L
D
P
Site 18
S108
L
Q
L
I
L
D
P
S
N
T
E
I
S
T
P
Site 19
T110
L
I
L
D
P
S
N
T
E
I
S
T
P
R
P
Site 20
S113
D
P
S
N
T
E
I
S
T
P
R
P
S
S
P
Site 21
T114
P
S
N
T
E
I
S
T
P
R
P
S
S
P
G
Site 22
S118
E
I
S
T
P
R
P
S
S
P
G
G
L
P
E
Site 23
S119
I
S
T
P
R
P
S
S
P
G
G
L
P
E
E
Site 24
S128
G
G
L
P
E
E
D
S
V
L
F
N
K
L
T
Site 25
S143
Y
L
G
C
M
K
V
S
S
P
R
N
E
V
E
Site 26
S144
L
G
C
M
K
V
S
S
P
R
N
E
V
E
A
Site 27
T157
E
A
L
R
A
M
A
T
M
K
S
S
S
Q
Y
Site 28
S160
R
A
M
A
T
M
K
S
S
S
Q
Y
P
F
P
Site 29
S162
M
A
T
M
K
S
S
S
Q
Y
P
F
P
V
T
Site 30
Y164
T
M
K
S
S
S
Q
Y
P
F
P
V
T
L
Y
Site 31
S179
V
P
N
V
P
E
G
S
V
R
I
I
D
Q
S
Site 32
S186
S
V
R
I
I
D
Q
S
S
N
V
E
I
A
S
Site 33
T209
C
A
R
G
H
D
G
T
T
E
S
N
C
F
A
Site 34
T210
A
R
G
H
D
G
T
T
E
S
N
C
F
A
F
Site 35
T218
E
S
N
C
F
A
F
T
E
S
S
H
G
S
E
Site 36
S220
N
C
F
A
F
T
E
S
S
H
G
S
E
E
F
Site 37
S221
C
F
A
F
T
E
S
S
H
G
S
E
E
F
Q
Site 38
S224
F
T
E
S
S
H
G
S
E
E
F
Q
I
H
V
Site 39
T249
R
I
L
Y
S
F
C
T
A
F
K
R
S
S
R
Site 40
S254
F
C
T
A
F
K
R
S
S
R
Q
V
S
D
V
Site 41
S255
C
T
A
F
K
R
S
S
R
Q
V
S
D
V
K
Site 42
S259
K
R
S
S
R
Q
V
S
D
V
K
D
S
V
I
Site 43
S264
Q
V
S
D
V
K
D
S
V
I
P
T
P
D
S
Site 44
T268
V
K
D
S
V
I
P
T
P
D
S
D
V
F
T
Site 45
S277
D
S
D
V
F
T
F
S
V
S
L
E
V
K
E
Site 46
S279
D
V
F
T
F
S
V
S
L
E
V
K
E
D
D
Site 47
S292
D
D
G
K
G
N
F
S
P
V
P
K
D
R
D
Site 48
Y302
P
K
D
R
D
K
F
Y
F
K
L
K
Q
G
I
Site 49
T316
I
E
K
K
V
V
I
T
V
Q
Q
L
S
N
K
Site 50
S321
V
I
T
V
Q
Q
L
S
N
K
E
L
A
I
E
Site 51
S336
R
C
F
G
M
L
L
S
P
G
R
N
V
K
N
Site 52
S344
P
G
R
N
V
K
N
S
D
M
H
L
L
D
M
Site 53
S353
M
H
L
L
D
M
E
S
M
G
K
S
Y
D
G
Site 54
S357
D
M
E
S
M
G
K
S
Y
D
G
R
A
Y
V
Site 55
Y358
M
E
S
M
G
K
S
Y
D
G
R
A
Y
V
I
Site 56
Y363
K
S
Y
D
G
R
A
Y
V
I
T
G
M
W
N
Site 57
T383
F
L
A
L
N
E
E
T
P
K
D
K
Q
V
Y
Site 58
Y417
L
E
T
V
V
R
V
Y
P
A
N
E
R
F
W
Site 59
Y425
P
A
N
E
R
F
W
Y
F
S
R
K
T
F
T
Site 60
S427
N
E
R
F
W
Y
F
S
R
K
T
F
T
E
T
Site 61
T434
S
R
K
T
F
T
E
T
F
F
M
R
L
K
Q
Site 62
S442
F
F
M
R
L
K
Q
S
E
G
K
G
H
T
N
Site 63
Y455
T
N
A
G
D
A
I
Y
E
V
V
S
L
Q
R
Site 64
S459
D
A
I
Y
E
V
V
S
L
Q
R
E
S
D
K
Site 65
S464
V
V
S
L
Q
R
E
S
D
K
E
E
P
V
T
Site 66
T471
S
D
K
E
E
P
V
T
P
T
S
G
G
G
P
Site 67
T473
K
E
E
P
V
T
P
T
S
G
G
G
P
M
S
Site 68
S474
E
E
P
V
T
P
T
S
G
G
G
P
M
S
P
Site 69
S480
T
S
G
G
G
P
M
S
P
Q
D
D
E
A
E
Site 70
S490
D
D
E
A
E
E
E
S
D
N
E
L
S
S
G
Site 71
S495
E
E
S
D
N
E
L
S
S
G
T
G
D
V
S
Site 72
S496
E
S
D
N
E
L
S
S
G
T
G
D
V
S
K
Site 73
S502
S
S
G
T
G
D
V
S
K
D
C
P
E
K
I
Site 74
Y511
D
C
P
E
K
I
L
Y
S
W
G
E
L
L
G
Site 75
S522
E
L
L
G
K
W
H
S
N
L
G
A
R
P
K
Site 76
S532
G
A
R
P
K
G
L
S
T
L
V
K
S
G
V
Site 77
T533
A
R
P
K
G
L
S
T
L
V
K
S
G
V
P
Site 78
Y564
N
Q
A
M
L
D
R
Y
R
I
L
I
T
K
D
Site 79
S572
R
I
L
I
T
K
D
S
A
Q
E
S
V
I
T
Site 80
S576
T
K
D
S
A
Q
E
S
V
I
T
R
D
I
H
Site 81
T579
S
A
Q
E
S
V
I
T
R
D
I
H
R
T
F
Site 82
Y591
R
T
F
P
A
H
D
Y
F
K
D
T
G
G
D
Site 83
T595
A
H
D
Y
F
K
D
T
G
G
D
G
Q
E
S
Site 84
S602
T
G
G
D
G
Q
E
S
L
Y
K
I
C
K
A
Site 85
Y604
G
D
G
Q
E
S
L
Y
K
I
C
K
A
Y
S
Site 86
Y613
I
C
K
A
Y
S
V
Y
D
E
D
I
G
Y
C
Site 87
Y619
V
Y
D
E
D
I
G
Y
C
Q
G
Q
S
F
L
Site 88
Y650
L
V
K
I
M
Y
D
Y
G
L
R
D
L
Y
R
Site 89
Y656
D
Y
G
L
R
D
L
Y
R
N
N
F
E
D
L
Site 90
Y668
E
D
L
H
C
K
F
Y
Q
L
E
R
L
M
Q
Site 91
S683
E
Q
L
P
D
L
H
S
H
F
S
D
L
N
L
Site 92
S686
P
D
L
H
S
H
F
S
D
L
N
L
E
A
H
Site 93
Y789
P
T
K
K
L
K
K
Y
E
K
E
Y
Q
T
M
Site 94
Y793
L
K
K
Y
E
K
E
Y
Q
T
M
R
E
S
Q
Site 95
T795
K
Y
E
K
E
Y
Q
T
M
R
E
S
Q
L
Q
Site 96
S799
E
Y
Q
T
M
R
E
S
Q
L
Q
Q
E
D
P
Site 97
Y810
Q
E
D
P
M
D
R
Y
K
F
V
Y
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation