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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PITRM1
Full Name:
Presequence protease, mitochondrial
Alias:
Pitrilysin metalloproteinase 1
Type:
Mass (Da):
117455
Number AA:
1037
UniProt ID:
Q5JRX3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
L
C
V
L
R
R
L
S
G
G
H
A
H
H
R
Site 2
Y40
A
C
E
R
A
L
Q
Y
K
L
G
D
K
I
H
Site 3
T50
G
D
K
I
H
G
F
T
V
N
Q
V
T
S
V
Site 4
T55
G
F
T
V
N
Q
V
T
S
V
P
E
L
F
L
Site 5
S56
F
T
V
N
Q
V
T
S
V
P
E
L
F
L
T
Site 6
T72
V
K
L
T
H
D
D
T
G
A
R
Y
L
H
L
Site 7
T84
L
H
L
A
R
E
D
T
N
N
L
F
S
V
Q
Site 8
T95
F
S
V
Q
F
R
T
T
P
M
D
S
T
G
V
Site 9
T100
R
T
T
P
M
D
S
T
G
V
P
H
I
L
E
Site 10
Y117
V
L
C
G
S
Q
K
Y
P
C
R
D
P
F
F
Site 11
S132
K
M
L
N
R
S
L
S
T
F
M
N
A
F
T
Site 12
T139
S
T
F
M
N
A
F
T
A
S
D
Y
T
L
Y
Site 13
Y143
N
A
F
T
A
S
D
Y
T
L
Y
P
F
S
T
Site 14
T144
A
F
T
A
S
D
Y
T
L
Y
P
F
S
T
Q
Site 15
Y146
T
A
S
D
Y
T
L
Y
P
F
S
T
Q
N
P
Site 16
T150
Y
T
L
Y
P
F
S
T
Q
N
P
K
D
F
Q
Site 17
S190
R
L
E
H
E
N
P
S
D
P
Q
T
P
L
V
Site 18
T194
E
N
P
S
D
P
Q
T
P
L
V
F
K
G
V
Site 19
S218
T
D
N
E
R
I
F
S
Q
H
L
Q
N
R
L
Site 20
T230
N
R
L
L
P
D
H
T
Y
S
V
V
S
G
G
Site 21
Y231
R
L
L
P
D
H
T
Y
S
V
V
S
G
G
D
Site 22
S232
L
L
P
D
H
T
Y
S
V
V
S
G
G
D
P
Site 23
T267
P
S
N
A
R
F
F
T
Y
G
N
F
P
L
E
Site 24
Y268
S
N
A
R
F
F
T
Y
G
N
F
P
L
E
Q
Site 25
S286
Q
I
H
E
E
A
L
S
K
F
Q
K
I
E
P
Site 26
T295
F
Q
K
I
E
P
S
T
V
V
P
A
Q
T
P
Site 27
T301
S
T
V
V
P
A
Q
T
P
W
D
K
P
R
E
Site 28
T312
K
P
R
E
F
Q
I
T
C
G
P
D
S
F
A
Site 29
S317
Q
I
T
C
G
P
D
S
F
A
T
D
P
S
K
Site 30
S323
D
S
F
A
T
D
P
S
K
Q
T
T
V
S
V
Site 31
T327
T
D
P
S
K
Q
T
T
V
S
V
S
F
L
L
Site 32
S329
P
S
K
Q
T
T
V
S
V
S
F
L
L
P
D
Site 33
Y362
S
G
P
N
S
P
F
Y
K
A
L
I
E
S
G
Site 34
S375
S
G
L
G
T
D
F
S
P
D
V
G
Y
N
G
Site 35
Y380
D
F
S
P
D
V
G
Y
N
G
Y
T
R
E
A
Site 36
Y383
P
D
V
G
Y
N
G
Y
T
R
E
A
Y
F
S
Site 37
Y388
N
G
Y
T
R
E
A
Y
F
S
V
G
L
Q
G
Site 38
T403
I
V
E
K
D
I
E
T
V
R
S
L
I
D
R
Site 39
S406
K
D
I
E
T
V
R
S
L
I
D
R
T
I
D
Site 40
S440
E
I
Q
M
K
H
Q
S
T
S
F
G
L
M
L
Site 41
S442
Q
M
K
H
Q
S
T
S
F
G
L
M
L
T
S
Site 42
Y492
L
Q
E
K
V
K
Q
Y
F
K
N
N
Q
H
K
Site 43
T501
K
N
N
Q
H
K
L
T
L
S
M
R
P
D
D
Site 44
S503
N
Q
H
K
L
T
L
S
M
R
P
D
D
K
Y
Site 45
Y510
S
M
R
P
D
D
K
Y
H
E
K
Q
A
Q
V
Site 46
S530
K
Q
K
V
E
A
L
S
P
G
D
R
Q
Q
I
Site 47
Y538
P
G
D
R
Q
Q
I
Y
E
K
G
L
E
L
R
Site 48
S546
E
K
G
L
E
L
R
S
Q
Q
S
K
P
Q
D
Site 49
S555
Q
S
K
P
Q
D
A
S
C
L
P
A
L
K
V
Site 50
Y587
A
G
D
I
P
V
Q
Y
C
A
Q
P
T
N
G
Site 51
Y597
Q
P
T
N
G
M
V
Y
F
R
A
F
S
S
L
Site 52
S603
V
Y
F
R
A
F
S
S
L
N
T
L
P
E
E
Site 53
T606
R
A
F
S
S
L
N
T
L
P
E
E
L
R
P
Site 54
Y632
L
G
C
G
L
L
D
Y
R
E
Q
A
Q
Q
I
Site 55
T643
A
Q
Q
I
E
L
K
T
G
G
M
S
A
S
P
Site 56
S649
K
T
G
G
M
S
A
S
P
H
V
L
P
D
D
Site 57
S657
P
H
V
L
P
D
D
S
H
M
D
T
Y
E
Q
Site 58
T661
P
D
D
S
H
M
D
T
Y
E
Q
G
V
L
F
Site 59
Y662
D
D
S
H
M
D
T
Y
E
Q
G
V
L
F
S
Site 60
S717
L
A
N
G
I
P
D
S
G
H
L
Y
A
S
I
Site 61
Y721
I
P
D
S
G
H
L
Y
A
S
I
R
A
G
R
Site 62
S723
D
S
G
H
L
Y
A
S
I
R
A
G
R
T
L
Site 63
T731
I
R
A
G
R
T
L
T
P
A
G
D
L
Q
E
Site 64
T739
P
A
G
D
L
Q
E
T
F
S
G
M
D
Q
V
Site 65
S741
G
D
L
Q
E
T
F
S
G
M
D
Q
V
R
L
Site 66
T756
M
K
R
I
A
E
M
T
D
I
K
P
I
L
R
Site 67
T785
M
R
C
S
V
N
A
T
P
Q
Q
M
P
Q
T
Site 68
S802
A
V
E
D
F
L
R
S
I
G
R
S
K
K
E
Site 69
S806
F
L
R
S
I
G
R
S
K
K
E
R
R
P
V
Site 70
T817
R
R
P
V
R
P
H
T
V
E
K
P
V
P
S
Site 71
S824
T
V
E
K
P
V
P
S
S
S
G
G
D
A
H
Site 72
S825
V
E
K
P
V
P
S
S
S
G
G
D
A
H
V
Site 73
S826
E
K
P
V
P
S
S
S
G
G
D
A
H
V
P
Site 74
S836
D
A
H
V
P
H
G
S
Q
V
I
R
K
L
V
Site 75
T847
R
K
L
V
M
E
P
T
F
K
P
W
Q
M
K
Site 76
T872
Y
V
G
E
C
I
R
T
V
P
Y
T
D
P
D
Site 77
Y875
E
C
I
R
T
V
P
Y
T
D
P
D
H
A
S
Site 78
T876
C
I
R
T
V
P
Y
T
D
P
D
H
A
S
L
Site 79
S882
Y
T
D
P
D
H
A
S
L
K
I
L
A
R
L
Site 80
Y921
H
N
G
I
F
T
L
Y
S
Y
R
D
P
N
T
Site 81
Y923
G
I
F
T
L
Y
S
Y
R
D
P
N
T
I
E
Site 82
T928
Y
S
Y
R
D
P
N
T
I
E
T
L
Q
S
F
Site 83
S934
N
T
I
E
T
L
Q
S
F
G
K
A
V
D
W
Site 84
S944
K
A
V
D
W
A
K
S
G
K
F
T
Q
Q
D
Site 85
Y979
K
G
M
D
H
F
L
Y
G
L
S
D
E
M
K
Site 86
S1005
H
D
K
L
L
A
V
S
D
R
Y
L
G
T
G
Site 87
Y1008
L
L
A
V
S
D
R
Y
L
G
T
G
K
S
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation