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Updated November 2019
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Protein Info
Short Name:
FSIP2
Full Name:
Fibrous sheath-interacting protein 2
Alias:
Type:
Mass (Da):
369862
Number AA:
3274
UniProt ID:
Q5CZC0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T39
E
R
R
Q
R
E
H
T
R
R
K
L
T
L
R
Site 2
T44
E
H
T
R
R
K
L
T
L
R
R
K
I
E
E
Site 3
T55
K
I
E
E
E
W
K
T
K
E
M
L
L
L
T
Site 4
S85
Q
H
R
N
R
E
E
S
D
R
K
K
Q
D
L
Site 5
T118
G
E
D
I
G
K
N
T
F
K
Y
R
G
Q
D
Site 6
Y121
I
G
K
N
T
F
K
Y
R
G
Q
D
G
T
H
Site 7
T127
K
Y
R
G
Q
D
G
T
H
A
S
P
K
N
K
Site 8
S130
G
Q
D
G
T
H
A
S
P
K
N
K
K
K
T
Site 9
T137
S
P
K
N
K
K
K
T
S
E
D
I
M
L
V
Site 10
S138
P
K
N
K
K
K
T
S
E
D
I
M
L
V
Y
Site 11
Y145
S
E
D
I
M
L
V
Y
P
A
G
D
Q
N
T
Site 12
Y153
P
A
G
D
Q
N
T
Y
K
E
T
H
G
H
T
Site 13
S170
A
A
H
Q
R
Q
N
S
S
N
N
F
T
K
K
Site 14
T175
Q
N
S
S
N
N
F
T
K
K
N
S
A
S
V
Site 15
S202
Q
K
R
D
G
M
V
S
K
N
S
S
I
F
D
Site 16
S206
G
M
V
S
K
N
S
S
I
F
D
D
R
G
G
Site 17
S217
D
R
G
G
I
N
I
S
G
Q
G
S
I
I
S
Site 18
S224
S
G
Q
G
S
I
I
S
A
Q
V
S
P
T
R
Site 19
S228
S
I
I
S
A
Q
V
S
P
T
R
N
F
S
R
Site 20
S234
V
S
P
T
R
N
F
S
R
V
S
Q
A
F
L
Site 21
S237
T
R
N
F
S
R
V
S
Q
A
F
L
D
P
S
Site 22
S244
S
Q
A
F
L
D
P
S
K
E
E
K
E
T
N
Site 23
T250
P
S
K
E
E
K
E
T
N
A
D
W
D
G
R
Site 24
T259
A
D
W
D
G
R
P
T
K
R
S
S
Y
L
C
Site 25
S262
D
G
R
P
T
K
R
S
S
Y
L
C
E
S
G
Site 26
S263
G
R
P
T
K
R
S
S
Y
L
C
E
S
G
P
Site 27
Y264
R
P
T
K
R
S
S
Y
L
C
E
S
G
P
Q
Site 28
S268
R
S
S
Y
L
C
E
S
G
P
Q
A
H
A
T
Site 29
T275
S
G
P
Q
A
H
A
T
D
P
G
I
F
S
S
Site 30
S282
T
D
P
G
I
F
S
S
P
V
Y
T
N
M
Q
Site 31
Y285
G
I
F
S
S
P
V
Y
T
N
M
Q
Q
N
L
Site 32
T286
I
F
S
S
P
V
Y
T
N
M
Q
Q
N
L
L
Site 33
Y332
L
Y
P
A
I
T
K
Y
E
K
R
L
Q
N
N
Site 34
T340
E
K
R
L
Q
N
N
T
Y
P
V
S
D
D
S
Site 35
Y341
K
R
L
Q
N
N
T
Y
P
V
S
D
D
S
I
Site 36
S344
Q
N
N
T
Y
P
V
S
D
D
S
I
L
S
S
Site 37
S347
T
Y
P
V
S
D
D
S
I
L
S
S
D
S
S
Site 38
S350
V
S
D
D
S
I
L
S
S
D
S
S
S
F
C
Site 39
S351
S
D
D
S
I
L
S
S
D
S
S
S
F
C
S
Site 40
S353
D
S
I
L
S
S
D
S
S
S
F
C
S
T
C
Site 41
S354
S
I
L
S
S
D
S
S
S
F
C
S
T
C
S
Site 42
S355
I
L
S
S
D
S
S
S
F
C
S
T
C
S
E
Site 43
S358
S
D
S
S
S
F
C
S
T
C
S
E
D
F
T
Site 44
T359
D
S
S
S
F
C
S
T
C
S
E
D
F
T
Y
Site 45
S361
S
S
F
C
S
T
C
S
E
D
F
T
Y
R
S
Site 46
T365
S
T
C
S
E
D
F
T
Y
R
S
Y
T
S
A
Site 47
Y366
T
C
S
E
D
F
T
Y
R
S
Y
T
S
A
T
Site 48
S368
S
E
D
F
T
Y
R
S
Y
T
S
A
T
T
K
Site 49
Y369
E
D
F
T
Y
R
S
Y
T
S
A
T
T
K
T
Site 50
T370
D
F
T
Y
R
S
Y
T
S
A
T
T
K
T
F
Site 51
T376
Y
T
S
A
T
T
K
T
F
Q
A
E
P
C
A
Site 52
T388
P
C
A
F
V
V
D
T
S
V
R
R
P
T
T
Site 53
S389
C
A
F
V
V
D
T
S
V
R
R
P
T
T
P
Site 54
T394
D
T
S
V
R
R
P
T
T
P
I
K
P
P
P
Site 55
T395
T
S
V
R
R
P
T
T
P
I
K
P
P
P
A
Site 56
T407
P
P
A
H
V
E
K
T
V
V
G
K
T
C
H
Site 57
Y426
S
I
I
S
K
H
K
Y
N
K
T
N
L
L
Y
Site 58
T429
S
K
H
K
Y
N
K
T
N
L
L
Y
S
Y
P
Site 59
Y433
Y
N
K
T
N
L
L
Y
S
Y
P
K
L
R
S
Site 60
S434
N
K
T
N
L
L
Y
S
Y
P
K
L
R
S
C
Site 61
Y435
K
T
N
L
L
Y
S
Y
P
K
L
R
S
C
K
Site 62
S440
Y
S
Y
P
K
L
R
S
C
K
S
D
S
H
L
Site 63
S443
P
K
L
R
S
C
K
S
D
S
H
L
L
A
S
Site 64
S445
L
R
S
C
K
S
D
S
H
L
L
A
S
F
E
Site 65
S450
S
D
S
H
L
L
A
S
F
E
T
G
T
K
K
Site 66
S458
F
E
T
G
T
K
K
S
K
D
A
T
T
E
T
Site 67
T462
T
K
K
S
K
D
A
T
T
E
T
D
S
L
G
Site 68
T463
K
K
S
K
D
A
T
T
E
T
D
S
L
G
S
Site 69
T465
S
K
D
A
T
T
E
T
D
S
L
G
S
S
L
Site 70
S467
D
A
T
T
E
T
D
S
L
G
S
S
L
H
C
Site 71
S471
E
T
D
S
L
G
S
S
L
H
C
D
K
T
A
Site 72
T477
S
S
L
H
C
D
K
T
A
K
A
M
D
E
M
Site 73
T518
R
E
I
M
S
D
L
T
Q
A
I
P
S
L
S
Site 74
S545
R
E
K
E
I
L
L
S
N
A
H
I
P
S
V
Site 75
S566
N
M
L
E
K
L
E
S
A
V
E
K
K
C
V
Site 76
S577
K
K
C
V
E
M
F
S
Q
D
L
S
V
D
I
Site 77
S581
E
M
F
S
Q
D
L
S
V
D
I
K
P
S
L
Site 78
S591
I
K
P
S
L
A
A
S
D
E
L
L
T
S
S
Site 79
S597
A
S
D
E
L
L
T
S
S
N
G
K
P
L
K
Site 80
S598
S
D
E
L
L
T
S
S
N
G
K
P
L
K
N
Site 81
S606
N
G
K
P
L
K
N
S
M
P
H
T
L
D
P
Site 82
T610
L
K
N
S
M
P
H
T
L
D
P
M
C
D
I
Site 83
S634
E
K
L
M
T
L
V
S
F
K
Q
N
E
F
L
Site 84
T646
E
F
L
H
L
K
D
T
N
K
L
S
C
Q
Q
Site 85
S671
Q
R
A
G
K
N
K
S
S
L
E
S
D
E
A
Site 86
S672
R
A
G
K
N
K
S
S
L
E
S
D
E
A
S
Site 87
S675
K
N
K
S
S
L
E
S
D
E
A
S
L
I
V
Site 88
S679
S
L
E
S
D
E
A
S
L
I
V
N
E
E
V
Site 89
S691
E
E
V
Q
N
L
I
S
N
I
F
S
Q
S
S
Site 90
S698
S
N
I
F
S
Q
S
S
L
V
A
Y
I
E
E
Site 91
S751
H
Q
E
P
V
N
E
S
F
Q
K
S
R
Q
P
Site 92
S755
V
N
E
S
F
Q
K
S
R
Q
P
R
I
S
S
Site 93
S761
K
S
R
Q
P
R
I
S
S
P
S
D
T
K
E
Site 94
S762
S
R
Q
P
R
I
S
S
P
S
D
T
K
E
K
Site 95
S764
Q
P
R
I
S
S
P
S
D
T
K
E
K
Y
R
Site 96
T766
R
I
S
S
P
S
D
T
K
E
K
Y
R
L
T
Site 97
Y770
P
S
D
T
K
E
K
Y
R
L
T
G
T
R
L
Site 98
T773
T
K
E
K
Y
R
L
T
G
T
R
L
S
N
S
Site 99
S778
R
L
T
G
T
R
L
S
N
S
P
R
S
G
R
Site 100
S780
T
G
T
R
L
S
N
S
P
R
S
G
R
P
F
Site 101
S783
R
L
S
N
S
P
R
S
G
R
P
F
P
P
I
Site 102
S799
V
P
G
M
V
L
Y
S
D
D
E
N
E
E
I
Site 103
T817
V
K
N
V
L
D
S
T
F
K
D
E
K
V
K
Site 104
S825
F
K
D
E
K
V
K
S
Q
E
Q
I
P
N
H
Site 105
T851
K
R
N
I
K
P
P
T
K
P
G
S
R
S
K
Site 106
S855
K
P
P
T
K
P
G
S
R
S
K
A
A
F
H
Site 107
S857
P
T
K
P
G
S
R
S
K
A
A
F
H
D
W
Site 108
T868
F
H
D
W
E
L
K
T
E
P
P
S
T
N
H
Site 109
S872
E
L
K
T
E
P
P
S
T
N
H
E
D
I
L
Site 110
T873
L
K
T
E
P
P
S
T
N
H
E
D
I
L
K
Site 111
S884
D
I
L
K
K
K
L
S
S
N
K
D
I
S
T
Site 112
S890
L
S
S
N
K
D
I
S
T
F
S
Q
D
Q
K
Site 113
T891
S
S
N
K
D
I
S
T
F
S
Q
D
Q
K
H
Site 114
S893
N
K
D
I
S
T
F
S
Q
D
Q
K
H
Q
I
Site 115
S920
K
E
M
L
K
D
I
S
S
V
P
F
G
H
L
Site 116
S921
E
M
L
K
D
I
S
S
V
P
F
G
H
L
D
Site 117
S929
V
P
F
G
H
L
D
S
K
T
G
S
E
A
S
Site 118
T931
F
G
H
L
D
S
K
T
G
S
E
A
S
V
L
Site 119
S933
H
L
D
S
K
T
G
S
E
A
S
V
L
V
S
Site 120
S936
S
K
T
G
S
E
A
S
V
L
V
S
E
K
P
Site 121
S940
S
E
A
S
V
L
V
S
E
K
P
Q
G
L
S
Site 122
S984
H
K
A
S
N
Y
I
S
N
T
T
K
S
S
I
Site 123
T986
A
S
N
Y
I
S
N
T
T
K
S
S
I
S
S
Site 124
T987
S
N
Y
I
S
N
T
T
K
S
S
I
S
S
S
Site 125
S989
Y
I
S
N
T
T
K
S
S
I
S
S
S
V
H
Site 126
S990
I
S
N
T
T
K
S
S
I
S
S
S
V
H
Q
Site 127
S992
N
T
T
K
S
S
I
S
S
S
V
H
Q
I
S
Site 128
S993
T
T
K
S
S
I
S
S
S
V
H
Q
I
S
L
Site 129
S994
T
K
S
S
I
S
S
S
V
H
Q
I
S
L
H
Site 130
S999
S
S
S
V
H
Q
I
S
L
H
N
S
D
T
E
Site 131
S1003
H
Q
I
S
L
H
N
S
D
T
E
H
I
V
K
Site 132
T1005
I
S
L
H
N
S
D
T
E
H
I
V
K
E
A
Site 133
Y1016
V
K
E
A
P
N
K
Y
P
L
K
T
W
F
D
Site 134
T1020
P
N
K
Y
P
L
K
T
W
F
D
S
E
K
K
Site 135
Y1030
D
S
E
K
K
M
K
Y
L
S
L
F
D
V
D
Site 136
S1032
E
K
K
M
K
Y
L
S
L
F
D
V
D
P
E
Site 137
S1046
E
K
P
P
W
L
K
S
G
K
S
E
P
K
P
Site 138
S1049
P
W
L
K
S
G
K
S
E
P
K
P
V
D
D
Site 139
S1083
K
L
H
M
G
F
K
S
S
L
R
S
Q
L
S
Site 140
S1084
L
H
M
G
F
K
S
S
L
R
S
Q
L
S
K
Site 141
S1087
G
F
K
S
S
L
R
S
Q
L
S
K
Y
T
A
Site 142
S1090
S
S
L
R
S
Q
L
S
K
Y
T
A
K
I
V
Site 143
Y1092
L
R
S
Q
L
S
K
Y
T
A
K
I
V
N
I
Site 144
T1123
N
L
R
E
I
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Site 296
S2483
K
K
T
H
L
G
L
S
A
A
K
A
K
S
K
Site 297
S2489
L
S
A
A
K
A
K
S
K
T
K
L
G
P
G
Site 298
T2499
K
L
G
P
G
E
K
T
L
K
D
S
R
S
K
Site 299
S2503
G
E
K
T
L
K
D
S
R
S
K
T
A
I
G
Site 300
S2505
K
T
L
K
D
S
R
S
K
T
A
I
G
L
S
Site 301
T2507
L
K
D
S
R
S
K
T
A
I
G
L
S
H
I
Site 302
T2526
D
A
K
N
L
L
D
T
K
L
P
T
S
E
L
Site 303
S2531
L
D
T
K
L
P
T
S
E
L
K
I
Y
A
K
Site 304
Y2536
P
T
S
E
L
K
I
Y
A
K
D
I
I
I
N
Site 305
Y2581
N
T
V
L
Q
E
L
Y
V
T
N
N
C
N
L
Site 306
Y2590
T
N
N
C
N
L
A
Y
P
M
K
S
S
H
L
Site 307
S2595
L
A
Y
P
M
K
S
S
H
L
R
L
S
Q
G
Site 308
S2600
K
S
S
H
L
R
L
S
Q
G
N
I
G
T
G
Site 309
S2608
Q
G
N
I
G
T
G
S
L
P
K
Q
Q
A
C
Site 310
Y2617
P
K
Q
Q
A
C
F
Y
L
E
N
V
S
S
Q
Site 311
S2623
F
Y
L
E
N
V
S
S
Q
L
E
H
I
F
P
Site 312
S2677
K
A
K
E
L
E
Y
S
L
S
L
L
N
L
P
Site 313
Y2694
E
N
C
E
S
R
F
Y
N
H
F
K
G
A
S
Site 314
S2701
Y
N
H
F
K
G
A
S
T
R
A
E
D
T
K
Site 315
S2732
K
L
Q
L
C
F
L
S
Q
I
P
T
P
D
S
Site 316
T2736
C
F
L
S
Q
I
P
T
P
D
S
E
E
T
L
Site 317
S2739
S
Q
I
P
T
P
D
S
E
E
T
L
S
N
S
Site 318
T2742
P
T
P
D
S
E
E
T
L
S
N
S
K
E
H
Site 319
S2744
P
D
S
E
E
T
L
S
N
S
K
E
H
I
T
Site 320
S2746
S
E
E
T
L
S
N
S
K
E
H
I
T
A
K
Site 321
S2754
K
E
H
I
T
A
K
S
K
Y
G
F
P
N
K
Site 322
Y2756
H
I
T
A
K
S
K
Y
G
F
P
N
K
H
S
Site 323
S2763
Y
G
F
P
N
K
H
S
L
S
S
L
P
I
Y
Site 324
S2765
F
P
N
K
H
S
L
S
S
L
P
I
Y
N
T
Site 325
Y2770
S
L
S
S
L
P
I
Y
N
T
K
T
K
D
Q
Site 326
T2772
S
S
L
P
I
Y
N
T
K
T
K
D
Q
I
S
Site 327
T2774
L
P
I
Y
N
T
K
T
K
D
Q
I
S
V
G
Site 328
S2779
T
K
T
K
D
Q
I
S
V
G
S
S
N
Q
I
Site 329
S2783
D
Q
I
S
V
G
S
S
N
Q
I
V
Q
E
I
Site 330
S2810
D
L
Q
F
K
H
I
S
K
Y
E
F
S
E
I
Site 331
Y2812
Q
F
K
H
I
S
K
Y
E
F
S
E
I
V
K
Site 332
S2827
M
P
I
E
N
L
S
S
I
Q
Q
K
L
L
N
Site 333
S2848
L
Q
P
L
K
M
F
S
D
K
S
E
S
N
T
Site 334
S2851
L
K
M
F
S
D
K
S
E
S
N
T
I
N
F
Site 335
T2855
S
D
K
S
E
S
N
T
I
N
F
K
E
N
I
Site 336
S2900
N
K
L
D
N
E
I
S
Q
M
E
P
S
S
I
Site 337
S2905
E
I
S
Q
M
E
P
S
S
I
S
I
L
K
E
Site 338
S2906
I
S
Q
M
E
P
S
S
I
S
I
L
K
E
N
Site 339
Y2929
T
L
M
D
Q
C
T
Y
F
N
E
S
L
I
Q
Site 340
S2939
E
S
L
I
Q
N
L
S
R
E
S
L
F
Q
G
Site 341
S2942
I
Q
N
L
S
R
E
S
L
F
Q
G
A
E
N
Site 342
T2952
Q
G
A
E
N
A
Y
T
V
N
Q
V
E
L
A
Site 343
S2973
T
S
K
L
K
E
G
S
L
G
I
N
P
S
Q
Site 344
S2979
G
S
L
G
I
N
P
S
Q
V
S
K
T
G
F
Site 345
T2984
N
P
S
Q
V
S
K
T
G
F
V
F
C
S
D
Site 346
S2990
K
T
G
F
V
F
C
S
D
E
D
M
K
E
K
Site 347
Y2998
D
E
D
M
K
E
K
Y
R
V
S
S
D
L
P
Site 348
S3001
M
K
E
K
Y
R
V
S
S
D
L
P
T
S
V
Site 349
S3002
K
E
K
Y
R
V
S
S
D
L
P
T
S
V
R
Site 350
T3006
R
V
S
S
D
L
P
T
S
V
R
S
S
V
E
Site 351
S3007
V
S
S
D
L
P
T
S
V
R
S
S
V
E
D
Site 352
S3011
L
P
T
S
V
R
S
S
V
E
D
T
V
K
N
Site 353
T3015
V
R
S
S
V
E
D
T
V
K
N
S
E
P
T
Site 354
S3027
E
P
T
K
R
P
D
S
E
T
M
P
S
C
S
Site 355
T3029
T
K
R
P
D
S
E
T
M
P
S
C
S
T
R
Site 356
S3032
P
D
S
E
T
M
P
S
C
S
T
R
N
K
V
Site 357
S3034
S
E
T
M
P
S
C
S
T
R
N
K
V
Q
D
Site 358
S3047
Q
D
H
R
P
R
E
S
N
F
G
S
F
D
Q
Site 359
S3051
P
R
E
S
N
F
G
S
F
D
Q
T
M
K
G
Site 360
T3055
N
F
G
S
F
D
Q
T
M
K
G
N
S
Y
L
Site 361
S3060
D
Q
T
M
K
G
N
S
Y
L
P
E
G
S
F
Site 362
Y3061
Q
T
M
K
G
N
S
Y
L
P
E
G
S
F
L
Site 363
S3066
N
S
Y
L
P
E
G
S
F
L
Q
K
L
L
R
Site 364
S3076
Q
K
L
L
R
K
A
S
D
S
T
E
A
A
L
Site 365
S3078
L
L
R
K
A
S
D
S
T
E
A
A
L
K
Q
Site 366
Y3103
E
N
L
R
V
F
H
Y
E
N
L
K
P
V
V
Site 367
T3118
E
P
N
Q
I
Q
T
T
I
S
P
L
K
I
C
Site 368
S3143
L
S
S
C
G
F
P
S
Q
P
H
T
N
E
N
Site 369
T3147
G
F
P
S
Q
P
H
T
N
E
N
R
E
I
M
Site 370
S3160
I
M
K
P
F
F
I
S
K
Q
S
S
L
S
E
Site 371
S3163
P
F
F
I
S
K
Q
S
S
L
S
E
V
S
G
Site 372
S3164
F
F
I
S
K
Q
S
S
L
S
E
V
S
G
G
Site 373
S3166
I
S
K
Q
S
S
L
S
E
V
S
G
G
Q
K
Site 374
S3178
G
Q
K
D
N
E
K
S
L
L
R
M
Q
D
K
Site 375
S3201
E
N
E
N
L
E
A
S
R
E
D
S
S
F
L
Site 376
S3205
L
E
A
S
R
E
D
S
S
F
L
Q
K
L
K
Site 377
S3206
E
A
S
R
E
D
S
S
F
L
Q
K
L
K
K
Site 378
Y3216
Q
K
L
K
K
K
E
Y
P
K
I
E
T
V
K
Site 379
T3229
V
K
E
V
E
A
F
T
F
A
D
H
E
M
G
Site 380
Y3268
T
G
K
Q
E
R
T
Y
L
K
I
C
M
I
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation