KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GNAS
Full Name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Alias:
Adenylate cyclase-stimulating G alpha protein; GNAS1
Type:
G protein, trimeric, alpha subunit
Mass (Da):
111025
Number AA:
1037
UniProt ID:
Q5JWF2
International Prot ID:
IPI00095891
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
GO:0016020
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0004871
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0001503
GO:0001958
GO:0002761
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
G
V
R
N
C
L
Y
G
N
N
M
S
G
Q
Site 2
S13
C
L
Y
G
N
N
M
S
G
Q
R
D
I
P
P
Site 3
S44
A
A
P
G
A
G
P
S
P
A
E
E
M
E
T
Site 4
T51
S
P
A
E
E
M
E
T
E
P
P
H
N
E
P
Site 5
S93
R
E
A
G
A
H
G
S
Y
S
P
P
P
E
E
Site 6
Y94
E
A
G
A
H
G
S
Y
S
P
P
P
E
E
A
Site 7
S95
A
G
A
H
G
S
Y
S
P
P
P
E
E
A
M
Site 8
S110
P
F
E
A
E
Q
P
S
L
G
G
F
W
P
T
Site 9
T117
S
L
G
G
F
W
P
T
L
E
Q
P
G
F
P
Site 10
Y154
A
R
P
G
L
G
G
Y
S
P
P
P
E
E
A
Site 11
S155
R
P
G
L
G
G
Y
S
P
P
P
E
E
A
M
Site 12
S175
Q
P
A
Q
R
G
C
S
Q
L
L
L
Q
V
P
Site 13
S212
L
R
P
A
K
A
G
S
R
G
G
Y
S
P
P
Site 14
Y216
K
A
G
S
R
G
G
Y
S
P
P
P
E
E
T
Site 15
S217
A
G
S
R
G
G
Y
S
P
P
P
E
E
T
M
Site 16
S237
G
E
G
F
G
D
D
S
P
P
P
G
L
S
R
Site 17
S243
D
S
P
P
P
G
L
S
R
V
I
A
Q
V
D
Site 18
T267
A
S
S
A
V
R
L
T
P
A
A
N
A
P
P
Site 19
S283
W
V
P
G
A
I
G
S
P
S
Q
E
A
V
R
Site 20
S285
P
G
A
I
G
S
P
S
Q
E
A
V
R
P
P
Site 21
S293
Q
E
A
V
R
P
P
S
N
F
T
G
S
S
P
Site 22
S299
P
S
N
F
T
G
S
S
P
W
M
E
I
S
G
Site 23
S305
S
S
P
W
M
E
I
S
G
P
P
F
E
I
G
Site 24
S313
G
P
P
F
E
I
G
S
A
P
A
G
V
D
D
Site 25
T321
A
P
A
G
V
D
D
T
P
V
N
M
D
S
P
Site 26
S327
D
T
P
V
N
M
D
S
P
P
I
A
L
D
G
Site 27
S375
A
E
G
G
K
V
P
S
P
G
Y
G
S
P
A
Site 28
Y378
G
K
V
P
S
P
G
Y
G
S
P
A
A
G
A
Site 29
S380
V
P
S
P
G
Y
G
S
P
A
A
G
A
A
S
Site 30
S404
A
A
P
A
D
P
D
S
G
A
T
P
E
D
P
Site 31
T407
A
D
P
D
S
G
A
T
P
E
D
P
D
S
G
Site 32
S413
A
T
P
E
D
P
D
S
G
T
A
P
A
D
P
Site 33
T415
P
E
D
P
D
S
G
T
A
P
A
D
P
D
S
Site 34
S422
T
A
P
A
D
P
D
S
G
A
F
A
A
D
P
Site 35
S431
A
F
A
A
D
P
D
S
G
A
A
P
A
A
P
Site 36
S443
A
A
P
A
D
P
D
S
G
A
A
P
D
A
P
Site 37
S455
D
A
P
A
D
P
D
S
G
A
A
P
D
A
P
Site 38
S515
A
Q
V
R
R
A
A
S
A
A
P
A
S
G
A
Site 39
S520
A
A
S
A
A
P
A
S
G
A
R
R
K
I
H
Site 40
S532
K
I
H
L
R
P
P
S
P
E
I
Q
A
A
D
Site 41
T542
I
Q
A
A
D
P
P
T
P
R
P
T
R
A
S
Site 42
T546
D
P
P
T
P
R
P
T
R
A
S
A
W
R
G
Site 43
S549
T
P
R
P
T
R
A
S
A
W
R
G
K
S
E
Site 44
S555
A
S
A
W
R
G
K
S
E
S
S
R
G
R
R
Site 45
S557
A
W
R
G
K
S
E
S
S
R
G
R
R
V
Y
Site 46
S558
W
R
G
K
S
E
S
S
R
G
R
R
V
Y
Y
Site 47
Y564
S
S
R
G
R
R
V
Y
Y
D
E
G
V
A
S
Site 48
Y565
S
R
G
R
R
V
Y
Y
D
E
G
V
A
S
S
Site 49
S571
Y
Y
D
E
G
V
A
S
S
D
D
D
S
S
G
Site 50
S572
Y
D
E
G
V
A
S
S
D
D
D
S
S
G
D
Site 51
S576
V
A
S
S
D
D
D
S
S
G
D
E
S
D
D
Site 52
S577
A
S
S
D
D
D
S
S
G
D
E
S
D
D
G
Site 53
S581
D
D
S
S
G
D
E
S
D
D
G
T
S
G
C
Site 54
T585
G
D
E
S
D
D
G
T
S
G
C
L
R
W
F
Site 55
S623
F
G
G
C
F
G
R
S
E
S
P
Q
P
K
A
Site 56
S625
G
C
F
G
R
S
E
S
P
Q
P
K
A
S
R
Site 57
S631
E
S
P
Q
P
K
A
S
R
S
L
K
V
K
K
Site 58
S633
P
Q
P
K
A
S
R
S
L
K
V
K
K
V
P
Site 59
Y680
L
Q
D
E
K
M
G
Y
M
C
T
H
R
L
L
Site 60
S697
G
A
G
E
S
G
K
S
T
I
V
K
Q
M
R
Site 61
T698
A
G
E
S
G
K
S
T
I
V
K
Q
M
R
I
Site 62
S725
E
D
P
Q
A
A
R
S
N
S
D
G
E
K
A
Site 63
S727
P
Q
A
A
R
S
N
S
D
G
E
K
A
T
K
Site 64
Y806
D
E
G
V
R
A
C
Y
E
R
S
N
E
Y
Q
Site 65
Y812
C
Y
E
R
S
N
E
Y
Q
L
I
D
C
A
Q
Site 66
Y820
Q
L
I
D
C
A
Q
Y
F
L
D
K
I
D
V
Site 67
Y833
D
V
I
K
Q
A
D
Y
V
P
S
D
Q
D
L
Site 68
T906
V
I
R
E
D
N
Q
T
N
R
L
Q
E
A
L
Site 69
S918
E
A
L
N
L
F
K
S
I
W
N
N
R
W
L
Site 70
S949
E
K
V
L
A
G
K
S
K
I
E
D
Y
F
P
Site 71
Y954
G
K
S
K
I
E
D
Y
F
P
E
F
A
R
Y
Site 72
Y961
Y
F
P
E
F
A
R
Y
T
T
P
E
D
A
T
Site 73
T962
F
P
E
F
A
R
Y
T
T
P
E
D
A
T
P
Site 74
T963
P
E
F
A
R
Y
T
T
P
E
D
A
T
P
E
Site 75
T968
Y
T
T
P
E
D
A
T
P
E
P
G
E
D
P
Site 76
T978
P
G
E
D
P
R
V
T
R
A
K
Y
F
I
R
Site 77
Y982
P
R
V
T
R
A
K
Y
F
I
R
D
E
F
L
Site 78
S992
R
D
E
F
L
R
I
S
T
A
S
G
D
G
R
Site 79
T993
D
E
F
L
R
I
S
T
A
S
G
D
G
R
H
Site 80
S995
F
L
R
I
S
T
A
S
G
D
G
R
H
Y
C
Site 81
Y1001
A
S
G
D
G
R
H
Y
C
Y
P
H
F
T
C
Site 82
Y1003
G
D
G
R
H
Y
C
Y
P
H
F
T
C
A
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation