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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALS2CR11
Full Name:
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein
Alias:
AL2SA
Type:
Uncharacterized
Mass (Da):
71159
Number AA:
623
UniProt ID:
Q53TS8
International Prot ID:
IPI00301617
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
E
P
P
Q
E
T
N
R
P
F
S
T
L
Site 2
S12
Q
E
T
N
R
P
F
S
T
L
D
N
R
S
G
Site 3
T13
E
T
N
R
P
F
S
T
L
D
N
R
S
G
Q
Site 4
S18
F
S
T
L
D
N
R
S
G
Q
V
Q
V
L
S
Site 5
T27
Q
V
Q
V
L
S
A
T
P
L
L
Q
R
N
P
Site 6
Y35
P
L
L
Q
R
N
P
Y
S
S
P
D
I
M
H
Site 7
S36
L
L
Q
R
N
P
Y
S
S
P
D
I
M
H
I
Site 8
S37
L
Q
R
N
P
Y
S
S
P
D
I
M
H
I
K
Site 9
S46
D
I
M
H
I
K
G
S
E
A
S
S
V
P
Y
Site 10
S50
I
K
G
S
E
A
S
S
V
P
Y
A
L
N
Q
Site 11
Y53
S
E
A
S
S
V
P
Y
A
L
N
Q
G
T
T
Site 12
T82
L
L
N
M
L
R
K
T
L
K
E
S
D
S
E
Site 13
S86
L
R
K
T
L
K
E
S
D
S
E
E
L
E
I
Site 14
S88
K
T
L
K
E
S
D
S
E
E
L
E
I
T
Q
Site 15
T94
D
S
E
E
L
E
I
T
Q
E
T
P
N
L
V
Site 16
T97
E
L
E
I
T
Q
E
T
P
N
L
V
P
F
G
Site 17
Y129
P
K
I
S
L
Q
H
Y
A
N
L
F
I
R
I
Site 18
S149
V
K
C
T
K
M
C
S
L
L
S
K
N
D
E
Site 19
S152
T
K
M
C
S
L
L
S
K
N
D
E
K
N
T
Site 20
Y168
I
K
F
D
E
V
K
Y
F
S
V
Q
V
P
R
Site 21
Y177
S
V
Q
V
P
R
R
Y
D
D
K
R
N
N
I
Site 22
Y191
I
L
L
E
L
I
Q
Y
D
N
R
E
K
R
A
Site 23
S249
G
N
F
G
Y
G
F
S
H
Q
L
K
P
L
Q
Site 24
T278
P
E
R
T
D
P
V
T
K
V
I
T
P
Q
T
Site 25
T282
D
P
V
T
K
V
I
T
P
Q
T
V
E
Y
P
Site 26
Y288
I
T
P
Q
T
V
E
Y
P
A
F
L
S
P
D
Site 27
T302
D
L
N
V
T
V
G
T
P
A
V
Q
S
S
N
Site 28
S308
G
T
P
A
V
Q
S
S
N
Q
P
S
V
V
R
Site 29
S312
V
Q
S
S
N
Q
P
S
V
V
R
L
E
K
L
Site 30
T339
K
E
Y
R
N
L
N
T
W
I
D
K
A
N
Y
Site 31
Y346
T
W
I
D
K
A
N
Y
L
E
S
I
L
M
P
Site 32
S349
D
K
A
N
Y
L
E
S
I
L
M
P
K
L
E
Site 33
S360
P
K
L
E
H
K
D
S
E
E
T
N
I
D
E
Site 34
S369
E
T
N
I
D
E
A
S
E
N
T
K
S
N
H
Site 35
S374
E
A
S
E
N
T
K
S
N
H
P
E
E
E
L
Site 36
T398
L
V
N
E
E
A
E
T
T
A
N
E
L
L
D
Site 37
T399
V
N
E
E
A
E
T
T
A
N
E
L
L
D
N
Site 38
S408
N
E
L
L
D
N
D
S
E
K
G
L
T
I
P
Site 39
T413
N
D
S
E
K
G
L
T
I
P
T
L
N
Q
S
Site 40
T416
E
K
G
L
T
I
P
T
L
N
Q
S
D
Q
D
Site 41
S420
T
I
P
T
L
N
Q
S
D
Q
D
N
S
T
A
Site 42
T426
Q
S
D
Q
D
N
S
T
A
D
A
S
K
N
D
Site 43
S430
D
N
S
T
A
D
A
S
K
N
D
E
S
T
P
Site 44
S435
D
A
S
K
N
D
E
S
T
P
S
P
T
E
V
Site 45
T436
A
S
K
N
D
E
S
T
P
S
P
T
E
V
H
Site 46
S438
K
N
D
E
S
T
P
S
P
T
E
V
H
S
L
Site 47
T440
D
E
S
T
P
S
P
T
E
V
H
S
L
C
T
Site 48
S444
P
S
P
T
E
V
H
S
L
C
T
I
S
N
Q
Site 49
T453
C
T
I
S
N
Q
E
T
I
K
A
G
R
I
P
Site 50
S467
P
P
L
G
E
R
Q
S
E
S
M
P
D
R
K
Site 51
S469
L
G
E
R
Q
S
E
S
M
P
D
R
K
M
K
Site 52
Y490
E
V
K
L
K
D
N
Y
P
S
I
L
K
A
D
Site 53
S501
L
K
A
D
S
S
L
S
E
V
A
F
S
P
K
Site 54
S506
S
L
S
E
V
A
F
S
P
K
E
Y
N
S
P
Site 55
Y510
V
A
F
S
P
K
E
Y
N
S
P
S
F
R
P
Site 56
S512
F
S
P
K
E
Y
N
S
P
S
F
R
P
E
Y
Site 57
S514
P
K
E
Y
N
S
P
S
F
R
P
E
Y
I
E
Site 58
Y519
S
P
S
F
R
P
E
Y
I
E
F
K
P
K
F
Site 59
S530
K
P
K
F
Q
D
C
S
D
K
F
E
D
L
H
Site 60
T540
F
E
D
L
H
D
M
T
S
F
T
H
L
K
K
Site 61
S541
E
D
L
H
D
M
T
S
F
T
H
L
K
K
V
Site 62
S550
T
H
L
K
K
V
K
S
R
S
R
L
L
G
K
Site 63
S552
L
K
K
V
K
S
R
S
R
L
L
G
K
S
S
Site 64
S558
R
S
R
L
L
G
K
S
S
D
D
I
H
N
H
Site 65
S559
S
R
L
L
G
K
S
S
D
D
I
H
N
H
A
Site 66
S569
I
H
N
H
A
R
H
S
A
R
P
Y
T
A
P
Site 67
Y573
A
R
H
S
A
R
P
Y
T
A
P
E
V
N
K
Site 68
T574
R
H
S
A
R
P
Y
T
A
P
E
V
N
K
Q
Site 69
S584
E
V
N
K
Q
R
E
S
Y
S
G
K
F
T
S
Site 70
Y585
V
N
K
Q
R
E
S
Y
S
G
K
F
T
S
R
Site 71
S586
N
K
Q
R
E
S
Y
S
G
K
F
T
S
R
R
Site 72
T590
E
S
Y
S
G
K
F
T
S
R
R
M
V
S
S
Site 73
S591
S
Y
S
G
K
F
T
S
R
R
M
V
S
S
G
Site 74
S596
F
T
S
R
R
M
V
S
S
G
L
V
H
I
N
Site 75
S597
T
S
R
R
M
V
S
S
G
L
V
H
I
N
D
Site 76
T606
L
V
H
I
N
D
K
T
S
D
Y
E
M
H
K
Site 77
Y609
I
N
D
K
T
S
D
Y
E
M
H
K
M
R
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation