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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VWA3B
Full Name:
von Willebrand factor A domain-containing protein 3B
Alias:
Type:
Mass (Da):
145748
Number AA:
1294
UniProt ID:
Q502W6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
K
S
G
P
S
S
T
I
S
E
Q
Q
L
Site 2
S11
S
G
P
S
S
T
I
S
E
Q
Q
L
Q
R
Q
Site 3
T26
E
G
W
I
N
T
K
T
D
L
A
E
Q
S
L
Site 4
S32
K
T
D
L
A
E
Q
S
L
I
S
S
E
K
W
Site 5
S36
A
E
Q
S
L
I
S
S
E
K
W
L
Q
L
H
Site 6
S47
L
Q
L
H
G
L
K
S
N
K
L
T
L
K
Q
Site 7
T51
G
L
K
S
N
K
L
T
L
K
Q
I
L
S
Q
Site 8
Y67
G
F
P
H
C
E
D
Y
V
A
S
L
G
R
P
Site 9
Y88
D
G
L
F
P
Q
L
Y
R
A
E
D
G
R
V
Site 10
Y96
R
A
E
D
G
R
V
Y
N
L
T
A
K
S
E
Site 11
T99
D
G
R
V
Y
N
L
T
A
K
S
E
L
I
Y
Site 12
S102
V
Y
N
L
T
A
K
S
E
L
I
Y
Q
F
V
Site 13
Y106
T
A
K
S
E
L
I
Y
Q
F
V
E
H
L
T
Site 14
T113
Y
Q
F
V
E
H
L
T
Q
A
V
E
S
Y
K
Site 15
T127
K
Q
R
M
D
W
L
T
S
K
S
R
Q
I
F
Site 16
S183
E
F
N
I
I
R
V
S
Q
E
P
V
K
W
Q
Site 17
T194
V
K
W
Q
E
N
A
T
P
V
T
E
Q
S
I
Site 18
T216
E
K
L
T
V
E
L
T
V
S
E
A
G
R
L
Site 19
T234
L
E
A
G
R
D
K
T
I
E
S
I
Y
Y
F
Site 20
S269
P
C
P
V
Y
T
V
S
F
N
A
R
G
E
G
Site 21
S285
I
A
F
L
K
D
L
S
A
K
T
H
S
R
F
Site 22
T288
L
K
D
L
S
A
K
T
H
S
R
F
H
A
F
Site 23
T350
E
M
E
E
A
C
S
T
L
A
Q
I
Q
R
L
Site 24
T368
P
P
K
P
D
V
A
T
V
D
C
E
S
E
T
Site 25
S377
D
C
E
S
E
T
T
S
V
E
I
A
S
N
P
Site 26
T387
I
A
S
N
P
E
D
T
W
D
S
K
T
W
L
Site 27
T392
E
D
T
W
D
S
K
T
W
L
Q
K
Y
G
L
Site 28
Y397
S
K
T
W
L
Q
K
Y
G
L
K
A
Q
K
L
Site 29
Y407
K
A
Q
K
L
S
L
Y
D
V
L
A
D
C
S
Site 30
S436
E
N
E
S
V
Q
T
S
A
E
T
N
K
K
T
Site 31
T443
S
A
E
T
N
K
K
T
V
H
A
K
Y
C
S
Site 32
Y448
K
K
T
V
H
A
K
Y
C
S
R
F
V
H
A
Site 33
T481
W
Y
S
E
R
I
H
T
A
L
A
R
I
R
R
Site 34
S497
I
K
W
L
Q
D
G
S
Q
S
L
F
G
R
L
Site 35
S499
W
L
Q
D
G
S
Q
S
L
F
G
R
L
H
N
Site 36
Y510
R
L
H
N
D
C
I
Y
I
L
I
D
T
S
H
Site 37
Y540
F
I
Q
E
Q
L
K
Y
K
S
K
F
N
F
V
Site 38
S583
R
D
I
K
I
G
S
S
T
N
T
L
S
A
L
Site 39
T584
D
I
K
I
G
S
S
T
N
T
L
S
A
L
K
Site 40
T586
K
I
G
S
S
T
N
T
L
S
A
L
K
T
A
Site 41
T592
N
T
L
S
A
L
K
T
A
F
A
D
K
E
T
Site 42
Y603
D
K
E
T
Q
A
I
Y
L
L
T
D
G
R
P
Site 43
T606
T
Q
A
I
Y
L
L
T
D
G
R
P
D
Q
P
Site 44
T616
R
P
D
Q
P
P
E
T
V
I
D
Q
V
K
R
Site 45
Y630
R
F
Q
E
I
P
I
Y
T
I
S
F
N
Y
N
Site 46
Y659
T
G
G
E
F
H
F
Y
N
F
G
C
K
D
P
Site 47
T667
N
F
G
C
K
D
P
T
P
P
E
A
V
Q
N
Site 48
T678
A
V
Q
N
E
D
V
T
L
L
V
K
E
M
E
Site 49
S689
K
E
M
E
Q
G
H
S
D
L
E
K
M
Q
D
Site 50
Y698
L
E
K
M
Q
D
L
Y
S
E
S
L
I
M
D
Site 51
S716
N
A
E
K
D
G
D
S
K
H
Q
K
E
I
C
Site 52
S724
K
H
Q
K
E
I
C
S
M
I
S
T
P
E
K
Site 53
T728
E
I
C
S
M
I
S
T
P
E
K
C
A
K
P
Site 54
S737
E
K
C
A
K
P
Q
S
D
V
D
S
T
Q
T
Site 55
S741
K
P
Q
S
D
V
D
S
T
Q
T
S
S
L
N
Site 56
T742
P
Q
S
D
V
D
S
T
Q
T
S
S
L
N
M
Site 57
S745
D
V
D
S
T
Q
T
S
S
L
N
M
L
K
G
Site 58
S746
V
D
S
T
Q
T
S
S
L
N
M
L
K
G
P
Site 59
S757
L
K
G
P
W
G
L
S
D
Q
K
V
Q
K
K
Site 60
S771
K
K
V
L
H
A
E
S
T
K
T
S
L
L
R
Site 61
T772
K
V
L
H
A
E
S
T
K
T
S
L
L
R
S
Site 62
T774
L
H
A
E
S
T
K
T
S
L
L
R
S
Q
M
Site 63
S775
H
A
E
S
T
K
T
S
L
L
R
S
Q
M
S
Site 64
S779
T
K
T
S
L
L
R
S
Q
M
S
S
L
R
S
Site 65
S782
S
L
L
R
S
Q
M
S
S
L
R
S
S
A
C
Site 66
S783
L
L
R
S
Q
M
S
S
L
R
S
S
A
C
S
Site 67
S786
S
Q
M
S
S
L
R
S
S
A
C
S
E
R
K
Site 68
S787
Q
M
S
S
L
R
S
S
A
C
S
E
R
K
D
Site 69
S790
S
L
R
S
S
A
C
S
E
R
K
D
G
L
S
Site 70
S797
S
E
R
K
D
G
L
S
N
A
S
S
R
R
T
Site 71
S800
K
D
G
L
S
N
A
S
S
R
R
T
A
L
S
Site 72
S801
D
G
L
S
N
A
S
S
R
R
T
A
L
S
D
Site 73
T804
S
N
A
S
S
R
R
T
A
L
S
D
K
E
M
Site 74
S807
S
S
R
R
T
A
L
S
D
K
E
M
S
I
L
Site 75
S824
E
E
W
L
D
D
K
S
S
E
K
V
T
R
E
Site 76
S825
E
W
L
D
D
K
S
S
E
K
V
T
R
E
G
Site 77
T829
D
K
S
S
E
K
V
T
R
E
G
S
Q
V
Y
Site 78
S833
E
K
V
T
R
E
G
S
Q
V
Y
D
H
D
S
Site 79
Y836
T
R
E
G
S
Q
V
Y
D
H
D
S
S
D
V
Site 80
S840
S
Q
V
Y
D
H
D
S
S
D
V
S
S
E
N
Site 81
S841
Q
V
Y
D
H
D
S
S
D
V
S
S
E
N
W
Site 82
S844
D
H
D
S
S
D
V
S
S
E
N
W
L
K
T
Site 83
S845
H
D
S
S
D
V
S
S
E
N
W
L
K
T
Y
Site 84
Y876
A
V
P
H
S
S
T
Y
V
P
V
L
D
K
H
Site 85
Y918
Q
G
A
K
L
N
I
Y
K
R
K
V
E
Q
A
Site 86
S942
K
I
V
W
R
A
L
S
Q
E
E
K
E
K
L
Site 87
T962
I
Q
Y
L
E
N
K
T
V
L
N
Q
A
L
E
Site 88
S976
E
R
L
N
W
P
I
S
L
K
E
L
S
M
L
Site 89
S985
K
E
L
S
M
L
E
S
E
I
L
A
G
K
M
Site 90
T1024
Q
K
L
Q
G
N
P
T
K
K
T
K
S
K
R
Site 91
T1027
Q
G
N
P
T
K
K
T
K
S
K
R
P
D
P
Site 92
S1029
N
P
T
K
K
T
K
S
K
R
P
D
P
L
K
Site 93
Y1050
R
C
D
E
N
G
F
Y
F
P
G
V
V
K
K
Site 94
Y1131
H
V
A
T
E
K
F
Y
T
V
L
K
C
N
N
Site 95
T1132
V
A
T
E
K
F
Y
T
V
L
K
C
N
N
R
Site 96
S1146
R
R
E
F
C
P
R
S
A
L
I
K
I
S
Q
Site 97
S1152
R
S
A
L
I
K
I
S
Q
N
K
Y
A
L
S
Site 98
Y1156
I
K
I
S
Q
N
K
Y
A
L
S
C
S
H
I
Site 99
S1159
S
Q
N
K
Y
A
L
S
C
S
H
I
K
S
P
Site 100
S1161
N
K
Y
A
L
S
C
S
H
I
K
S
P
P
I
Site 101
S1165
L
S
C
S
H
I
K
S
P
P
I
P
E
D
P
Site 102
S1182
E
D
V
E
A
R
N
S
A
F
L
F
W
P
L
Site 103
T1194
W
P
L
K
E
A
D
T
Q
D
S
R
E
P
R
Site 104
S1197
K
E
A
D
T
Q
D
S
R
E
P
R
R
E
K
Site 105
S1222
P
L
Q
Q
A
A
P
S
D
S
D
G
S
S
H
Site 106
S1224
Q
Q
A
A
P
S
D
S
D
G
S
S
H
G
I
Site 107
S1227
A
P
S
D
S
D
G
S
S
H
G
I
S
S
H
Site 108
S1228
P
S
D
S
D
G
S
S
H
G
I
S
S
H
G
Site 109
S1232
D
G
S
S
H
G
I
S
S
H
G
S
C
Q
G
Site 110
S1233
G
S
S
H
G
I
S
S
H
G
S
C
Q
G
T
Site 111
S1236
H
G
I
S
S
H
G
S
C
Q
G
T
H
P
E
Site 112
T1240
S
H
G
S
C
Q
G
T
H
P
E
P
K
T
A
Site 113
T1246
G
T
H
P
E
P
K
T
A
H
L
H
F
P
A
Site 114
T1277
P
R
A
A
L
P
C
T
L
Q
A
T
H
S
S
Site 115
T1281
L
P
C
T
L
Q
A
T
H
S
S
K
G
L
R
Site 116
S1283
C
T
L
Q
A
T
H
S
S
K
G
L
R
S
V
Site 117
S1289
H
S
S
K
G
L
R
S
V
P
E
T
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation