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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC88A
Full Name:
Girdin
Alias:
Akt phosphorylation enhancer; Akt-phosphorylation enhancer; APE; Coiled-coil domain containing 88A; Coiled-coil domain-containing protein 88A; FLJ10392; G alpha-interacting vesicle-associated protein; Galpha-interacting vesicle-associated protein; Girders of actin filament; GIV; GRDN; HkRP1; Hook-related protein 1; KIAA1212
Type:
Membrane, Cytoplasm, Cytosol, Cytoplasmic vesicle protein
Mass (Da):
216042
Number AA:
1871
UniProt ID:
Q3V6T2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0016023
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0008017
GO:0035091
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0032148
GO:0016477
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S61
Q
I
N
P
K
L
E
S
Q
R
V
N
K
K
V
Site 2
S73
K
K
V
N
N
D
A
S
L
R
M
H
N
L
S
Site 3
S80
S
L
R
M
H
N
L
S
I
L
V
R
Q
I
K
Site 4
Y89
L
V
R
Q
I
K
F
Y
Y
Q
E
T
L
Q
Q
Site 5
Y90
V
R
Q
I
K
F
Y
Y
Q
E
T
L
Q
Q
L
Site 6
S114
I
I
G
K
N
P
F
S
E
Q
G
T
E
E
V
Site 7
T118
N
P
F
S
E
Q
G
T
E
E
V
K
K
L
L
Site 8
S182
W
M
E
V
T
D
M
S
Q
E
D
I
E
P
L
Site 9
S208
I
D
E
R
D
E
H
S
E
T
I
I
E
L
S
Site 10
T210
E
R
D
E
H
S
E
T
I
I
E
L
S
E
E
Site 11
S215
S
E
T
I
I
E
L
S
E
E
R
D
G
L
H
Site 12
S228
L
H
F
L
P
H
A
S
S
S
A
Q
S
P
C
Site 13
S229
H
F
L
P
H
A
S
S
S
A
Q
S
P
C
G
Site 14
S230
F
L
P
H
A
S
S
S
A
Q
S
P
C
G
S
Site 15
S233
H
A
S
S
S
A
Q
S
P
C
G
S
P
G
M
Site 16
S237
S
A
Q
S
P
C
G
S
P
G
M
K
R
T
E
Site 17
T243
G
S
P
G
M
K
R
T
E
S
R
Q
H
L
S
Site 18
S245
P
G
M
K
R
T
E
S
R
Q
H
L
S
V
E
Site 19
S300
Q
E
N
M
N
L
L
S
D
A
R
S
A
R
M
Site 20
S304
N
L
L
S
D
A
R
S
A
R
M
Y
R
D
E
Site 21
Y308
D
A
R
S
A
R
M
Y
R
D
E
L
D
A
L
Site 22
S330
D
K
L
E
S
E
V
S
R
Y
K
E
R
L
H
Site 23
Y332
L
E
S
E
V
S
R
Y
K
E
R
L
H
D
I
Site 24
Y342
R
L
H
D
I
E
F
Y
K
A
R
V
E
E
L
Site 25
S374
L
E
G
T
R
A
R
S
D
K
L
H
E
L
E
Site 26
T414
E
L
M
E
E
N
M
T
L
E
M
A
Q
K
Q
Site 27
S422
L
E
M
A
Q
K
Q
S
M
D
E
S
L
H
L
Site 28
S426
Q
K
Q
S
M
D
E
S
L
H
L
G
W
E
L
Site 29
S437
G
W
E
L
E
Q
I
S
R
T
S
E
L
S
E
Site 30
S440
L
E
Q
I
S
R
T
S
E
L
S
E
A
P
Q
Site 31
S443
I
S
R
T
S
E
L
S
E
A
P
Q
K
S
L
Site 32
S449
L
S
E
A
P
Q
K
S
L
G
H
E
V
N
E
Site 33
T458
G
H
E
V
N
E
L
T
S
S
R
L
L
K
L
Site 34
S460
E
V
N
E
L
T
S
S
R
L
L
K
L
E
M
Site 35
S471
K
L
E
M
E
N
Q
S
L
T
K
T
V
E
E
Site 36
T475
E
N
Q
S
L
T
K
T
V
E
E
L
R
T
T
Site 37
T481
K
T
V
E
E
L
R
T
T
V
D
S
V
E
G
Site 38
T482
T
V
E
E
L
R
T
T
V
D
S
V
E
G
N
Site 39
S485
E
L
R
T
T
V
D
S
V
E
G
N
A
S
K
Site 40
S491
D
S
V
E
G
N
A
S
K
I
L
K
M
E
K
Site 41
S504
E
K
E
N
Q
R
L
S
K
K
V
E
I
L
E
Site 42
T544
Q
L
E
K
T
I
E
T
L
R
E
N
S
E
R
Site 43
S549
I
E
T
L
R
E
N
S
E
R
Q
I
K
I
L
Site 44
T566
E
N
E
H
L
N
Q
T
V
S
S
L
R
Q
R
Site 45
S568
E
H
L
N
Q
T
V
S
S
L
R
Q
R
S
Q
Site 46
S569
H
L
N
Q
T
V
S
S
L
R
Q
R
S
Q
I
Site 47
S574
V
S
S
L
R
Q
R
S
Q
I
S
A
E
A
R
Site 48
S595
E
N
K
I
L
H
E
S
I
K
E
T
S
S
K
Site 49
T599
L
H
E
S
I
K
E
T
S
S
K
L
S
K
I
Site 50
S600
H
E
S
I
K
E
T
S
S
K
L
S
K
I
E
Site 51
S601
E
S
I
K
E
T
S
S
K
L
S
K
I
E
F
Site 52
S604
K
E
T
S
S
K
L
S
K
I
E
F
E
K
R
Site 53
Y620
I
K
K
E
L
E
H
Y
K
E
K
G
E
R
A
Site 54
S666
E
A
L
E
Q
E
N
S
E
L
E
R
E
N
R
Site 55
T678
E
N
R
K
L
K
K
T
L
D
S
F
K
N
L
Site 56
S681
K
L
K
K
T
L
D
S
F
K
N
L
T
F
Q
Site 57
T686
L
D
S
F
K
N
L
T
F
Q
L
E
S
L
E
Site 58
S697
E
S
L
E
K
E
N
S
Q
L
D
E
E
N
L
Site 59
S712
E
L
R
R
N
V
E
S
L
K
C
A
S
M
K
Site 60
S747
G
L
E
L
L
K
A
S
F
K
K
T
E
R
L
Site 61
T751
L
K
A
S
F
K
K
T
E
R
L
E
V
S
Y
Site 62
S757
K
T
E
R
L
E
V
S
Y
Q
G
L
D
I
E
Site 63
Y758
T
E
R
L
E
V
S
Y
Q
G
L
D
I
E
N
Site 64
T771
E
N
Q
R
L
Q
K
T
L
E
N
S
N
K
K
Site 65
S807
L
E
E
L
K
I
S
S
K
R
L
E
Q
L
E
Site 66
S819
Q
L
E
K
E
N
K
S
L
E
Q
E
T
S
Q
Site 67
S825
K
S
L
E
Q
E
T
S
Q
L
E
K
D
K
K
Site 68
T850
Q
Q
A
E
I
K
D
T
T
L
E
E
N
N
V
Site 69
T851
Q
A
E
I
K
D
T
T
L
E
E
N
N
V
K
Site 70
T868
N
L
E
K
E
N
K
T
L
S
K
E
I
G
I
Site 71
S870
E
K
E
N
K
T
L
S
K
E
I
G
I
Y
K
Site 72
Y876
L
S
K
E
I
G
I
Y
K
E
S
C
V
R
L
Site 73
T903
R
A
T
I
D
I
K
T
L
V
T
L
R
E
D
Site 74
S913
T
L
R
E
D
L
V
S
E
K
L
K
T
Q
Q
Site 75
T918
L
V
S
E
K
L
K
T
Q
Q
M
N
N
D
L
Site 76
S948
R
L
L
H
D
E
Q
S
T
D
D
S
R
Y
K
Site 77
S952
D
E
Q
S
T
D
D
S
R
Y
K
L
L
E
S
Site 78
Y954
Q
S
T
D
D
S
R
Y
K
L
L
E
S
K
L
Site 79
S959
S
R
Y
K
L
L
E
S
K
L
E
S
T
L
K
Site 80
S963
L
L
E
S
K
L
E
S
T
L
K
K
S
L
E
Site 81
T964
L
E
S
K
L
E
S
T
L
K
K
S
L
E
I
Site 82
S968
L
E
S
T
L
K
K
S
L
E
I
K
E
E
K
Site 83
T987
E
A
R
L
E
E
S
T
N
Y
N
Q
Q
L
R
Site 84
Y989
R
L
E
E
S
T
N
Y
N
Q
Q
L
R
Q
E
Site 85
T999
Q
L
R
Q
E
L
K
T
V
K
K
N
Y
E
A
Site 86
S1020
E
E
R
M
V
Q
S
S
P
P
I
S
G
E
D
Site 87
S1024
V
Q
S
S
P
P
I
S
G
E
D
N
K
W
E
Site 88
S1034
D
N
K
W
E
R
E
S
Q
E
T
T
R
E
L
Site 89
T1037
W
E
R
E
S
Q
E
T
T
R
E
L
L
K
V
Site 90
T1090
I
L
A
L
Q
R
Q
T
V
S
L
Q
E
Q
N
Site 91
T1099
S
L
Q
E
Q
N
T
T
L
Q
T
Q
N
A
K
Site 92
S1112
A
K
L
Q
V
E
N
S
T
L
N
S
Q
S
T
Site 93
T1113
K
L
Q
V
E
N
S
T
L
N
S
Q
S
T
S
Site 94
S1116
V
E
N
S
T
L
N
S
Q
S
T
S
L
M
N
Site 95
S1120
T
L
N
S
Q
S
T
S
L
M
N
Q
N
A
Q
Site 96
S1134
Q
L
L
I
Q
Q
S
S
L
E
N
E
N
E
S
Site 97
S1151
K
E
R
E
D
L
K
S
L
Y
D
S
L
I
K
Site 98
Y1153
R
E
D
L
K
S
L
Y
D
S
L
I
K
D
H
Site 99
S1155
D
L
K
S
L
Y
D
S
L
I
K
D
H
E
K
Site 100
S1172
L
L
H
E
R
Q
A
S
E
Y
E
S
L
I
S
Site 101
Y1174
H
E
R
Q
A
S
E
Y
E
S
L
I
S
K
H
Site 102
S1176
R
Q
A
S
E
Y
E
S
L
I
S
K
H
G
T
Site 103
S1179
S
E
Y
E
S
L
I
S
K
H
G
T
L
K
S
Site 104
T1183
S
L
I
S
K
H
G
T
L
K
S
A
H
K
N
Site 105
S1186
S
K
H
G
T
L
K
S
A
H
K
N
L
E
V
Site 106
Y1202
H
R
D
L
E
D
R
Y
N
Q
L
L
K
Q
K
Site 107
T1235
L
E
N
K
N
H
E
T
V
A
A
E
Y
K
K
Site 108
Y1254
N
D
R
L
N
H
T
Y
S
Q
L
L
K
E
T
Site 109
S1255
D
R
L
N
H
T
Y
S
Q
L
L
K
E
T
E
Site 110
T1266
K
E
T
E
V
L
Q
T
D
H
K
N
L
K
S
Site 111
S1273
T
D
H
K
N
L
K
S
L
L
N
N
S
K
L
Site 112
S1290
T
R
L
E
A
E
F
S
K
L
K
E
Q
Y
Q
Site 113
T1302
Q
Y
Q
Q
L
D
I
T
S
T
K
L
N
N
Q
Site 114
S1314
N
N
Q
C
E
L
L
S
Q
L
K
G
N
L
E
Site 115
Y1359
F
H
V
E
Q
R
Q
Y
I
D
K
L
N
E
L
Site 116
Y1381
E
E
K
I
M
D
Q
Y
K
F
Y
D
P
S
P
Site 117
Y1384
I
M
D
Q
Y
K
F
Y
D
P
S
P
P
R
R
Site 118
S1387
Q
Y
K
F
Y
D
P
S
P
P
R
R
R
G
N
Site 119
T1397
R
R
R
G
N
W
I
T
L
K
M
R
K
L
I
Site 120
S1406
K
M
R
K
L
I
K
S
K
K
D
I
N
R
E
Site 121
S1417
I
N
R
E
R
Q
K
S
L
T
L
T
P
T
R
Site 122
T1419
R
E
R
Q
K
S
L
T
L
T
P
T
R
S
D
Site 123
T1421
R
Q
K
S
L
T
L
T
P
T
R
S
D
S
S
Site 124
T1423
K
S
L
T
L
T
P
T
R
S
D
S
S
E
G
Site 125
S1425
L
T
L
T
P
T
R
S
D
S
S
E
G
F
L
Site 126
S1427
L
T
P
T
R
S
D
S
S
E
G
F
L
Q
L
Site 127
S1439
L
Q
L
P
H
Q
D
S
Q
D
S
S
S
V
G
Site 128
S1442
P
H
Q
D
S
Q
D
S
S
S
V
G
S
N
S
Site 129
S1443
H
Q
D
S
Q
D
S
S
S
V
G
S
N
S
L
Site 130
S1444
Q
D
S
Q
D
S
S
S
V
G
S
N
S
L
E
Site 131
S1447
Q
D
S
S
S
V
G
S
N
S
L
E
D
G
Q
Site 132
S1449
S
S
S
V
G
S
N
S
L
E
D
G
Q
T
L
Site 133
T1455
N
S
L
E
D
G
Q
T
L
G
T
K
K
S
S
Site 134
T1458
E
D
G
Q
T
L
G
T
K
K
S
S
M
V
A
Site 135
S1461
Q
T
L
G
T
K
K
S
S
M
V
A
L
K
R
Site 136
S1462
T
L
G
T
K
K
S
S
M
V
A
L
K
R
L
Site 137
Y1486
K
D
K
M
K
A
C
Y
R
R
S
M
S
M
N
Site 138
S1491
A
C
Y
R
R
S
M
S
M
N
D
L
V
Q
S
Site 139
S1508
L
A
G
Q
W
T
G
S
T
E
N
L
E
V
P
Site 140
S1519
L
E
V
P
D
D
I
S
T
G
K
R
R
K
E
Site 141
S1540
S
T
T
A
I
N
F
S
T
V
N
S
S
A
G
Site 142
S1544
I
N
F
S
T
V
N
S
S
A
G
F
R
S
K
Site 143
S1545
N
F
S
T
V
N
S
S
A
G
F
R
S
K
Q
Site 144
T1559
Q
L
V
N
N
K
D
T
T
S
F
E
D
I
S
Site 145
T1560
L
V
N
N
K
D
T
T
S
F
E
D
I
S
P
Site 146
S1561
V
N
N
K
D
T
T
S
F
E
D
I
S
P
Q
Site 147
S1566
T
T
S
F
E
D
I
S
P
Q
G
V
S
D
D
Site 148
S1571
D
I
S
P
Q
G
V
S
D
D
S
S
T
G
S
Site 149
S1574
P
Q
G
V
S
D
D
S
S
T
G
S
R
V
H
Site 150
S1575
Q
G
V
S
D
D
S
S
T
G
S
R
V
H
A
Site 151
T1576
G
V
S
D
D
S
S
T
G
S
R
V
H
A
S
Site 152
S1578
S
D
D
S
S
T
G
S
R
V
H
A
S
R
P
Site 153
S1583
T
G
S
R
V
H
A
S
R
P
A
S
L
D
S
Site 154
S1587
V
H
A
S
R
P
A
S
L
D
S
G
R
T
S
Site 155
S1590
S
R
P
A
S
L
D
S
G
R
T
S
T
S
N
Site 156
T1593
A
S
L
D
S
G
R
T
S
T
S
N
S
N
N
Site 157
S1594
S
L
D
S
G
R
T
S
T
S
N
S
N
N
N
Site 158
T1595
L
D
S
G
R
T
S
T
S
N
S
N
N
N
A
Site 159
S1596
D
S
G
R
T
S
T
S
N
S
N
N
N
A
S
Site 160
S1598
G
R
T
S
T
S
N
S
N
N
N
A
S
L
H
Site 161
S1603
S
N
S
N
N
N
A
S
L
H
E
V
K
A
G
Site 162
S1616
A
G
A
V
N
N
Q
S
R
P
Q
S
H
S
S
Site 163
S1620
N
N
Q
S
R
P
Q
S
H
S
S
G
E
F
S
Site 164
S1622
Q
S
R
P
Q
S
H
S
S
G
E
F
S
L
L
Site 165
S1623
S
R
P
Q
S
H
S
S
G
E
F
S
L
L
H
Site 166
S1627
S
H
S
S
G
E
F
S
L
L
H
D
H
E
A
Site 167
S1636
L
H
D
H
E
A
W
S
S
S
G
S
S
P
I
Site 168
S1637
H
D
H
E
A
W
S
S
S
G
S
S
P
I
Q
Site 169
S1638
D
H
E
A
W
S
S
S
G
S
S
P
I
Q
Y
Site 170
S1640
E
A
W
S
S
S
G
S
S
P
I
Q
Y
L
K
Site 171
S1641
A
W
S
S
S
G
S
S
P
I
Q
Y
L
K
R
Site 172
Y1645
S
G
S
S
P
I
Q
Y
L
K
R
Q
T
R
S
Site 173
T1650
I
Q
Y
L
K
R
Q
T
R
S
S
P
V
L
Q
Site 174
S1652
Y
L
K
R
Q
T
R
S
S
P
V
L
Q
H
K
Site 175
S1653
L
K
R
Q
T
R
S
S
P
V
L
Q
H
K
I
Site 176
S1661
P
V
L
Q
H
K
I
S
E
T
L
E
S
R
H
Site 177
T1663
L
Q
H
K
I
S
E
T
L
E
S
R
H
H
K
Site 178
S1666
K
I
S
E
T
L
E
S
R
H
H
K
I
K
T
Site 179
T1673
S
R
H
H
K
I
K
T
G
S
P
G
S
E
V
Site 180
S1675
H
H
K
I
K
T
G
S
P
G
S
E
V
V
T
Site 181
S1678
I
K
T
G
S
P
G
S
E
V
V
T
L
Q
Q
Site 182
T1682
S
P
G
S
E
V
V
T
L
Q
Q
F
L
E
E
Site 183
S1690
L
Q
Q
F
L
E
E
S
N
K
L
T
S
V
Q
Site 184
T1694
L
E
E
S
N
K
L
T
S
V
Q
I
K
S
S
Site 185
S1695
E
E
S
N
K
L
T
S
V
Q
I
K
S
S
S
Site 186
S1700
L
T
S
V
Q
I
K
S
S
S
Q
E
N
L
L
Site 187
S1701
T
S
V
Q
I
K
S
S
S
Q
E
N
L
L
D
Site 188
S1702
S
V
Q
I
K
S
S
S
Q
E
N
L
L
D
E
Site 189
S1715
D
E
V
M
K
S
L
S
V
S
S
D
F
L
G
Site 190
S1717
V
M
K
S
L
S
V
S
S
D
F
L
G
K
D
Site 191
S1728
L
G
K
D
K
P
V
S
C
G
L
A
R
S
V
Site 192
S1734
V
S
C
G
L
A
R
S
V
S
G
K
T
P
G
Site 193
S1736
C
G
L
A
R
S
V
S
G
K
T
P
G
D
F
Site 194
T1739
A
R
S
V
S
G
K
T
P
G
D
F
Y
D
R
Site 195
Y1744
G
K
T
P
G
D
F
Y
D
R
R
T
T
K
P
Site 196
T1748
G
D
F
Y
D
R
R
T
T
K
P
E
F
L
R
Site 197
T1749
D
F
Y
D
R
R
T
T
K
P
E
F
L
R
P
Site 198
T1761
L
R
P
G
P
R
K
T
E
D
T
Y
F
I
S
Site 199
T1764
G
P
R
K
T
E
D
T
Y
F
I
S
S
A
G
Site 200
Y1765
P
R
K
T
E
D
T
Y
F
I
S
S
A
G
K
Site 201
T1774
I
S
S
A
G
K
P
T
P
G
T
Q
G
K
I
Site 202
T1777
A
G
K
P
T
P
G
T
Q
G
K
I
K
L
V
Site 203
S1787
K
I
K
L
V
K
E
S
S
L
S
R
Q
S
K
Site 204
S1788
I
K
L
V
K
E
S
S
L
S
R
Q
S
K
D
Site 205
S1790
L
V
K
E
S
S
L
S
R
Q
S
K
D
S
N
Site 206
S1793
E
S
S
L
S
R
Q
S
K
D
S
N
P
Y
A
Site 207
S1796
L
S
R
Q
S
K
D
S
N
P
Y
A
T
L
P
Site 208
Y1799
Q
S
K
D
S
N
P
Y
A
T
L
P
R
A
S
Site 209
T1801
K
D
S
N
P
Y
A
T
L
P
R
A
S
S
V
Site 210
S1807
A
T
L
P
R
A
S
S
V
I
S
T
A
E
G
Site 211
S1810
P
R
A
S
S
V
I
S
T
A
E
G
T
T
R
Site 212
T1811
R
A
S
S
V
I
S
T
A
E
G
T
T
R
R
Site 213
T1815
V
I
S
T
A
E
G
T
T
R
R
T
S
I
H
Site 214
T1816
I
S
T
A
E
G
T
T
R
R
T
S
I
H
D
Site 215
T1819
A
E
G
T
T
R
R
T
S
I
H
D
F
L
T
Site 216
S1820
E
G
T
T
R
R
T
S
I
H
D
F
L
T
K
Site 217
T1826
T
S
I
H
D
F
L
T
K
D
S
R
L
P
I
Site 218
S1829
H
D
F
L
T
K
D
S
R
L
P
I
S
V
D
Site 219
S1834
K
D
S
R
L
P
I
S
V
D
S
P
P
A
A
Site 220
S1837
R
L
P
I
S
V
D
S
P
P
A
A
A
D
S
Site 221
S1844
S
P
P
A
A
A
D
S
N
T
T
A
A
S
N
Site 222
T1846
P
A
A
A
D
S
N
T
T
A
A
S
N
V
D
Site 223
S1858
N
V
D
K
V
Q
E
S
R
N
S
K
S
R
S
Site 224
S1861
K
V
Q
E
S
R
N
S
K
S
R
S
R
E
Q
Site 225
S1863
Q
E
S
R
N
S
K
S
R
S
R
E
Q
Q
S
Site 226
S1865
S
R
N
S
K
S
R
S
R
E
Q
Q
S
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation