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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA0774
Full Name:
Microtubule-associated tumor suppressor candidate 2
Alias:
+TIP of 150 kDa; Cardiac zipper protein; CAZIP; K0774; Microtubule associated tumor suppressor candidate 2; Microtubule plus-end tracking protein TIP150; TIP150
Type:
Mass (Da):
150195
Number AA:
1369
UniProt ID:
Q5JR59
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0008017
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
V
P
V
A
P
K
K
Site 2
S10
V
P
V
A
P
K
K
S
C
Y
T
Q
L
R
D
Site 3
S28
A
A
R
N
N
N
E
S
I
L
S
L
G
D
T
Site 4
S31
N
N
N
E
S
I
L
S
L
G
D
T
N
A
N
Site 5
S46
Q
I
M
L
E
V
S
S
S
H
D
E
S
K
T
Site 6
S47
I
M
L
E
V
S
S
S
H
D
E
S
K
T
C
Site 7
S51
V
S
S
S
H
D
E
S
K
T
C
D
L
G
D
Site 8
T53
S
S
H
D
E
S
K
T
C
D
L
G
D
E
I
Site 9
T63
L
G
D
E
I
G
N
T
N
S
S
E
P
E
N
Site 10
S65
D
E
I
G
N
T
N
S
S
E
P
E
N
R
T
Site 11
S66
E
I
G
N
T
N
S
S
E
P
E
N
R
T
H
Site 12
S88
L
Q
G
F
G
K
G
S
Q
A
G
S
A
S
L
Site 13
S92
G
K
G
S
Q
A
G
S
A
S
L
K
D
F
R
Site 14
S94
G
S
Q
A
G
S
A
S
L
K
D
F
R
L
S
Site 15
S101
S
L
K
D
F
R
L
S
S
T
I
Q
R
E
L
Site 16
S102
L
K
D
F
R
L
S
S
T
I
Q
R
E
L
N
Site 17
T103
K
D
F
R
L
S
S
T
I
Q
R
E
L
N
E
Site 18
T113
R
E
L
N
E
E
H
T
V
E
R
G
T
D
S
Site 19
T118
E
H
T
V
E
R
G
T
D
S
L
Q
T
T
R
Site 20
S120
T
V
E
R
G
T
D
S
L
Q
T
T
R
S
I
Site 21
T123
R
G
T
D
S
L
Q
T
T
R
S
I
Q
G
P
Site 22
T124
G
T
D
S
L
Q
T
T
R
S
I
Q
G
P
S
Site 23
S126
D
S
L
Q
T
T
R
S
I
Q
G
P
S
L
S
Site 24
S131
T
R
S
I
Q
G
P
S
L
S
S
W
R
N
V
Site 25
S133
S
I
Q
G
P
S
L
S
S
W
R
N
V
M
S
Site 26
S134
I
Q
G
P
S
L
S
S
W
R
N
V
M
S
E
Site 27
S140
S
S
W
R
N
V
M
S
E
A
S
L
D
V
L
Site 28
S143
R
N
V
M
S
E
A
S
L
D
V
L
A
K
R
Site 29
T166
P
K
D
K
L
A
K
T
L
D
N
E
E
L
R
Site 30
S176
N
E
E
L
R
R
H
S
L
E
R
A
S
S
S
Site 31
S181
R
H
S
L
E
R
A
S
S
S
V
A
A
V
G
Site 32
S182
H
S
L
E
R
A
S
S
S
V
A
A
V
G
S
Site 33
S189
S
S
V
A
A
V
G
S
L
T
P
Q
H
P
Q
Site 34
S199
P
Q
H
P
Q
P
L
S
L
D
S
R
E
A
R
Site 35
T219
G
G
E
G
P
Q
K
T
L
P
D
H
A
V
P
Site 36
T232
V
P
A
A
F
P
A
T
D
S
T
S
E
G
K
Site 37
S234
A
A
F
P
A
T
D
S
T
S
E
G
K
S
V
Site 38
T235
A
F
P
A
T
D
S
T
S
E
G
K
S
V
R
Site 39
S236
F
P
A
T
D
S
T
S
E
G
K
S
V
R
H
Site 40
S240
D
S
T
S
E
G
K
S
V
R
H
P
K
P
S
Site 41
S247
S
V
R
H
P
K
P
S
T
S
E
S
K
Q
S
Site 42
T248
V
R
H
P
K
P
S
T
S
E
S
K
Q
S
T
Site 43
S249
R
H
P
K
P
S
T
S
E
S
K
Q
S
T
P
Site 44
S251
P
K
P
S
T
S
E
S
K
Q
S
T
P
S
E
Site 45
S254
S
T
S
E
S
K
Q
S
T
P
S
E
T
Q
T
Site 46
T255
T
S
E
S
K
Q
S
T
P
S
E
T
Q
T
V
Site 47
T261
S
T
P
S
E
T
Q
T
V
G
A
H
V
L
Q
Site 48
S275
Q
V
C
S
E
H
T
S
H
S
A
H
P
E
P
Site 49
S277
C
S
E
H
T
S
H
S
A
H
P
E
P
A
L
Site 50
T287
P
E
P
A
L
N
L
T
L
A
S
K
E
I
P
Site 51
Y314
E
A
K
L
D
L
K
Y
V
P
P
R
R
V
E
Site 52
S391
V
N
P
G
E
Q
D
S
L
H
T
T
P
K
Q
Site 53
T395
E
Q
D
S
L
H
T
T
P
K
Q
G
S
A
S
Site 54
S400
H
T
T
P
K
Q
G
S
A
S
L
G
G
A
D
Site 55
S402
T
P
K
Q
G
S
A
S
L
G
G
A
D
N
Q
Site 56
T411
G
G
A
D
N
Q
P
T
G
K
I
S
P
C
A
Site 57
S415
N
Q
P
T
G
K
I
S
P
C
A
G
E
K
L
Site 58
T426
G
E
K
L
G
E
R
T
S
S
S
F
S
P
G
Site 59
S427
E
K
L
G
E
R
T
S
S
S
F
S
P
G
D
Site 60
S428
K
L
G
E
R
T
S
S
S
F
S
P
G
D
S
Site 61
S429
L
G
E
R
T
S
S
S
F
S
P
G
D
S
H
Site 62
S431
E
R
T
S
S
S
F
S
P
G
D
S
H
V
A
Site 63
S435
S
S
F
S
P
G
D
S
H
V
A
F
I
P
N
Site 64
T445
A
F
I
P
N
N
L
T
D
S
K
P
L
D
V
Site 65
S447
I
P
N
N
L
T
D
S
K
P
L
D
V
I
E
Site 66
S461
E
E
E
R
R
L
G
S
G
N
K
D
S
V
M
Site 67
S466
L
G
S
G
N
K
D
S
V
M
V
L
V
F
N
Site 68
S475
M
V
L
V
F
N
P
S
V
G
E
N
K
T
E
Site 69
T481
P
S
V
G
E
N
K
T
E
V
P
E
P
L
D
Site 70
S491
P
E
P
L
D
P
Q
S
G
R
S
E
A
R
E
Site 71
S494
L
D
P
Q
S
G
R
S
E
A
R
E
S
K
E
Site 72
S499
G
R
S
E
A
R
E
S
K
E
V
T
T
S
V
Site 73
T503
A
R
E
S
K
E
V
T
T
S
V
A
E
N
R
Site 74
S505
E
S
K
E
V
T
T
S
V
A
E
N
R
N
L
Site 75
S523
A
D
K
I
E
S
T
S
A
R
A
D
S
V
L
Site 76
S528
S
T
S
A
R
A
D
S
V
L
N
I
P
A
P
Site 77
T540
P
A
P
L
H
P
E
T
T
V
N
M
T
Y
Q
Site 78
T545
P
E
T
T
V
N
M
T
Y
Q
P
T
T
P
S
Site 79
Y546
E
T
T
V
N
M
T
Y
Q
P
T
T
P
S
S
Site 80
T549
V
N
M
T
Y
Q
P
T
T
P
S
S
S
F
Q
Site 81
T550
N
M
T
Y
Q
P
T
T
P
S
S
S
F
Q
D
Site 82
S553
Y
Q
P
T
T
P
S
S
S
F
Q
D
V
S
V
Site 83
S554
Q
P
T
T
P
S
S
S
F
Q
D
V
S
V
F
Site 84
S559
S
S
S
F
Q
D
V
S
V
F
G
M
D
A
G
Site 85
S577
V
V
P
P
P
T
D
S
A
R
L
L
N
T
S
Site 86
S584
S
A
R
L
L
N
T
S
P
K
V
P
D
K
N
Site 87
T592
P
K
V
P
D
K
N
T
C
P
S
G
I
P
K
Site 88
S595
P
D
K
N
T
C
P
S
G
I
P
K
P
V
F
Site 89
T603
G
I
P
K
P
V
F
T
H
S
K
D
T
P
S
Site 90
S605
P
K
P
V
F
T
H
S
K
D
T
P
S
S
Q
Site 91
T608
V
F
T
H
S
K
D
T
P
S
S
Q
E
G
M
Site 92
S610
T
H
S
K
D
T
P
S
S
Q
E
G
M
E
N
Site 93
S611
H
S
K
D
T
P
S
S
Q
E
G
M
E
N
Y
Site 94
Y618
S
Q
E
G
M
E
N
Y
Q
V
E
K
T
E
E
Site 95
T623
E
N
Y
Q
V
E
K
T
E
E
R
T
E
T
K
Site 96
T629
K
T
E
E
R
T
E
T
K
P
I
I
M
P
K
Site 97
T646
H
V
R
P
K
I
I
T
Y
I
R
R
N
P
Q
Site 98
Y647
V
R
P
K
I
I
T
Y
I
R
R
N
P
Q
A
Site 99
T673
G
L
P
Y
A
P
P
T
C
T
M
P
L
P
H
Site 100
S692
A
G
G
D
L
K
P
S
A
N
L
Y
E
K
F
Site 101
Y696
L
K
P
S
A
N
L
Y
E
K
F
K
P
D
L
Site 102
S726
K
P
P
G
H
P
F
S
Q
M
S
E
K
F
L
Site 103
S729
G
H
P
F
S
Q
M
S
E
K
F
L
Q
E
V
Site 104
T737
E
K
F
L
Q
E
V
T
D
H
P
G
K
E
E
Site 105
S747
P
G
K
E
E
F
C
S
P
P
Y
A
H
Y
E
Site 106
Y750
E
E
F
C
S
P
P
Y
A
H
Y
E
V
P
P
Site 107
Y753
C
S
P
P
Y
A
H
Y
E
V
P
P
T
F
Y
Site 108
T758
A
H
Y
E
V
P
P
T
F
Y
R
S
A
M
L
Site 109
S776
Q
L
G
L
G
A
M
S
R
L
P
S
A
K
S
Site 110
S780
G
A
M
S
R
L
P
S
A
K
S
R
I
L
I
Site 111
S783
S
R
L
P
S
A
K
S
R
I
L
I
A
S
Q
Site 112
S789
K
S
R
I
L
I
A
S
Q
R
S
S
A
S
A
Site 113
S793
L
I
A
S
Q
R
S
S
A
S
A
I
H
P
P
Site 114
S795
A
S
Q
R
S
S
A
S
A
I
H
P
P
G
P
Site 115
T804
I
H
P
P
G
P
I
T
T
A
T
S
L
Y
S
Site 116
T807
P
G
P
I
T
T
A
T
S
L
Y
S
S
D
P
Site 117
S808
G
P
I
T
T
A
T
S
L
Y
S
S
D
P
S
Site 118
S812
T
A
T
S
L
Y
S
S
D
P
S
A
D
L
K
Site 119
S815
S
L
Y
S
S
D
P
S
A
D
L
K
K
A
S
Site 120
S823
A
D
L
K
K
A
S
S
S
N
A
A
K
S
N
Site 121
S824
D
L
K
K
A
S
S
S
N
A
A
K
S
N
L
Site 122
S829
S
S
S
N
A
A
K
S
N
L
P
K
S
G
L
Site 123
S834
A
K
S
N
L
P
K
S
G
L
R
P
P
G
Y
Site 124
Y841
S
G
L
R
P
P
G
Y
S
R
L
P
A
A
K
Site 125
S842
G
L
R
P
P
G
Y
S
R
L
P
A
A
K
L
Site 126
S861
F
V
R
S
S
S
V
S
S
V
S
S
T
Q
S
Site 127
S862
V
R
S
S
S
V
S
S
V
S
S
T
Q
S
G
Site 128
S864
S
S
S
V
S
S
V
S
S
T
Q
S
G
D
S
Site 129
S865
S
S
V
S
S
V
S
S
T
Q
S
G
D
S
A
Site 130
T866
S
V
S
S
V
S
S
T
Q
S
G
D
S
A
Q
Site 131
S868
S
S
V
S
S
T
Q
S
G
D
S
A
Q
P
E
Site 132
S871
S
S
T
Q
S
G
D
S
A
Q
P
E
Q
G
R
Site 133
T881
P
E
Q
G
R
P
A
T
R
S
T
F
G
N
E
Site 134
S883
Q
G
R
P
A
T
R
S
T
F
G
N
E
E
Q
Site 135
T884
G
R
P
A
T
R
S
T
F
G
N
E
E
Q
P
Site 136
S896
E
Q
P
V
L
K
A
S
L
P
S
K
D
T
P
Site 137
T902
A
S
L
P
S
K
D
T
P
K
G
A
G
R
V
Site 138
S914
G
R
V
A
P
P
A
S
S
S
V
T
A
P
R
Site 139
S916
V
A
P
P
A
S
S
S
V
T
A
P
R
R
S
Site 140
T918
P
P
A
S
S
S
V
T
A
P
R
R
S
L
L
Site 141
S923
S
V
T
A
P
R
R
S
L
L
P
A
P
K
S
Site 142
S930
S
L
L
P
A
P
K
S
T
S
T
P
A
G
T
Site 143
S932
L
P
A
P
K
S
T
S
T
P
A
G
T
K
K
Site 144
T933
P
A
P
K
S
T
S
T
P
A
G
T
K
K
D
Site 145
T937
S
T
S
T
P
A
G
T
K
K
D
A
Q
K
D
Site 146
T947
D
A
Q
K
D
Q
D
T
N
K
P
A
V
S
S
Site 147
S953
T
N
K
P
A
V
S
S
P
K
R
V
A
A
S
Site 148
S954
T
N
K
P
A
V
S
S
P
K
R
V
A
A
S
Site 149
S961
S
P
K
R
V
A
A
S
T
T
K
L
H
S
P
Site 150
T962
P
K
R
V
A
A
S
T
T
K
L
H
S
P
G
Site 151
T963
K
R
V
A
A
S
T
T
K
L
H
S
P
G
Y
Site 152
S967
A
S
T
T
K
L
H
S
P
G
Y
P
K
Q
R
Site 153
Y970
T
K
L
H
S
P
G
Y
P
K
Q
R
T
A
A
Site 154
T975
P
G
Y
P
K
Q
R
T
A
A
A
R
N
G
F
Site 155
S1051
L
V
K
E
K
E
L
S
I
E
L
A
N
I
R
Site 156
S1125
E
H
G
D
Q
L
L
S
I
R
C
Q
H
Q
E
Site 157
T1138
Q
E
Q
V
E
D
L
T
A
S
H
D
A
A
L
Site 158
T1173
K
V
Q
E
L
M
S
T
H
E
L
E
K
K
E
Site 159
S1191
N
F
E
K
L
R
L
S
L
Q
D
Q
V
D
T
Site 160
T1198
S
L
Q
D
Q
V
D
T
L
T
F
Q
S
Q
S
Site 161
T1200
Q
D
Q
V
D
T
L
T
F
Q
S
Q
S
L
R
Site 162
S1203
V
D
T
L
T
F
Q
S
Q
S
L
R
D
R
A
Site 163
S1205
T
L
T
F
Q
S
Q
S
L
R
D
R
A
R
R
Site 164
T1221
E
E
A
L
R
K
N
T
E
E
Q
L
E
I
A
Site 165
S1241
H
L
E
E
D
M
K
S
L
K
Q
V
L
E
M
Site 166
T1295
K
A
R
I
D
Q
N
T
V
V
T
R
Q
L
S
Site 167
S1302
T
V
V
T
R
Q
L
S
E
E
N
A
N
L
Q
Site 168
Y1311
E
N
A
N
L
Q
E
Y
V
E
K
E
T
Q
E
Site 169
S1323
T
Q
E
K
K
R
L
S
R
T
N
E
E
L
L
Site 170
T1325
E
K
K
R
L
S
R
T
N
E
E
L
L
W
K
Site 171
T1335
E
L
L
W
K
L
Q
T
G
D
P
T
S
P
I
Site 172
T1339
K
L
Q
T
G
D
P
T
S
P
I
K
L
S
P
Site 173
S1340
L
Q
T
G
D
P
T
S
P
I
K
L
S
P
T
Site 174
S1345
P
T
S
P
I
K
L
S
P
T
S
P
V
Y
R
Site 175
T1347
S
P
I
K
L
S
P
T
S
P
V
Y
R
G
S
Site 176
S1348
P
I
K
L
S
P
T
S
P
V
Y
R
G
S
S
Site 177
Y1351
L
S
P
T
S
P
V
Y
R
G
S
S
S
G
P
Site 178
S1354
T
S
P
V
Y
R
G
S
S
S
G
P
S
S
P
Site 179
S1355
S
P
V
Y
R
G
S
S
S
G
P
S
S
P
A
Site 180
S1356
P
V
Y
R
G
S
S
S
G
P
S
S
P
A
R
Site 181
S1359
R
G
S
S
S
G
P
S
S
P
A
R
V
S
T
Site 182
S1360
G
S
S
S
G
P
S
S
P
A
R
V
S
T
T
Site 183
S1365
P
S
S
P
A
R
V
S
T
T
P
R
_
_
_
Site 184
T1366
S
S
P
A
R
V
S
T
T
P
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation