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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHO1
Full Name:
Pleckstrin homology domain-containing family O member 1
Alias:
Casein kinase 2-interacting protein 1; C-Jun-binding protein; CK2 interacting protein 1; CKIP-1; HQ0024c; JBP; OC120; PKHO1; Pleckstrin homology domain containing, O1
Type:
Mass (Da):
46237
Number AA:
409
UniProt ID:
Q53GL0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0045786
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
M
K
K
N
N
S
A
K
R
G
P
Q
D
Site 2
Y45
R
E
I
W
K
N
R
Y
V
V
L
K
G
D
Q
Site 3
Y54
V
L
K
G
D
Q
L
Y
I
S
E
K
E
V
K
Site 4
S56
K
G
D
Q
L
Y
I
S
E
K
E
V
K
D
E
Site 5
S73
I
Q
E
V
F
D
L
S
D
Y
E
K
C
E
E
Site 6
Y75
E
V
F
D
L
S
D
Y
E
K
C
E
E
L
R
Site 7
S84
K
C
E
E
L
R
K
S
K
S
R
S
K
K
N
Site 8
S86
E
E
L
R
K
S
K
S
R
S
K
K
N
H
S
Site 9
S88
L
R
K
S
K
S
R
S
K
K
N
H
S
K
F
Site 10
S93
S
R
S
K
K
N
H
S
K
F
T
L
A
H
S
Site 11
T96
K
K
N
H
S
K
F
T
L
A
H
S
K
Q
P
Site 12
S116
N
L
I
F
L
A
V
S
P
E
E
K
E
S
W
Site 13
S122
V
S
P
E
E
K
E
S
W
I
N
A
L
N
S
Site 14
T143
N
R
I
L
D
E
V
T
V
E
E
D
S
Y
L
Site 15
Y149
V
T
V
E
E
D
S
Y
L
A
H
P
T
R
D
Site 16
S163
D
R
A
K
I
Q
H
S
R
R
P
P
T
R
G
Site 17
T168
Q
H
S
R
R
P
P
T
R
G
H
L
M
A
V
Site 18
T186
S
T
S
D
G
M
L
T
L
D
L
I
Q
E
E
Site 19
S196
L
I
Q
E
E
D
P
S
P
E
E
P
T
S
C
Site 20
S202
P
S
P
E
E
P
T
S
C
A
E
S
F
R
V
Site 21
S206
E
P
T
S
C
A
E
S
F
R
V
D
L
D
K
Site 22
S214
F
R
V
D
L
D
K
S
V
A
Q
L
A
G
S
Site 23
S221
S
V
A
Q
L
A
G
S
R
R
R
A
D
S
D
Site 24
S227
G
S
R
R
R
A
D
S
D
R
I
Q
P
S
A
Site 25
S233
D
S
D
R
I
Q
P
S
A
D
R
A
S
S
L
Site 26
S238
Q
P
S
A
D
R
A
S
S
L
S
R
P
W
E
Site 27
S239
P
S
A
D
R
A
S
S
L
S
R
P
W
E
K
Site 28
S241
A
D
R
A
S
S
L
S
R
P
W
E
K
T
D
Site 29
T247
L
S
R
P
W
E
K
T
D
K
G
A
T
Y
T
Site 30
Y253
K
T
D
K
G
A
T
Y
T
P
Q
A
P
K
K
Site 31
T254
T
D
K
G
A
T
Y
T
P
Q
A
P
K
K
L
Site 32
T262
P
Q
A
P
K
K
L
T
P
T
E
K
G
R
C
Site 33
T264
A
P
K
K
L
T
P
T
E
K
G
R
C
A
S
Site 34
S271
T
E
K
G
R
C
A
S
L
E
E
I
L
S
Q
Site 35
S277
A
S
L
E
E
I
L
S
Q
R
D
A
A
S
A
Site 36
S283
L
S
Q
R
D
A
A
S
A
R
T
L
Q
L
R
Site 37
T296
L
R
A
E
E
P
P
T
P
A
L
P
N
P
G
Site 38
T319
V
A
R
K
L
E
E
T
Q
E
L
L
A
E
V
Site 39
S342
K
A
K
D
P
P
R
S
P
P
D
S
E
S
E
Site 40
S346
P
P
R
S
P
P
D
S
E
S
E
Q
L
L
L
Site 41
S348
R
S
P
P
D
S
E
S
E
Q
L
L
L
E
T
Site 42
T355
S
E
Q
L
L
L
E
T
E
R
L
L
G
E
A
Site 43
S363
E
R
L
L
G
E
A
S
S
N
W
S
Q
A
K
Site 44
S364
R
L
L
G
E
A
S
S
N
W
S
Q
A
K
R
Site 45
S367
G
E
A
S
S
N
W
S
Q
A
K
R
V
L
Q
Site 46
Y383
V
R
E
L
R
D
L
Y
R
Q
M
D
L
Q
T
Site 47
T390
Y
R
Q
M
D
L
Q
T
P
D
S
H
L
R
Q
Site 48
S393
M
D
L
Q
T
P
D
S
H
L
R
Q
T
T
P
Site 49
T398
P
D
S
H
L
R
Q
T
T
P
H
S
Q
Y
R
Site 50
T399
D
S
H
L
R
Q
T
T
P
H
S
Q
Y
R
K
Site 51
S402
L
R
Q
T
T
P
H
S
Q
Y
R
K
S
L
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation