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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PREPL
Full Name:
Prolyl endopeptidase-like
Alias:
EC 3.4.21.-; Flj16627; Kiaa0436; Ppcel; Prepl; Prepl protein
Type:
Protease
Mass (Da):
83927
Number AA:
727
UniProt ID:
Q4J6C6
International Prot ID:
IPI00442171
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y38
Y
N
F
A
D
H
C
Y
N
R
I
K
L
K
K
Site 2
Y46
N
R
I
K
L
K
K
Y
H
L
T
K
C
L
Q
Site 3
S67
E
L
A
R
N
I
P
S
R
S
F
S
C
K
D
Site 4
S69
A
R
N
I
P
S
R
S
F
S
C
K
D
L
Q
Site 5
S71
N
I
P
S
R
S
F
S
C
K
D
L
Q
P
V
Site 6
T102
K
V
R
T
K
L
E
T
Q
P
Q
E
E
Y
E
Site 7
S132
E
G
C
C
L
V
R
S
K
D
E
E
A
D
N
Site 8
Y142
E
E
A
D
N
D
N
Y
E
V
L
F
N
L
E
Site 9
Y169
R
V
A
P
D
E
K
Y
V
A
A
K
I
R
T
Site 10
S179
A
K
I
R
T
E
D
S
E
A
S
T
C
V
I
Site 11
S198
D
Q
P
V
M
E
A
S
F
P
N
V
S
S
F
Site 12
S204
A
S
F
P
N
V
S
S
F
E
W
V
K
D
E
Site 13
T220
D
E
D
V
L
F
Y
T
F
Q
R
N
L
R
C
Site 14
Y231
N
L
R
C
H
D
V
Y
R
A
T
F
G
D
N
Site 15
Y245
N
K
R
N
E
R
F
Y
T
E
K
D
P
S
Y
Site 16
T246
K
R
N
E
R
F
Y
T
E
K
D
P
S
Y
F
Site 17
Y252
Y
T
E
K
D
P
S
Y
F
V
F
L
Y
L
T
Site 18
Y257
P
S
Y
F
V
F
L
Y
L
T
K
D
S
R
F
Site 19
T266
T
K
D
S
R
F
L
T
I
N
I
M
N
K
T
Site 20
Y301
K
R
I
H
G
V
L
Y
Y
V
E
H
R
D
D
Site 21
Y302
R
I
H
G
V
L
Y
Y
V
E
H
R
D
D
E
Site 22
Y311
E
H
R
D
D
E
L
Y
I
L
T
N
V
G
E
Site 23
T327
T
E
F
K
L
M
R
T
A
A
D
T
P
A
I
Site 24
T331
L
M
R
T
A
A
D
T
P
A
I
M
N
W
D
Site 25
S383
L
A
D
D
S
V
R
S
L
K
L
P
P
W
A
Site 26
T397
A
C
G
F
I
M
D
T
N
S
D
P
K
N
C
Site 27
S410
N
C
P
F
Q
L
C
S
P
I
R
P
P
K
Y
Site 28
Y417
S
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
Site 29
Y418
P
I
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
Site 30
Y420
R
P
P
K
Y
Y
T
Y
K
F
A
E
G
K
L
Site 31
T438
T
G
H
E
D
P
I
T
K
T
S
R
V
L
R
Site 32
T440
H
E
D
P
I
T
K
T
S
R
V
L
R
L
E
Site 33
S450
V
L
R
L
E
A
K
S
K
D
G
K
L
V
P
Site 34
T459
D
G
K
L
V
P
M
T
V
F
H
K
T
D
S
Site 35
T464
P
M
T
V
F
H
K
T
D
S
E
D
L
Q
K
Site 36
Y479
K
P
L
L
V
H
V
Y
G
A
Y
G
M
D
L
Site 37
Y482
L
V
H
V
Y
G
A
Y
G
M
D
L
K
M
N
Site 38
Y506
D
D
G
W
I
L
A
Y
C
H
V
R
G
G
G
Site 39
T526
W
H
A
D
G
R
L
T
K
K
L
N
G
L
A
Site 40
T541
D
L
E
A
C
I
K
T
L
H
G
Q
G
F
S
Site 41
S548
T
L
H
G
Q
G
F
S
Q
P
S
L
T
T
L
Site 42
S551
G
Q
G
F
S
Q
P
S
L
T
T
L
T
A
F
Site 43
T600
M
D
T
T
L
P
L
T
L
E
E
L
E
E
W
Site 44
S612
E
E
W
G
N
P
S
S
D
E
K
H
K
N
Y
Site 45
Y619
S
D
E
K
H
K
N
Y
I
K
R
Y
C
P
Y
Site 46
Y623
H
K
N
Y
I
K
R
Y
C
P
Y
Q
N
I
K
Site 47
Y626
Y
I
K
R
Y
C
P
Y
Q
N
I
K
P
Q
H
Site 48
Y634
Q
N
I
K
P
Q
H
Y
P
S
I
H
I
T
A
Site 49
Y642
P
S
I
H
I
T
A
Y
E
N
D
E
R
V
P
Site 50
S655
V
P
L
K
G
I
V
S
Y
T
E
K
L
K
E
Site 51
Y675
A
K
D
T
G
E
G
Y
Q
T
P
N
I
I
L
Site 52
T677
D
T
G
E
G
Y
Q
T
P
N
I
I
L
D
I
Site 53
Y707
T
A
Q
I
K
F
L
Y
E
E
L
G
L
D
S
Site 54
S714
Y
E
E
L
G
L
D
S
T
S
V
F
E
D
L
Site 55
T715
E
E
L
G
L
D
S
T
S
V
F
E
D
L
K
Site 56
S716
E
L
G
L
D
S
T
S
V
F
E
D
L
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation