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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SETMAR
Full Name:
Histone-lysine N-methyltransferase SETMAR
Alias:
Hsmar1; Metnase; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion gene-containing protein
Type:
Methyltransferase; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation
Mass (Da):
76669
Number AA:
671
UniProt ID:
Q53H47
International Prot ID:
IPI00171821
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T41
A
P
A
P
F
Q
Y
T
P
D
H
V
V
G
P
Site 2
T55
P
G
A
D
I
D
P
T
Q
I
T
F
P
G
C
Site 3
T73
K
T
P
C
L
P
G
T
C
S
C
L
R
H
G
Site 4
Y83
C
L
R
H
G
E
N
Y
D
D
N
S
C
L
R
Site 5
S87
G
E
N
Y
D
D
N
S
C
L
R
D
I
G
S
Site 6
S94
S
C
L
R
D
I
G
S
G
G
K
Y
A
E
P
Site 7
Y98
D
I
G
S
G
G
K
Y
A
E
P
V
F
E
C
Site 8
T142
K
K
G
W
G
L
R
T
L
E
F
I
P
K
G
Site 9
T173
Q
R
R
I
H
L
Q
T
K
S
D
S
N
Y
I
Site 10
S175
R
I
H
L
Q
T
K
S
D
S
N
Y
I
I
A
Site 11
Y179
Q
T
K
S
D
S
N
Y
I
I
A
I
R
E
H
Site 12
T200
M
E
T
F
V
D
P
T
Y
I
G
N
I
G
R
Site 13
Y201
E
T
F
V
D
P
T
Y
I
G
N
I
G
R
F
Site 14
S212
I
G
R
F
L
N
H
S
C
E
P
N
L
L
M
Site 15
S246
I
V
P
E
E
E
L
S
Y
D
Y
S
G
R
Y
Site 16
Y247
V
P
E
E
E
L
S
Y
D
Y
S
G
R
Y
L
Site 17
Y249
E
E
E
L
S
Y
D
Y
S
G
R
Y
L
N
L
Site 18
S250
E
E
L
S
Y
D
Y
S
G
R
Y
L
N
L
T
Site 19
Y253
S
Y
D
Y
S
G
R
Y
L
N
L
T
V
S
E
Site 20
T257
S
G
R
Y
L
N
L
T
V
S
E
D
K
E
R
Site 21
S259
R
Y
L
N
L
T
V
S
E
D
K
E
R
L
D
Site 22
Y275
G
K
L
R
K
P
C
Y
C
G
A
K
S
C
T
Site 23
Y292
L
P
F
D
S
S
L
Y
C
P
V
E
K
S
N
Site 24
S309
C
G
N
E
K
E
P
S
M
C
G
S
A
P
S
Site 25
S313
K
E
P
S
M
C
G
S
A
P
S
V
F
P
S
Site 26
S316
S
M
C
G
S
A
P
S
V
F
P
S
C
K
R
Site 27
S320
S
A
P
S
V
F
P
S
C
K
R
L
T
L
E
Site 28
T325
F
P
S
C
K
R
L
T
L
E
T
M
K
M
M
Site 29
T328
C
K
R
L
T
L
E
T
M
K
M
M
L
D
K
Site 30
T355
M
G
R
K
A
A
E
T
T
R
N
I
N
N
A
Site 31
S386
K
F
C
K
G
D
E
S
L
E
D
E
E
R
S
Site 32
S393
S
L
E
D
E
E
R
S
G
R
P
S
E
V
D
Site 33
S397
E
E
R
S
G
R
P
S
E
V
D
N
D
Q
L
Site 34
T414
I
I
E
A
D
P
L
T
T
T
R
E
V
A
E
Site 35
T429
E
L
N
V
N
H
S
T
V
V
R
H
L
K
Q
Site 36
S463
K
N
R
R
F
E
V
S
S
S
L
I
L
R
N
Site 37
S464
N
R
R
F
E
V
S
S
S
L
I
L
R
N
H
Site 38
S465
R
R
F
E
V
S
S
S
L
I
L
R
N
H
N
Site 39
Y489
C
D
E
K
W
I
L
Y
D
N
R
R
R
S
A
Site 40
S495
L
Y
D
N
R
R
R
S
A
Q
W
L
D
Q
E
Site 41
S543
N
P
G
E
T
I
T
S
E
K
Y
A
Q
E
I
Site 42
Y602
E
V
L
P
H
P
P
Y
S
P
D
L
L
P
T
Site 43
S603
V
L
P
H
P
P
Y
S
P
D
L
L
P
T
N
Site 44
Y611
P
D
L
L
P
T
N
Y
H
V
F
K
H
L
N
Site 45
S642
A
F
Q
E
F
V
E
S
Q
S
T
D
F
Y
A
Site 46
T645
E
F
V
E
S
Q
S
T
D
F
Y
A
T
G
I
Site 47
Y648
E
S
Q
S
T
D
F
Y
A
T
G
I
N
Q
L
Site 48
S657
T
G
I
N
Q
L
I
S
R
W
Q
K
C
V
D
Site 49
Y669
C
V
D
C
N
G
S
Y
F
D
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation