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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRSS36
Full Name:
Polyserase-2
Alias:
Polyserine protease 2;Serine protease 36
Type:
Mass (Da):
91955
Number AA:
855
UniProt ID:
Q5K4E3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
I
P
G
A
F
Q
D
S
A
L
S
P
T
Q
E
Site 2
S27
A
F
Q
D
S
A
L
S
P
T
Q
E
E
P
E
Site 3
S44
D
C
G
R
P
E
P
S
A
R
I
V
G
G
S
Site 4
S51
S
A
R
I
V
G
G
S
N
A
Q
P
G
T
W
Site 5
T57
G
S
N
A
Q
P
G
T
W
P
W
Q
V
S
L
Site 6
S109
S
V
L
L
G
V
H
S
Q
D
G
P
L
D
G
Site 7
S164
P
V
C
L
P
R
A
S
H
R
F
V
H
G
T
Site 8
Y210
E
A
T
C
Q
C
L
Y
S
Q
P
G
P
F
N
Site 9
Y231
P
G
M
L
C
A
G
Y
P
E
G
R
R
D
T
Site 10
T238
Y
P
E
G
R
R
D
T
C
Q
G
D
S
G
G
Site 11
T277
R
N
R
P
G
V
F
T
A
V
A
T
Y
E
A
Site 12
S308
T
Q
P
Q
K
T
Q
S
D
P
Q
E
P
R
E
Site 13
T319
E
P
R
E
E
N
C
T
I
A
L
P
E
C
G
Site 14
S370
S
C
F
L
D
P
N
S
S
D
S
P
P
R
D
Site 15
S371
C
F
L
D
P
N
S
S
D
S
P
P
R
D
L
Site 16
S373
L
D
P
N
S
S
D
S
P
P
R
D
L
D
A
Site 17
S387
A
W
R
V
L
L
P
S
R
P
R
A
E
R
V
Site 18
S409
N
A
S
W
D
N
A
S
D
L
A
L
L
Q
L
Site 19
Y437
C
L
P
H
P
E
H
Y
F
L
P
G
S
R
C
Site 20
Y497
P
H
A
L
C
P
A
Y
Q
E
K
E
E
V
G
Site 21
S532
A
G
I
R
D
F
P
S
G
C
L
R
P
R
A
Site 22
Y558
S
H
V
T
R
G
A
Y
L
E
D
Q
L
A
W
Site 23
T576
P
D
G
E
E
T
E
T
Q
T
C
P
P
H
T
Site 24
T578
G
E
E
T
E
T
Q
T
C
P
P
H
T
E
H
Site 25
S637
H
C
V
L
R
P
G
S
T
T
V
P
Y
I
E
Site 26
Y642
P
G
S
T
T
V
P
Y
I
E
V
Y
L
G
R
Site 27
S654
L
G
R
A
G
A
S
S
L
P
Q
G
H
Q
V
Site 28
S686
P
L
A
L
L
E
L
S
S
R
V
E
P
S
P
Site 29
S687
L
A
L
L
E
L
S
S
R
V
E
P
S
P
S
Site 30
S694
S
R
V
E
P
S
P
S
A
L
P
I
C
L
H
Site 31
Y754
P
G
T
L
C
V
L
Y
A
E
G
Q
E
N
R
Site 32
S766
E
N
R
C
E
M
T
S
A
P
P
L
L
C
Q
Site 33
S804
G
P
E
E
A
W
I
S
Q
T
V
G
E
A
N
Site 34
T806
E
E
A
W
I
S
Q
T
V
G
E
A
N
F
L
Site 35
S816
E
A
N
F
L
P
P
S
G
S
P
H
W
P
T
Site 36
S818
N
F
L
P
P
S
G
S
P
H
W
P
T
G
G
Site 37
T823
S
G
S
P
H
W
P
T
G
G
S
N
L
C
P
Site 38
S837
P
P
E
L
A
K
A
S
G
S
P
H
A
V
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation