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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOMO2
Full Name:
Nodal modulator 2
Alias:
NODAL modulator 2; NOMO; PM5; PM5 protein 2; PM5 protein, centromeric copy
Type:
Cell surface
Mass (Da):
139439
Number AA:
1267
UniProt ID:
Q5JPE7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0030246
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
G
C
G
G
F
V
K
S
D
V
E
I
N
Y
S
Site 2
Y59
S
L
I
E
I
K
L
Y
T
K
H
G
T
L
K
Site 3
Y67
T
K
H
G
T
L
K
Y
Q
T
D
C
A
P
N
Site 4
Y77
D
C
A
P
N
N
G
Y
F
M
I
P
L
Y
D
Site 5
S99
I
E
P
P
L
G
W
S
F
E
P
T
T
V
E
Site 6
T103
L
G
W
S
F
E
P
T
T
V
E
L
H
V
D
Site 7
T104
G
W
S
F
E
P
T
T
V
E
L
H
V
D
G
Site 8
S113
E
L
H
V
D
G
V
S
D
I
C
T
K
G
G
Site 9
T117
D
G
V
S
D
I
C
T
K
G
G
D
I
N
F
Site 10
S137
S
V
N
G
K
V
L
S
K
G
Q
P
L
G
P
Site 11
S150
G
P
A
G
V
Q
V
S
L
R
N
T
G
T
E
Site 12
T154
V
Q
V
S
L
R
N
T
G
T
E
A
K
I
Q
Site 13
T156
V
S
L
R
N
T
G
T
E
A
K
I
Q
S
T
Site 14
S162
G
T
E
A
K
I
Q
S
T
V
T
Q
P
G
G
Site 15
T163
T
E
A
K
I
Q
S
T
V
T
Q
P
G
G
K
Site 16
T186
G
D
Y
E
I
L
A
T
H
P
T
W
A
L
K
Site 17
T197
W
A
L
K
E
A
S
T
T
V
R
V
T
N
S
Site 18
T198
A
L
K
E
A
S
T
T
V
R
V
T
N
S
N
Site 19
T202
A
S
T
T
V
R
V
T
N
S
N
A
N
A
A
Site 20
S220
I
V
A
G
Y
N
V
S
G
S
V
R
S
D
G
Site 21
S222
A
G
Y
N
V
S
G
S
V
R
S
D
G
E
P
Site 22
Y267
P
Q
D
E
S
L
V
Y
L
C
Y
T
V
S
R
Site 23
Y270
E
S
L
V
Y
L
C
Y
T
V
S
R
E
D
G
Site 24
T271
S
L
V
Y
L
C
Y
T
V
S
R
E
D
G
S
Site 25
S273
V
Y
L
C
Y
T
V
S
R
E
D
G
S
F
S
Site 26
S278
T
V
S
R
E
D
G
S
F
S
F
Y
S
L
P
Site 27
S280
S
R
E
D
G
S
F
S
F
Y
S
L
P
S
G
Site 28
Y282
E
D
G
S
F
S
F
Y
S
L
P
S
G
G
Y
Site 29
S283
D
G
S
F
S
F
Y
S
L
P
S
G
G
Y
T
Site 30
T290
S
L
P
S
G
G
Y
T
V
I
P
F
Y
R
G
Site 31
Y295
G
Y
T
V
I
P
F
Y
R
G
E
R
I
T
F
Site 32
T301
F
Y
R
G
E
R
I
T
F
D
V
A
P
S
R
Site 33
T312
A
P
S
R
L
D
F
T
V
E
H
D
S
L
K
Site 34
S317
D
F
T
V
E
H
D
S
L
K
I
E
P
V
F
Site 35
T359
N
N
Q
I
K
V
K
T
K
A
D
G
S
F
R
Site 36
S364
V
K
T
K
A
D
G
S
F
R
L
E
N
I
T
Site 37
T371
S
F
R
L
E
N
I
T
T
G
T
Y
T
I
H
Site 38
T372
F
R
L
E
N
I
T
T
G
T
Y
T
I
H
A
Site 39
Y385
H
A
Q
K
E
H
L
Y
F
E
T
V
T
I
K
Site 40
T388
K
E
H
L
Y
F
E
T
V
T
I
K
I
A
P
Site 41
T422
S
I
I
R
F
P
D
T
V
K
Q
M
N
K
Y
Site 42
Y429
T
V
K
Q
M
N
K
Y
K
V
V
L
S
S
Q
Site 43
S434
N
K
Y
K
V
V
L
S
S
Q
D
K
D
K
S
Site 44
S435
K
Y
K
V
V
L
S
S
Q
D
K
D
K
S
L
Site 45
S441
S
S
Q
D
K
D
K
S
L
V
T
V
E
T
D
Site 46
T444
D
K
D
K
S
L
V
T
V
E
T
D
A
H
G
Site 47
T447
K
S
L
V
T
V
E
T
D
A
H
G
S
F
C
Site 48
S452
V
E
T
D
A
H
G
S
F
C
F
K
A
K
P
Site 49
T478
A
E
T
R
A
G
L
T
L
K
P
Q
T
F
P
Site 50
T487
K
P
Q
T
F
P
L
T
V
T
D
R
P
V
M
Site 51
T489
Q
T
F
P
L
T
V
T
D
R
P
V
M
D
V
Site 52
S524
D
L
L
V
T
L
Q
S
L
S
R
Q
G
E
K
Site 53
S526
L
V
T
L
Q
S
L
S
R
Q
G
E
K
R
S
Site 54
S533
S
R
Q
G
E
K
R
S
L
Q
L
S
G
K
V
Site 55
S537
E
K
R
S
L
Q
L
S
G
K
V
N
A
M
T
Site 56
Y555
D
N
V
L
P
G
K
Y
K
I
S
I
M
H
E
Site 57
S581
E
V
L
E
D
D
V
S
A
V
E
F
R
Q
T
Site 58
T588
S
A
V
E
F
R
Q
T
G
Y
M
L
R
C
S
Site 59
Y590
V
E
F
R
Q
T
G
Y
M
L
R
C
S
L
S
Site 60
T601
C
S
L
S
H
A
I
T
L
E
F
Y
Q
D
G
Site 61
Y605
H
A
I
T
L
E
F
Y
Q
D
G
N
G
R
E
Site 62
Y617
G
R
E
N
V
G
I
Y
N
L
S
K
G
V
N
Site 63
T637
K
P
G
V
Y
K
V
T
P
R
S
C
H
R
F
Site 64
Y649
H
R
F
E
Q
A
F
Y
T
Y
D
T
S
S
P
Site 65
T650
R
F
E
Q
A
F
Y
T
Y
D
T
S
S
P
S
Site 66
Y651
F
E
Q
A
F
Y
T
Y
D
T
S
S
P
S
I
Site 67
T653
Q
A
F
Y
T
Y
D
T
S
S
P
S
I
L
T
Site 68
S655
F
Y
T
Y
D
T
S
S
P
S
I
L
T
L
T
Site 69
T660
T
S
S
P
S
I
L
T
L
T
A
I
R
H
H
Site 70
T683
K
M
M
D
V
T
V
T
I
K
S
S
I
D
S
Site 71
S686
D
V
T
V
T
I
K
S
S
I
D
S
E
P
A
Site 72
S701
L
V
L
G
P
L
K
S
V
Q
E
L
R
R
E
Site 73
T734
E
E
G
E
E
R
M
T
K
P
P
V
Q
E
M
Site 74
S750
D
E
L
Q
G
P
F
S
Y
D
F
S
Y
W
A
Site 75
S754
G
P
F
S
Y
D
F
S
Y
W
A
R
S
G
E
Site 76
Y755
P
F
S
Y
D
F
S
Y
W
A
R
S
G
E
K
Site 77
S759
D
F
S
Y
W
A
R
S
G
E
K
I
T
V
T
Site 78
T764
A
R
S
G
E
K
I
T
V
T
P
S
S
K
E
Site 79
T766
S
G
E
K
I
T
V
T
P
S
S
K
E
L
L
Site 80
S768
E
K
I
T
V
T
P
S
S
K
E
L
L
F
Y
Site 81
S769
K
I
T
V
T
P
S
S
K
E
L
L
F
Y
P
Site 82
Y775
S
S
K
E
L
L
F
Y
P
P
S
M
E
A
V
Site 83
S784
P
S
M
E
A
V
V
S
G
E
S
C
P
G
K
Site 84
S819
E
G
V
E
I
V
I
S
E
K
G
A
S
S
P
Site 85
T829
G
A
S
S
P
L
I
T
V
F
T
D
D
K
G
Site 86
T832
S
P
L
I
T
V
F
T
D
D
K
G
A
Y
S
Site 87
S839
T
D
D
K
G
A
Y
S
V
G
P
L
H
S
D
Site 88
Y849
P
L
H
S
D
L
E
Y
T
V
T
S
Q
K
E
Site 89
T850
L
H
S
D
L
E
Y
T
V
T
S
Q
K
E
G
Site 90
T852
S
D
L
E
Y
T
V
T
S
Q
K
E
G
Y
V
Site 91
Y858
V
T
S
Q
K
E
G
Y
V
L
T
A
V
E
G
Site 92
S904
L
S
G
G
L
F
R
S
N
L
L
T
Q
D
N
Site 93
T915
T
Q
D
N
G
I
L
T
F
S
N
L
S
P
G
Site 94
S917
D
N
G
I
L
T
F
S
N
L
S
P
G
Q
Y
Site 95
S920
I
L
T
F
S
N
L
S
P
G
Q
Y
Y
F
K
Site 96
Y924
S
N
L
S
P
G
Q
Y
Y
F
K
P
M
M
K
Site 97
Y925
N
L
S
P
G
Q
Y
Y
F
K
P
M
M
K
E
Site 98
S939
E
F
R
F
E
P
S
S
Q
M
I
E
V
Q
E
Site 99
T955
Q
N
L
K
I
T
I
T
G
Y
R
T
A
Y
S
Site 100
Y961
I
T
G
Y
R
T
A
Y
S
C
Y
G
T
V
S
Site 101
S962
T
G
Y
R
T
A
Y
S
C
Y
G
T
V
S
S
Site 102
Y964
Y
R
T
A
Y
S
C
Y
G
T
V
S
S
L
N
Site 103
T966
T
A
Y
S
C
Y
G
T
V
S
S
L
N
G
E
Site 104
S969
S
C
Y
G
T
V
S
S
L
N
G
E
P
E
Q
Site 105
Y991
G
Q
N
D
C
S
I
Y
G
E
D
T
V
T
D
Site 106
T995
C
S
I
Y
G
E
D
T
V
T
D
E
E
G
K
Site 107
T997
I
Y
G
E
D
T
V
T
D
E
E
G
K
F
R
Site 108
S1060
Q
I
N
Q
F
D
L
S
G
N
V
I
T
S
S
Site 109
S1067
S
G
N
V
I
T
S
S
E
Y
L
P
T
L
W
Site 110
T1072
T
S
S
E
Y
L
P
T
L
W
V
K
L
Y
K
Site 111
Y1078
P
T
L
W
V
K
L
Y
K
S
E
N
L
D
N
Site 112
T1089
N
L
D
N
P
I
Q
T
V
S
L
G
Q
S
L
Site 113
S1116
N
Y
V
V
L
L
D
S
T
L
P
R
S
Q
Y
Site 114
T1117
Y
V
V
L
L
D
S
T
L
P
R
S
Q
Y
D
Site 115
S1121
L
D
S
T
L
P
R
S
Q
Y
D
Y
I
L
P
Site 116
Y1123
S
T
L
P
R
S
Q
Y
D
Y
I
L
P
Q
V
Site 117
Y1125
L
P
R
S
Q
Y
D
Y
I
L
P
Q
V
S
F
Site 118
Y1137
V
S
F
T
A
V
G
Y
H
K
H
I
T
L
I
Site 119
S1202
G
A
L
G
Q
A
A
S
D
N
S
G
P
E
D
Site 120
S1205
G
Q
A
A
S
D
N
S
G
P
E
D
A
K
R
Site 121
T1219
R
Q
A
K
K
Q
K
T
R
R
T
L
R
L
Q
Site 122
T1222
K
K
Q
K
T
R
R
T
L
R
L
Q
E
E
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation