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Updated November 2019
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Protein Info
Short Name:
FAM123B
Full Name:
Protein FAM123B
Alias:
AMER1; Family with sequence similarity 123B; FLJ39827; RP11-403E24.2; Wilms tumor gene on the X chromosome protein; Wilms Tumor on the X; WTX
Type:
Mass (Da):
124030
Number AA:
UniProt ID:
Q5JTC6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
K
G
A
A
A
S
G
S
T
R
E
Q
T
A
E
Site 2
T24
S
G
S
T
R
E
Q
T
A
E
K
G
A
K
N
Site 3
T41
A
E
A
T
E
G
P
T
S
E
P
S
S
S
G
Site 4
S42
E
A
T
E
G
P
T
S
E
P
S
S
S
G
P
Site 5
S45
E
G
P
T
S
E
P
S
S
S
G
P
G
R
L
Site 6
S46
G
P
T
S
E
P
S
S
S
G
P
G
R
L
K
Site 7
S47
P
T
S
E
P
S
S
S
G
P
G
R
L
K
K
Site 8
T55
G
P
G
R
L
K
K
T
A
M
K
L
F
G
G
Site 9
S78
S
F
F
G
G
G
R
S
K
G
S
G
K
G
S
Site 10
S81
G
G
G
R
S
K
G
S
G
K
G
S
S
K
K
Site 11
S85
S
K
G
S
G
K
G
S
S
K
K
G
L
S
K
Site 12
S86
K
G
S
G
K
G
S
S
K
K
G
L
S
K
S
Site 13
S91
G
S
S
K
K
G
L
S
K
S
K
T
H
D
G
Site 14
S93
S
K
K
G
L
S
K
S
K
T
H
D
G
L
S
Site 15
T95
K
G
L
S
K
S
K
T
H
D
G
L
S
E
A
Site 16
S100
S
K
T
H
D
G
L
S
E
A
A
H
G
P
E
Site 17
S111
H
G
P
E
D
V
V
S
E
G
T
G
F
S
L
Site 18
S130
L
P
C
Q
F
P
S
S
Q
S
A
H
G
A
L
Site 19
S141
H
G
A
L
E
T
G
S
R
C
K
T
S
V
A
Site 20
T145
E
T
G
S
R
C
K
T
S
V
A
G
A
T
E
Site 21
S146
T
G
S
R
C
K
T
S
V
A
G
A
T
E
K
Site 22
S161
A
V
A
E
K
F
P
S
M
P
K
P
K
K
G
Site 23
S174
K
G
L
K
G
F
F
S
S
I
R
R
H
R
K
Site 24
S175
G
L
K
G
F
F
S
S
I
R
R
H
R
K
S
Site 25
S182
S
I
R
R
H
R
K
S
K
V
T
G
A
E
Q
Site 26
T185
R
H
R
K
S
K
V
T
G
A
E
Q
S
E
P
Site 27
S210
R
P
H
E
H
V
S
S
A
P
Q
V
P
C
F
Site 28
S240
D
A
P
G
P
K
V
S
P
T
P
E
P
S
P
Site 29
T242
P
G
P
K
V
S
P
T
P
E
P
S
P
P
A
Site 30
S246
V
S
P
T
P
E
P
S
P
P
A
T
E
K
M
Site 31
T250
P
E
P
S
P
P
A
T
E
K
M
A
C
K
D
Site 32
S267
K
P
M
E
A
C
A
S
A
H
V
Q
P
K
P
Site 33
S279
P
K
P
A
P
E
A
S
S
L
E
E
P
H
S
Site 34
S280
K
P
A
P
E
A
S
S
L
E
E
P
H
S
P
Site 35
S286
S
S
L
E
E
P
H
S
P
E
T
G
E
K
V
Site 36
S321
G
D
V
T
S
L
K
S
F
D
S
L
T
G
C
Site 37
S324
T
S
L
K
S
F
D
S
L
T
G
C
G
D
I
Site 38
S339
I
A
E
Q
D
M
D
S
M
T
D
S
M
A
S
Site 39
T341
E
Q
D
M
D
S
M
T
D
S
M
A
S
G
G
Site 40
S343
D
M
D
S
M
T
D
S
M
A
S
G
G
Q
R
Site 41
T356
Q
R
A
N
R
D
G
T
K
R
S
S
C
L
V
Site 42
S359
N
R
D
G
T
K
R
S
S
C
L
V
T
Y
Q
Site 43
S360
R
D
G
T
K
R
S
S
C
L
V
T
Y
Q
G
Site 44
T364
K
R
S
S
C
L
V
T
Y
Q
G
G
G
E
E
Site 45
Y365
R
S
S
C
L
V
T
Y
Q
G
G
G
E
E
M
Site 46
Y408
E
E
D
D
D
L
E
Y
L
W
E
T
A
Q
M
Site 47
Y416
L
W
E
T
A
Q
M
Y
P
R
P
N
M
N
L
Site 48
Y425
R
P
N
M
N
L
G
Y
H
P
T
T
S
P
G
Site 49
T429
N
L
G
Y
H
P
T
T
S
P
G
H
H
G
Y
Site 50
Y436
T
S
P
G
H
H
G
Y
M
L
L
D
P
V
R
Site 51
Y445
L
L
D
P
V
R
S
Y
P
G
L
A
P
G
E
Site 52
T455
L
A
P
G
E
L
L
T
P
Q
S
D
Q
Q
E
Site 53
S458
G
E
L
L
T
P
Q
S
D
Q
Q
E
S
A
P
Site 54
S463
P
Q
S
D
Q
Q
E
S
A
P
N
S
D
E
G
Site 55
S467
Q
Q
E
S
A
P
N
S
D
E
G
Y
Y
D
S
Site 56
Y471
A
P
N
S
D
E
G
Y
Y
D
S
T
T
P
G
Site 57
Y472
P
N
S
D
E
G
Y
Y
D
S
T
T
P
G
F
Site 58
S474
S
D
E
G
Y
Y
D
S
T
T
P
G
F
E
D
Site 59
T475
D
E
G
Y
Y
D
S
T
T
P
G
F
E
D
D
Site 60
T476
E
G
Y
Y
D
S
T
T
P
G
F
E
D
D
S
Site 61
S483
T
P
G
F
E
D
D
S
G
E
A
L
G
L
V
Site 62
S499
R
D
C
L
P
R
D
S
Y
S
G
D
A
L
Y
Site 63
Y500
D
C
L
P
R
D
S
Y
S
G
D
A
L
Y
E
Site 64
S501
C
L
P
R
D
S
Y
S
G
D
A
L
Y
E
F
Site 65
Y506
S
Y
S
G
D
A
L
Y
E
F
Y
E
P
D
D
Site 66
S514
E
F
Y
E
P
D
D
S
L
E
N
S
P
P
G
Site 67
S518
P
D
D
S
L
E
N
S
P
P
G
D
D
C
L
Site 68
Y526
P
P
G
D
D
C
L
Y
D
L
H
G
R
S
S
Site 69
S532
L
Y
D
L
H
G
R
S
S
E
M
F
D
P
F
Site 70
S533
Y
D
L
H
G
R
S
S
E
M
F
D
P
F
L
Site 71
S547
L
N
F
E
P
F
L
S
S
R
P
P
G
A
M
Site 72
S548
N
F
E
P
F
L
S
S
R
P
P
G
A
M
E
Site 73
T563
T
E
E
E
R
L
V
T
I
Q
K
Q
L
L
Y
Site 74
Y570
T
I
Q
K
Q
L
L
Y
W
E
L
R
R
E
Q
Site 75
Y599
E
A
H
A
R
E
A
Y
T
R
E
A
Y
G
R
Site 76
Y604
E
A
Y
T
R
E
A
Y
G
R
E
A
Y
A
R
Site 77
Y609
E
A
Y
G
R
E
A
Y
A
R
E
A
H
T
W
Site 78
T638
R
E
V
R
C
R
E
T
Q
V
R
E
T
Q
A
Site 79
T643
R
E
T
Q
V
R
E
T
Q
A
R
Q
E
K
P
Site 80
S677
V
S
G
T
S
Q
I
S
H
R
G
I
T
S
A
Site 81
T682
Q
I
S
H
R
G
I
T
S
A
F
P
T
T
A
Site 82
S683
I
S
H
R
G
I
T
S
A
F
P
T
T
A
S
Site 83
T687
G
I
T
S
A
F
P
T
T
A
S
S
E
P
D
Site 84
T688
I
T
S
A
F
P
T
T
A
S
S
E
P
D
W
Site 85
S691
A
F
P
T
T
A
S
S
E
P
D
W
R
D
F
Site 86
S710
K
R
Y
E
G
T
C
S
K
K
D
Q
S
T
C
Site 87
S740
Q
E
A
N
F
G
G
S
P
R
R
A
Y
P
T
Site 88
Y745
G
G
S
P
R
R
A
Y
P
T
Y
S
P
P
E
Site 89
T747
S
P
R
R
A
Y
P
T
Y
S
P
P
E
D
P
Site 90
Y748
P
R
R
A
Y
P
T
Y
S
P
P
E
D
P
E
Site 91
S749
R
R
A
Y
P
T
Y
S
P
P
E
D
P
E
E
Site 92
T766
V
E
K
E
G
N
A
T
V
S
F
S
Q
A
L
Site 93
S768
K
E
G
N
A
T
V
S
F
S
Q
A
L
V
E
Site 94
S778
Q
A
L
V
E
F
T
S
N
G
N
L
F
S
S
Site 95
S784
T
S
N
G
N
L
F
S
S
M
S
C
S
S
D
Site 96
S785
S
N
G
N
L
F
S
S
M
S
C
S
S
D
S
Site 97
S787
G
N
L
F
S
S
M
S
C
S
S
D
S
D
S
Site 98
S789
L
F
S
S
M
S
C
S
S
D
S
D
S
S
F
Site 99
S790
F
S
S
M
S
C
S
S
D
S
D
S
S
F
T
Site 100
S792
S
M
S
C
S
S
D
S
D
S
S
F
T
Q
N
Site 101
S794
S
C
S
S
D
S
D
S
S
F
T
Q
N
L
P
Site 102
S795
C
S
S
D
S
D
S
S
F
T
Q
N
L
P
E
Site 103
Y846
E
A
F
E
L
G
Y
Y
H
K
H
A
F
N
N
Site 104
Y854
H
K
H
A
F
N
N
Y
H
S
R
F
Y
Q
G
Site 105
Y859
N
N
Y
H
S
R
F
Y
Q
G
L
P
W
G
V
Site 106
S867
Q
G
L
P
W
G
V
S
S
L
P
R
Y
L
G
Site 107
S893
A
M
A
L
N
R
R
S
R
S
L
D
T
A
E
Site 108
S895
A
L
N
R
R
S
R
S
L
D
T
A
E
T
L
Site 109
T901
R
S
L
D
T
A
E
T
L
E
M
E
L
S
N
Site 110
S907
E
T
L
E
M
E
L
S
N
S
H
L
V
Q
G
Site 111
S909
L
E
M
E
L
S
N
S
H
L
V
Q
G
Y
L
Site 112
S928
L
Q
A
Q
Q
E
D
S
D
E
E
D
E
E
E
Site 113
S941
E
E
E
E
G
E
W
S
R
D
S
P
L
S
L
Site 114
S944
E
G
E
W
S
R
D
S
P
L
S
L
Y
T
E
Site 115
S947
W
S
R
D
S
P
L
S
L
Y
T
E
P
P
G
Site 116
Y949
R
D
S
P
L
S
L
Y
T
E
P
P
G
A
Y
Site 117
T950
D
S
P
L
S
L
Y
T
E
P
P
G
A
Y
D
Site 118
Y956
Y
T
E
P
P
G
A
Y
D
W
P
A
W
A
P
Site 119
S976
G
P
G
P
A
W
I
S
P
N
Q
L
D
R
P
Site 120
S984
P
N
Q
L
D
R
P
S
S
Q
S
P
Y
R
Q
Site 121
S985
N
Q
L
D
R
P
S
S
Q
S
P
Y
R
Q
A
Site 122
S987
L
D
R
P
S
S
Q
S
P
Y
R
Q
A
T
C
Site 123
Y989
R
P
S
S
Q
S
P
Y
R
Q
A
T
C
C
I
Site 124
T993
Q
S
P
Y
R
Q
A
T
C
C
I
P
P
M
T
Site 125
S1004
P
P
M
T
M
S
I
S
L
S
V
P
E
S
R
Site 126
S1006
M
T
M
S
I
S
L
S
V
P
E
S
R
A
P
Site 127
S1010
I
S
L
S
V
P
E
S
R
A
P
G
E
S
G
Site 128
S1016
E
S
R
A
P
G
E
S
G
P
Q
L
A
R
P
Site 129
S1024
G
P
Q
L
A
R
P
S
H
L
H
L
P
M
G
Site 130
Y1034
H
L
P
M
G
P
C
Y
N
L
Q
P
Q
A
S
Site 131
S1041
Y
N
L
Q
P
Q
A
S
Q
S
M
R
A
R
P
Site 132
S1043
L
Q
P
Q
A
S
Q
S
M
R
A
R
P
R
D
Site 133
S1059
L
L
P
V
D
E
P
S
C
S
S
S
S
G
G
Site 134
S1061
P
V
D
E
P
S
C
S
S
S
S
G
G
F
S
Site 135
S1062
V
D
E
P
S
C
S
S
S
S
G
G
F
S
P
Site 136
S1063
D
E
P
S
C
S
S
S
S
G
G
F
S
P
S
Site 137
S1064
E
P
S
C
S
S
S
S
G
G
F
S
P
S
P
Site 138
S1068
S
S
S
S
G
G
F
S
P
S
P
L
P
Q
A
Site 139
S1070
S
S
G
G
F
S
P
S
P
L
P
Q
A
K
P
Site 140
T1100
E
H
P
Q
P
Q
P
T
H
Y
G
P
S
S
L
Site 141
Y1102
P
Q
P
Q
P
T
H
Y
G
P
S
S
L
D
L
Site 142
S1106
P
T
H
Y
G
P
S
S
L
D
L
S
K
E
R
Site 143
S1110
G
P
S
S
L
D
L
S
K
E
R
A
E
Q
G
Site 144
S1119
E
R
A
E
Q
G
A
S
L
A
T
S
Y
S
S
Site 145
S1123
Q
G
A
S
L
A
T
S
Y
S
S
T
A
M
N
Site 146
S1125
A
S
L
A
T
S
Y
S
S
T
A
M
N
G
N
Site 147
S1126
S
L
A
T
S
Y
S
S
T
A
M
N
G
N
L
Site 148
T1127
L
A
T
S
Y
S
S
T
A
M
N
G
N
L
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation