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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARP14
Full Name:
Poly [ADP-ribose] polymerase 14
Alias:
B aggressive lymphoma protein 2; B-aggressive lymphoma 2; BAL2; EC 2.4.2.30; KIAA1268; PAR14; PARP-14; Poly (ADP-ribose) polymerase 14; Poly (ADP-ribose) polymerase family, member 14
Type:
EC 2.4.2.30; Transcription, coactivator/corepressor; Transferase
Mass (Da):
193753
Number AA:
1720
UniProt ID:
Q460N5
International Prot ID:
IPI00291215
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003950
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
F
P
L
L
V
E
G
S
W
G
P
D
P
P
K
Site 2
Y30
L
N
T
K
L
Q
M
Y
F
Q
S
P
K
R
S
Site 3
S33
K
L
Q
M
Y
F
Q
S
P
K
R
S
G
G
G
Site 4
S37
Y
F
Q
S
P
K
R
S
G
G
G
E
C
E
V
Site 5
S50
E
V
R
Q
D
P
R
S
P
S
R
F
L
V
F
Site 6
S52
R
Q
D
P
R
S
P
S
R
F
L
V
F
F
Y
Site 7
Y59
S
R
F
L
V
F
F
Y
P
E
D
V
R
Q
K
Site 8
T86
G
K
G
T
F
K
L
T
V
Q
L
P
A
T
P
Site 9
T92
L
T
V
Q
L
P
A
T
P
D
E
I
D
H
V
Site 10
T106
V
F
E
E
E
L
L
T
K
E
S
K
T
K
E
Site 11
T120
E
D
V
K
E
P
D
T
I
R
F
V
D
D
C
Site 12
S139
S
I
K
Q
L
Q
L
S
P
R
L
L
E
V
T
Site 13
T146
S
P
R
L
L
E
V
T
N
T
I
R
V
E
N
Site 14
T148
R
L
L
E
V
T
N
T
I
R
V
E
N
L
P
Site 15
Y161
L
P
P
G
A
D
D
Y
S
L
K
L
F
F
E
Site 16
S162
P
P
G
A
D
D
Y
S
L
K
L
F
F
E
N
Site 17
Y182
G
R
V
A
N
V
E
Y
F
P
E
E
S
S
A
Site 18
T201
F
D
R
K
V
L
D
T
I
M
A
T
K
L
D
Site 19
S215
D
F
N
K
M
P
L
S
V
F
P
Y
Y
A
S
Site 20
S244
L
P
A
P
F
E
E
S
L
D
L
P
L
W
K
Site 21
T275
R
R
C
H
C
E
L
T
W
S
Q
L
S
G
K
Site 22
T301
E
G
R
P
R
I
K
T
W
Q
A
D
T
S
T
Site 23
S307
K
T
W
Q
A
D
T
S
T
T
L
S
S
I
R
Site 24
T308
T
W
Q
A
D
T
S
T
T
L
S
S
I
R
S
Site 25
T309
W
Q
A
D
T
S
T
T
L
S
S
I
R
S
K
Site 26
S311
A
D
T
S
T
T
L
S
S
I
R
S
K
Y
K
Site 27
S312
D
T
S
T
T
L
S
S
I
R
S
K
Y
K
V
Site 28
S315
T
T
L
S
S
I
R
S
K
Y
K
V
N
P
I
Site 29
Y317
L
S
S
I
R
S
K
Y
K
V
N
P
I
K
V
Site 30
S363
G
K
S
E
D
V
Q
S
I
E
V
Q
V
R
E
Site 31
S374
Q
V
R
E
L
I
E
S
T
T
Q
K
I
K
R
Site 32
S385
K
I
K
R
E
E
Q
S
L
K
E
K
M
I
I
Site 33
S393
L
K
E
K
M
I
I
S
P
G
R
Y
F
L
L
Site 34
Y420
C
P
E
I
E
I
C
Y
D
R
V
T
Q
H
L
Site 35
Y437
K
G
P
S
A
D
V
Y
K
A
K
C
E
I
Q
Site 36
T449
E
I
Q
E
K
V
Y
T
M
A
Q
K
N
I
Q
Site 37
S458
A
Q
K
N
I
Q
V
S
P
E
I
F
Q
F
L
Site 38
S513
E
A
E
K
Q
M
L
S
A
L
N
Y
K
R
I
Site 39
Y517
Q
M
L
S
A
L
N
Y
K
R
I
E
V
E
N
Site 40
S546
N
L
L
K
K
Q
N
S
S
P
N
T
V
I
I
Site 41
S547
L
L
K
K
Q
N
S
S
P
N
T
V
I
I
N
Site 42
T550
K
Q
N
S
S
P
N
T
V
I
I
N
E
L
T
Site 43
Y604
K
P
S
L
V
I
D
Y
L
K
T
E
K
K
L
Site 44
S624
K
K
V
N
V
Q
V
S
F
N
P
E
N
K
Q
Site 45
Y680
F
Q
D
K
A
R
F
Y
Q
S
E
I
K
R
L
Site 46
Y691
I
K
R
L
F
G
C
Y
I
E
L
Q
E
N
E
Site 47
S705
E
V
M
K
E
G
G
S
P
A
G
Q
K
C
F
Site 48
Y749
S
N
E
D
L
K
H
Y
G
G
L
A
A
A
L
Site 49
S786
L
P
G
N
A
T
I
S
K
A
G
K
L
P
Y
Site 50
Y793
S
K
A
G
K
L
P
Y
H
H
V
I
H
A
V
Site 51
S805
H
A
V
G
P
R
W
S
G
Y
E
A
P
R
C
Site 52
Y807
V
G
P
R
W
S
G
Y
E
A
P
R
C
V
Y
Site 53
Y814
Y
E
A
P
R
C
V
Y
L
L
R
R
A
V
Q
Site 54
Y830
S
L
C
L
A
E
K
Y
K
Y
R
S
I
A
I
Site 55
Y832
C
L
A
E
K
Y
K
Y
R
S
I
A
I
P
A
Site 56
S858
R
C
V
E
T
I
V
S
A
I
K
E
N
F
Q
Site 57
Y877
G
H
C
L
K
E
I
Y
L
V
D
V
S
E
K
Site 58
T904
F
K
A
T
L
P
D
T
A
A
P
P
G
L
P
Site 59
S921
A
A
G
P
G
K
T
S
W
E
K
G
S
L
V
Site 60
S926
K
T
S
W
E
K
G
S
L
V
S
P
G
G
L
Site 61
S929
W
E
K
G
S
L
V
S
P
G
G
L
Q
M
L
Site 62
T947
E
G
V
Q
N
A
K
T
D
V
V
V
N
S
V
Site 63
S966
V
L
S
R
G
P
L
S
K
S
L
L
E
K
A
Site 64
S968
S
R
G
P
L
S
K
S
L
L
E
K
A
G
P
Site 65
T983
E
L
Q
E
E
L
D
T
V
G
Q
G
V
A
V
Site 66
T998
S
M
G
T
V
L
K
T
S
S
W
N
L
D
C
Site 67
S1000
G
T
V
L
K
T
S
S
W
N
L
D
C
R
Y
Site 68
S1020
A
P
E
W
R
N
G
S
T
S
S
L
K
I
M
Site 69
S1022
E
W
R
N
G
S
T
S
S
L
K
I
M
E
D
Site 70
T1038
I
R
E
C
M
E
I
T
E
S
L
S
L
K
S
Site 71
T1082
S
S
K
N
Q
L
K
T
L
Q
E
V
H
F
L
Site 72
S1093
V
H
F
L
L
H
P
S
D
H
E
N
I
Q
A
Site 73
S1115
R
A
N
G
N
L
V
S
D
K
I
P
K
A
K
Site 74
T1124
K
I
P
K
A
K
D
T
Q
G
F
Y
G
T
V
Site 75
Y1128
A
K
D
T
Q
G
F
Y
G
T
V
S
S
P
D
Site 76
T1130
D
T
Q
G
F
Y
G
T
V
S
S
P
D
S
G
Site 77
S1132
Q
G
F
Y
G
T
V
S
S
P
D
S
G
V
Y
Site 78
S1133
G
F
Y
G
T
V
S
S
P
D
S
G
V
Y
E
Site 79
S1136
G
T
V
S
S
P
D
S
G
V
Y
E
M
K
I
Site 80
Y1139
S
S
P
D
S
G
V
Y
E
M
K
I
G
S
I
Site 81
T1156
Q
V
A
S
G
D
I
T
K
E
E
A
D
V
I
Site 82
S1166
E
A
D
V
I
V
N
S
T
S
N
S
F
N
L
Site 83
S1194
Q
N
V
E
R
E
C
S
Q
Q
A
Q
Q
R
K
Site 84
Y1204
A
Q
Q
R
K
N
D
Y
I
I
T
G
G
G
F
Site 85
T1207
R
K
N
D
Y
I
I
T
G
G
G
F
L
R
C
Site 86
S1228
I
G
G
N
D
V
K
S
S
V
S
S
V
L
Q
Site 87
S1229
G
G
N
D
V
K
S
S
V
S
S
V
L
Q
E
Site 88
S1232
D
V
K
S
S
V
S
S
V
L
Q
E
C
E
K
Site 89
Y1242
Q
E
C
E
K
K
N
Y
S
S
I
C
L
P
A
Site 90
S1281
V
Q
K
G
S
A
Q
S
V
K
K
V
K
V
V
Site 91
Y1299
P
Q
V
L
D
V
F
Y
A
N
M
K
K
R
E
Site 92
T1308
N
M
K
K
R
E
G
T
Q
L
S
S
Q
Q
S
Site 93
S1311
K
R
E
G
T
Q
L
S
S
Q
Q
S
V
M
S
Site 94
S1312
R
E
G
T
Q
L
S
S
Q
Q
S
V
M
S
K
Site 95
S1315
T
Q
L
S
S
Q
Q
S
V
M
S
K
L
A
S
Site 96
S1318
S
S
Q
Q
S
V
M
S
K
L
A
S
F
L
G
Site 97
S1330
F
L
G
F
S
K
Q
S
P
Q
K
K
N
H
L
Site 98
S1345
V
L
E
K
K
T
E
S
A
T
F
R
V
C
G
Site 99
T1347
E
K
K
T
E
S
A
T
F
R
V
C
G
E
N
Site 100
Y1376
I
E
K
E
Q
C
P
Y
T
S
E
D
E
C
I
Site 101
T1377
E
K
E
Q
C
P
Y
T
S
E
D
E
C
I
K
Site 102
S1378
K
E
Q
C
P
Y
T
S
E
D
E
C
I
K
D
Site 103
S1406
K
K
L
N
I
N
I
S
L
D
H
K
R
P
L
Site 104
T1485
A
R
R
E
K
K
K
T
V
D
V
K
I
N
H
Site 105
Y1495
V
K
I
N
H
R
H
Y
T
V
N
L
N
T
Y
Site 106
T1507
N
T
Y
T
A
T
D
T
K
G
H
S
L
S
V
Site 107
S1511
A
T
D
T
K
G
H
S
L
S
V
Q
R
L
T
Site 108
S1513
D
T
K
G
H
S
L
S
V
Q
R
L
T
K
S
Site 109
T1518
S
L
S
V
Q
R
L
T
K
S
K
V
D
I
P
Site 110
S1520
S
V
Q
R
L
T
K
S
K
V
D
I
P
A
H
Site 111
Y1548
L
L
P
S
D
P
E
Y
N
T
V
A
S
K
F
Site 112
T1550
P
S
D
P
E
Y
N
T
V
A
S
K
F
N
Q
Site 113
T1603
E
K
Q
L
F
H
G
T
D
A
G
S
V
P
H
Site 114
S1607
F
H
G
T
D
A
G
S
V
P
H
V
N
R
N
Site 115
S1619
N
R
N
G
F
N
R
S
Y
A
G
K
N
A
V
Site 116
Y1620
R
N
G
F
N
R
S
Y
A
G
K
N
A
V
A
Site 117
Y1628
A
G
K
N
A
V
A
Y
G
K
G
T
Y
F
A
Site 118
Y1633
V
A
Y
G
K
G
T
Y
F
A
V
N
A
N
Y
Site 119
T1645
A
N
Y
S
A
N
D
T
Y
S
R
P
D
A
N
Site 120
Y1646
N
Y
S
A
N
D
T
Y
S
R
P
D
A
N
G
Site 121
Y1658
A
N
G
R
K
H
V
Y
Y
V
R
V
L
T
G
Site 122
Y1659
N
G
R
K
H
V
Y
Y
V
R
V
L
T
G
I
Site 123
S1673
I
Y
T
H
G
N
H
S
L
I
V
P
P
S
K
Site 124
S1679
H
S
L
I
V
P
P
S
K
N
P
Q
N
P
T
Site 125
Y1689
P
Q
N
P
T
D
L
Y
D
T
V
T
D
N
V
Site 126
T1691
N
P
T
D
L
Y
D
T
V
T
D
N
V
H
H
Site 127
T1693
T
D
L
Y
D
T
V
T
D
N
V
H
H
P
S
Site 128
Y1706
P
S
L
F
V
A
F
Y
D
Y
Q
A
Y
P
E
Site 129
Y1711
A
F
Y
D
Y
Q
A
Y
P
E
Y
L
I
T
F
Site 130
Y1714
D
Y
Q
A
Y
P
E
Y
L
I
T
F
R
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation