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Updated November 2019
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Protein Info
Short Name:
DOCK11
Full Name:
Dedicator of cytokinesis protein 11
Alias:
ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Cdc42-associated guanine nucleotide exchange factor ACG/DOCK11; Dedicator of cytokinesis 11; DOC11; FLJ32122; FLJ43653; ZIZ2; Zizimin2; Zizimin-2
Type:
Unknown function
Mass (Da):
237671
Number AA:
2073
UniProt ID:
Q5JSL3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0051020
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
A
E
V
R
K
F
T
K
R
L
S
K
P
G
Site 2
S12
R
K
F
T
K
R
L
S
K
P
G
T
A
A
E
Site 3
T16
K
R
L
S
K
P
G
T
A
A
E
L
R
Q
S
Site 4
S23
T
A
A
E
L
R
Q
S
V
S
E
A
V
R
G
Site 5
S25
A
E
L
R
Q
S
V
S
E
A
V
R
G
S
V
Site 6
Y45
K
V
V
E
P
L
D
Y
E
N
V
I
A
Q
R
Site 7
T54
N
V
I
A
Q
R
K
T
Q
I
Y
S
D
P
L
Site 8
Y57
A
Q
R
K
T
Q
I
Y
S
D
P
L
R
D
L
Site 9
S58
Q
R
K
T
Q
I
Y
S
D
P
L
R
D
L
L
Site 10
S75
P
M
E
D
I
S
I
S
V
I
G
R
Q
R
R
Site 11
T83
V
I
G
R
Q
R
R
T
V
Q
S
T
V
P
E
Site 12
S86
R
Q
R
R
T
V
Q
S
T
V
P
E
D
A
E
Site 13
T87
Q
R
R
T
V
Q
S
T
V
P
E
D
A
E
K
Site 14
S98
D
A
E
K
R
A
Q
S
L
F
V
K
E
C
I
Site 15
Y119
W
H
V
V
N
Y
K
Y
E
D
F
S
G
D
F
Site 16
S133
F
R
M
L
P
C
K
S
L
R
P
E
K
I
P
Site 17
S156
D
C
E
K
D
E
D
S
S
S
L
C
S
Q
K
Site 18
S157
C
E
K
D
E
D
S
S
S
L
C
S
Q
K
G
Site 19
S158
E
K
D
E
D
S
S
S
L
C
S
Q
K
G
G
Site 20
S161
E
D
S
S
S
L
C
S
Q
K
G
G
V
I
K
Site 21
Y192
M
K
V
F
K
R
R
Y
F
Y
L
T
Q
L
P
Site 22
Y194
V
F
K
R
R
Y
F
Y
L
T
Q
L
P
D
G
Site 23
T196
K
R
R
Y
F
Y
L
T
Q
L
P
D
G
S
Y
Site 24
S202
L
T
Q
L
P
D
G
S
Y
I
L
N
S
Y
K
Site 25
Y203
T
Q
L
P
D
G
S
Y
I
L
N
S
Y
K
D
Site 26
S207
D
G
S
Y
I
L
N
S
Y
K
D
E
K
N
S
Site 27
Y208
G
S
Y
I
L
N
S
Y
K
D
E
K
N
S
K
Site 28
Y248
E
L
K
M
L
D
K
Y
S
H
Y
L
A
A
E
Site 29
S249
L
K
M
L
D
K
Y
S
H
Y
L
A
A
E
T
Site 30
Y251
M
L
D
K
Y
S
H
Y
L
A
A
E
T
E
Q
Site 31
T266
E
M
E
E
W
L
I
T
L
K
K
I
I
Q
I
Site 32
T275
K
K
I
I
Q
I
N
T
D
S
L
V
Q
E
K
Site 33
S277
I
I
Q
I
N
T
D
S
L
V
Q
E
K
K
E
Site 34
T285
L
V
Q
E
K
K
E
T
V
E
T
A
Q
D
D
Site 35
T288
E
K
K
E
T
V
E
T
A
Q
D
D
E
T
S
Site 36
T294
E
T
A
Q
D
D
E
T
S
S
Q
G
K
A
E
Site 37
S296
A
Q
D
D
E
T
S
S
Q
G
K
A
E
N
I
Site 38
S306
K
A
E
N
I
M
A
S
L
E
R
S
M
H
P
Site 39
S310
I
M
A
S
L
E
R
S
M
H
P
E
L
M
K
Site 40
Y318
M
H
P
E
L
M
K
Y
G
R
E
T
E
Q
L
Site 41
T322
L
M
K
Y
G
R
E
T
E
Q
L
N
K
L
S
Site 42
S329
T
E
Q
L
N
K
L
S
R
G
D
G
R
Q
N
Site 43
S339
D
G
R
Q
N
L
F
S
F
D
S
E
V
Q
R
Site 44
S342
Q
N
L
F
S
F
D
S
E
V
Q
R
L
D
F
Site 45
S423
H
V
D
L
N
P
P
S
V
R
E
M
L
W
G
Site 46
T433
E
M
L
W
G
S
S
T
Q
L
A
S
D
G
S
Site 47
S437
G
S
S
T
Q
L
A
S
D
G
S
P
K
G
S
Site 48
S440
T
Q
L
A
S
D
G
S
P
K
G
S
S
P
E
Site 49
S444
S
D
G
S
P
K
G
S
S
P
E
S
Y
I
H
Site 50
S445
D
G
S
P
K
G
S
S
P
E
S
Y
I
H
G
Site 51
S448
P
K
G
S
S
P
E
S
Y
I
H
G
I
A
E
Site 52
Y449
K
G
S
S
P
E
S
Y
I
H
G
I
A
E
S
Site 53
Y460
I
A
E
S
Q
L
R
Y
I
Q
Q
G
I
F
S
Site 54
T490
K
V
L
Q
G
N
I
T
H
C
A
E
P
Y
I
Site 55
S500
A
E
P
Y
I
K
N
S
D
P
V
K
T
A
Q
Site 56
Y523
V
C
S
R
L
G
Q
Y
R
M
P
F
A
W
A
Site 57
T538
A
R
P
I
F
K
D
T
Q
G
S
L
D
L
D
Site 58
S549
L
D
L
D
G
R
F
S
P
L
Y
K
Q
D
S
Site 59
Y552
D
G
R
F
S
P
L
Y
K
Q
D
S
S
K
L
Site 60
S556
S
P
L
Y
K
Q
D
S
S
K
L
S
S
E
D
Site 61
S557
P
L
Y
K
Q
D
S
S
K
L
S
S
E
D
I
Site 62
S560
K
Q
D
S
S
K
L
S
S
E
D
I
L
K
L
Site 63
S561
Q
D
S
S
K
L
S
S
E
D
I
L
K
L
L
Site 64
S569
E
D
I
L
K
L
L
S
E
Y
K
K
P
E
K
Site 65
Y571
I
L
K
L
L
S
E
Y
K
K
P
E
K
T
K
Site 66
Y605
S
N
C
I
T
S
S
Y
V
P
L
K
P
F
E
Site 67
T619
E
K
N
C
Q
N
I
T
V
E
V
E
E
F
V
Site 68
Y644
T
I
Y
K
N
H
L
Y
V
Y
P
L
Q
L
K
Site 69
Y646
Y
K
N
H
L
Y
V
Y
P
L
Q
L
K
Y
D
Site 70
Y652
V
Y
P
L
Q
L
K
Y
D
S
Q
K
T
F
A
Site 71
S654
P
L
Q
L
K
Y
D
S
Q
K
T
F
A
K
A
Site 72
T657
L
K
Y
D
S
Q
K
T
F
A
K
A
R
N
I
Site 73
S673
V
C
V
E
F
R
D
S
D
E
S
D
A
S
A
Site 74
S676
E
F
R
D
S
D
E
S
D
A
S
A
L
K
C
Site 75
S679
D
S
D
E
S
D
A
S
A
L
K
C
I
Y
G
Site 76
S691
I
Y
G
K
P
A
G
S
V
F
T
T
N
A
Y
Site 77
Y698
S
V
F
T
T
N
A
Y
A
V
V
S
H
H
N
Site 78
T750
G
T
T
K
K
Q
D
T
V
E
T
P
V
G
F
Site 79
T753
K
K
Q
D
T
V
E
T
P
V
G
F
A
W
V
Site 80
T770
L
K
D
G
R
I
I
T
F
E
Q
Q
L
P
V
Site 81
S778
F
E
Q
Q
L
P
V
S
A
N
L
P
P
G
Y
Site 82
Y785
S
A
N
L
P
P
G
Y
L
N
L
N
D
A
E
Site 83
S793
L
N
L
N
D
A
E
S
R
R
Q
C
N
V
D
Site 84
S815
K
P
L
L
K
I
K
S
H
L
E
S
T
I
Y
Site 85
S819
K
I
K
S
H
L
E
S
T
I
Y
T
Q
D
L
Site 86
Y822
S
H
L
E
S
T
I
Y
T
Q
D
L
H
V
H
Site 87
T823
H
L
E
S
T
I
Y
T
Q
D
L
H
V
H
K
Site 88
S842
C
Q
L
I
Q
S
G
S
K
E
V
P
G
E
L
Site 89
T880
M
Q
L
F
R
V
L
T
N
M
T
H
E
D
D
Site 90
S910
C
H
E
E
G
L
D
S
Y
L
R
S
F
I
K
Site 91
Y911
H
E
E
G
L
D
S
Y
L
R
S
F
I
K
Y
Site 92
S914
G
L
D
S
Y
L
R
S
F
I
K
Y
S
F
R
Site 93
Y918
Y
L
R
S
F
I
K
Y
S
F
R
P
E
K
P
Site 94
S919
L
R
S
F
I
K
Y
S
F
R
P
E
K
P
S
Site 95
S926
S
F
R
P
E
K
P
S
A
P
Q
A
Q
L
I
Site 96
S953
K
Q
S
A
D
F
L
S
I
N
K
L
L
K
Y
Site 97
Y975
I
A
K
S
M
A
T
Y
L
L
E
E
N
K
I
Site 98
T993
R
G
Q
R
F
P
E
T
Y
H
H
V
L
H
S
Site 99
Y994
G
Q
R
F
P
E
T
Y
H
H
V
L
H
S
L
Site 100
S1026
E
S
R
N
V
N
Y
S
L
A
S
F
L
K
R
Site 101
S1029
N
V
N
Y
S
L
A
S
F
L
K
R
C
L
T
Site 102
S1052
N
L
I
N
D
Y
I
S
G
F
S
P
K
D
P
Site 103
S1055
N
D
Y
I
S
G
F
S
P
K
D
P
K
V
L
Site 104
Y1079
T
I
C
N
H
E
H
Y
I
P
L
N
L
P
M
Site 105
S1099
K
L
Q
R
V
Q
D
S
N
L
E
Y
S
L
S
Site 106
Y1103
V
Q
D
S
N
L
E
Y
S
L
S
D
E
Y
C
Site 107
S1104
Q
D
S
N
L
E
Y
S
L
S
D
E
Y
C
K
Site 108
S1106
S
N
L
E
Y
S
L
S
D
E
Y
C
K
H
H
Site 109
Y1109
E
Y
S
L
S
D
E
Y
C
K
H
H
F
L
V
Site 110
S1124
G
L
L
L
R
E
T
S
I
A
L
Q
D
N
Y
Site 111
Y1131
S
I
A
L
Q
D
N
Y
E
I
R
Y
T
A
I
Site 112
Y1135
Q
D
N
Y
E
I
R
Y
T
A
I
S
V
I
K
Site 113
T1136
D
N
Y
E
I
R
Y
T
A
I
S
V
I
K
N
Site 114
Y1154
K
H
A
F
D
T
R
Y
Q
H
K
N
Q
Q
A
Site 115
T1186
Q
R
L
A
G
R
D
T
L
Y
S
C
A
A
M
Site 116
Y1188
L
A
G
R
D
T
L
Y
S
C
A
A
M
P
N
Site 117
S1189
A
G
R
D
T
L
Y
S
C
A
A
M
P
N
S
Site 118
S1196
S
C
A
A
M
P
N
S
A
S
R
D
E
F
P
Site 119
S1198
A
A
M
P
N
S
A
S
R
D
E
F
P
C
G
Site 120
S1208
E
F
P
C
G
F
T
S
P
A
N
R
G
S
L
Site 121
S1214
T
S
P
A
N
R
G
S
L
S
T
D
K
D
T
Site 122
S1216
P
A
N
R
G
S
L
S
T
D
K
D
T
A
Y
Site 123
T1217
A
N
R
G
S
L
S
T
D
K
D
T
A
Y
G
Site 124
T1221
S
L
S
T
D
K
D
T
A
Y
G
S
F
Q
N
Site 125
Y1223
S
T
D
K
D
T
A
Y
G
S
F
Q
N
G
H
Site 126
S1225
D
K
D
T
A
Y
G
S
F
Q
N
G
H
G
I
Site 127
S1237
H
G
I
K
R
E
D
S
R
G
S
L
I
P
E
Site 128
S1240
K
R
E
D
S
R
G
S
L
I
P
E
G
A
T
Site 129
T1259
Q
G
N
T
G
E
N
T
R
Q
S
S
T
R
S
Site 130
S1262
T
G
E
N
T
R
Q
S
S
T
R
S
S
V
S
Site 131
S1263
G
E
N
T
R
Q
S
S
T
R
S
S
V
S
Q
Site 132
T1264
E
N
T
R
Q
S
S
T
R
S
S
V
S
Q
Y
Site 133
S1266
T
R
Q
S
S
T
R
S
S
V
S
Q
Y
N
R
Site 134
S1267
R
Q
S
S
T
R
S
S
V
S
Q
Y
N
R
L
Site 135
S1269
S
S
T
R
S
S
V
S
Q
Y
N
R
L
D
Q
Site 136
Y1271
T
R
S
S
V
S
Q
Y
N
R
L
D
Q
Y
E
Site 137
Y1277
Q
Y
N
R
L
D
Q
Y
E
I
R
S
L
L
M
Site 138
Y1288
S
L
L
M
C
Y
L
Y
I
V
K
M
I
S
E
Site 139
T1300
I
S
E
D
T
L
L
T
Y
W
N
K
V
S
P
Site 140
Y1301
S
E
D
T
L
L
T
Y
W
N
K
V
S
P
Q
Site 141
S1306
L
T
Y
W
N
K
V
S
P
Q
E
L
I
N
I
Site 142
S1350
H
F
G
I
D
R
K
S
Q
T
M
P
A
L
R
Site 143
T1352
G
I
D
R
K
S
Q
T
M
P
A
L
R
N
R
Site 144
S1360
M
P
A
L
R
N
R
S
G
V
M
Q
A
R
L
Site 145
S1371
Q
A
R
L
Q
H
L
S
S
L
E
S
S
F
T
Site 146
S1372
A
R
L
Q
H
L
S
S
L
E
S
S
F
T
L
Site 147
S1375
Q
H
L
S
S
L
E
S
S
F
T
L
N
H
S
Site 148
S1376
H
L
S
S
L
E
S
S
F
T
L
N
H
S
S
Site 149
T1378
S
S
L
E
S
S
F
T
L
N
H
S
S
T
T
Site 150
S1382
S
S
F
T
L
N
H
S
S
T
T
T
E
A
D
Site 151
S1383
S
F
T
L
N
H
S
S
T
T
T
E
A
D
I
Site 152
T1386
L
N
H
S
S
T
T
T
E
A
D
I
F
H
Q
Site 153
S1449
A
F
L
K
N
G
Q
S
E
V
S
L
K
H
V
Site 154
S1452
K
N
G
Q
S
E
V
S
L
K
H
V
F
A
S
Site 155
S1492
E
V
L
K
C
C
T
S
K
I
S
S
T
R
N
Site 156
S1496
C
C
T
S
K
I
S
S
T
R
N
E
A
S
A
Site 157
Y1515
L
M
R
N
N
F
E
Y
T
K
R
K
T
F
L
Site 158
T1516
M
R
N
N
F
E
Y
T
K
R
K
T
F
L
R
Site 159
T1520
F
E
Y
T
K
R
K
T
F
L
R
T
H
L
Q
Site 160
S1550
G
G
S
R
F
Q
E
S
L
F
I
I
N
N
F
Site 161
T1567
S
D
R
P
M
K
A
T
A
F
P
A
E
V
K
Site 162
T1577
P
A
E
V
K
D
L
T
K
R
I
R
T
V
L
Site 163
T1582
D
L
T
K
R
I
R
T
V
L
M
A
T
A
Q
Site 164
S1610
L
Q
Y
S
L
A
K
S
Y
A
S
T
P
E
L
Site 165
T1614
L
A
K
S
Y
A
S
T
P
E
L
R
K
T
W
Site 166
T1620
S
T
P
E
L
R
K
T
W
L
D
S
M
A
K
Site 167
S1624
L
R
K
T
W
L
D
S
M
A
K
I
H
V
K
Site 168
S1636
H
V
K
N
G
D
F
S
E
A
A
M
C
Y
V
Site 169
T1670
C
S
A
F
K
K
I
T
P
N
I
D
E
E
G
Site 170
Y1712
G
L
W
K
A
E
R
Y
E
I
I
S
E
I
S
Site 171
Y1726
S
K
L
I
V
P
I
Y
E
K
R
R
E
F
E
Site 172
T1736
R
R
E
F
E
K
L
T
Q
V
Y
R
T
L
H
Site 173
T1755
K
I
L
E
V
M
H
T
K
K
R
L
L
G
T
Site 174
S1772
R
V
A
F
Y
G
Q
S
F
F
E
E
E
D
G
Site 175
Y1782
E
E
E
D
G
K
E
Y
I
Y
K
E
P
K
L
Site 176
Y1784
E
D
G
K
E
Y
I
Y
K
E
P
K
L
T
G
Site 177
T1790
I
Y
K
E
P
K
L
T
G
L
S
E
I
S
L
Site 178
Y1803
S
L
R
L
V
K
L
Y
G
E
K
F
G
T
E
Site 179
T1809
L
Y
G
E
K
F
G
T
E
N
V
K
I
I
Q
Site 180
S1818
N
V
K
I
I
Q
D
S
D
K
V
N
A
K
E
Site 181
Y1830
A
K
E
L
D
P
K
Y
A
H
I
Q
V
T
Y
Site 182
Y1837
Y
A
H
I
Q
V
T
Y
V
K
P
Y
F
D
D
Site 183
Y1841
Q
V
T
Y
V
K
P
Y
F
D
D
K
E
L
T
Site 184
T1848
Y
F
D
D
K
E
L
T
E
R
K
T
E
F
E
Site 185
T1852
K
E
L
T
E
R
K
T
E
F
E
R
N
H
N
Site 186
S1861
F
E
R
N
H
N
I
S
R
F
V
F
E
A
P
Site 187
Y1869
R
F
V
F
E
A
P
Y
T
L
S
G
K
K
Q
Site 188
T1870
F
V
F
E
A
P
Y
T
L
S
G
K
K
Q
G
Site 189
T1887
E
E
Q
C
K
R
R
T
I
L
T
T
S
N
S
Site 190
T1890
C
K
R
R
T
I
L
T
T
S
N
S
F
P
Y
Site 191
T1891
K
R
R
T
I
L
T
T
S
N
S
F
P
Y
V
Site 192
S1892
R
R
T
I
L
T
T
S
N
S
F
P
Y
V
K
Site 193
S1894
T
I
L
T
T
S
N
S
F
P
Y
V
K
K
R
Site 194
Y1897
T
T
S
N
S
F
P
Y
V
K
K
R
I
P
I
Site 195
T1926
T
D
E
I
K
D
K
T
A
E
L
Q
K
L
C
Site 196
Y1962
V
N
A
G
P
L
A
Y
A
R
A
F
L
N
D
Site 197
S1970
A
R
A
F
L
N
D
S
Q
A
S
K
Y
P
P
Site 198
Y1975
N
D
S
Q
A
S
K
Y
P
P
K
K
V
S
E
Site 199
S2018
E
Y
H
E
G
L
K
S
N
F
R
D
M
V
K
Site 200
S2028
R
D
M
V
K
E
L
S
D
I
I
H
E
Q
I
Site 201
S2043
L
Q
E
D
T
M
H
S
P
W
M
S
N
T
L
Site 202
S2061
C
A
I
S
G
T
S
S
D
R
G
Y
G
S
P
Site 203
Y2065
G
T
S
S
D
R
G
Y
G
S
P
R
Y
A
E
Site 204
S2067
S
S
D
R
G
Y
G
S
P
R
Y
A
E
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation