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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FILIP1L
Full Name:
Filamin A-interacting protein 1-like
Alias:
130 kDa GPBP-interacting protein; 90 kDa GPBP-interacting protein; DOC1; DOC-1; Downregulated in ovarian cancer 1; FIL1L; Filamin A interacting 1-like; Filamin A interacting protein 1-like; GIP90; GPBP-interacting 90; Protein down-regulated in ovarian cancer 1
Type:
Unknown function
Mass (Da):
130382
Number AA:
1135
UniProt ID:
Q4L180
International Prot ID:
IPI00297578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016459
GO:0032991
GO:0043234
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
R
S
R
G
S
D
T
E
G
S
A
Q
Site 2
S11
R
G
S
D
T
E
G
S
A
Q
K
K
F
P
R
Site 3
T20
Q
K
K
F
P
R
H
T
K
G
H
S
F
Q
G
Site 4
S24
P
R
H
T
K
G
H
S
F
Q
G
P
K
N
M
Site 5
S40
H
R
Q
Q
D
K
D
S
P
S
E
S
D
V
I
Site 6
S42
Q
Q
D
K
D
S
P
S
E
S
D
V
I
L
P
Site 7
S44
D
K
D
S
P
S
E
S
D
V
I
L
P
C
P
Site 8
S58
P
K
A
E
K
P
H
S
G
N
G
H
Q
A
E
Site 9
S68
G
H
Q
A
E
D
L
S
R
D
D
L
L
F
L
Site 10
T111
E
A
Q
Y
G
F
V
T
P
K
K
V
L
E
A
Site 11
S128
R
D
A
F
Q
A
K
S
T
P
W
Q
E
D
I
Site 12
T129
D
A
F
Q
A
K
S
T
P
W
Q
E
D
I
Y
Site 13
Y136
T
P
W
Q
E
D
I
Y
E
K
P
M
N
E
L
Site 14
S153
V
V
E
K
H
K
E
S
Y
R
R
I
L
G
Q
Site 15
Y154
V
E
K
H
K
E
S
Y
R
R
I
L
G
Q
L
Site 16
S167
Q
L
L
V
A
E
K
S
R
R
Q
T
I
L
E
Site 17
T171
A
E
K
S
R
R
Q
T
I
L
E
L
E
E
E
Site 18
Y185
E
K
R
K
H
K
E
Y
M
E
K
S
D
E
F
Site 19
S213
L
I
D
Q
E
I
K
S
Q
E
E
K
E
Q
E
Site 20
T226
Q
E
K
E
K
R
V
T
T
L
K
E
E
L
T
Site 21
T227
E
K
E
K
R
V
T
T
L
K
E
E
L
T
K
Site 22
T233
T
T
L
K
E
E
L
T
K
L
K
S
F
A
L
Site 23
T250
V
D
E
Q
Q
R
L
T
A
Q
L
T
L
Q
R
Site 24
T254
Q
R
L
T
A
Q
L
T
L
Q
R
Q
K
I
Q
Site 25
T308
K
F
H
Q
D
Q
D
T
I
M
A
K
L
T
N
Site 26
T314
D
T
I
M
A
K
L
T
N
E
D
S
Q
N
R
Site 27
S318
A
K
L
T
N
E
D
S
Q
N
R
Q
L
Q
Q
Site 28
T340
Q
I
D
E
L
E
E
T
N
R
S
L
R
K
A
Site 29
S343
E
L
E
E
T
N
R
S
L
R
K
A
E
E
E
Site 30
Y363
E
K
I
S
K
G
E
Y
G
N
A
G
I
M
A
Site 31
T407
N
K
R
L
E
R
E
T
L
Q
S
K
D
F
K
Site 32
S410
L
E
R
E
T
L
Q
S
K
D
F
K
L
E
V
Site 33
S421
K
L
E
V
E
K
L
S
K
R
I
M
A
L
E
Site 34
S443
K
S
K
Q
E
C
Y
S
L
K
C
N
L
E
K
Site 35
T454
N
L
E
K
E
R
M
T
T
K
Q
L
S
Q
E
Site 36
T455
L
E
K
E
R
M
T
T
K
Q
L
S
Q
E
L
Site 37
S459
R
M
T
T
K
Q
L
S
Q
E
L
E
S
L
K
Site 38
S477
K
E
L
E
A
I
E
S
R
L
E
K
T
E
F
Site 39
T485
R
L
E
K
T
E
F
T
L
K
E
D
L
T
K
Site 40
T495
E
D
L
T
K
L
K
T
L
T
V
M
F
V
D
Site 41
T506
M
F
V
D
E
R
K
T
M
S
E
K
L
K
K
Site 42
S523
D
K
L
Q
A
A
S
S
Q
L
Q
V
E
Q
N
Site 43
T551
K
R
A
L
K
S
K
T
D
V
E
E
K
M
Y
Site 44
Y558
T
D
V
E
E
K
M
Y
S
V
T
K
E
R
D
Site 45
S559
D
V
E
E
K
M
Y
S
V
T
K
E
R
D
D
Site 46
S583
E
K
G
N
D
L
L
S
R
V
N
M
L
K
N
Site 47
S594
M
L
K
N
R
L
Q
S
L
E
A
I
E
K
D
Site 48
T615
N
Q
D
S
G
K
S
T
T
A
L
H
Q
E
N
Site 49
S629
N
N
K
I
K
E
L
S
Q
E
V
E
R
L
K
Site 50
Y656
L
M
K
T
E
D
E
Y
E
T
L
E
R
R
Y
Site 51
Y663
Y
E
T
L
E
R
R
Y
A
N
E
R
D
K
A
Site 52
Y687
V
K
M
E
L
A
K
Y
K
L
A
E
K
T
E
Site 53
T693
K
Y
K
L
A
E
K
T
E
T
S
H
E
Q
W
Site 54
T695
K
L
A
E
K
T
E
T
S
H
E
Q
W
L
F
Site 55
S712
L
Q
E
E
E
A
K
S
G
H
L
S
R
E
V
Site 56
S716
E
A
K
S
G
H
L
S
R
E
V
D
A
L
K
Site 57
Y729
L
K
E
K
I
H
E
Y
M
A
T
E
D
L
I
Site 58
S744
C
H
L
Q
G
D
H
S
V
L
Q
K
K
L
N
Site 59
T768
G
R
E
I
E
N
L
T
K
E
L
E
R
Y
R
Site 60
Y774
L
T
K
E
L
E
R
Y
R
H
F
S
K
S
L
Site 61
S778
L
E
R
Y
R
H
F
S
K
S
L
R
P
S
L
Site 62
S780
R
Y
R
H
F
S
K
S
L
R
P
S
L
N
G
Site 63
S784
F
S
K
S
L
R
P
S
L
N
G
R
R
I
S
Site 64
S791
S
L
N
G
R
R
I
S
D
P
Q
V
F
S
K
Site 65
Y812
V
D
N
E
P
P
D
Y
K
S
L
I
P
L
E
Site 66
S814
N
E
P
P
D
Y
K
S
L
I
P
L
E
R
A
Site 67
Y828
A
V
I
N
G
Q
L
Y
E
E
S
E
N
Q
D
Site 68
S843
E
D
P
N
D
E
G
S
V
L
S
F
K
C
S
Site 69
S846
N
D
E
G
S
V
L
S
F
K
C
S
Q
S
T
Site 70
S852
L
S
F
K
C
S
Q
S
T
P
C
P
V
N
R
Site 71
T853
S
F
K
C
S
Q
S
T
P
C
P
V
N
R
K
Site 72
S895
Q
P
G
D
L
V
L
S
H
T
P
G
Q
P
L
Site 73
T897
G
D
L
V
L
S
H
T
P
G
Q
P
L
H
I
Site 74
T907
Q
P
L
H
I
K
V
T
P
D
H
V
Q
N
T
Site 75
T916
D
H
V
Q
N
T
A
T
L
E
I
T
S
P
T
Site 76
S921
T
A
T
L
E
I
T
S
P
T
T
E
S
P
H
Site 77
T924
L
E
I
T
S
P
T
T
E
S
P
H
S
Y
T
Site 78
S926
I
T
S
P
T
T
E
S
P
H
S
Y
T
S
T
Site 79
S929
P
T
T
E
S
P
H
S
Y
T
S
T
A
V
I
Site 80
Y930
T
T
E
S
P
H
S
Y
T
S
T
A
V
I
P
Site 81
S932
E
S
P
H
S
Y
T
S
T
A
V
I
P
N
C
Site 82
T933
S
P
H
S
Y
T
S
T
A
V
I
P
N
C
G
Site 83
T947
G
T
P
K
Q
R
I
T
I
L
Q
N
A
S
I
Site 84
T955
I
L
Q
N
A
S
I
T
P
V
K
S
K
T
S
Site 85
S959
A
S
I
T
P
V
K
S
K
T
S
T
E
D
L
Site 86
T963
P
V
K
S
K
T
S
T
E
D
L
M
N
L
E
Site 87
T986
A
T
F
A
R
A
Q
T
P
E
S
C
G
S
L
Site 88
S989
A
R
A
Q
T
P
E
S
C
G
S
L
T
P
E
Site 89
S992
Q
T
P
E
S
C
G
S
L
T
P
E
R
T
M
Site 90
T994
P
E
S
C
G
S
L
T
P
E
R
T
M
S
P
Site 91
T998
G
S
L
T
P
E
R
T
M
S
P
I
Q
V
L
Site 92
S1010
Q
V
L
A
V
T
G
S
A
S
S
P
E
Q
G
Site 93
S1012
L
A
V
T
G
S
A
S
S
P
E
Q
G
R
S
Site 94
S1013
A
V
T
G
S
A
S
S
P
E
Q
G
R
S
P
Site 95
S1019
S
S
P
E
Q
G
R
S
P
E
P
T
E
I
S
Site 96
T1023
Q
G
R
S
P
E
P
T
E
I
S
A
K
H
A
Site 97
S1035
K
H
A
I
F
R
V
S
P
D
R
Q
S
S
W
Site 98
S1040
R
V
S
P
D
R
Q
S
S
W
Q
F
Q
R
S
Site 99
S1041
V
S
P
D
R
Q
S
S
W
Q
F
Q
R
S
N
Site 100
S1047
S
S
W
Q
F
Q
R
S
N
S
N
S
S
S
V
Site 101
S1049
W
Q
F
Q
R
S
N
S
N
S
S
S
V
I
T
Site 102
S1051
F
Q
R
S
N
S
N
S
S
S
V
I
T
T
E
Site 103
S1052
Q
R
S
N
S
N
S
S
S
V
I
T
T
E
D
Site 104
S1053
R
S
N
S
N
S
S
S
V
I
T
T
E
D
N
Site 105
T1056
S
N
S
S
S
V
I
T
T
E
D
N
K
I
H
Site 106
T1057
N
S
S
S
V
I
T
T
E
D
N
K
I
H
I
Site 107
S1076
P
Y
M
Q
A
V
A
S
P
V
R
P
A
S
P
Site 108
S1082
A
S
P
V
R
P
A
S
P
S
A
P
L
Q
D
Site 109
S1084
P
V
R
P
A
S
P
S
A
P
L
Q
D
N
R
Site 110
T1092
A
P
L
Q
D
N
R
T
Q
G
L
I
N
G
A
Site 111
T1103
I
N
G
A
L
N
K
T
T
N
K
V
T
S
S
Site 112
S1110
T
T
N
K
V
T
S
S
I
T
I
T
P
T
A
Site 113
T1116
S
S
I
T
I
T
P
T
A
T
P
L
P
R
Q
Site 114
T1118
I
T
I
T
P
T
A
T
P
L
P
R
Q
S
Q
Site 115
S1124
A
T
P
L
P
R
Q
S
Q
I
T
V
E
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation