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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MELL1
Full Name:
Membrane metallo-endopeptidase-like 1
Alias:
EC 3.4.24.11; Mel transforming oncogene-like 1; MMEL1; MMEL2; NEPII; NL1; NL2; SEP; Soluble secreted endopeptidase
Type:
Membrane, Extracellular region, Integral membrane protein
Mass (Da):
89367
Number AA:
779
UniProt ID:
Q495T6
International Prot ID:
IPI00044461
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
P
V
G
M
V
E
S
A
G
R
A
G
Q
K
Site 2
S60
K
Q
L
P
R
L
A
S
R
L
C
F
L
Q
E
Site 3
T70
C
F
L
Q
E
E
R
T
F
V
K
R
K
P
R
Site 4
T91
E
V
S
E
V
C
T
T
P
G
C
V
I
A
A
Site 5
T108
I
L
Q
N
M
D
P
T
T
E
P
C
D
D
F
Site 6
T132
R
R
H
V
I
P
E
T
N
S
R
Y
S
I
F
Site 7
S137
P
E
T
N
S
R
Y
S
I
F
D
V
L
R
D
Site 8
T170
P
A
V
E
K
A
R
T
L
Y
R
S
C
M
N
Site 9
Y172
V
E
K
A
R
T
L
Y
R
S
C
M
N
Q
S
Site 10
S174
K
A
R
T
L
Y
R
S
C
M
N
Q
S
V
I
Site 11
S179
Y
R
S
C
M
N
Q
S
V
I
E
K
R
G
S
Site 12
S186
S
V
I
E
K
R
G
S
Q
P
L
L
D
I
L
Site 13
S225
R
Q
L
A
L
M
N
S
Q
F
N
R
R
V
L
Site 14
T255
I
I
Y
I
D
Q
P
T
L
G
M
P
S
R
E
Site 15
Y263
L
G
M
P
S
R
E
Y
Y
F
N
G
G
S
N
Site 16
Y264
G
M
P
S
R
E
Y
Y
F
N
G
G
S
N
R
Site 17
S269
E
Y
Y
F
N
G
G
S
N
R
K
V
R
E
A
Site 18
Y277
N
R
K
V
R
E
A
Y
L
Q
F
M
V
S
V
Site 19
S298
D
A
N
L
P
R
D
S
C
L
V
Q
E
D
M
Site 20
Y332
R
H
D
V
I
A
L
Y
H
R
M
G
L
E
E
Site 21
S342
M
G
L
E
E
L
Q
S
Q
F
G
L
K
G
F
Site 22
Y375
P
D
E
E
V
V
V
Y
G
I
P
Y
L
Q
N
Site 23
Y379
V
V
V
Y
G
I
P
Y
L
Q
N
L
E
N
I
Site 24
T389
N
L
E
N
I
I
D
T
Y
S
A
R
T
I
Q
Site 25
Y390
L
E
N
I
I
D
T
Y
S
A
R
T
I
Q
N
Site 26
S410
L
V
L
D
R
I
G
S
L
S
Q
R
F
K
D
Site 27
S412
L
D
R
I
G
S
L
S
Q
R
F
K
D
T
R
Site 28
Y422
F
K
D
T
R
V
N
Y
R
K
A
L
F
G
T
Site 29
Y442
R
W
R
E
C
V
G
Y
V
N
S
N
M
E
N
Site 30
S453
N
M
E
N
A
V
G
S
L
Y
V
R
E
A
F
Site 31
Y455
E
N
A
V
G
S
L
Y
V
R
E
A
F
P
G
Site 32
S466
A
F
P
G
D
S
K
S
M
V
R
E
L
I
D
Site 33
S493
L
G
W
M
D
E
E
S
K
K
K
A
Q
E
K
Site 34
S503
K
A
Q
E
K
A
M
S
I
R
E
Q
I
G
H
Site 35
Y513
E
Q
I
G
H
P
D
Y
I
L
E
E
M
N
R
Site 36
Y526
N
R
R
L
D
E
E
Y
S
N
L
N
F
S
E
Site 37
S527
R
R
L
D
E
E
Y
S
N
L
N
F
S
E
D
Site 38
Y536
L
N
F
S
E
D
L
Y
F
E
N
S
L
Q
N
Site 39
S540
E
D
L
Y
F
E
N
S
L
Q
N
L
K
V
G
Site 40
S551
L
K
V
G
A
Q
R
S
L
R
K
L
R
E
K
Site 41
S576
A
V
V
N
A
F
Y
S
P
N
R
N
Q
I
V
Site 42
Y688
N
G
G
V
R
Q
A
Y
K
A
Y
L
K
W
M
Site 43
S735
R
P
E
F
A
I
Q
S
I
K
T
D
V
H
S
Site 44
T738
F
A
I
Q
S
I
K
T
D
V
H
S
P
L
K
Site 45
S742
S
I
K
T
D
V
H
S
P
L
K
Y
R
V
L
Site 46
Y746
D
V
H
S
P
L
K
Y
R
V
L
G
S
L
Q
Site 47
T768
T
F
H
C
A
R
G
T
P
M
H
P
K
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation