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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HSP90AB3P
Full Name:
Putative heat shock protein HSP 90-beta-3
Alias:
HSP90BC
Type:
Uncharacterized protein
Mass (Da):
68325
Number AA:
597
UniProt ID:
Q58FF7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
H
G
E
E
E
V
E
T
F
A
F
Q
A
E
I
Site 2
Y56
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
Site 3
S58
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Site 4
T60
K
I
R
Y
E
S
L
T
D
P
S
K
L
D
S
Site 5
S63
Y
E
S
L
T
D
P
S
K
L
D
S
G
K
E
Site 6
S67
T
D
P
S
K
L
D
S
G
K
E
L
K
I
D
Site 7
T104
D
L
I
N
N
L
R
T
I
A
K
S
G
T
K
Site 8
S108
N
L
R
T
I
A
K
S
G
T
K
A
C
M
E
Site 9
Y134
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
Site 10
S138
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
Site 11
S143
W
E
S
S
A
G
G
S
F
T
V
H
A
D
H
Site 12
T145
S
S
A
G
G
S
F
T
V
H
A
D
H
G
E
Site 13
T158
G
E
P
I
G
R
G
T
K
V
I
L
H
L
K
Site 14
T169
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
Site 15
Y171
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
Site 16
S185
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
Site 17
Y190
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
E
Site 18
T193
Q
F
I
G
Y
P
I
T
L
Y
L
E
K
E
Q
Site 19
Y195
I
G
Y
P
I
T
L
Y
L
E
K
E
Q
D
K
Site 20
S205
K
E
Q
D
K
E
I
S
D
D
E
A
E
E
E
Site 21
S234
P
K
I
K
D
V
G
S
D
E
E
D
D
S
K
Site 22
S240
G
S
D
E
E
D
D
S
K
E
Y
G
E
F
Y
Site 23
Y243
E
E
D
D
S
K
E
Y
G
E
F
Y
K
S
L
Site 24
Y247
S
K
E
Y
G
E
F
Y
K
S
L
T
S
D
W
Site 25
S249
E
Y
G
E
F
Y
K
S
L
T
S
D
W
E
D
Site 26
S277
E
F
R
A
L
L
F
S
P
R
R
A
P
F
D
Site 27
Y298
K
K
N
N
I
K
L
Y
V
R
R
V
F
I
M
Site 28
S307
R
R
V
F
I
M
D
S
C
D
E
L
I
P
E
Site 29
S333
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
Site 30
S340
S
R
E
M
L
Q
Q
S
K
I
L
K
Y
V
S
Site 31
Y345
Q
Q
S
K
I
L
K
Y
V
S
H
M
K
E
T
Site 32
S347
S
K
I
L
K
Y
V
S
H
M
K
E
T
Q
K
Site 33
Y357
K
E
T
Q
K
S
T
Y
Y
I
T
G
E
S
K
Site 34
Y358
E
T
Q
K
S
T
Y
Y
I
T
G
E
S
K
E
Site 35
S370
S
K
E
Q
V
A
N
S
A
F
V
E
R
V
R
Site 36
Y393
M
T
E
P
I
D
E
Y
C
V
Q
Q
L
K
E
Site 37
S405
L
K
E
F
D
G
K
S
L
V
S
V
T
K
E
Site 38
S408
F
D
G
K
S
L
V
S
V
T
K
E
G
L
E
Site 39
S429
E
K
K
K
M
E
E
S
K
E
K
F
E
N
L
Site 40
S454
K
V
E
K
V
T
I
S
N
R
L
V
S
S
P
Site 41
Y469
C
C
I
V
T
S
T
Y
G
W
T
A
N
M
E
Site 42
T489
Q
A
L
R
D
N
S
T
M
G
Y
M
M
A
K
Site 43
Y492
R
D
N
S
T
M
G
Y
M
M
A
K
K
H
L
Site 44
S542
A
L
L
S
S
G
F
S
L
E
D
P
Q
T
H
Site 45
Y554
Q
T
H
S
N
H
I
Y
H
M
I
K
L
G
L
Site 46
S591
L
E
G
D
E
D
A
S
R
M
E
E
V
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation