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Updated November 2019
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Protein Info
Short Name:
ARID4B
Full Name:
AT-rich interactive domain-containing protein 4B
Alias:
ARI4B; AT rich interactive domain 4B; BCAA; BRCAA1; Breast cancer-associated antigen BRCAA1; RBBP1L1; RBP1L1; RBP1-like; RBP1-like protein; Retinoblastoma-binding protein 1-like 1; SAP180; SIN3A-associated protein 180
Type:
Intracellular, Chromatin, Cytoplasm, Nucleus protein
Mass (Da):
147809
Number AA:
1312
UniProt ID:
Q4LE39
International Prot ID:
IPI00302917
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
K
A
L
D
E
P
P
Y
L
T
V
G
T
D
V
Site 2
T11
L
D
E
P
P
Y
L
T
V
G
T
D
V
S
A
Site 3
Y20
G
T
D
V
S
A
K
Y
R
G
A
F
C
E
A
Site 4
T41
R
L
V
K
V
K
V
T
F
R
H
D
S
S
T
Site 5
S46
K
V
T
F
R
H
D
S
S
T
V
E
V
Q
D
Site 6
T48
T
F
R
H
D
S
S
T
V
E
V
Q
D
D
H
Site 7
Y75
V
K
N
L
D
G
A
Y
Q
E
A
V
I
N
K
Site 8
Y89
K
L
T
D
A
S
W
Y
T
V
V
F
D
D
G
Site 9
T90
L
T
D
A
S
W
Y
T
V
V
F
D
D
G
D
Site 10
T100
F
D
D
G
D
E
K
T
L
R
R
S
S
L
C
Site 11
S104
D
E
K
T
L
R
R
S
S
L
C
L
K
G
E
Site 12
S105
E
K
T
L
R
R
S
S
L
C
L
K
G
E
R
Site 13
S117
G
E
R
H
F
A
E
S
E
T
L
D
Q
L
P
Site 14
T126
T
L
D
Q
L
P
L
T
N
P
E
H
F
G
T
Site 15
T133
T
N
P
E
H
F
G
T
P
V
I
G
K
K
T
Site 16
T140
T
P
V
I
G
K
K
T
N
R
G
R
R
S
N
Site 17
S146
K
T
N
R
G
R
R
S
N
H
I
P
E
E
E
Site 18
S154
N
H
I
P
E
E
E
S
S
S
S
S
S
D
E
Site 19
S155
H
I
P
E
E
E
S
S
S
S
S
S
D
E
D
Site 20
S156
I
P
E
E
E
S
S
S
S
S
S
D
E
D
E
Site 21
S157
P
E
E
E
S
S
S
S
S
S
D
E
D
E
D
Site 22
S158
E
E
E
S
S
S
S
S
S
D
E
D
E
D
D
Site 23
S159
E
E
S
S
S
S
S
S
D
E
D
E
D
D
R
Site 24
Y181
G
K
V
V
C
V
D
Y
I
S
L
D
K
K
K
Site 25
S216
K
D
N
I
L
V
R
S
F
K
D
G
K
F
T
Site 26
S224
F
K
D
G
K
F
T
S
V
P
R
K
D
V
H
Site 27
T267
T
I
P
A
N
W
K
T
E
L
K
E
D
S
S
Site 28
S273
K
T
E
L
K
E
D
S
S
S
S
E
A
E
E
Site 29
S274
T
E
L
K
E
D
S
S
S
S
E
A
E
E
E
Site 30
S275
E
L
K
E
D
S
S
S
S
E
A
E
E
E
E
Site 31
S276
L
K
E
D
S
S
S
S
E
A
E
E
E
E
E
Site 32
S295
E
K
E
K
E
D
N
S
S
E
E
E
E
E
I
Site 33
S296
K
E
K
E
D
N
S
S
E
E
E
E
E
I
E
Site 34
Y317
E
N
F
L
Q
Q
L
Y
K
F
M
E
D
R
G
Site 35
T325
K
F
M
E
D
R
G
T
P
I
N
K
R
P
V
Site 36
Y335
N
K
R
P
V
L
G
Y
R
N
L
N
L
F
K
Site 37
Y389
V
K
C
A
Y
K
K
Y
L
Y
G
F
E
E
Y
Site 38
Y391
C
A
Y
K
K
Y
L
Y
G
F
E
E
Y
C
R
Site 39
Y396
Y
L
Y
G
F
E
E
Y
C
R
S
A
N
I
E
Site 40
T434
K
V
K
E
E
N
E
T
E
I
K
E
I
K
M
Site 41
S468
R
K
E
N
I
K
P
S
L
G
S
K
K
N
L
Site 42
S478
S
K
K
N
L
L
E
S
I
P
T
H
S
D
Q
Site 43
T481
N
L
L
E
S
I
P
T
H
S
D
Q
E
K
E
Site 44
S483
L
E
S
I
P
T
H
S
D
Q
E
K
E
V
N
Site 45
T507
L
D
D
K
D
D
D
T
T
R
V
D
E
S
L
Site 46
T508
D
D
K
D
D
D
T
T
R
V
D
E
S
L
N
Site 47
S513
D
T
T
R
V
D
E
S
L
N
I
K
V
E
A
Site 48
S527
A
E
E
E
K
A
K
S
G
D
E
T
N
K
E
Site 49
T531
K
A
K
S
G
D
E
T
N
K
E
E
D
E
D
Site 50
Y569
E
E
E
E
F
E
C
Y
P
P
G
M
K
V
Q
Site 51
Y579
G
M
K
V
Q
V
R
Y
G
R
G
K
N
Q
K
Site 52
Y588
R
G
K
N
Q
K
M
Y
E
A
S
I
K
D
S
Site 53
S591
N
Q
K
M
Y
E
A
S
I
K
D
S
D
V
E
Site 54
S595
Y
E
A
S
I
K
D
S
D
V
E
G
G
E
V
Site 55
Y655
E
K
D
K
D
E
K
Y
S
P
K
N
C
K
L
Site 56
S656
K
D
K
D
E
K
Y
S
P
K
N
C
K
L
R
Site 57
S666
N
C
K
L
R
R
L
S
K
P
P
F
Q
T
N
Site 58
S675
P
P
F
Q
T
N
P
S
P
E
M
V
S
K
L
Site 59
S680
N
P
S
P
E
M
V
S
K
L
D
L
T
D
A
Site 60
T685
M
V
S
K
L
D
L
T
D
A
K
N
S
D
T
Site 61
T692
T
D
A
K
N
S
D
T
A
H
I
K
S
I
E
Site 62
S710
I
L
N
G
L
Q
A
S
E
S
S
A
E
D
S
Site 63
S712
N
G
L
Q
A
S
E
S
S
A
E
D
S
E
Q
Site 64
S713
G
L
Q
A
S
E
S
S
A
E
D
S
E
Q
E
Site 65
S717
S
E
S
S
A
E
D
S
E
Q
E
D
E
R
G
Site 66
T742
E
S
K
I
D
H
L
T
N
N
R
N
D
L
I
Site 67
S750
N
N
R
N
D
L
I
S
K
E
E
Q
N
S
S
Site 68
S756
I
S
K
E
E
Q
N
S
S
S
L
L
E
E
N
Site 69
S757
S
K
E
E
Q
N
S
S
S
L
L
E
E
N
K
Site 70
S758
K
E
E
Q
N
S
S
S
L
L
E
E
N
K
V
Site 71
S772
V
H
A
D
L
V
I
S
K
P
V
S
K
S
P
Site 72
S776
L
V
I
S
K
P
V
S
K
S
P
E
R
L
R
Site 73
S778
I
S
K
P
V
S
K
S
P
E
R
L
R
K
D
Site 74
S790
R
K
D
I
E
V
L
S
E
D
T
D
Y
E
E
Site 75
T793
I
E
V
L
S
E
D
T
D
Y
E
E
D
E
V
Site 76
Y795
V
L
S
E
D
T
D
Y
E
E
D
E
V
T
K
Site 77
T801
D
Y
E
E
D
E
V
T
K
K
R
K
D
V
K
Site 78
T811
R
K
D
V
K
K
D
T
T
D
K
S
S
K
P
Site 79
T812
K
D
V
K
K
D
T
T
D
K
S
S
K
P
Q
Site 80
S815
K
K
D
T
T
D
K
S
S
K
P
Q
I
K
R
Site 81
Y827
I
K
R
G
K
R
R
Y
C
N
T
E
E
C
L
Site 82
T830
G
K
R
R
Y
C
N
T
E
E
C
L
K
T
G
Site 83
T836
N
T
E
E
C
L
K
T
G
S
P
G
K
K
E
Site 84
S838
E
E
C
L
K
T
G
S
P
G
K
K
E
E
K
Site 85
S851
E
K
A
K
N
K
E
S
L
C
M
E
N
S
S
Site 86
S857
E
S
L
C
M
E
N
S
S
N
S
S
S
D
E
Site 87
S858
S
L
C
M
E
N
S
S
N
S
S
S
D
E
D
Site 88
S862
E
N
S
S
N
S
S
S
D
E
D
E
E
E
T
Site 89
T874
E
E
T
K
A
K
M
T
P
T
K
K
Y
N
G
Site 90
S888
G
L
E
E
K
R
K
S
L
R
T
T
G
F
Y
Site 91
T891
E
K
R
K
S
L
R
T
T
G
F
Y
S
G
F
Site 92
T892
K
R
K
S
L
R
T
T
G
F
Y
S
G
F
S
Site 93
Y895
S
L
R
T
T
G
F
Y
S
G
F
S
E
V
A
Site 94
S896
L
R
T
T
G
F
Y
S
G
F
S
E
V
A
E
Site 95
S899
T
G
F
Y
S
G
F
S
E
V
A
E
K
R
I
Site 96
S912
R
I
K
L
L
N
N
S
D
E
R
L
Q
N
S
Site 97
T939
Q
G
Q
W
P
K
K
T
L
K
E
L
F
S
D
Site 98
S945
K
T
L
K
E
L
F
S
D
S
D
T
E
A
A
Site 99
S947
L
K
E
L
F
S
D
S
D
T
E
A
A
A
S
Site 100
T949
E
L
F
S
D
S
D
T
E
A
A
A
S
P
P
Site 101
S954
S
D
T
E
A
A
A
S
P
P
H
P
A
P
E
Site 102
T971
V
A
E
E
S
L
Q
T
V
A
E
E
E
S
C
Site 103
S977
Q
T
V
A
E
E
E
S
C
S
P
S
V
E
L
Site 104
S979
V
A
E
E
E
S
C
S
P
S
V
E
L
E
K
Site 105
S981
E
E
E
S
C
S
P
S
V
E
L
E
K
P
P
Site 106
S994
P
P
P
V
N
V
D
S
K
P
I
E
E
K
T
Site 107
T1001
S
K
P
I
E
E
K
T
V
E
V
N
D
R
K
Site 108
S1014
R
K
A
E
F
P
S
S
G
S
N
S
V
L
N
Site 109
S1016
A
E
F
P
S
S
G
S
N
S
V
L
N
T
P
Site 110
S1018
F
P
S
S
G
S
N
S
V
L
N
T
P
P
T
Site 111
T1022
G
S
N
S
V
L
N
T
P
P
T
T
P
E
S
Site 112
T1025
S
V
L
N
T
P
P
T
T
P
E
S
P
S
S
Site 113
T1026
V
L
N
T
P
P
T
T
P
E
S
P
S
S
V
Site 114
S1029
T
P
P
T
T
P
E
S
P
S
S
V
T
V
T
Site 115
S1031
P
T
T
P
E
S
P
S
S
V
T
V
T
E
G
Site 116
S1032
T
T
P
E
S
P
S
S
V
T
V
T
E
G
S
Site 117
T1034
P
E
S
P
S
S
V
T
V
T
E
G
S
R
Q
Site 118
T1036
S
P
S
S
V
T
V
T
E
G
S
R
Q
Q
S
Site 119
S1039
S
V
T
V
T
E
G
S
R
Q
Q
S
S
V
T
Site 120
S1043
T
E
G
S
R
Q
Q
S
S
V
T
V
S
E
P
Site 121
S1044
E
G
S
R
Q
Q
S
S
V
T
V
S
E
P
L
Site 122
T1046
S
R
Q
Q
S
S
V
T
V
S
E
P
L
A
P
Site 123
S1048
Q
Q
S
S
V
T
V
S
E
P
L
A
P
N
Q
Site 124
S1060
P
N
Q
E
E
V
R
S
I
K
S
E
T
D
S
Site 125
S1063
E
E
V
R
S
I
K
S
E
T
D
S
T
I
E
Site 126
S1067
S
I
K
S
E
T
D
S
T
I
E
V
D
S
V
Site 127
T1068
I
K
S
E
T
D
S
T
I
E
V
D
S
V
A
Site 128
S1073
D
S
T
I
E
V
D
S
V
A
G
E
L
Q
D
Site 129
S1083
G
E
L
Q
D
L
Q
S
E
G
N
S
S
P
A
Site 130
S1087
D
L
Q
S
E
G
N
S
S
P
A
G
F
D
A
Site 131
S1088
L
Q
S
E
G
N
S
S
P
A
G
F
D
A
S
Site 132
S1095
S
P
A
G
F
D
A
S
V
S
S
S
S
S
N
Site 133
S1097
A
G
F
D
A
S
V
S
S
S
S
S
N
Q
P
Site 134
S1098
G
F
D
A
S
V
S
S
S
S
S
N
Q
P
E
Site 135
S1099
F
D
A
S
V
S
S
S
S
S
N
Q
P
E
P
Site 136
S1101
A
S
V
S
S
S
S
S
N
Q
P
E
P
E
H
Site 137
T1114
E
H
P
E
K
A
C
T
G
Q
K
R
V
K
D
Site 138
S1129
A
Q
G
G
G
S
S
S
K
K
Q
K
R
S
H
Site 139
T1139
Q
K
R
S
H
K
A
T
V
V
N
N
K
K
K
Site 140
T1150
N
K
K
K
G
K
G
T
N
S
S
D
S
E
E
Site 141
S1152
K
K
G
K
G
T
N
S
S
D
S
E
E
L
S
Site 142
S1153
K
G
K
G
T
N
S
S
D
S
E
E
L
S
A
Site 143
S1155
K
G
T
N
S
S
D
S
E
E
L
S
A
G
E
Site 144
S1159
S
S
D
S
E
E
L
S
A
G
E
S
I
T
K
Site 145
S1163
E
E
L
S
A
G
E
S
I
T
K
S
Q
P
V
Site 146
S1167
A
G
E
S
I
T
K
S
Q
P
V
K
S
V
S
Site 147
S1172
T
K
S
Q
P
V
K
S
V
S
T
G
M
K
S
Site 148
S1174
S
Q
P
V
K
S
V
S
T
G
M
K
S
H
S
Site 149
S1179
S
V
S
T
G
M
K
S
H
S
T
K
S
P
A
Site 150
S1181
S
T
G
M
K
S
H
S
T
K
S
P
A
R
T
Site 151
S1184
M
K
S
H
S
T
K
S
P
A
R
T
Q
S
P
Site 152
T1188
S
T
K
S
P
A
R
T
Q
S
P
G
K
C
G
Site 153
S1190
K
S
P
A
R
T
Q
S
P
G
K
C
G
K
N
Site 154
S1208
D
P
D
L
K
E
P
S
N
R
L
P
K
V
Y
Site 155
Y1215
S
N
R
L
P
K
V
Y
K
W
S
F
Q
M
S
Site 156
S1218
L
P
K
V
Y
K
W
S
F
Q
M
S
D
L
E
Site 157
S1229
S
D
L
E
N
M
T
S
A
E
R
I
T
I
L
Site 158
T1234
M
T
S
A
E
R
I
T
I
L
Q
E
K
L
Q
Site 159
Y1247
L
Q
E
I
R
K
H
Y
L
S
L
K
S
E
V
Site 160
S1249
E
I
R
K
H
Y
L
S
L
K
S
E
V
A
S
Site 161
S1252
K
H
Y
L
S
L
K
S
E
V
A
S
I
D
R
Site 162
S1256
S
L
K
S
E
V
A
S
I
D
R
R
R
K
R
Site 163
S1271
L
K
K
K
E
R
E
S
A
A
T
S
S
S
S
Site 164
T1274
K
E
R
E
S
A
A
T
S
S
S
S
S
S
P
Site 165
S1275
E
R
E
S
A
A
T
S
S
S
S
S
S
P
S
Site 166
S1276
R
E
S
A
A
T
S
S
S
S
S
S
P
S
S
Site 167
S1277
E
S
A
A
T
S
S
S
S
S
S
P
S
S
S
Site 168
S1278
S
A
A
T
S
S
S
S
S
S
P
S
S
S
S
Site 169
S1279
A
A
T
S
S
S
S
S
S
P
S
S
S
S
I
Site 170
S1280
A
T
S
S
S
S
S
S
P
S
S
S
S
I
T
Site 171
S1282
S
S
S
S
S
S
P
S
S
S
S
I
T
A
A
Site 172
S1283
S
S
S
S
S
P
S
S
S
S
I
T
A
A
V
Site 173
S1284
S
S
S
S
P
S
S
S
S
I
T
A
A
V
M
Site 174
S1298
M
L
T
L
A
E
P
S
M
S
S
A
S
Q
N
Site 175
S1300
T
L
A
E
P
S
M
S
S
A
S
Q
N
G
M
Site 176
S1301
L
A
E
P
S
M
S
S
A
S
Q
N
G
M
S
Site 177
S1303
E
P
S
M
S
S
A
S
Q
N
G
M
S
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation