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Updated November 2019
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Protein Info
Short Name:
FRMPD3
Full Name:
FERM and PDZ domain-containing protein 3
Alias:
Type:
Mass (Da):
199209
Number AA:
1810
UniProt ID:
Q5JV73
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
T
L
D
S
Q
R
V
Q
D
R
L
Site 2
S21
L
A
A
P
G
C
S
S
P
S
G
Q
Q
E
L
Site 3
S23
A
P
G
C
S
S
P
S
G
Q
Q
E
L
F
S
Site 4
S31
G
Q
Q
E
L
F
S
S
H
V
M
Q
E
E
S
Site 5
T56
A
E
I
L
R
Q
V
T
V
H
R
D
P
I
Y
Site 6
S79
E
R
P
V
V
V
R
S
V
R
P
G
G
P
S
Site 7
S86
S
V
R
P
G
G
P
S
E
N
K
L
L
A
G
Site 8
S105
A
I
N
E
E
D
V
S
E
A
P
R
E
R
L
Site 9
S133
T
V
L
H
T
H
Q
S
P
K
S
A
F
I
S
Site 10
S136
H
T
H
Q
S
P
K
S
A
F
I
S
A
A
K
Site 11
S140
S
P
K
S
A
F
I
S
A
A
K
K
A
K
L
Site 12
S149
A
K
K
A
K
L
R
S
N
P
V
K
V
R
F
Site 13
S157
N
P
V
K
V
R
F
S
E
Q
V
A
V
G
E
Site 14
S193
L
E
N
G
Q
I
K
S
F
T
F
D
G
R
T
Site 15
T195
N
G
Q
I
K
S
F
T
F
D
G
R
T
T
V
Site 16
T200
S
F
T
F
D
G
R
T
T
V
K
D
V
M
L
Site 17
T201
F
T
F
D
G
R
T
T
V
K
D
V
M
L
T
Site 18
S214
L
T
L
Q
D
R
L
S
L
R
F
I
E
H
F
Site 19
Y227
H
F
A
L
V
L
E
Y
A
G
P
E
Q
N
H
Site 20
Y247
Q
D
K
Q
P
L
A
Y
V
V
Q
R
T
H
Y
Site 21
Y254
Y
V
V
Q
R
T
H
Y
H
G
M
K
C
L
F
Site 22
Y283
R
D
P
A
A
F
E
Y
L
Y
I
Q
S
R
N
Site 23
Y285
P
A
A
F
E
Y
L
Y
I
Q
S
R
N
D
V
Site 24
S319
L
H
I
Y
I
T
V
S
A
T
R
P
S
Q
K
Site 25
S324
T
V
S
A
T
R
P
S
Q
K
I
S
L
K
N
Site 26
S328
T
R
P
S
Q
K
I
S
L
K
N
V
E
K
E
Site 27
S345
L
E
P
F
L
P
P
S
L
L
Q
V
I
K
E
Site 28
S358
K
E
K
N
L
R
K
S
L
S
Q
Q
L
K
A
Site 29
S360
K
N
L
R
K
S
L
S
Q
Q
L
K
A
H
Q
Site 30
T368
Q
Q
L
K
A
H
Q
T
H
P
S
C
G
T
K
Site 31
S371
K
A
H
Q
T
H
P
S
C
G
T
K
G
S
A
Site 32
S437
T
N
L
T
T
V
L
S
E
F
S
K
I
S
K
Site 33
T459
Q
G
V
A
R
V
E
T
S
I
M
D
A
K
P
Site 34
S493
Y
C
R
L
L
L
D
S
R
K
M
V
F
S
R
Site 35
S499
D
S
R
K
M
V
F
S
R
P
A
S
Q
P
L
Site 36
S503
M
V
F
S
R
P
A
S
Q
P
L
P
P
P
M
Site 37
Y515
P
P
M
I
K
A
D
Y
M
H
S
A
H
R
P
Site 38
T524
H
S
A
H
R
P
V
T
G
G
H
L
G
K
K
Site 39
S533
G
H
L
G
K
K
E
S
S
Y
V
G
S
V
G
Site 40
S534
H
L
G
K
K
E
S
S
Y
V
G
S
V
G
T
Site 41
Y535
L
G
K
K
E
S
S
Y
V
G
S
V
G
T
S
Site 42
S538
K
E
S
S
Y
V
G
S
V
G
T
S
P
R
K
Site 43
T541
S
Y
V
G
S
V
G
T
S
P
R
K
S
S
R
Site 44
S542
Y
V
G
S
V
G
T
S
P
R
K
S
S
R
C
Site 45
S546
V
G
T
S
P
R
K
S
S
R
C
T
P
P
P
Site 46
S547
G
T
S
P
R
K
S
S
R
C
T
P
P
P
A
Site 47
T550
P
R
K
S
S
R
C
T
P
P
P
A
D
S
E
Site 48
S560
P
A
D
S
E
L
V
S
F
C
Y
L
H
M
R
Site 49
Y563
S
E
L
V
S
F
C
Y
L
H
M
R
E
Q
R
Site 50
S575
E
Q
R
K
E
Q
E
S
R
T
D
V
N
E
N
Site 51
T593
F
E
E
T
R
P
R
T
K
S
D
P
T
S
K
Site 52
S595
E
T
R
P
R
T
K
S
D
P
T
S
K
S
S
Site 53
T598
P
R
T
K
S
D
P
T
S
K
S
S
G
Q
G
Site 54
S599
R
T
K
S
D
P
T
S
K
S
S
G
Q
G
Y
Site 55
S601
K
S
D
P
T
S
K
S
S
G
Q
G
Y
E
V
Site 56
Y606
S
K
S
S
G
Q
G
Y
E
V
V
P
D
D
F
Site 57
S617
P
D
D
F
D
A
A
S
L
D
H
E
P
C
A
Site 58
S625
L
D
H
E
P
C
A
S
R
A
R
S
Y
T
L
Site 59
S629
P
C
A
S
R
A
R
S
Y
T
L
D
N
S
L
Site 60
Y630
C
A
S
R
A
R
S
Y
T
L
D
N
S
L
G
Site 61
T631
A
S
R
A
R
S
Y
T
L
D
N
S
L
G
A
Site 62
Y644
G
A
E
A
L
N
F
Y
C
D
S
C
K
A
K
Site 63
S666
R
K
G
G
K
P
G
S
S
R
D
N
I
V
D
Site 64
S676
D
N
I
V
D
L
M
S
L
P
P
P
G
S
E
Site 65
S682
M
S
L
P
P
P
G
S
E
E
E
E
E
E
E
Site 66
T692
E
E
E
E
E
D
E
T
T
S
L
L
P
A
I
Site 67
T693
E
E
E
E
D
E
T
T
S
L
L
P
A
I
A
Site 68
S710
P
P
G
F
R
D
N
S
S
D
E
D
D
P
K
Site 69
S711
P
G
F
R
D
N
S
S
D
E
D
D
P
K
R
Site 70
S723
P
K
R
R
A
V
Q
S
Q
E
Q
G
R
H
L
Site 71
T750
I
D
S
V
Q
T
R
T
V
R
D
H
A
Q
E
Site 72
S799
L
A
T
I
T
P
E
S
S
L
D
S
G
H
E
Site 73
S800
A
T
I
T
P
E
S
S
L
D
S
G
H
E
T
Site 74
S803
T
P
E
S
S
L
D
S
G
H
E
T
N
S
S
Site 75
T807
S
L
D
S
G
H
E
T
N
S
S
E
L
T
D
Site 76
S809
D
S
G
H
E
T
N
S
S
E
L
T
D
M
S
Site 77
S810
S
G
H
E
T
N
S
S
E
L
T
D
M
S
E
Site 78
T813
E
T
N
S
S
E
L
T
D
M
S
E
M
M
S
Site 79
S816
S
S
E
L
T
D
M
S
E
M
M
S
A
M
K
Site 80
Y830
K
Q
H
Q
N
T
T
Y
F
L
A
Q
H
L
N
Site 81
S865
A
V
L
T
A
P
Y
S
L
G
R
P
D
P
N
Site 82
S874
G
R
P
D
P
N
P
S
L
Q
P
I
A
T
G
Site 83
T880
P
S
L
Q
P
I
A
T
G
Q
S
P
G
P
P
Site 84
S883
Q
P
I
A
T
G
Q
S
P
G
P
P
G
A
R
Site 85
S896
A
R
R
K
L
P
Q
S
E
G
Q
V
Q
G
E
Site 86
Y906
Q
V
Q
G
E
R
T
Y
S
L
A
V
H
P
A
Site 87
S907
V
Q
G
E
R
T
Y
S
L
A
V
H
P
A
L
Site 88
S915
L
A
V
H
P
A
L
S
P
Q
L
S
E
Q
K
Site 89
S919
P
A
L
S
P
Q
L
S
E
Q
K
N
L
S
L
Site 90
S925
L
S
E
Q
K
N
L
S
L
L
S
P
V
P
E
Site 91
S928
Q
K
N
L
S
L
L
S
P
V
P
E
D
K
G
Site 92
S946
T
R
A
G
L
E
M
S
L
R
A
A
T
S
S
Site 93
T951
E
M
S
L
R
A
A
T
S
S
L
S
E
E
Q
Site 94
S952
M
S
L
R
A
A
T
S
S
L
S
E
E
Q
V
Site 95
S953
S
L
R
A
A
T
S
S
L
S
E
E
Q
V
S
Site 96
S955
R
A
A
T
S
S
L
S
E
E
Q
V
S
E
L
Site 97
S960
S
L
S
E
E
Q
V
S
E
L
R
D
N
L
P
Site 98
S973
L
P
K
E
V
R
L
S
P
K
L
I
L
D
P
Site 99
S1001
Q
Q
V
V
H
N
K
S
L
V
T
A
G
G
A
Site 100
S1014
G
A
L
G
N
P
P
S
R
G
E
R
R
L
E
Site 101
S1023
G
E
R
R
L
E
A
S
M
G
R
P
E
V
S
Site 102
S1030
S
M
G
R
P
E
V
S
M
M
S
S
S
A
S
Site 103
S1033
R
P
E
V
S
M
M
S
S
S
A
S
K
N
L
Site 104
S1034
P
E
V
S
M
M
S
S
S
A
S
K
N
L
K
Site 105
S1035
E
V
S
M
M
S
S
S
A
S
K
N
L
K
F
Site 106
S1037
S
M
M
S
S
S
A
S
K
N
L
K
F
K
I
Site 107
S1045
K
N
L
K
F
K
I
S
P
S
A
P
E
T
S
Site 108
S1047
L
K
F
K
I
S
P
S
A
P
E
T
S
W
N
Site 109
T1051
I
S
P
S
A
P
E
T
S
W
N
S
Q
H
Q
Site 110
S1052
S
P
S
A
P
E
T
S
W
N
S
Q
H
Q
L
Site 111
S1064
H
Q
L
G
A
E
V
S
S
S
P
R
A
P
T
Site 112
S1066
L
G
A
E
V
S
S
S
P
R
A
P
T
G
S
Site 113
T1071
S
S
S
P
R
A
P
T
G
S
R
A
D
S
L
Site 114
S1073
S
P
R
A
P
T
G
S
R
A
D
S
L
H
L
Site 115
S1077
P
T
G
S
R
A
D
S
L
H
L
S
Q
Q
E
Site 116
S1081
R
A
D
S
L
H
L
S
Q
Q
E
D
S
L
P
Site 117
S1086
H
L
S
Q
Q
E
D
S
L
P
V
Q
N
F
P
Site 118
S1096
V
Q
N
F
P
P
K
S
Y
L
L
R
T
S
R
Site 119
T1101
P
K
S
Y
L
L
R
T
S
R
E
S
V
G
K
Site 120
S1102
K
S
Y
L
L
R
T
S
R
E
S
V
G
K
Q
Site 121
S1105
L
L
R
T
S
R
E
S
V
G
K
Q
A
T
G
Site 122
T1132
P
T
L
Q
K
Q
G
T
I
S
S
Q
G
E
K
Site 123
S1134
L
Q
K
Q
G
T
I
S
S
Q
G
E
K
A
Q
Site 124
S1135
Q
K
Q
G
T
I
S
S
Q
G
E
K
A
Q
L
Site 125
T1145
E
K
A
Q
L
E
S
T
P
K
R
S
K
L
E
Site 126
S1155
R
S
K
L
E
E
T
S
L
V
P
R
A
T
Y
Site 127
T1161
T
S
L
V
P
R
A
T
Y
P
M
A
L
Q
S
Site 128
Y1162
S
L
V
P
R
A
T
Y
P
M
A
L
Q
S
P
Site 129
S1168
T
Y
P
M
A
L
Q
S
P
S
C
Q
S
R
S
Site 130
S1170
P
M
A
L
Q
S
P
S
C
Q
S
R
S
H
S
Site 131
S1173
L
Q
S
P
S
C
Q
S
R
S
H
S
P
S
C
Site 132
S1175
S
P
S
C
Q
S
R
S
H
S
P
S
C
Q
P
Site 133
S1177
S
C
Q
S
R
S
H
S
P
S
C
Q
P
H
G
Site 134
S1179
Q
S
R
S
H
S
P
S
C
Q
P
H
G
H
S
Site 135
S1186
S
C
Q
P
H
G
H
S
P
S
S
Q
S
R
G
Site 136
S1188
Q
P
H
G
H
S
P
S
S
Q
S
R
G
Q
S
Site 137
S1189
P
H
G
H
S
P
S
S
Q
S
R
G
Q
S
P
Site 138
S1191
G
H
S
P
S
S
Q
S
R
G
Q
S
P
S
C
Site 139
S1195
S
S
Q
S
R
G
Q
S
P
S
C
Q
P
R
G
Site 140
S1197
Q
S
R
G
Q
S
P
S
C
Q
P
R
G
Q
S
Site 141
S1204
S
C
Q
P
R
G
Q
S
P
L
R
S
Q
A
A
Site 142
S1208
R
G
Q
S
P
L
R
S
Q
A
A
S
R
Q
V
Site 143
S1212
P
L
R
S
Q
A
A
S
R
Q
V
S
T
M
P
Site 144
S1216
Q
A
A
S
R
Q
V
S
T
M
P
S
R
K
L
Site 145
S1220
R
Q
V
S
T
M
P
S
R
K
L
E
T
T
L
Site 146
T1226
P
S
R
K
L
E
T
T
L
N
G
A
H
S
T
Site 147
S1232
T
T
L
N
G
A
H
S
T
S
E
G
P
A
K
Site 148
S1234
L
N
G
A
H
S
T
S
E
G
P
A
K
P
K
Site 149
S1242
E
G
P
A
K
P
K
S
S
R
G
P
F
R
L
Site 150
S1254
F
R
L
R
N
L
F
S
A
T
F
P
T
R
Q
Site 151
T1256
L
R
N
L
F
S
A
T
F
P
T
R
Q
K
K
Site 152
T1265
P
T
R
Q
K
K
E
T
D
E
R
Q
A
Q
L
Site 153
S1291
E
E
L
L
K
P
P
S
Q
G
E
L
P
G
T
Site 154
T1298
S
Q
G
E
L
P
G
T
E
Y
L
Q
P
P
A
Site 155
Y1300
G
E
L
P
G
T
E
Y
L
Q
P
P
A
P
G
Site 156
S1310
P
P
A
P
G
R
C
S
C
Q
L
R
S
S
P
Site 157
S1316
C
S
C
Q
L
R
S
S
P
V
Q
Q
G
P
G
Site 158
T1346
R
G
G
R
P
Q
A
T
Q
T
P
V
P
S
L
Site 159
T1348
G
R
P
Q
A
T
Q
T
P
V
P
S
L
R
G
Site 160
S1352
A
T
Q
T
P
V
P
S
L
R
G
R
E
R
D
Site 161
S1364
E
R
D
R
V
L
P
S
Q
R
Q
P
E
A
G
Site 162
S1377
A
G
P
G
V
S
L
S
S
P
I
N
V
Q
R
Site 163
S1387
I
N
V
Q
R
I
R
S
T
S
L
E
S
R
E
Site 164
T1388
N
V
Q
R
I
R
S
T
S
L
E
S
R
E
C
Site 165
S1389
V
Q
R
I
R
S
T
S
L
E
S
R
E
C
R
Site 166
S1397
L
E
S
R
E
C
R
S
D
P
E
S
G
V
S
Site 167
S1401
E
C
R
S
D
P
E
S
G
V
S
C
L
T
T
Site 168
S1404
S
D
P
E
S
G
V
S
C
L
T
T
C
A
S
Site 169
T1407
E
S
G
V
S
C
L
T
T
C
A
S
G
G
E
Site 170
Y1421
E
C
L
G
A
P
N
Y
R
K
L
M
R
R
Y
Site 171
Y1428
Y
R
K
L
M
R
R
Y
S
I
S
E
L
D
Q
Site 172
S1429
R
K
L
M
R
R
Y
S
I
S
E
L
D
Q
G
Site 173
S1431
L
M
R
R
Y
S
I
S
E
L
D
Q
G
D
R
Site 174
S1440
L
D
Q
G
D
R
A
S
L
T
S
D
V
Y
P
Site 175
T1442
Q
G
D
R
A
S
L
T
S
D
V
Y
P
H
P
Site 176
S1443
G
D
R
A
S
L
T
S
D
V
Y
P
H
P
P
Site 177
Y1446
A
S
L
T
S
D
V
Y
P
H
P
P
L
G
M
Site 178
S1473
P
I
A
L
G
P
K
S
R
S
L
E
S
P
T
Site 179
S1475
A
L
G
P
K
S
R
S
L
E
S
P
T
L
G
Site 180
S1478
P
K
S
R
S
L
E
S
P
T
L
G
D
P
S
Site 181
T1480
S
R
S
L
E
S
P
T
L
G
D
P
S
Y
V
Site 182
Y1486
P
T
L
G
D
P
S
Y
V
Q
V
A
P
E
T
Site 183
T1493
Y
V
Q
V
A
P
E
T
K
G
P
R
Q
M
A
Site 184
Y1509
F
S
L
P
E
E
V
Y
R
K
P
A
E
L
D
Site 185
S1519
P
A
E
L
D
E
D
S
E
S
S
K
C
C
S
Site 186
S1521
E
L
D
E
D
S
E
S
S
K
C
C
S
I
R
Site 187
S1522
L
D
E
D
S
E
S
S
K
C
C
S
I
R
Y
Site 188
S1543
C
D
M
A
D
D
A
S
D
G
K
D
E
L
S
Site 189
S1550
S
D
G
K
D
E
L
S
Y
S
I
P
M
K
I
Site 190
Y1551
D
G
K
D
E
L
S
Y
S
I
P
M
K
I
L
Site 191
S1552
G
K
D
E
L
S
Y
S
I
P
M
K
I
L
P
Site 192
T1582
L
Q
V
L
D
A
A
T
C
S
S
S
S
P
E
Site 193
S1584
V
L
D
A
A
T
C
S
S
S
S
P
E
A
S
Site 194
S1585
L
D
A
A
T
C
S
S
S
S
P
E
A
S
R
Site 195
S1586
D
A
A
T
C
S
S
S
S
P
E
A
S
R
T
Site 196
S1587
A
A
T
C
S
S
S
S
P
E
A
S
R
T
Q
Site 197
S1591
S
S
S
S
P
E
A
S
R
T
Q
E
I
D
L
Site 198
T1593
S
S
P
E
A
S
R
T
Q
E
I
D
L
R
V
Site 199
S1601
Q
E
I
D
L
R
V
S
T
F
E
G
S
L
A
Site 200
T1602
E
I
D
L
R
V
S
T
F
E
G
S
L
A
K
Site 201
S1644
V
L
R
Q
C
V
A
S
P
E
A
R
A
P
K
Site 202
Y1653
E
A
R
A
P
K
P
Y
V
S
Q
I
S
E
Y
Site 203
S1655
R
A
P
K
P
Y
V
S
Q
I
S
E
Y
K
L
Site 204
S1674
K
F
K
E
L
R
A
S
C
R
R
V
A
N
V
Site 205
S1684
R
V
A
N
V
D
K
S
P
T
H
M
L
A
A
Site 206
S1715
R
L
V
F
I
V
R
S
E
A
Q
R
Q
E
L
Site 207
T1734
E
E
V
V
R
N
Y
T
F
L
L
R
A
A
E
Site 208
S1743
L
L
R
A
A
E
E
S
T
A
R
N
L
N
Q
Site 209
T1785
A
A
A
A
G
A
A
T
E
H
P
P
G
S
P
Site 210
S1791
A
T
E
H
P
P
G
S
P
T
S
A
T
V
M
Site 211
S1794
H
P
P
G
S
P
T
S
A
T
V
M
S
T
F
Site 212
T1796
P
G
S
P
T
S
A
T
V
M
S
T
F
T
H
Site 213
S1799
P
T
S
A
T
V
M
S
T
F
T
H
S
L
K
Site 214
T1800
T
S
A
T
V
M
S
T
F
T
H
S
L
K
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation