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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMEK2
Full Name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3B
Alias:
FLFL2; FLJ31474; KIAA1387; PP4R3B; PPP4R3B; PSY2; SMEK 2; SMEK 2, suppressor of mek1
Type:
Cell cycle regulation
Mass (Da):
97444
Number AA:
849
UniProt ID:
Q5MIZ7
International Prot ID:
IPI00414323
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
T
R
R
R
V
K
V
Y
T
L
N
E
D
R
Q
Site 2
T12
R
R
R
V
K
V
Y
T
L
N
E
D
R
Q
W
Site 3
T24
R
Q
W
D
D
R
G
T
G
H
V
S
S
T
Y
Site 4
S29
R
G
T
G
H
V
S
S
T
Y
V
E
E
L
K
Site 5
T30
G
T
G
H
V
S
S
T
Y
V
E
E
L
K
G
Site 6
Y31
T
G
H
V
S
S
T
Y
V
E
E
L
K
G
M
Site 7
S46
S
L
L
V
R
A
E
S
D
G
S
L
L
L
E
Site 8
S49
V
R
A
E
S
D
G
S
L
L
L
E
S
K
I
Site 9
T60
E
S
K
I
N
P
N
T
A
Y
Q
K
Q
Q
D
Site 10
T68
A
Y
Q
K
Q
Q
D
T
L
I
V
W
S
E
A
Site 11
Y78
V
W
S
E
A
E
N
Y
D
L
A
L
S
F
Q
Site 12
S83
E
N
Y
D
L
A
L
S
F
Q
E
K
A
G
C
Site 13
S106
Q
V
Q
G
K
D
P
S
V
E
V
T
Q
D
L
Site 14
T110
K
D
P
S
V
E
V
T
Q
D
L
I
D
E
S
Site 15
S117
T
Q
D
L
I
D
E
S
E
E
E
R
F
E
E
Site 16
T128
R
F
E
E
M
P
E
T
S
H
L
I
D
L
P
Site 17
T136
S
H
L
I
D
L
P
T
C
E
L
N
K
L
E
Site 18
Y171
L
A
L
E
N
E
G
Y
I
K
K
L
L
Q
L
Site 19
T255
F
K
E
V
I
P
I
T
D
S
E
L
R
Q
K
Site 20
T266
L
R
Q
K
I
H
Q
T
Y
R
V
Q
Y
I
Q
Site 21
Y271
H
Q
T
Y
R
V
Q
Y
I
Q
D
I
I
L
P
Site 22
S314
Q
E
D
E
K
F
L
S
E
V
F
A
Q
L
T
Site 23
T325
A
Q
L
T
D
E
A
T
D
D
D
K
R
R
E
Site 24
T346
E
F
C
A
F
S
Q
T
L
Q
P
Q
N
R
D
Site 25
S409
V
M
Q
E
A
Q
Q
S
D
D
D
I
L
L
I
Site 26
T427
I
E
Q
M
I
C
D
T
D
P
E
L
G
G
A
Site 27
S483
A
P
L
L
T
N
T
S
E
D
K
C
E
K
D
Site 28
Y496
K
D
F
F
L
K
H
Y
R
Y
S
W
S
F
V
Site 29
S509
F
V
C
T
P
S
H
S
H
S
H
S
T
P
S
Site 30
S511
C
T
P
S
H
S
H
S
H
S
T
P
S
S
S
Site 31
S513
P
S
H
S
H
S
H
S
T
P
S
S
S
I
S
Site 32
T514
S
H
S
H
S
H
S
T
P
S
S
S
I
S
Q
Site 33
S516
S
H
S
H
S
T
P
S
S
S
I
S
Q
D
N
Site 34
S517
H
S
H
S
T
P
S
S
S
I
S
Q
D
N
I
Site 35
S518
S
H
S
T
P
S
S
S
I
S
Q
D
N
I
V
Site 36
S520
S
T
P
S
S
S
I
S
Q
D
N
I
V
G
S
Site 37
Y538
N
T
I
C
P
D
N
Y
Q
T
A
Q
L
L
A
Site 38
Y605
I
G
L
K
D
E
F
Y
N
R
Y
I
T
K
G
Site 39
Y608
K
D
E
F
Y
N
R
Y
I
T
K
G
N
L
F
Site 40
T610
E
F
Y
N
R
Y
I
T
K
G
N
L
F
E
P
Site 41
T627
N
A
L
L
D
N
G
T
R
Y
N
L
L
N
S
Site 42
Y629
L
L
D
N
G
T
R
Y
N
L
L
N
S
A
V
Site 43
Y668
K
A
L
E
S
I
E
Y
V
Q
T
F
K
G
L
Site 44
T671
E
S
I
E
Y
V
Q
T
F
K
G
L
K
T
K
Site 45
Y679
F
K
G
L
K
T
K
Y
E
Q
E
K
D
R
Q
Site 46
S692
R
Q
N
Q
K
L
N
S
V
P
S
I
L
R
S
Site 47
S695
Q
K
L
N
S
V
P
S
I
L
R
S
N
R
F
Site 48
S699
S
V
P
S
I
L
R
S
N
R
F
R
R
D
A
Site 49
Y745
E
D
D
F
P
D
N
Y
E
K
F
M
E
T
K
Site 50
S768
E
N
L
P
K
R
T
S
P
G
G
F
K
F
T
Site 51
T775
S
P
G
G
F
K
F
T
F
S
H
S
A
S
A
Site 52
S777
G
G
F
K
F
T
F
S
H
S
A
S
A
A
N
Site 53
S779
F
K
F
T
F
S
H
S
A
S
A
A
N
G
T
Site 54
S781
F
T
F
S
H
S
A
S
A
A
N
G
T
N
S
Site 55
T786
S
A
S
A
A
N
G
T
N
S
K
S
V
V
A
Site 56
S788
S
A
A
N
G
T
N
S
K
S
V
V
A
Q
I
Site 57
S790
A
N
G
T
N
S
K
S
V
V
A
Q
I
P
P
Site 58
T799
V
A
Q
I
P
P
A
T
S
N
G
S
S
S
K
Site 59
S800
A
Q
I
P
P
A
T
S
N
G
S
S
S
K
T
Site 60
S804
P
A
T
S
N
G
S
S
S
K
T
T
N
L
P
Site 61
S805
A
T
S
N
G
S
S
S
K
T
T
N
L
P
T
Site 62
T807
S
N
G
S
S
S
K
T
T
N
L
P
T
S
V
Site 63
T808
N
G
S
S
S
K
T
T
N
L
P
T
S
V
T
Site 64
S813
K
T
T
N
L
P
T
S
V
T
A
T
K
G
S
Site 65
Y827
S
L
V
G
L
V
D
Y
P
D
D
E
E
E
D
Site 66
S839
E
E
D
E
E
E
E
S
S
P
R
K
R
P
R
Site 67
S840
E
D
E
E
E
E
S
S
P
R
K
R
P
R
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation