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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KBTBD12
Full Name:
Kelch repeat and BTB domain-containing protein 12
Alias:
Kelch domain-containing protein 6
Type:
Mass (Da):
71096
Number AA:
623
UniProt ID:
Q3ZCT8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
K
I
E
G
K
E
K
Y
Q
H
S
L
N
L
L
Site 2
S14
G
K
E
K
Y
Q
H
S
L
N
L
L
N
K
I
Site 3
Y75
N
Q
R
E
V
I
L
Y
D
I
T
A
E
S
V
Site 4
S149
Q
I
G
A
E
D
L
S
D
R
S
K
K
Y
L
Site 5
Y155
L
S
D
R
S
K
K
Y
L
Y
Q
H
F
A
E
Site 6
Y157
D
R
S
K
K
Y
L
Y
Q
H
F
A
E
V
S
Site 7
S164
Y
Q
H
F
A
E
V
S
L
H
E
E
I
L
E
Site 8
S183
Q
F
L
T
L
I
K
S
D
D
L
N
I
S
R
Site 9
S189
K
S
D
D
L
N
I
S
R
E
E
S
I
L
D
Site 10
S228
R
L
E
L
V
N
P
S
F
L
R
Q
A
L
R
Site 11
T238
R
Q
A
L
R
R
N
T
M
L
L
C
D
A
D
Site 12
T259
N
A
F
K
A
I
K
T
P
Q
Q
H
S
L
N
Site 13
S285
L
C
I
G
N
N
S
S
G
I
R
S
R
H
R
Site 14
S289
N
N
S
S
G
I
R
S
R
H
R
S
Y
G
D
Site 15
S293
G
I
R
S
R
H
R
S
Y
G
D
A
S
F
C
Site 16
Y294
I
R
S
R
H
R
S
Y
G
D
A
S
F
C
Y
Site 17
S298
H
R
S
Y
G
D
A
S
F
C
Y
D
P
V
S
Site 18
Y301
Y
G
D
A
S
F
C
Y
D
P
V
S
R
K
T
Site 19
T308
Y
D
P
V
S
R
K
T
Y
F
I
S
S
P
K
Site 20
Y309
D
P
V
S
R
K
T
Y
F
I
S
S
P
K
Y
Site 21
S312
S
R
K
T
Y
F
I
S
S
P
K
Y
G
E
G
Site 22
S313
R
K
T
Y
F
I
S
S
P
K
Y
G
E
G
L
Site 23
Y316
Y
F
I
S
S
P
K
Y
G
E
G
L
G
T
V
Site 24
S343
V
A
G
E
A
S
A
S
K
L
S
R
Q
K
N
Site 25
Y358
K
N
V
E
I
Y
R
Y
H
D
R
G
N
Q
F
Site 26
Y378
T
A
E
F
R
E
L
Y
A
L
G
S
I
H
N
Site 27
S382
R
E
L
Y
A
L
G
S
I
H
N
D
L
Y
V
Site 28
Y388
G
S
I
H
N
D
L
Y
V
I
G
G
Q
M
K
Site 29
Y409
I
T
N
C
V
D
K
Y
S
V
E
R
D
N
W
Site 30
S420
R
D
N
W
K
R
V
S
P
L
P
L
Q
L
A
Site 31
S459
D
E
E
P
D
R
L
S
N
K
L
L
Q
Y
D
Site 32
Y465
L
S
N
K
L
L
Q
Y
D
P
S
Q
D
Q
W
Site 33
S468
K
L
L
Q
Y
D
P
S
Q
D
Q
W
S
V
R
Site 34
Y480
S
V
R
A
P
M
K
Y
S
K
Y
R
F
S
T
Site 35
S481
V
R
A
P
M
K
Y
S
K
Y
R
F
S
T
A
Site 36
Y483
A
P
M
K
Y
S
K
Y
R
F
S
T
A
V
V
Site 37
S486
K
Y
S
K
Y
R
F
S
T
A
V
V
N
S
E
Site 38
T487
Y
S
K
Y
R
F
S
T
A
V
V
N
S
E
I
Site 39
S492
F
S
T
A
V
V
N
S
E
I
Y
V
L
G
G
Site 40
Y520
C
L
D
V
V
E
I
Y
N
P
D
G
D
F
W
Site 41
S535
R
E
G
P
P
M
P
S
P
L
L
S
L
R
T
Site 42
S539
P
M
P
S
P
L
L
S
L
R
T
N
S
T
N
Site 43
S544
L
L
S
L
R
T
N
S
T
N
A
G
A
V
D
Site 44
S570
A
D
R
H
E
V
I
S
K
E
I
L
E
L
D
Site 45
S614
R
D
L
I
P
P
P
S
D
L
V
E
E
G
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation