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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EFHC2
Full Name:
EF-hand domain-containing family member C2
Alias:
Type:
Mass (Da):
87397
Number AA:
749
UniProt ID:
Q5JST6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
P
L
L
P
G
N
S
F
N
R
N
V
G
K
Site 2
S37
N
N
V
M
M
L
V
S
D
E
K
P
G
I
G
Site 3
S58
Q
K
I
K
P
K
C
S
I
Y
P
K
G
D
G
Site 4
Y60
I
K
P
K
C
S
I
Y
P
K
G
D
G
S
D
Site 5
S66
I
Y
P
K
G
D
G
S
D
V
P
S
W
V
A
Site 6
S70
G
D
G
S
D
V
P
S
W
V
A
F
D
K
Q
Site 7
S80
A
F
D
K
Q
V
L
S
F
D
A
Y
L
E
E
Site 8
Y84
Q
V
L
S
F
D
A
Y
L
E
E
E
V
L
D
Site 9
S93
E
E
E
V
L
D
K
S
Q
T
N
Y
R
I
R
Site 10
T95
E
V
L
D
K
S
Q
T
N
Y
R
I
R
Y
Y
Site 11
Y97
L
D
K
S
Q
T
N
Y
R
I
R
Y
Y
K
I
Site 12
Y101
Q
T
N
Y
R
I
R
Y
Y
K
I
Y
F
Y
P
Site 13
Y102
T
N
Y
R
I
R
Y
Y
K
I
Y
F
Y
P
E
Site 14
Y105
R
I
R
Y
Y
K
I
Y
F
Y
P
E
D
D
T
Site 15
Y107
R
Y
Y
K
I
Y
F
Y
P
E
D
D
T
I
Q
Site 16
T112
Y
F
Y
P
E
D
D
T
I
Q
V
N
E
P
E
Site 17
S130
S
G
L
L
Q
G
T
S
I
R
R
H
R
I
T
Site 18
T137
S
I
R
R
H
R
I
T
L
P
P
P
D
E
D
Site 19
Y147
P
P
D
E
D
Q
F
Y
T
V
Y
H
F
N
V
Site 20
Y150
E
D
Q
F
Y
T
V
Y
H
F
N
V
G
T
E
Site 21
Y168
Y
G
R
T
F
K
I
Y
D
C
D
A
F
T
R
Site 22
Y196
V
Q
C
P
E
D
P
Y
M
K
I
R
R
E
V
Site 23
Y213
H
V
E
P
L
R
P
Y
E
S
L
D
T
L
K
Site 24
S215
E
P
L
R
P
Y
E
S
L
D
T
L
K
Q
F
Site 25
T218
R
P
Y
E
S
L
D
T
L
K
Q
F
L
Q
Y
Site 26
S269
I
K
E
L
L
P
H
S
S
G
R
D
A
L
K
Site 27
S270
K
E
L
L
P
H
S
S
G
R
D
A
L
K
M
Site 28
S282
L
K
M
F
L
R
R
S
K
L
P
K
N
C
P
Site 29
Y293
K
N
C
P
P
R
V
Y
Q
P
G
Q
I
T
D
Site 30
T299
V
Y
Q
P
G
Q
I
T
D
R
A
V
L
N
S
Site 31
S306
T
D
R
A
V
L
N
S
Y
G
D
F
I
K
N
Site 32
Y318
I
K
N
Q
A
D
G
Y
L
F
D
R
Y
K
L
Site 33
Y323
D
G
Y
L
F
D
R
Y
K
L
G
K
V
D
Q
Site 34
S336
D
Q
E
F
Y
K
D
S
D
L
S
L
G
V
T
Site 35
T343
S
D
L
S
L
G
V
T
I
N
V
W
G
R
K
Site 36
Y354
W
G
R
K
V
L
L
Y
D
C
D
E
F
T
K
Site 37
T360
L
Y
D
C
D
E
F
T
K
S
Y
Y
K
S
K
Site 38
Y364
D
E
F
T
K
S
Y
Y
K
S
K
Y
G
I
E
Site 39
S375
Y
G
I
E
N
F
T
S
V
S
C
K
P
P
S
Site 40
S377
I
E
N
F
T
S
V
S
C
K
P
P
S
P
P
Site 41
S382
S
V
S
C
K
P
P
S
P
P
P
K
I
E
R
Site 42
Y394
I
E
R
K
F
P
P
Y
N
G
F
G
S
E
E
Site 43
S399
P
P
Y
N
G
F
G
S
E
E
D
S
L
R
N
Site 44
S403
G
F
G
S
E
E
D
S
L
R
N
C
I
D
L
Site 45
T413
N
C
I
D
L
K
P
T
P
H
R
R
N
F
K
Site 46
S427
K
K
F
M
E
K
D
S
Y
G
S
K
S
N
I
Site 47
Y428
K
F
M
E
K
D
S
Y
G
S
K
S
N
I
L
Site 48
S430
M
E
K
D
S
Y
G
S
K
S
N
I
L
R
F
Site 49
S432
K
D
S
Y
G
S
K
S
N
I
L
R
F
F
A
Site 50
S465
Y
L
G
D
D
T
I
S
V
F
E
P
I
E
R
Site 51
S474
F
E
P
I
E
R
N
S
G
I
A
G
G
M
F
Site 52
S485
G
G
M
F
L
K
R
S
R
V
K
K
P
G
Q
Site 53
S497
P
G
Q
E
V
F
K
S
E
L
S
E
Y
I
K
Site 54
Y502
F
K
S
E
L
S
E
Y
I
K
A
E
E
L
Y
Site 55
Y529
R
L
L
N
A
D
E
Y
T
L
N
Y
M
E
Q
Site 56
T530
L
L
N
A
D
E
Y
T
L
N
Y
M
E
Q
N
Site 57
Y533
A
D
E
Y
T
L
N
Y
M
E
Q
N
T
D
K
Site 58
Y541
M
E
Q
N
T
D
K
Y
P
F
S
N
L
K
L
Site 59
S544
N
T
D
K
Y
P
F
S
N
L
K
L
A
L
Q
Site 60
S560
L
K
Q
E
E
G
K
S
R
E
L
K
Q
V
F
Site 61
Y580
K
H
T
N
M
V
D
Y
N
T
F
R
D
I
L
Site 62
Y607
F
V
T
I
A
R
H
Y
R
V
P
E
G
T
C
Site 63
Y641
E
N
F
D
T
F
I
Y
S
C
V
Y
E
D
R
Site 64
Y645
T
F
I
Y
S
C
V
Y
E
D
R
E
K
K
N
Site 65
T656
E
K
K
N
V
L
P
T
K
D
I
K
R
L
C
Site 66
S665
D
I
K
R
L
C
K
S
S
R
L
P
L
S
D
Site 67
S666
I
K
R
L
C
K
S
S
R
L
P
L
S
D
D
Site 68
S671
K
S
S
R
L
P
L
S
D
D
L
L
E
S
L
Site 69
S677
L
S
D
D
L
L
E
S
L
L
S
R
F
E
D
Site 70
S680
D
L
L
E
S
L
L
S
R
F
E
D
S
E
K
Site 71
S685
L
L
S
R
F
E
D
S
E
K
Q
I
D
Y
K
Site 72
Y691
D
S
E
K
Q
I
D
Y
K
S
F
F
S
A
L
Site 73
S712
V
P
E
L
Q
P
A
S
Y
L
K
E
R
C
E
Site 74
Y713
P
E
L
Q
P
A
S
Y
L
K
E
R
C
E
D
Site 75
Y733
P
S
P
I
P
A
K
Y
I
D
Y
W
T
F
L
Site 76
Y736
I
P
A
K
Y
I
D
Y
W
T
F
L
K
D
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation