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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RALGPS1
Full Name:
Ras-specific guanine nucleotide-releasing factor RalGPS1
Alias:
Ral GEF with PH domain and SH3-binding motif 1;Ral guanine nucleotide exchange factor 2;RalA exchange factor RalGPS1
Type:
Mass (Da):
62133
Number AA:
557
UniProt ID:
Q5JS13
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
S
V
L
V
T
S
A
T
P
Q
G
S
S
S
S
Site 2
S21
T
S
A
T
P
Q
G
S
S
S
S
D
S
L
E
Site 3
S22
S
A
T
P
Q
G
S
S
S
S
D
S
L
E
G
Site 4
S23
A
T
P
Q
G
S
S
S
S
D
S
L
E
G
Q
Site 5
S24
T
P
Q
G
S
S
S
S
D
S
L
E
G
Q
S
Site 6
S26
Q
G
S
S
S
S
D
S
L
E
G
Q
S
C
D
Site 7
Y34
L
E
G
Q
S
C
D
Y
A
S
K
S
Y
D
A
Site 8
S36
G
Q
S
C
D
Y
A
S
K
S
Y
D
A
V
V
Site 9
S38
S
C
D
Y
A
S
K
S
Y
D
A
V
V
F
D
Site 10
S76
I
Q
P
E
E
L
A
S
C
G
W
S
K
K
E
Site 11
S80
E
L
A
S
C
G
W
S
K
K
E
K
H
S
L
Site 12
S86
W
S
K
K
E
K
H
S
L
A
P
N
V
V
A
Site 13
T159
P
I
F
R
L
T
K
T
W
A
L
L
N
R
K
Site 14
T169
L
L
N
R
K
D
K
T
T
F
E
K
L
D
Y
Site 15
T170
L
N
R
K
D
K
T
T
F
E
K
L
D
Y
L
Site 16
Y176
T
T
F
E
K
L
D
Y
L
M
S
K
E
D
N
Site 17
S179
E
K
L
D
Y
L
M
S
K
E
D
N
Y
K
R
Site 18
Y184
L
M
S
K
E
D
N
Y
K
R
T
R
E
Y
I
Site 19
Y190
N
Y
K
R
T
R
E
Y
I
R
S
L
K
M
V
Site 20
S193
R
T
R
E
Y
I
R
S
L
K
M
V
P
S
I
Site 21
S220
I
D
S
A
Y
P
A
S
G
S
I
M
E
N
E
Site 22
S222
S
A
Y
P
A
S
G
S
I
M
E
N
E
Q
R
Site 23
S248
A
D
L
Q
V
S
C
S
Y
D
H
L
T
T
L
Site 24
T253
S
C
S
Y
D
H
L
T
T
L
P
H
V
Q
K
Site 25
Y261
T
L
P
H
V
Q
K
Y
L
K
S
V
R
Y
I
Site 26
S264
H
V
Q
K
Y
L
K
S
V
R
Y
I
E
E
L
Site 27
Y280
K
F
V
E
D
D
N
Y
K
L
S
L
R
I
E
Site 28
S283
E
D
D
N
Y
K
L
S
L
R
I
E
P
G
S
Site 29
S290
S
L
R
I
E
P
G
S
S
S
P
R
L
V
S
Site 30
S291
L
R
I
E
P
G
S
S
S
P
R
L
V
S
S
Site 31
S292
R
I
E
P
G
S
S
S
P
R
L
V
S
S
K
Site 32
S297
S
S
S
P
R
L
V
S
S
K
E
D
L
A
G
Site 33
S298
S
S
P
R
L
V
S
S
K
E
D
L
A
G
P
Site 34
S309
L
A
G
P
S
A
G
S
G
S
A
R
F
S
R
Site 35
S311
G
P
S
A
G
S
G
S
A
R
F
S
R
R
P
Site 36
S315
G
S
G
S
A
R
F
S
R
R
P
T
C
P
D
Site 37
T319
A
R
F
S
R
R
P
T
C
P
D
T
S
V
A
Site 38
T323
R
R
P
T
C
P
D
T
S
V
A
G
S
L
P
Site 39
S324
R
P
T
C
P
D
T
S
V
A
G
S
L
P
T
Site 40
S328
P
D
T
S
V
A
G
S
L
P
T
P
P
V
P
Site 41
T331
S
V
A
G
S
L
P
T
P
P
V
P
R
H
R
Site 42
S340
P
V
P
R
H
R
K
S
H
S
L
G
N
N
M
Site 43
S352
N
N
M
M
C
Q
L
S
V
V
E
S
K
S
A
Site 44
S356
C
Q
L
S
V
V
E
S
K
S
A
T
F
P
S
Site 45
S358
L
S
V
V
E
S
K
S
A
T
F
P
S
E
K
Site 46
T360
V
V
E
S
K
S
A
T
F
P
S
E
K
A
R
Site 47
S373
A
R
H
L
L
D
D
S
V
L
E
S
R
S
P
Site 48
S377
L
D
D
S
V
L
E
S
R
S
P
R
R
G
L
Site 49
S379
D
S
V
L
E
S
R
S
P
R
R
G
L
A
L
Site 50
T387
P
R
R
G
L
A
L
T
S
S
S
A
V
T
N
Site 51
S388
R
R
G
L
A
L
T
S
S
S
A
V
T
N
G
Site 52
S397
S
A
V
T
N
G
L
S
L
G
S
S
E
S
S
Site 53
S400
T
N
G
L
S
L
G
S
S
E
S
S
E
F
S
Site 54
S401
N
G
L
S
L
G
S
S
E
S
S
E
F
S
E
Site 55
S403
L
S
L
G
S
S
E
S
S
E
F
S
E
E
M
Site 56
S404
S
L
G
S
S
E
S
S
E
F
S
E
E
M
S
Site 57
S407
S
S
E
S
S
E
F
S
E
E
M
S
S
G
L
Site 58
S411
S
E
F
S
E
E
M
S
S
G
L
E
S
P
T
Site 59
S412
E
F
S
E
E
M
S
S
G
L
E
S
P
T
G
Site 60
S416
E
M
S
S
G
L
E
S
P
T
G
P
C
I
C
Site 61
T442
E
G
P
L
R
R
K
T
L
L
K
E
G
R
K
Site 62
S453
E
G
R
K
P
A
L
S
S
W
T
R
Y
W
V
Site 63
S454
G
R
K
P
A
L
S
S
W
T
R
Y
W
V
I
Site 64
Y469
L
S
G
S
T
L
L
Y
Y
G
A
K
S
L
R
Site 65
Y470
S
G
S
T
L
L
Y
Y
G
A
K
S
L
R
G
Site 66
S474
L
L
Y
Y
G
A
K
S
L
R
G
T
D
R
K
Site 67
T478
G
A
K
S
L
R
G
T
D
R
K
H
Y
K
S
Site 68
Y483
R
G
T
D
R
K
H
Y
K
S
T
P
G
K
K
Site 69
S485
T
D
R
K
H
Y
K
S
T
P
G
K
K
V
S
Site 70
T486
D
R
K
H
Y
K
S
T
P
G
K
K
V
S
I
Site 71
S492
S
T
P
G
K
K
V
S
I
V
G
W
M
V
Q
Site 72
Y521
N
P
D
K
G
N
V
Y
K
F
Q
T
G
S
R
Site 73
S544
H
L
D
D
A
C
K
S
N
R
P
Q
V
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation