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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TDRD12
Full Name:
Tudor domain-containing protein 12
Alias:
ECAT8; FLJ13072; TDR12; tudor domain containing 12
Type:
Mass (Da):
132580
Number AA:
UniProt ID:
Q587J7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
F
L
D
H
D
V
D
Y
Q
K
L
N
S
A
M
Site 2
Y43
N
S
A
M
N
D
F
Y
N
S
T
C
Q
D
I
Site 3
T56
D
I
E
I
K
P
L
T
L
E
E
G
Q
V
C
Site 4
S80
W
C
R
A
I
V
K
S
I
T
S
S
A
D
Q
Site 5
S84
I
V
K
S
I
T
S
S
A
D
Q
Y
L
A
E
Site 6
Y120
E
S
F
M
Q
L
P
Y
R
A
K
K
F
S
L
Site 7
S126
P
Y
R
A
K
K
F
S
L
Y
C
T
K
P
V
Site 8
Y128
R
A
K
K
F
S
L
Y
C
T
K
P
V
T
L
Site 9
S143
H
I
D
F
C
R
D
S
T
D
I
V
P
A
K
Site 10
T144
I
D
F
C
R
D
S
T
D
I
V
P
A
K
K
Site 11
Y159
W
D
N
A
A
I
Q
Y
F
Q
N
L
L
K
A
Site 12
Y185
E
E
D
T
F
E
V
Y
L
Y
V
T
I
K
D
Site 13
Y187
D
T
F
E
V
Y
L
Y
V
T
I
K
D
E
K
Site 14
Y206
D
D
L
V
A
K
N
Y
A
C
Y
M
S
P
T
Site 15
Y209
V
A
K
N
Y
A
C
Y
M
S
P
T
K
N
K
Site 16
Y220
T
K
N
K
N
L
D
Y
L
E
K
P
R
L
N
Site 17
S230
K
P
R
L
N
I
K
S
A
P
S
F
N
K
L
Site 18
S233
L
N
I
K
S
A
P
S
F
N
K
L
N
P
A
Site 19
S259
D
V
Q
G
M
E
D
S
H
G
V
N
F
P
A
Site 20
T272
P
A
Q
S
L
Q
H
T
W
C
K
G
I
V
G
Site 21
T284
I
V
G
D
L
R
P
T
A
T
A
Q
D
K
A
Site 22
S298
A
V
K
C
N
M
D
S
L
R
D
S
P
K
D
Site 23
S302
N
M
D
S
L
R
D
S
P
K
D
K
S
E
K
Site 24
S307
R
D
S
P
K
D
K
S
E
K
K
H
H
C
I
Site 25
S315
E
K
K
H
H
C
I
S
L
K
D
T
N
K
R
Site 26
T319
H
C
I
S
L
K
D
T
N
K
R
V
E
S
S
Site 27
S325
D
T
N
K
R
V
E
S
S
V
Y
W
P
A
K
Site 28
Y328
K
R
V
E
S
S
V
Y
W
P
A
K
R
G
I
Site 29
T336
W
P
A
K
R
G
I
T
I
Y
A
D
P
D
V
Site 30
Y338
A
K
R
G
I
T
I
Y
A
D
P
D
V
P
E
Site 31
S347
D
P
D
V
P
E
A
S
A
L
S
Q
K
S
N
Site 32
S353
A
S
A
L
S
Q
K
S
N
E
K
P
L
R
L
Site 33
T361
N
E
K
P
L
R
L
T
E
K
K
E
Y
D
E
Site 34
Y366
R
L
T
E
K
K
E
Y
D
E
K
N
S
C
V
Site 35
S390
P
L
R
A
D
G
I
S
D
L
Q
Q
L
Q
K
Site 36
T417
N
K
I
K
P
C
L
T
I
D
S
S
P
L
S
Site 37
S424
T
I
D
S
S
P
L
S
A
D
L
K
K
A
L
Site 38
S440
R
N
K
F
P
G
P
S
H
T
E
S
Y
S
W
Site 39
T442
K
F
P
G
P
S
H
T
E
S
Y
S
W
P
P
Site 40
S444
P
G
P
S
H
T
E
S
Y
S
W
P
P
I
A
Site 41
Y445
G
P
S
H
T
E
S
Y
S
W
P
P
I
A
R
Site 42
S446
P
S
H
T
E
S
Y
S
W
P
P
I
A
R
G
Site 43
S485
Q
T
G
A
C
Y
K
S
L
P
S
R
N
G
P
Site 44
Y514
I
F
E
L
L
G
E
Y
S
M
S
S
R
P
L
Site 45
S515
F
E
L
L
G
E
Y
S
M
S
S
R
P
L
H
Site 46
S517
L
L
G
E
Y
S
M
S
S
R
P
L
H
P
V
Site 47
T538
H
K
E
E
A
K
N
T
K
L
P
R
G
C
D
Site 48
S605
I
E
V
E
E
R
E
S
A
P
H
Q
I
V
A
Site 49
Y633
K
E
F
M
N
D
P
Y
I
V
I
T
A
M
E
Site 50
S663
L
E
C
E
K
T
S
S
L
L
Q
A
L
D
F
Site 51
S725
E
Q
W
K
K
K
L
S
S
G
S
Q
I
I
L
Site 52
S758
I
H
F
S
F
P
A
S
P
K
V
F
G
G
R
Site 53
Y767
K
V
F
G
G
R
L
Y
C
M
S
D
H
F
H
Site 54
S779
H
F
H
A
E
Q
G
S
P
A
E
Q
G
D
K
Site 55
S790
Q
G
D
K
K
A
K
S
V
L
L
L
T
E
K
Site 56
T795
A
K
S
V
L
L
L
T
E
K
D
A
S
H
A
Site 57
T866
R
H
R
I
N
P
E
T
D
L
P
R
K
L
S
Site 58
S873
T
D
L
P
R
K
L
S
S
Q
A
L
P
S
F
Site 59
S874
D
L
P
R
K
L
S
S
Q
A
L
P
S
F
G
Site 60
Y882
Q
A
L
P
S
F
G
Y
I
K
I
I
P
F
Y
Site 61
Y896
Y
I
L
N
A
T
N
Y
F
G
R
I
V
D
K
Site 62
Y908
V
D
K
H
M
D
L
Y
A
T
L
N
A
E
M
Site 63
Y918
L
N
A
E
M
N
E
Y
F
K
D
S
N
K
T
Site 64
T926
F
K
D
S
N
K
T
T
V
E
K
V
E
K
F
Site 65
T978
E
G
R
T
G
L
V
T
R
D
Q
L
L
H
L
Site 66
T991
H
L
P
E
H
F
H
T
L
P
P
Q
A
V
E
Site 67
S1055
V
H
I
T
N
L
S
S
L
K
T
S
V
I
D
Site 68
T1058
T
N
L
S
S
L
K
T
S
V
I
D
Y
N
V
Site 69
S1059
N
L
S
S
L
K
T
S
V
I
D
Y
N
V
R
Site 70
S1100
K
I
P
A
C
E
E
S
L
S
Q
T
P
P
R
Site 71
S1102
P
A
C
E
E
S
L
S
Q
T
P
P
R
V
T
Site 72
T1104
C
E
E
S
L
S
Q
T
P
P
R
V
T
G
T
Site 73
T1109
S
Q
T
P
P
R
V
T
G
T
S
P
A
Q
D
Site 74
S1112
P
P
R
V
T
G
T
S
P
A
Q
D
Q
D
H
Site 75
S1121
A
Q
D
Q
D
H
P
S
E
E
Q
G
G
Q
G
Site 76
T1129
E
E
Q
G
G
Q
G
T
P
P
A
E
D
A
A
Site 77
S1140
E
D
A
A
C
L
Q
S
P
Q
P
E
D
T
G
Site 78
T1146
Q
S
P
Q
P
E
D
T
G
A
E
G
G
A
E
Site 79
S1154
G
A
E
G
G
A
E
S
K
T
S
S
E
N
Q
Site 80
T1156
E
G
G
A
E
S
K
T
S
S
E
N
Q
K
P
Site 81
S1157
G
G
A
E
S
K
T
S
S
E
N
Q
K
P
G
Site 82
S1158
G
A
E
S
K
T
S
S
E
N
Q
K
P
G
G
Site 83
Y1166
E
N
Q
K
P
G
G
Y
L
V
F
K
R
W
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation