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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PUS10
Full Name:
Putative tRNA pseudouridine synthase Pus10
Alias:
CCDC139; Coiled-coil domain-containing protein 139; EC=5.4.99.-; TRNA pseudouridine 55 synthase; TRNA pseudouridylate synthase; TRNA-uridine isomerase
Type:
RNA processing, Isomerase
Mass (Da):
60244
Number AA:
529
UniProt ID:
Q3MIT2
International Prot ID:
IPI00065521
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016853
PhosphoSite+
KinaseNET
Biological Process:
GO:0008033
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
G
V
D
F
H
A
P
Y
K
L
P
Y
K
E
L
Site 2
S79
R
L
Q
E
L
E
D
S
I
D
N
L
S
Q
N
Site 3
S84
E
D
S
I
D
N
L
S
Q
N
G
E
G
R
I
Site 4
S92
Q
N
G
E
G
R
I
S
V
S
H
V
G
S
T
Site 5
S94
G
E
G
R
I
S
V
S
H
V
G
S
T
A
S
Site 6
S98
I
S
V
S
H
V
G
S
T
A
S
K
N
S
N
Site 7
T99
S
V
S
H
V
G
S
T
A
S
K
N
S
N
L
Site 8
S101
S
H
V
G
S
T
A
S
K
N
S
N
L
N
V
Site 9
S153
V
S
F
P
P
Q
L
S
V
R
E
H
A
A
W
Site 10
S171
K
Q
E
M
G
K
Q
S
L
S
L
G
R
D
D
Site 11
S173
E
M
G
K
Q
S
L
S
L
G
R
D
D
I
V
Site 12
S242
K
P
A
K
N
K
Q
S
V
F
T
R
M
A
V
Site 13
Y297
V
A
G
R
Y
N
K
Y
S
R
N
L
P
Q
T
Site 14
S298
A
G
R
Y
N
K
Y
S
R
N
L
P
Q
T
P
Site 15
T304
Y
S
R
N
L
P
Q
T
P
W
I
I
D
G
E
Site 16
S316
D
G
E
R
K
L
E
S
S
V
E
E
L
I
S
Site 17
S317
G
E
R
K
L
E
S
S
V
E
E
L
I
S
D
Site 18
S338
K
A
E
S
F
N
F
S
S
S
G
R
E
D
V
Site 19
S339
A
E
S
F
N
F
S
S
S
G
R
E
D
V
D
Site 20
S340
E
S
F
N
F
S
S
S
G
R
E
D
V
D
V
Site 21
T349
R
E
D
V
D
V
R
T
L
G
N
G
R
P
F
Site 22
S370
P
H
R
V
H
F
T
S
Q
E
I
K
E
L
Q
Site 23
T411
K
E
G
E
E
E
K
T
K
T
Y
S
A
L
I
Site 24
T413
G
E
E
E
K
T
K
T
Y
S
A
L
I
W
T
Site 25
T444
D
L
K
I
D
Q
K
T
P
L
R
V
L
H
R
Site 26
T480
H
F
R
L
H
L
K
T
Q
A
G
T
Y
I
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation