KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZC3H12B
Full Name:
Probable ribonuclease ZC3H12B
Alias:
MCP-induced protein 2;Zinc finger CCCH domain-containing protein 12B
Type:
Mass (Da):
87384
Number AA:
772
UniProt ID:
Q5HYM0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
K
S
A
S
K
E
E
K
Q
Q
P
Site 2
S25
T
E
Q
G
N
A
D
S
E
E
W
M
S
S
E
Site 3
S30
A
D
S
E
E
W
M
S
S
E
S
D
P
E
Q
Site 4
S31
D
S
E
E
W
M
S
S
E
S
D
P
E
Q
I
Site 5
S33
E
E
W
M
S
S
E
S
D
P
E
Q
I
S
L
Site 6
S39
E
S
D
P
E
Q
I
S
L
K
S
S
D
N
S
Site 7
S42
P
E
Q
I
S
L
K
S
S
D
N
S
K
S
C
Site 8
S43
E
Q
I
S
L
K
S
S
D
N
S
K
S
C
Q
Site 9
S46
S
L
K
S
S
D
N
S
K
S
C
Q
P
R
D
Site 10
S48
K
S
S
D
N
S
K
S
C
Q
P
R
D
G
Q
Site 11
S63
L
K
K
K
E
M
H
S
K
P
H
R
Q
L
C
Site 12
S72
P
H
R
Q
L
C
R
S
P
C
L
D
R
P
S
Site 13
S79
S
P
C
L
D
R
P
S
F
S
Q
N
H
L
L
Site 14
Y89
Q
N
H
L
L
M
M
Y
W
Q
S
L
S
D
L
Site 15
T98
Q
S
L
S
D
L
G
T
K
V
I
Q
K
G
S
Site 16
S105
T
K
V
I
Q
K
G
S
S
R
E
I
A
S
P
Site 17
S111
G
S
S
R
E
I
A
S
P
E
L
S
L
E
D
Site 18
S115
E
I
A
S
P
E
L
S
L
E
D
E
I
D
N
Site 19
S123
L
E
D
E
I
D
N
S
D
N
L
R
P
V
V
Site 20
S134
R
P
V
V
I
D
G
S
N
V
A
M
S
H
G
Site 21
S139
D
G
S
N
V
A
M
S
H
G
N
K
E
E
F
Site 22
S147
H
G
N
K
E
E
F
S
C
R
G
I
Q
L
A
Site 23
T167
D
K
G
H
K
D
I
T
V
F
V
P
A
W
R
Site 24
T185
S
R
P
D
A
P
I
T
D
Q
D
I
L
R
K
Site 25
T202
K
E
K
I
L
V
F
T
P
S
R
R
V
Q
G
Site 26
S204
K
I
L
V
F
T
P
S
R
R
V
Q
G
R
R
Site 27
Y215
Q
G
R
R
V
V
C
Y
D
D
R
F
I
V
K
Site 28
S233
D
S
D
G
I
I
V
S
N
D
N
Y
R
D
L
Site 29
Y237
I
I
V
S
N
D
N
Y
R
D
L
Q
V
E
K
Site 30
S259
E
E
R
L
L
M
Y
S
F
V
N
D
K
F
M
Site 31
S278
P
L
G
R
H
G
P
S
L
E
N
F
L
R
K
Site 32
Y305
P
Y
G
K
K
C
T
Y
G
H
K
C
K
Y
Y
Site 33
Y311
T
Y
G
H
K
C
K
Y
Y
H
P
E
R
A
N
Site 34
Y312
Y
G
H
K
C
K
Y
Y
H
P
E
R
A
N
Q
Site 35
S323
R
A
N
Q
P
Q
R
S
V
A
D
E
L
R
I
Site 36
S335
L
R
I
S
A
K
L
S
T
V
K
T
M
S
E
Site 37
T336
R
I
S
A
K
L
S
T
V
K
T
M
S
E
G
Site 38
T339
A
K
L
S
T
V
K
T
M
S
E
G
T
L
A
Site 39
T350
G
T
L
A
K
C
G
T
G
M
S
S
A
K
G
Site 40
S361
S
A
K
G
E
I
T
S
E
V
K
R
V
A
P
Site 41
S372
R
V
A
P
K
R
Q
S
D
P
S
I
R
S
V
Site 42
S375
P
K
R
Q
S
D
P
S
I
R
S
V
A
M
E
Site 43
S378
Q
S
D
P
S
I
R
S
V
A
M
E
P
E
E
Site 44
S388
M
E
P
E
E
W
L
S
I
A
R
K
P
E
A
Site 45
S396
I
A
R
K
P
E
A
S
S
V
P
S
L
V
T
Site 46
S397
A
R
K
P
E
A
S
S
V
P
S
L
V
T
A
Site 47
S415
P
T
I
P
P
P
K
S
H
A
V
G
A
L
N
Site 48
T423
H
A
V
G
A
L
N
T
R
S
A
S
S
P
V
Site 49
S425
V
G
A
L
N
T
R
S
A
S
S
P
V
P
G
Site 50
S427
A
L
N
T
R
S
A
S
S
P
V
P
G
S
S
Site 51
S428
L
N
T
R
S
A
S
S
P
V
P
G
S
S
H
Site 52
S433
A
S
S
P
V
P
G
S
S
H
F
P
H
Q
K
Site 53
S434
S
S
P
V
P
G
S
S
H
F
P
H
Q
K
A
Site 54
Y451
E
H
M
A
S
M
Q
Y
P
P
I
L
V
T
N
Site 55
S459
P
P
I
L
V
T
N
S
H
G
T
P
I
S
Y
Site 56
T462
L
V
T
N
S
H
G
T
P
I
S
Y
A
E
Q
Site 57
S465
N
S
H
G
T
P
I
S
Y
A
E
Q
Y
P
K
Site 58
Y466
S
H
G
T
P
I
S
Y
A
E
Q
Y
P
K
F
Site 59
Y470
P
I
S
Y
A
E
Q
Y
P
K
F
E
S
M
G
Site 60
Y481
E
S
M
G
D
H
G
Y
Y
S
M
L
G
D
F
Site 61
Y482
S
M
G
D
H
G
Y
Y
S
M
L
G
D
F
S
Site 62
S489
Y
S
M
L
G
D
F
S
K
L
N
I
N
S
M
Site 63
Y501
N
S
M
H
N
R
E
Y
Y
M
A
E
V
D
R
Site 64
Y502
S
M
H
N
R
E
Y
Y
M
A
E
V
D
R
G
Site 65
Y511
A
E
V
D
R
G
V
Y
A
R
N
P
N
L
C
Site 66
S519
A
R
N
P
N
L
C
S
D
S
R
V
S
H
T
Site 67
S521
N
P
N
L
C
S
D
S
R
V
S
H
T
R
N
Site 68
S524
L
C
S
D
S
R
V
S
H
T
R
N
D
N
Y
Site 69
Y531
S
H
T
R
N
D
N
Y
S
S
Y
N
N
V
Y
Site 70
Y534
R
N
D
N
Y
S
S
Y
N
N
V
Y
L
A
V
Site 71
Y538
Y
S
S
Y
N
N
V
Y
L
A
V
A
D
T
H
Site 72
T544
V
Y
L
A
V
A
D
T
H
P
E
G
N
L
K
Site 73
S555
G
N
L
K
L
H
R
S
A
S
Q
N
R
L
Q
Site 74
S557
L
K
L
H
R
S
A
S
Q
N
R
L
Q
P
F
Site 75
T573
H
G
Y
H
E
A
L
T
R
V
Q
S
Y
G
P
Site 76
S577
E
A
L
T
R
V
Q
S
Y
G
P
E
D
S
K
Site 77
S583
Q
S
Y
G
P
E
D
S
K
Q
G
P
H
K
Q
Site 78
T604
L
H
A
Q
H
P
S
T
G
T
R
S
S
C
P
Site 79
S608
H
P
S
T
G
T
R
S
S
C
P
A
D
Y
P
Site 80
S609
P
S
T
G
T
R
S
S
C
P
A
D
Y
P
M
Site 81
Y614
R
S
S
C
P
A
D
Y
P
M
P
P
N
I
H
Site 82
T625
P
N
I
H
P
G
A
T
P
Q
P
G
R
A
L
Site 83
T635
P
G
R
A
L
V
M
T
R
M
D
S
I
S
D
Site 84
S639
L
V
M
T
R
M
D
S
I
S
D
S
R
L
Y
Site 85
S641
M
T
R
M
D
S
I
S
D
S
R
L
Y
E
S
Site 86
S643
R
M
D
S
I
S
D
S
R
L
Y
E
S
N
P
Site 87
Y646
S
I
S
D
S
R
L
Y
E
S
N
P
V
R
Q
Site 88
S648
S
D
S
R
L
Y
E
S
N
P
V
R
Q
R
R
Site 89
Y676
L
P
C
T
T
D
S
Y
G
Y
H
S
Y
P
L
Site 90
S680
T
D
S
Y
G
Y
H
S
Y
P
L
S
N
S
L
Site 91
Y681
D
S
Y
G
Y
H
S
Y
P
L
S
N
S
L
M
Site 92
S684
G
Y
H
S
Y
P
L
S
N
S
L
M
Q
P
C
Site 93
S686
H
S
Y
P
L
S
N
S
L
M
Q
P
C
Y
E
Site 94
Y692
N
S
L
M
Q
P
C
Y
E
P
V
M
V
R
S
Site 95
S699
Y
E
P
V
M
V
R
S
V
P
E
K
M
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation