KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KIAA2022
Full Name:
Uncharacterized protein KIAA2022
Alias:
Type:
Mass (Da):
167551
Number AA:
1516
UniProt ID:
Q5QGS0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
N
G
V
K
E
N
D
S
E
D
Q
D
V
A
M
Site 2
T50
A
A
A
P
I
Q
P
T
P
V
A
Q
K
E
T
Site 3
Y60
A
Q
K
E
T
L
M
Y
P
R
G
L
L
P
L
Site 4
S69
R
G
L
L
P
L
P
S
K
K
P
C
M
Q
S
Site 5
S76
S
K
K
P
C
M
Q
S
P
P
S
P
L
G
L
Site 6
S93
A
P
E
H
A
A
N
S
A
S
V
N
A
I
S
Site 7
S95
E
H
A
A
N
S
A
S
V
N
A
I
S
L
T
Site 8
S113
A
K
G
L
N
T
W
S
L
P
N
E
C
E
K
Site 9
S164
V
D
P
E
P
G
I
S
L
K
V
G
D
L
N
Site 10
Y174
V
G
D
L
N
R
D
Y
E
T
C
A
V
S
D
Site 11
T176
D
L
N
R
D
Y
E
T
C
A
V
S
D
I
G
Site 12
Y195
N
A
G
E
N
M
K
Y
G
E
Q
L
L
S
D
Site 13
S201
K
Y
G
E
Q
L
L
S
D
Q
L
L
G
F
P
Site 14
S212
L
G
F
P
L
H
K
S
R
A
G
D
R
R
E
Site 15
T220
R
A
G
D
R
R
E
T
E
K
P
D
I
D
L
Site 16
Y236
D
P
A
Q
K
S
Y
Y
E
A
L
L
L
D
K
Site 17
Y260
N
S
N
Q
D
W
G
Y
F
E
T
F
I
S
E
Site 18
S282
L
C
S
K
N
E
L
S
V
N
L
F
S
E
E
Site 19
Y294
S
E
E
D
V
D
N
Y
M
F
D
D
D
E
S
Site 20
S301
Y
M
F
D
D
D
E
S
T
L
G
S
D
V
C
Site 21
T302
M
F
D
D
D
E
S
T
L
G
S
D
V
C
S
Site 22
S305
D
D
E
S
T
L
G
S
D
V
C
S
L
K
I
Site 23
S309
T
L
G
S
D
V
C
S
L
K
I
R
Y
E
S
Site 24
S316
S
L
K
I
R
Y
E
S
F
Q
D
N
V
R
D
Site 25
T325
Q
D
N
V
R
D
K
T
T
L
L
M
Q
E
D
Site 26
T326
D
N
V
R
D
K
T
T
L
L
M
Q
E
D
A
Site 27
T344
F
F
P
S
V
F
T
T
C
P
K
R
E
S
K
Site 28
S350
T
T
C
P
K
R
E
S
K
S
G
A
L
K
Q
Site 29
S352
C
P
K
R
E
S
K
S
G
A
L
K
Q
S
S
Site 30
S358
K
S
G
A
L
K
Q
S
S
D
F
S
Q
F
K
Site 31
S362
L
K
Q
S
S
D
F
S
Q
F
K
V
P
D
V
Site 32
S414
P
A
L
N
K
P
C
S
G
T
E
V
E
Q
L
Site 33
S432
K
Q
G
H
L
A
N
S
L
E
T
S
G
S
F
Site 34
S436
L
A
N
S
L
E
T
S
G
S
F
S
D
D
S
Site 35
S438
N
S
L
E
T
S
G
S
F
S
D
D
S
S
F
Site 36
S440
L
E
T
S
G
S
F
S
D
D
S
S
F
I
E
Site 37
S443
S
G
S
F
S
D
D
S
S
F
I
E
I
S
Y
Site 38
S444
G
S
F
S
D
D
S
S
F
I
E
I
S
Y
D
Site 39
S449
D
S
S
F
I
E
I
S
Y
D
A
M
G
E
I
Site 40
Y450
S
S
F
I
E
I
S
Y
D
A
M
G
E
I
K
Site 41
Y462
E
I
K
D
C
S
R
Y
M
A
R
D
T
N
S
Site 42
T467
S
R
Y
M
A
R
D
T
N
S
G
S
S
S
S
Site 43
S469
Y
M
A
R
D
T
N
S
G
S
S
S
S
Q
Q
Site 44
S471
A
R
D
T
N
S
G
S
S
S
S
Q
Q
N
Y
Site 45
S473
D
T
N
S
G
S
S
S
S
Q
Q
N
Y
G
L
Site 46
S474
T
N
S
G
S
S
S
S
Q
Q
N
Y
G
L
R
Site 47
Y478
S
S
S
S
Q
Q
N
Y
G
L
R
A
K
R
K
Site 48
Y488
R
A
K
R
K
V
R
Y
S
E
D
Y
L
Y
D
Site 49
S489
A
K
R
K
V
R
Y
S
E
D
Y
L
Y
D
V
Site 50
Y492
K
V
R
Y
S
E
D
Y
L
Y
D
V
D
S
L
Site 51
Y494
R
Y
S
E
D
Y
L
Y
D
V
D
S
L
E
G
Site 52
S498
D
Y
L
Y
D
V
D
S
L
E
G
E
K
V
N
Site 53
T532
P
K
K
R
R
K
V
T
R
K
E
P
P
V
I
Site 54
T567
K
V
D
A
S
E
T
T
V
N
L
S
E
N
Q
Site 55
Y578
S
E
N
Q
L
N
K
Y
A
K
L
A
P
L
K
Site 56
T597
K
K
K
K
Q
R
N
T
N
T
D
S
I
K
T
Site 57
T599
K
K
Q
R
N
T
N
T
D
S
I
K
T
P
F
Site 58
T604
T
N
T
D
S
I
K
T
P
F
S
Q
K
Q
S
Site 59
S607
D
S
I
K
T
P
F
S
Q
K
Q
S
F
E
P
Site 60
S611
T
P
F
S
Q
K
Q
S
F
E
P
G
S
F
E
Site 61
S616
K
Q
S
F
E
P
G
S
F
E
V
S
F
L
P
Site 62
S620
E
P
G
S
F
E
V
S
F
L
P
P
A
R
K
Site 63
S630
P
P
A
R
K
R
K
S
K
L
G
N
R
H
R
Site 64
S643
H
R
I
Q
R
I
P
S
I
E
I
S
A
S
S
Site 65
S647
R
I
P
S
I
E
I
S
A
S
S
K
Q
I
S
Site 66
S650
S
I
E
I
S
A
S
S
K
Q
I
S
L
C
N
Site 67
S654
S
A
S
S
K
Q
I
S
L
C
N
D
Q
R
H
Site 68
S663
C
N
D
Q
R
H
A
S
N
H
K
E
D
G
G
Site 69
T674
E
D
G
G
L
K
G
T
L
K
S
A
P
L
G
Site 70
S677
G
L
K
G
T
L
K
S
A
P
L
G
A
P
S
Site 71
S684
S
A
P
L
G
A
P
S
C
A
N
G
S
H
L
Site 72
S689
A
P
S
C
A
N
G
S
H
L
N
D
I
T
G
Site 73
T695
G
S
H
L
N
D
I
T
G
P
D
S
V
K
V
Site 74
S699
N
D
I
T
G
P
D
S
V
K
V
K
A
Q
D
Site 75
T707
V
K
V
K
A
Q
D
T
E
F
K
G
P
E
R
Site 76
S724
L
N
K
I
K
F
K
S
E
A
R
L
K
S
K
Site 77
S730
K
S
E
A
R
L
K
S
K
K
V
K
A
A
G
Site 78
S747
S
K
P
I
V
Q
M
S
P
L
L
E
N
Q
S
Site 79
S754
S
P
L
L
E
N
Q
S
S
K
A
N
L
K
N
Site 80
S755
P
L
L
E
N
Q
S
S
K
A
N
L
K
N
E
Site 81
T767
K
N
E
V
I
P
G
T
S
N
S
S
R
L
S
Site 82
S768
N
E
V
I
P
G
T
S
N
S
S
R
L
S
E
Site 83
S770
V
I
P
G
T
S
N
S
S
R
L
S
E
F
H
Site 84
S771
I
P
G
T
S
N
S
S
R
L
S
E
F
H
E
Site 85
S774
T
S
N
S
S
R
L
S
E
F
H
E
A
K
A
Site 86
S784
H
E
A
K
A
A
K
S
S
T
F
L
P
T
T
Site 87
T786
A
K
A
A
K
S
S
T
F
L
P
T
T
C
S
Site 88
T790
K
S
S
T
F
L
P
T
T
C
S
S
E
M
P
Site 89
T791
S
S
T
F
L
P
T
T
C
S
S
E
M
P
L
Site 90
S793
T
F
L
P
T
T
C
S
S
E
M
P
L
S
S
Site 91
S799
C
S
S
E
M
P
L
S
S
A
N
V
T
T
N
Site 92
S800
S
S
E
M
P
L
S
S
A
N
V
T
T
N
I
Site 93
S825
L
L
D
A
S
D
L
S
N
N
T
S
I
S
Y
Site 94
T828
A
S
D
L
S
N
N
T
S
I
S
Y
F
S
H
Site 95
S829
S
D
L
S
N
N
T
S
I
S
Y
F
S
H
H
Site 96
S831
L
S
N
N
T
S
I
S
Y
F
S
H
H
S
P
Site 97
Y832
S
N
N
T
S
I
S
Y
F
S
H
H
S
P
E
Site 98
S834
N
T
S
I
S
Y
F
S
H
H
S
P
E
Q
N
Site 99
S837
I
S
Y
F
S
H
H
S
P
E
Q
N
E
G
S
Site 100
S844
S
P
E
Q
N
E
G
S
L
T
Q
T
E
K
S
Site 101
T846
E
Q
N
E
G
S
L
T
Q
T
E
K
S
F
V
Site 102
T848
N
E
G
S
L
T
Q
T
E
K
S
F
V
P
L
Site 103
S851
S
L
T
Q
T
E
K
S
F
V
P
L
Q
P
T
Site 104
T864
P
T
Q
D
C
V
L
T
S
S
S
D
S
E
L
Site 105
S865
T
Q
D
C
V
L
T
S
S
S
D
S
E
L
Q
Site 106
S867
D
C
V
L
T
S
S
S
D
S
E
L
Q
Q
S
Site 107
S869
V
L
T
S
S
S
D
S
E
L
Q
Q
S
S
H
Site 108
S874
S
D
S
E
L
Q
Q
S
S
H
N
F
K
M
E
Site 109
S875
D
S
E
L
Q
Q
S
S
H
N
F
K
M
E
S
Site 110
S883
H
N
F
K
M
E
S
S
N
Y
R
N
V
W
P
Site 111
Y885
F
K
M
E
S
S
N
Y
R
N
V
W
P
N
K
Site 112
T911
V
S
R
E
I
A
P
T
Q
S
S
E
F
G
A
Site 113
S919
Q
S
S
E
F
G
A
S
Q
V
V
S
M
E
N
Site 114
S923
F
G
A
S
Q
V
V
S
M
E
N
N
L
T
P
Site 115
T929
V
S
M
E
N
N
L
T
P
T
T
Y
N
P
I
Site 116
T932
E
N
N
L
T
P
T
T
Y
N
P
I
C
L
N
Site 117
Y933
N
N
L
T
P
T
T
Y
N
P
I
C
L
N
S
Site 118
Y950
S
N
C
N
K
V
L
Y
D
S
M
Q
D
T
Q
Site 119
T956
L
Y
D
S
M
Q
D
T
Q
L
P
S
D
D
S
Site 120
S960
M
Q
D
T
Q
L
P
S
D
D
S
Y
Q
L
C
Site 121
Y964
Q
L
P
S
D
D
S
Y
Q
L
C
H
F
N
N
Site 122
S992
M
D
D
G
R
L
F
S
F
D
S
M
A
P
L
Site 123
S1000
F
D
S
M
A
P
L
S
V
S
S
S
N
Y
C
Site 124
Y1006
L
S
V
S
S
S
N
Y
C
S
L
S
L
K
S
Site 125
S1008
V
S
S
S
N
Y
C
S
L
S
L
K
S
C
E
Site 126
S1010
S
S
N
Y
C
S
L
S
L
K
S
C
E
K
D
Site 127
S1013
Y
C
S
L
S
L
K
S
C
E
K
D
G
D
D
Site 128
T1023
K
D
G
D
D
D
I
T
D
D
F
L
A
H
C
Site 129
S1031
D
D
F
L
A
H
C
S
P
K
L
V
I
Q
Q
Site 130
S1056
S
T
D
L
L
D
I
S
N
F
T
P
D
K
F
Site 131
T1059
L
L
D
I
S
N
F
T
P
D
K
F
R
H
S
Site 132
S1066
T
P
D
K
F
R
H
S
S
L
S
E
M
S
P
Site 133
S1067
P
D
K
F
R
H
S
S
L
S
E
M
S
P
P
Site 134
S1069
K
F
R
H
S
S
L
S
E
M
S
P
P
D
T
Site 135
S1072
H
S
S
L
S
E
M
S
P
P
D
T
P
S
L
Site 136
T1076
S
E
M
S
P
P
D
T
P
S
L
S
P
Q
I
Site 137
S1078
M
S
P
P
D
T
P
S
L
S
P
Q
I
T
R
Site 138
S1080
P
P
D
T
P
S
L
S
P
Q
I
T
R
C
E
Site 139
T1084
P
S
L
S
P
Q
I
T
R
C
E
S
M
K
T
Site 140
S1088
P
Q
I
T
R
C
E
S
M
K
T
L
G
T
L
Site 141
T1091
T
R
C
E
S
M
K
T
L
G
T
L
K
G
F
Site 142
T1094
E
S
M
K
T
L
G
T
L
K
G
F
Q
E
G
Site 143
S1108
G
V
P
G
P
L
D
S
V
E
K
I
K
W
D
Site 144
S1117
E
K
I
K
W
D
C
S
T
L
S
R
Q
V
Q
Site 145
T1130
V
Q
M
E
D
G
F
T
L
N
N
H
Q
F
Q
Site 146
S1146
H
M
F
N
D
E
D
S
V
S
L
L
Q
K
N
Site 147
S1148
F
N
D
E
D
S
V
S
L
L
Q
K
N
P
C
Site 148
S1157
L
Q
K
N
P
C
L
S
T
F
N
D
P
S
G
Site 149
T1158
Q
K
N
P
C
L
S
T
F
N
D
P
S
G
Q
Site 150
S1163
L
S
T
F
N
D
P
S
G
Q
I
S
T
N
N
Site 151
S1167
N
D
P
S
G
Q
I
S
T
N
N
K
V
S
K
Site 152
S1173
I
S
T
N
N
K
V
S
K
S
R
K
K
S
S
Site 153
S1175
T
N
N
K
V
S
K
S
R
K
K
S
S
P
S
Site 154
S1179
V
S
K
S
R
K
K
S
S
P
S
K
S
G
A
Site 155
S1180
S
K
S
R
K
K
S
S
P
S
K
S
G
A
M
Site 156
S1182
S
R
K
K
S
S
P
S
K
S
G
A
M
N
Q
Site 157
S1184
K
K
S
S
P
S
K
S
G
A
M
N
Q
S
S
Site 158
S1192
G
A
M
N
Q
S
S
S
Q
K
N
T
R
K
K
Site 159
T1196
Q
S
S
S
Q
K
N
T
R
K
K
S
L
K
G
Site 160
S1200
Q
K
N
T
R
K
K
S
L
K
G
N
N
K
G
Site 161
S1216
E
K
P
P
G
K
N
S
R
Q
V
P
K
S
T
Site 162
S1222
N
S
R
Q
V
P
K
S
T
K
K
G
K
Y
M
Site 163
Y1228
K
S
T
K
K
G
K
Y
M
A
A
I
N
G
E
Site 164
S1246
I
G
I
G
R
G
G
S
Q
T
N
T
I
S
S
Site 165
T1248
I
G
R
G
G
S
Q
T
N
T
I
S
S
T
G
Site 166
T1250
R
G
G
S
Q
T
N
T
I
S
S
T
G
K
T
Site 167
S1252
G
S
Q
T
N
T
I
S
S
T
G
K
T
L
A
Site 168
T1257
T
I
S
S
T
G
K
T
L
A
E
C
I
Q
H
Site 169
S1270
Q
H
G
G
P
M
A
S
M
K
M
P
S
Q
K
Site 170
S1275
M
A
S
M
K
M
P
S
Q
K
G
L
S
G
D
Site 171
S1289
D
W
A
L
G
K
E
S
S
P
G
W
S
D
M
Site 172
S1290
W
A
L
G
K
E
S
S
P
G
W
S
D
M
S
Site 173
S1294
K
E
S
S
P
G
W
S
D
M
S
M
G
T
N
Site 174
S1297
S
P
G
W
S
D
M
S
M
G
T
N
T
N
S
Site 175
T1300
W
S
D
M
S
M
G
T
N
T
N
S
L
L
D
Site 176
S1304
S
M
G
T
N
T
N
S
L
L
D
D
D
Q
R
Site 177
S1317
Q
R
E
F
Q
E
P
S
Y
I
L
S
N
I
A
Site 178
Y1318
R
E
F
Q
E
P
S
Y
I
L
S
N
I
A
S
Site 179
S1321
Q
E
P
S
Y
I
L
S
N
I
A
S
G
M
A
Site 180
S1337
V
Q
R
F
M
M
A
S
I
E
P
L
W
E
P
Site 181
Y1355
H
G
D
P
N
I
F
Y
S
P
E
S
N
S
L
Site 182
S1356
G
D
P
N
I
F
Y
S
P
E
S
N
S
L
K
Site 183
S1359
N
I
F
Y
S
P
E
S
N
S
L
K
L
K
T
Site 184
S1361
F
Y
S
P
E
S
N
S
L
K
L
K
T
L
K
Site 185
T1373
T
L
K
I
L
A
G
T
P
Q
E
S
K
K
K
Site 186
S1385
K
K
K
I
N
S
G
S
Q
G
A
T
K
N
H
Site 187
T1389
N
S
G
S
Q
G
A
T
K
N
H
R
S
I
K
Site 188
S1394
G
A
T
K
N
H
R
S
I
K
G
V
S
K
S
Site 189
S1401
S
I
K
G
V
S
K
S
N
G
K
T
A
I
G
Site 190
T1405
V
S
K
S
N
G
K
T
A
I
G
D
P
G
R
Site 191
Y1418
G
R
A
N
M
P
G
Y
N
E
D
S
R
S
T
Site 192
S1422
M
P
G
Y
N
E
D
S
R
S
T
F
F
D
K
Site 193
S1424
G
Y
N
E
D
S
R
S
T
F
F
D
K
K
Y
Site 194
T1425
Y
N
E
D
S
R
S
T
F
F
D
K
K
Y
S
Site 195
Y1431
S
T
F
F
D
K
K
Y
S
N
M
S
T
L
G
Site 196
T1436
K
K
Y
S
N
M
S
T
L
G
N
N
G
P
T
Site 197
Y1448
G
P
T
H
K
K
L
Y
R
H
K
S
S
S
K
Site 198
S1452
K
K
L
Y
R
H
K
S
S
S
K
A
L
R
D
Site 199
S1454
L
Y
R
H
K
S
S
S
K
A
L
R
D
E
K
Site 200
S1477
E
Q
V
H
K
D
E
S
G
T
A
S
F
E
K
Site 201
S1481
K
D
E
S
G
T
A
S
F
E
K
L
R
D
S
Site 202
S1488
S
F
E
K
L
R
D
S
D
Y
N
L
L
K
A
Site 203
Y1490
E
K
L
R
D
S
D
Y
N
L
L
K
A
E
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation