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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FLJ21901
Full Name:
FAST kinase domain-containing protein 1
Alias:
FAKD1; FLJ23722
Type:
Apoptosis protein
Mass (Da):
97411
Number AA:
847
UniProt ID:
Q53R41
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S64
E
R
N
K
A
I
L
S
E
K
Q
V
G
C
A
Site 2
T83
W
K
L
Q
K
Q
K
T
S
L
L
K
N
A
E
Site 3
Y91
S
L
L
K
N
A
E
Y
V
R
D
H
P
Q
F
Site 4
T100
R
D
H
P
Q
F
L
T
L
H
N
L
A
T
N
Site 5
Y122
D
T
L
V
N
V
L
Y
V
T
Q
Q
F
A
G
Site 6
T124
L
V
N
V
L
Y
V
T
Q
Q
F
A
G
E
A
Site 7
S160
K
L
L
S
E
F
S
S
C
L
A
D
Q
H
L
Site 8
T187
V
H
R
N
L
E
T
T
Q
D
L
S
S
L
S
Site 9
S205
V
N
I
S
S
L
I
S
R
H
F
Q
Q
Q
L
Site 10
T222
K
T
E
L
L
F
D
T
I
D
S
S
E
V
N
Site 11
S233
S
E
V
N
V
A
K
S
I
A
K
F
L
R
N
Site 12
Y245
L
R
N
V
R
Y
R
Y
Q
P
L
L
E
R
C
Site 13
S269
H
L
D
L
D
S
I
S
K
I
L
S
V
Y
K
Site 14
S327
E
E
K
K
Q
L
K
S
T
M
L
L
M
S
E
Site 15
S353
G
A
M
G
D
M
E
S
R
N
S
C
L
I
K
Site 16
S356
G
D
M
E
S
R
N
S
C
L
I
K
R
V
T
Site 17
Y373
L
H
K
H
L
D
G
Y
K
P
L
E
L
L
K
Site 18
T386
L
K
I
T
Q
E
L
T
F
L
H
F
Q
R
K
Site 19
S428
R
A
I
S
L
L
P
S
P
H
L
D
E
V
G
Site 20
T456
N
N
L
S
S
F
A
T
S
V
L
R
W
I
Q
Site 21
S457
N
L
S
S
F
A
T
S
V
L
R
W
I
Q
H
Site 22
Y486
L
L
Q
K
L
D
H
Y
G
R
Q
R
L
Q
H
Site 23
S496
Q
R
L
Q
H
S
N
S
L
D
L
L
R
K
E
Site 24
S506
L
L
R
K
E
L
K
S
L
K
G
N
T
F
P
Site 25
T511
L
K
S
L
K
G
N
T
F
P
E
S
L
L
E
Site 26
S515
K
G
N
T
F
P
E
S
L
L
E
E
M
I
A
Site 27
Y585
R
P
F
S
V
L
N
Y
D
P
P
Q
R
D
E
Site 28
T596
Q
R
D
E
F
L
G
T
C
V
Q
H
L
N
S
Site 29
S651
D
S
Q
L
E
I
L
S
P
S
R
S
A
R
V
Site 30
S653
Q
L
E
I
L
S
P
S
R
S
A
R
V
Q
F
Site 31
S655
E
I
L
S
P
S
R
S
A
R
V
Q
F
H
L
Site 32
S668
H
L
M
E
L
N
R
S
V
C
L
E
C
P
E
Site 33
Y689
H
D
R
F
C
Q
Q
Y
N
K
G
I
G
G
M
Site 34
T699
G
I
G
G
M
D
G
T
Q
Q
Q
I
F
K
M
Site 35
T723
C
V
K
A
S
V
L
T
P
Y
Y
H
K
V
D
Site 36
Y725
K
A
S
V
L
T
P
Y
Y
H
K
V
D
F
E
Site 37
Y726
A
S
V
L
T
P
Y
Y
H
K
V
D
F
E
C
Site 38
S768
S
N
I
E
I
V
G
S
R
L
P
P
G
A
E
Site 39
S798
I
P
H
M
K
G
K
S
A
M
K
K
R
H
L
Site 40
Y810
R
H
L
E
I
L
G
Y
R
V
I
Q
I
S
Q
Site 41
S822
I
S
Q
F
E
W
N
S
M
A
L
S
T
K
D
Site 42
S826
E
W
N
S
M
A
L
S
T
K
D
A
R
M
D
Site 43
Y834
T
K
D
A
R
M
D
Y
L
R
E
C
I
F
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation