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Updated November 2019
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Protein Info
Short Name:
KIAA1117
Full Name:
Protein dopey-1
Alias:
dJ202D23.2; DOP1; dopey family member 1; DOPEY1; LOC23033
Type:
Vesicle protein
Mass (Da):
277336
Number AA:
2465
UniProt ID:
Q5JWR5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
N
T
E
E
L
E
L
L
S
Site 2
S10
T
E
E
L
E
L
L
S
D
S
K
Y
R
N
Y
Site 3
Y14
E
L
L
S
D
S
K
Y
R
N
Y
V
A
A
I
Site 4
Y17
S
D
S
K
Y
R
N
Y
V
A
A
I
D
K
A
Site 5
S32
L
K
N
F
E
Y
S
S
E
W
A
D
L
I
S
Site 6
S39
S
E
W
A
D
L
I
S
A
L
G
K
L
N
K
Site 7
Y54
V
L
Q
N
N
A
K
Y
Q
V
V
P
K
K
L
Site 8
T139
Y
Y
L
P
L
G
K
T
L
K
P
G
L
Q
G
Site 9
Y161
G
L
E
E
G
S
E
Y
Y
E
R
T
N
M
L
Site 10
Y162
L
E
E
G
S
E
Y
Y
E
R
T
N
M
L
L
Site 11
S212
A
H
L
N
R
K
L
S
M
E
D
Q
L
Y
I
Site 12
S232
E
L
M
V
E
A
V
S
T
S
V
Q
D
S
S
Site 13
S238
V
S
T
S
V
Q
D
S
S
V
L
V
Q
R
S
Site 14
S239
S
T
S
V
Q
D
S
S
V
L
V
Q
R
S
T
Site 15
S283
V
V
L
R
R
D
M
S
L
N
R
R
L
Y
A
Site 16
S306
G
A
I
I
G
P
R
S
T
R
H
S
N
P
E
Site 17
T307
A
I
I
G
P
R
S
T
R
H
S
N
P
E
E
Site 18
S310
G
P
R
S
T
R
H
S
N
P
E
E
H
A
T
Site 19
T317
S
N
P
E
E
H
A
T
Y
Y
F
T
T
F
S
Site 20
Y318
N
P
E
E
H
A
T
Y
Y
F
T
T
F
S
K
Site 21
Y319
P
E
E
H
A
T
Y
Y
F
T
T
F
S
K
E
Site 22
S384
E
V
F
R
T
L
Y
S
Q
C
K
A
E
L
D
Site 23
T394
K
A
E
L
D
L
Q
T
E
P
P
F
S
K
D
Site 24
S399
L
Q
T
E
P
P
F
S
K
D
H
A
Q
L
S
Site 25
S406
S
K
D
H
A
Q
L
S
S
K
L
R
E
N
K
Site 26
S407
K
D
H
A
Q
L
S
S
K
L
R
E
N
K
K
Site 27
T415
K
L
R
E
N
K
K
T
A
E
L
I
K
T
A
Site 28
Y432
L
F
N
S
F
E
P
Y
Y
M
W
D
Y
V
A
Site 29
S461
L
Q
I
G
P
G
D
S
N
D
S
S
E
L
Q
Site 30
S464
G
P
G
D
S
N
D
S
S
E
L
Q
L
T
N
Site 31
S465
P
G
D
S
N
D
S
S
E
L
Q
L
T
N
F
Site 32
Y498
R
V
L
C
Q
E
T
Y
I
E
I
Q
T
E
H
Site 33
S527
H
L
Q
T
L
H
L
S
E
L
T
D
S
L
R
Site 34
S532
H
L
S
E
L
T
D
S
L
R
L
C
S
K
I
Site 35
S537
T
D
S
L
R
L
C
S
K
I
L
S
K
V
Q
Site 36
S565
F
P
S
G
Q
N
N
S
V
K
E
W
E
D
K
Site 37
S576
W
E
D
K
K
V
S
S
V
S
H
E
N
P
T
Site 38
S578
D
K
K
V
S
S
V
S
H
E
N
P
T
E
V
Site 39
S594
E
D
G
E
N
P
P
S
S
R
S
S
E
S
G
Site 40
S595
D
G
E
N
P
P
S
S
R
S
S
E
S
G
F
Site 41
S597
E
N
P
P
S
S
R
S
S
E
S
G
F
T
E
Site 42
S598
N
P
P
S
S
R
S
S
E
S
G
F
T
E
F
Site 43
S600
P
S
S
R
S
S
E
S
G
F
T
E
F
I
Q
Site 44
T603
R
S
S
E
S
G
F
T
E
F
I
Q
Y
Q
A
Site 45
Y608
G
F
T
E
F
I
Q
Y
Q
A
D
R
T
D
D
Site 46
S621
D
D
I
D
R
E
L
S
E
G
Q
G
A
A
A
Site 47
S633
A
A
A
I
P
I
G
S
T
S
S
E
T
E
T
Site 48
S636
I
P
I
G
S
T
S
S
E
T
E
T
A
S
T
Site 49
T638
I
G
S
T
S
S
E
T
E
T
A
S
T
V
G
Site 50
T640
S
T
S
S
E
T
E
T
A
S
T
V
G
S
E
Site 51
S642
S
S
E
T
E
T
A
S
T
V
G
S
E
E
T
Site 52
T643
S
E
T
E
T
A
S
T
V
G
S
E
E
T
I
Site 53
S646
E
T
A
S
T
V
G
S
E
E
T
I
I
Q
T
Site 54
T653
S
E
E
T
I
I
Q
T
P
S
V
V
T
Q
G
Site 55
T661
P
S
V
V
T
Q
G
T
A
T
R
S
R
K
T
Site 56
T668
T
A
T
R
S
R
K
T
A
Q
K
T
A
M
Q
Site 57
S698
L
Y
I
I
Q
N
N
S
F
S
Q
S
L
A
T
Site 58
S700
I
I
Q
N
N
S
F
S
Q
S
L
A
T
E
H
Site 59
S702
Q
N
N
S
F
S
Q
S
L
A
T
E
H
Q
G
Site 60
T718
L
G
R
E
Q
G
E
T
S
K
W
D
R
N
S
Site 61
S725
T
S
K
W
D
R
N
S
Q
G
D
V
K
E
K
Site 62
S735
D
V
K
E
K
N
I
S
K
Q
K
T
S
K
E
Site 63
T739
K
N
I
S
K
Q
K
T
S
K
E
Y
L
S
A
Site 64
Y743
K
Q
K
T
S
K
E
Y
L
S
A
F
L
A
A
Site 65
Y763
E
C
S
S
F
P
V
Y
I
A
E
G
N
H
T
Site 66
T770
Y
I
A
E
G
N
H
T
S
E
L
R
S
E
K
Site 67
S771
I
A
E
G
N
H
T
S
E
L
R
S
E
K
L
Site 68
S775
N
H
T
S
E
L
R
S
E
K
L
E
T
D
C
Site 69
T780
L
R
S
E
K
L
E
T
D
C
E
H
V
Q
P
Site 70
S799
Q
T
L
M
N
A
C
S
Q
A
S
D
F
S
V
Site 71
S802
M
N
A
C
S
Q
A
S
D
F
S
V
Q
S
V
Site 72
S834
V
T
G
E
N
I
N
S
V
E
P
A
Q
P
L
Site 73
S842
V
E
P
A
Q
P
L
S
P
N
Q
G
R
V
A
Site 74
T886
W
D
Q
L
G
D
G
T
P
Q
H
H
Q
K
S
Site 75
S893
T
P
Q
H
H
Q
K
S
V
E
L
F
Y
Q
L
Site 76
S915
S
I
C
E
D
V
I
S
Q
Q
L
T
H
K
D
Site 77
T919
D
V
I
S
Q
Q
L
T
H
K
D
K
K
I
R
Site 78
S948
R
D
L
H
I
N
K
S
S
S
F
V
R
S
F
Site 79
S950
L
H
I
N
K
S
S
S
F
V
R
S
F
D
R
Site 80
S954
K
S
S
S
F
V
R
S
F
D
R
S
L
F
I
Site 81
S968
I
M
L
D
S
L
N
S
L
D
G
S
T
S
S
Site 82
S972
S
L
N
S
L
D
G
S
T
S
S
V
G
Q
A
Site 83
T973
L
N
S
L
D
G
S
T
S
S
V
G
Q
A
W
Site 84
S974
N
S
L
D
G
S
T
S
S
V
G
Q
A
W
L
Site 85
S975
S
L
D
G
S
T
S
S
V
G
Q
A
W
L
N
Site 86
T1006
L
L
L
L
H
P
K
T
Q
R
V
S
V
Q
R
Site 87
S1010
H
P
K
T
Q
R
V
S
V
Q
R
V
Q
A
E
Site 88
Y1019
Q
R
V
Q
A
E
R
Y
W
N
K
S
P
C
Y
Site 89
S1023
A
E
R
Y
W
N
K
S
P
C
Y
P
G
E
E
Site 90
Y1026
Y
W
N
K
S
P
C
Y
P
G
E
E
S
D
K
Site 91
T1061
G
N
G
E
K
P
L
T
M
D
E
I
E
N
F
Site 92
T1071
E
I
E
N
F
S
L
T
V
N
P
L
S
D
R
Site 93
S1080
N
P
L
S
D
R
L
S
L
L
S
T
S
S
E
Site 94
S1083
S
D
R
L
S
L
L
S
T
S
S
E
T
I
P
Site 95
T1084
D
R
L
S
L
L
S
T
S
S
E
T
I
P
M
Site 96
S1094
E
T
I
P
M
V
V
S
D
F
D
L
P
D
Q
Site 97
S1108
Q
Q
I
E
I
L
Q
S
S
D
S
G
C
S
Q
Site 98
S1109
Q
I
E
I
L
Q
S
S
D
S
G
C
S
Q
S
Site 99
S1111
E
I
L
Q
S
S
D
S
G
C
S
Q
S
S
A
Site 100
S1114
Q
S
S
D
S
G
C
S
Q
S
S
A
G
D
N
Site 101
S1116
S
D
S
G
C
S
Q
S
S
A
G
D
N
L
S
Site 102
S1117
D
S
G
C
S
Q
S
S
A
G
D
N
L
S
Y
Site 103
S1123
S
S
A
G
D
N
L
S
Y
E
V
D
P
E
T
Site 104
Y1124
S
A
G
D
N
L
S
Y
E
V
D
P
E
T
V
Site 105
T1130
S
Y
E
V
D
P
E
T
V
N
A
Q
E
D
S
Site 106
S1137
T
V
N
A
Q
E
D
S
Q
M
P
K
E
S
S
Site 107
S1144
S
Q
M
P
K
E
S
S
P
D
D
D
V
Q
Q
Site 108
S1200
T
I
K
I
E
D
D
S
I
Q
Q
S
Q
N
A
Site 109
S1204
E
D
D
S
I
Q
Q
S
Q
N
A
L
L
S
N
Site 110
S1210
Q
S
Q
N
A
L
L
S
N
E
S
S
Q
F
L
Site 111
S1213
N
A
L
L
S
N
E
S
S
Q
F
L
S
V
S
Site 112
S1218
N
E
S
S
Q
F
L
S
V
S
A
E
G
G
H
Site 113
S1220
S
S
Q
F
L
S
V
S
A
E
G
G
H
E
C
Site 114
S1233
E
C
V
A
N
G
I
S
R
N
S
S
S
P
C
Site 115
S1236
A
N
G
I
S
R
N
S
S
S
P
C
I
S
G
Site 116
S1237
N
G
I
S
R
N
S
S
S
P
C
I
S
G
T
Site 117
S1238
G
I
S
R
N
S
S
S
P
C
I
S
G
T
T
Site 118
S1242
N
S
S
S
P
C
I
S
G
T
T
H
T
L
H
Site 119
T1244
S
S
P
C
I
S
G
T
T
H
T
L
H
D
S
Site 120
T1247
C
I
S
G
T
T
H
T
L
H
D
S
S
V
A
Site 121
S1251
T
T
H
T
L
H
D
S
S
V
A
S
I
E
T
Site 122
S1252
T
H
T
L
H
D
S
S
V
A
S
I
E
T
K
Site 123
S1255
L
H
D
S
S
V
A
S
I
E
T
K
S
R
Q
Site 124
S1260
V
A
S
I
E
T
K
S
R
Q
R
S
H
S
S
Site 125
S1264
E
T
K
S
R
Q
R
S
H
S
S
I
Q
F
S
Site 126
S1266
K
S
R
Q
R
S
H
S
S
I
Q
F
S
F
K
Site 127
S1267
S
R
Q
R
S
H
S
S
I
Q
F
S
F
K
E
Site 128
S1271
S
H
S
S
I
Q
F
S
F
K
E
K
L
S
E
Site 129
S1277
F
S
F
K
E
K
L
S
E
K
V
S
E
K
E
Site 130
S1281
E
K
L
S
E
K
V
S
E
K
E
T
I
V
K
Site 131
T1285
E
K
V
S
E
K
E
T
I
V
K
E
S
G
K
Site 132
S1313
K
D
D
D
K
K
K
S
S
N
E
K
L
K
Q
Site 133
S1322
N
E
K
L
K
Q
T
S
V
F
F
S
D
G
L
Site 134
S1326
K
Q
T
S
V
F
F
S
D
G
L
D
L
E
N
Site 135
Y1335
G
L
D
L
E
N
W
Y
S
C
G
E
G
D
I
Site 136
S1336
L
D
L
E
N
W
Y
S
C
G
E
G
D
I
S
Site 137
S1343
S
C
G
E
G
D
I
S
E
I
E
S
D
M
G
Site 138
S1347
G
D
I
S
E
I
E
S
D
M
G
S
P
G
S
Site 139
S1351
E
I
E
S
D
M
G
S
P
G
S
R
K
S
P
Site 140
S1354
S
D
M
G
S
P
G
S
R
K
S
P
N
F
N
Site 141
S1357
G
S
P
G
S
R
K
S
P
N
F
N
I
H
P
Site 142
S1378
L
Y
L
Q
L
Y
D
S
S
R
T
L
Y
A
F
Site 143
Y1383
Y
D
S
S
R
T
L
Y
A
F
S
A
I
K
A
Site 144
S1407
V
N
A
I
S
T
T
S
V
N
N
A
Y
T
P
Site 145
T1413
T
S
V
N
N
A
Y
T
P
Q
L
S
L
L
Q
Site 146
S1429
L
L
A
R
H
R
I
S
V
M
G
K
D
F
Y
Site 147
Y1436
S
V
M
G
K
D
F
Y
S
H
I
P
V
D
S
Site 148
S1443
Y
S
H
I
P
V
D
S
N
H
N
F
R
S
S
Site 149
Y1468
L
Y
Y
M
R
S
H
Y
P
T
H
V
K
V
T
Site 150
T1470
Y
M
R
S
H
Y
P
T
H
V
K
V
T
A
Q
Site 151
S1513
S
S
A
K
G
F
P
S
F
I
S
D
M
L
S
Site 152
S1516
K
G
F
P
S
F
I
S
D
M
L
S
K
C
K
Site 153
S1520
S
F
I
S
D
M
L
S
K
C
K
V
Q
K
V
Site 154
S1538
C
L
L
S
S
I
F
S
A
Q
K
W
H
S
E
Site 155
S1563
E
E
G
F
S
E
D
S
L
I
N
F
S
E
D
Site 156
S1568
E
D
S
L
I
N
F
S
E
D
E
F
D
N
G
Site 157
S1576
E
D
E
F
D
N
G
S
T
L
Q
S
Q
L
L
Site 158
S1580
D
N
G
S
T
L
Q
S
Q
L
L
K
V
L
Q
Site 159
T1598
V
L
E
H
R
V
M
T
I
P
E
E
N
E
T
Site 160
T1605
T
I
P
E
E
N
E
T
G
F
D
F
V
V
S
Site 161
S1618
V
S
D
L
E
H
I
S
P
H
Q
P
M
T
S
Site 162
T1624
I
S
P
H
Q
P
M
T
S
L
Q
Y
L
H
A
Site 163
Y1628
Q
P
M
T
S
L
Q
Y
L
H
A
Q
P
I
T
Site 164
Y1699
N
L
I
Q
Q
Y
K
Y
E
T
G
L
S
D
S
Site 165
S1704
Y
K
Y
E
T
G
L
S
D
S
R
P
L
W
M
Site 166
S1706
Y
E
T
G
L
S
D
S
R
P
L
W
M
A
S
Site 167
S1748
Q
Y
H
Q
L
L
V
S
V
D
Q
K
H
L
F
Site 168
S1784
S
I
L
H
Q
A
D
S
S
E
K
M
T
I
A
Site 169
T1789
A
D
S
S
E
K
M
T
I
A
A
S
A
S
L
Site 170
T1842
N
E
R
R
Q
N
K
T
T
T
R
T
K
V
I
Site 171
T1843
E
R
R
Q
N
K
T
T
T
R
T
K
V
I
P
Site 172
S1896
A
K
D
K
K
H
L
S
L
E
V
C
M
L
Q
Site 173
S1935
L
K
D
S
I
Q
L
S
L
P
A
P
G
Q
F
Site 174
S1957
E
F
I
M
K
N
P
S
L
E
N
K
K
D
Q
Site 175
T1971
Q
R
D
L
Q
D
V
T
H
K
I
V
D
A
I
Site 176
T1989
A
G
S
S
L
E
Q
T
T
W
L
R
R
N
L
Site 177
S2001
R
N
L
E
V
K
P
S
P
K
I
M
V
D
G
Site 178
T2009
P
K
I
M
V
D
G
T
N
L
E
S
D
V
E
Site 179
S2013
V
D
G
T
N
L
E
S
D
V
E
D
M
L
S
Site 180
S2020
S
D
V
E
D
M
L
S
P
A
M
E
T
A
N
Site 181
S2055
L
L
D
M
V
F
Y
S
D
E
K
E
R
V
I
Site 182
Y2075
I
M
H
Y
V
V
P
Y
L
R
N
H
S
A
H
Site 183
S2080
V
P
Y
L
R
N
H
S
A
H
N
A
P
S
Y
Site 184
S2086
H
S
A
H
N
A
P
S
Y
R
A
C
V
Q
L
Site 185
Y2087
S
A
H
N
A
P
S
Y
R
A
C
V
Q
L
L
Site 186
S2098
V
Q
L
L
S
S
L
S
G
Y
Q
Y
T
R
R
Site 187
Y2100
L
L
S
S
L
S
G
Y
Q
Y
T
R
R
A
W
Site 188
Y2102
S
S
L
S
G
Y
Q
Y
T
R
R
A
W
K
K
Site 189
T2144
N
L
M
T
H
D
K
T
T
F
R
D
L
M
T
Site 190
T2145
L
M
T
H
D
K
T
T
F
R
D
L
M
T
R
Site 191
S2160
V
A
V
A
Q
S
S
S
L
N
L
F
A
N
R
Site 192
Y2193
F
S
S
E
I
D
Q
Y
Q
K
Y
L
P
D
I
Site 193
Y2196
E
I
D
Q
Y
Q
K
Y
L
P
D
I
Q
E
R
Site 194
S2207
I
Q
E
R
L
V
E
S
L
R
L
P
Q
V
P
Site 195
T2259
L
L
M
E
Q
E
L
T
A
D
E
D
I
S
R
Site 196
S2265
L
T
A
D
E
D
I
S
R
T
S
G
P
S
V
Site 197
T2267
A
D
E
D
I
S
R
T
S
G
P
S
V
A
G
Site 198
S2268
D
E
D
I
S
R
T
S
G
P
S
V
A
G
L
Site 199
S2271
I
S
R
T
S
G
P
S
V
A
G
L
E
T
T
Site 200
Y2279
V
A
G
L
E
T
T
Y
T
G
G
N
G
F
S
Site 201
T2280
A
G
L
E
T
T
Y
T
G
G
N
G
F
S
T
Site 202
S2286
Y
T
G
G
N
G
F
S
T
S
Y
N
S
Q
R
Site 203
T2287
T
G
G
N
G
F
S
T
S
Y
N
S
Q
R
W
Site 204
S2288
G
G
N
G
F
S
T
S
Y
N
S
Q
R
W
L
Site 205
Y2289
G
N
G
F
S
T
S
Y
N
S
Q
R
W
L
N
Site 206
S2291
G
F
S
T
S
Y
N
S
Q
R
W
L
N
L
Y
Site 207
S2331
W
A
F
I
P
E
A
S
D
D
S
G
L
E
V
Site 208
Y2351
H
Q
R
E
F
K
P
Y
V
V
R
L
A
K
L
Site 209
S2372
K
N
P
E
E
D
N
S
G
R
T
L
G
W
E
Site 210
S2409
V
L
S
Q
V
F
N
S
K
V
T
S
R
C
G
Site 211
T2412
Q
V
F
N
S
K
V
T
S
R
C
G
G
H
S
Site 212
S2413
V
F
N
S
K
V
T
S
R
C
G
G
H
S
G
Site 213
S2419
T
S
R
C
G
G
H
S
G
S
P
I
L
Y
S
Site 214
S2421
R
C
G
G
H
S
G
S
P
I
L
Y
S
N
A
Site 215
Y2425
H
S
G
S
P
I
L
Y
S
N
A
F
P
N
K
Site 216
S2426
S
G
S
P
I
L
Y
S
N
A
F
P
N
K
D
Site 217
S2444
E
N
H
K
P
C
S
S
K
A
R
Q
K
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation